CN105395574A - Medicinal and edible compound squalene and fish oil soft capsule for preventing and treating cardiovascular and cerebtovascular disease - Google Patents
Medicinal and edible compound squalene and fish oil soft capsule for preventing and treating cardiovascular and cerebtovascular disease Download PDFInfo
- Publication number
- CN105395574A CN105395574A CN201511017984.5A CN201511017984A CN105395574A CN 105395574 A CN105395574 A CN 105395574A CN 201511017984 A CN201511017984 A CN 201511017984A CN 105395574 A CN105395574 A CN 105395574A
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- China
- Prior art keywords
- fish oil
- capsule
- squalene
- medicine
- soft
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
Abstract
The invention relates to a soft capsule for preventing and treating the cardiovascular and cerebtovascular disease, in particular to a compound squalene and fish oil soft capsule. The medicinal and edible compound squalene and fish oil soft capsule is prepared from a capsule material and effective components, wherein the capsule material is gelatin, and the effective components are prepared by mixing fish oil with squalene according to the mass percent ratio of 3 to 1. The soft capsule has a remarkable effect on preventing and treating the cardiovascular and cerebtovascular disease.
Description
Technical field
The present invention relates to a kind of soft capsule preventing and treating cardiovascular and cerebrovascular disease, especially a kind of compound recipe Squalene fish oil soft capsule.
Background technology
Along with increasing substantially of people's living standard, the intake of people to higher fatty acid meat product constantly increases, greatly surmount desired level, therefore the fat content in blood also constantly raises, bring various cardiovascular and cerebrovascular disease thus, What is more, and cardiovascular and cerebrovascular disease has become the healthy number one killer of harm humans.Existing market also has the medicine for preventing and treating cardiovascular and cerebrovascular disease, but therapeutic effect is poor.
Fish oil is the general designation of the whole oily substances in fish body, it comprises body oil, liver oil and cerebrol, main fish oil is a kind of oils and fats extracted from greasiness Fish, and being rich in ω-3 is polyunsaturated fatty acid (DHA and EPA), has the health benefits such as antiinflammatory, adjusting blood lipid.Sensu lato fish oil had both referred to the fish oil preparation of the forms such as capsule, referred to again the fat in fish body, and main function composition is ω-3 is wherein polyunsaturated fatty acid.
Squalene is a kind of lipid non-saponifiable matter, has following effect:
1, hepatoprotective effect, promotes liver cell regeneration and protects hepatocyte, thus improving liver function.
2, the resistance against diseases of resisting fatigue and enhancing body, improves immune function of human body.
3, protect adrenal cortex function, improve the stress ability of body.
4, antitumor, especially use when carcinectomy surgical site infections or employing chemicotherapy, Be very effective, its maximum feature prevents cancer from shifting to pulmonary.
5, the effect of leukocyte increasing.
In view of this, special proposition the present invention.
Summary of the invention
The technical problem to be solved in the present invention is to overcome the deficiencies in the prior art, provide a kind of can medicine-food two-purpose, for preventing and treating cardiovascular and cerebrovascular disease, and respond well soft capsule.
For solving the problems of the technologies described above, the present invention adopts the basic conception of technical scheme to be: a kind of effective ingredient of medicine-food two-purpose control cardiovascular and cerebrovascular disease, is formed according to mass percent 3:1 proportioning by fish oil and Squalene.
A kind of medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule, be made up of capsule material and effective ingredient, capsule material is gelatin, and effective ingredient is described above, and the clear area of described soft capsule as follows more than 100,000 grades is prepared from:
(1) prepare burden; Take fish oil, Squalene mixing by above proportioning, stir, be evacuated to 0.08MPa;
(2) glue is prepared; In throwing into of the batching glue pot that step (1) is obtained, heat to 70 DEG C ~ 80 DEG C, stir 30min, make it to dissolve uniformly glue, be incubated more than 1 hour, be evacuated to 0.08MPa;
(3) capsule material is prepared; Gelatin is formed rubber under rubber wheel rotates, and rubber enters and rolls mould formation capsule material;
(4) pill; Feed liquid is injected the capsule material for preparing to form soft gelatin capsule;
(5) cleaning and sterilizing soft gelatin capsule; Soft gelatin capsule out after natural drying 24 ~ 48 hours, be the ethanol purge soft gelatin capsule of 95% with concentration of volume percent, then be 75% ethanol disinfection with concentration of volume percent;
(6) dry soft gelatin capsule; By the soft gelatin capsule after cleaning and sterilizing, 22 ~ 26 DEG C, the environment inner drying 2 hours that relative humidity is less than 40%.
Further, in described step (2), gelatin viscosity is 2.8 ~ 3.2 degree.
Further, in described step (2), gel pot is shifted to an earlier date preheating.
Further, in described step (4), feed liquid injects capsule material by charging pump.
Further, described Squalene extracts from plant.
Further, described fish oil is bathypelagic fish oil.
Further, described bathypelagic fish oil is any one bathypelagic fish oil in tunny fish oil, cod fish oil and shark oil or the two or more mixture mixed in any proportion.
After adopting technique scheme, the present invention compared with prior art has following beneficial effect: adopt soft capsule of the present invention, has a significant effect in treatment and prevention treating cardiac and cerebral vascular diseases.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, to help understanding content of the present invention.
Embodiment 1:
A kind of medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule, is prepared from according to the clear area of mass percent 3:1 as follows more than 100,000 grades by fish oil and Squalene:
(1) prepare burden; Take tunny fish oil, Squalene mixing by above proportioning, stir, be evacuated to 0.08MPa;
(2) glue is prepared; The batching that step (1) obtains thrown in the change glue pot of preheating in advance, heat to 70 DEG C ~ 80 DEG C, stir 30min, make it to dissolve uniformly glue, gelatin viscosity is 2.8 degree, is incubated 2 hours, is evacuated to 0.08MPa;
(3) capsule material is prepared; Gelatin is formed rubber under rubber wheel rotates, and rubber enters and rolls mould formation capsule material;
(4) pill; Feed liquid is injected the glue shell for preparing to form soft gelatin capsule;
(5) cleaning and sterilizing soft gelatin capsule; Soft gelatin capsule out after natural drying 24 ~ 48 hours, be the ethanol purge soft gelatin capsule of 95% with concentration of volume percent, then be 75% ethanol disinfection soft gelatin capsule with concentration of volume percent;
(6) dry soft gelatin capsule; By the soft gelatin capsule after cleaning and sterilizing, 22 DEG C, relative humidity is the environment inner drying 2 hours of 30%.
The soft capsule prepared according to the method described in the present embodiment is taken to hyperpietic respectively, age 55-60 one full year of life, 50 people one group; Age 61-65 one full year of life, 50 people one group; Age 66-70 one full year of life, 50 people one group; Every day 3 times, each one, take medicine continuously in this way 2 weeks, the continuous observation 1 month when not taking medicine, finds that the state of an illness of hyperpietic has alleviation in various degree, and wherein the recovery of age 55-60 one full year of life is better, and remission rate reaches 97%; Age 61-65 one full year of life, coefficient of stabilization reaches 94%; Age 66-70 one full year of life, coefficient of stabilization reaches 90%.
Health care medicinal of the present invention is taken to hyperlipemic patients respectively, age 35-40 one full year of life, 50 people one group; Age 41-45 one full year of life, 50 people one group; Age 46-50 one full year of life, 50 people one group; Every day 3 times, each one, take medicine continuously in this way 2 weeks, the continuous observation 1 month when not taking medicine, find that the state of an illness of hyperlipemic patients has reduction in various degree, wherein the recovery of age 35-40 one full year of life is better, reduces and maintain coefficient of stabilization to reach 98%; Age 41-45 one full year of life, reduce and maintain coefficient of stabilization reach 94%; Age 46-50 one full year of life, coefficient of stabilization reaches 91%.
Embodiment 2:
Substantially the same manner as Example 1, be 3.2 degree unlike gelatin viscosity; Fish oil is that tunny fish oil and cod fish oil mix according to 1:1.
In like manner, take the product described in the present embodiment to the hypertensive subject identical with embodiment 1, every day 3 times, each one, take medicine continuously in this way 2 weeks, the continuous observation 1 month when not taking medicine, finds that the state of an illness of hyperpietic has alleviation in various degree, wherein the recovery of age 55-60 one full year of life is better, and remission rate reaches 95%; Age 61-65 one full year of life, coefficient of stabilization reaches 93%; Age 66-70 one full year of life, coefficient of stabilization reaches 90%.
Take the product described in the present embodiment to the hyperlipidemia experimenter identical with embodiment 1, every day 3 times, each one, take medicine continuously in this way 2 weeks, the continuous observation 1 month when not taking medicine, find that the state of an illness of hyperlipemic patients has reduction in various degree, wherein the recovery of age 35-40 one full year of life is better, reduces and maintain coefficient of stabilization to reach 96%; Age 41-45 one full year of life, reduce and maintain coefficient of stabilization reach 92%; Age 46-50 one full year of life, coefficient of stabilization reaches 91%.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (8)
1. a medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule, is characterized in that, comprises by fish oil and the Squalene effective ingredient according to quality 3:1 proportioning.
2. a medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule, it is characterized in that, be made up of capsule material and effective ingredient, capsule material is gelatin, as described in the appended claim 1, the clear area of described soft capsule as follows more than 100,000 grades is prepared from effective ingredient:
(1) prepare burden; Take fish oil, Squalene mixing by above proportioning, stir, be evacuated to 0.08MPa;
(2) glue is prepared; In throwing into of the batching glue pot that step (1) is obtained, heat to 70 DEG C ~ 80 DEG C, stir 30min, make it to dissolve uniformly glue, be incubated more than 1 hour, be evacuated to 0.08MPa;
(3) capsule material is prepared; Gelatin is formed rubber under rubber wheel rotates, and rubber enters and rolls mould formation capsule material;
(4) pill; Feed liquid is injected the capsule material for preparing to form soft gelatin capsule;
(5) cleaning and sterilizing soft gelatin capsule; Soft gelatin capsule out after natural drying 24 ~ 48 hours, be the ethanol purge soft gelatin capsule of 95% with concentration of volume percent, then be 75% ethanol disinfection with concentration of volume percent;
(6) dry soft gelatin capsule; By the soft gelatin capsule after cleaning and sterilizing, 22 ~ 26 DEG C, the environment inner drying 2 hours that relative humidity is less than 40%.
3. a kind of medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule as claimed in claim 1, it is characterized in that, in described step (2), gelatin viscosity is 2.8 ~ 3.2 degree.
4. a kind of medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule as claimed in claim 1, it is characterized in that, in described step (2), gel pot is by preheating in advance.
5. a kind of medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule as claimed in claim 1, it is characterized in that, in described step (4), feed liquid injects capsule material by charging pump.
6. a kind of medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule as claimed in claim 1, it is characterized in that, described Squalene extracts from plant.
7. a kind of medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule as claimed in claim 1, it is characterized in that, described fish oil is bathypelagic fish oil.
8. a kind of medicine-food two-purpose control cardiovascular and cerebrovascular disease compound recipe Squalene fish oil soft capsule as claimed in claim 7, it is characterized in that, described bathypelagic fish oil is any one bathypelagic fish oil in tunny fish oil, cod fish oil and shark oil or the two or more mixture mixed in any proportion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511017984.5A CN105395574A (en) | 2015-12-29 | 2015-12-29 | Medicinal and edible compound squalene and fish oil soft capsule for preventing and treating cardiovascular and cerebtovascular disease |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511017984.5A CN105395574A (en) | 2015-12-29 | 2015-12-29 | Medicinal and edible compound squalene and fish oil soft capsule for preventing and treating cardiovascular and cerebtovascular disease |
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| Publication Number | Publication Date |
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| CN105395574A true CN105395574A (en) | 2016-03-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511017984.5A Pending CN105395574A (en) | 2015-12-29 | 2015-12-29 | Medicinal and edible compound squalene and fish oil soft capsule for preventing and treating cardiovascular and cerebtovascular disease |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692758A (en) * | 2017-01-10 | 2017-05-24 | 威海百合生物技术股份有限公司 | Double-layer medicinal and edible dual-purpose soft capsule capable of protecting liver and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1227109A (en) * | 1998-02-27 | 1999-09-01 | 烟台大学 | Medicine for curing atherosclerosis |
| CN101194913A (en) * | 2006-12-05 | 2008-06-11 | 张金生 | Natural seal oil compression biological preparation for treating hyperlipidemia and technique of preparing the same |
| CN103371984A (en) * | 2012-04-28 | 2013-10-30 | 芜湖中加生物制药股份有限公司 | Seal oil omega-3 polyunsaturated fatty acid capsule |
| CN104000208A (en) * | 2014-05-25 | 2014-08-27 | 宁波市成大机械研究所 | Soft deep sea fish oil capsule containing squalene |
-
2015
- 2015-12-29 CN CN201511017984.5A patent/CN105395574A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1227109A (en) * | 1998-02-27 | 1999-09-01 | 烟台大学 | Medicine for curing atherosclerosis |
| CN101194913A (en) * | 2006-12-05 | 2008-06-11 | 张金生 | Natural seal oil compression biological preparation for treating hyperlipidemia and technique of preparing the same |
| CN103371984A (en) * | 2012-04-28 | 2013-10-30 | 芜湖中加生物制药股份有限公司 | Seal oil omega-3 polyunsaturated fatty acid capsule |
| CN104000208A (en) * | 2014-05-25 | 2014-08-27 | 宁波市成大机械研究所 | Soft deep sea fish oil capsule containing squalene |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692758A (en) * | 2017-01-10 | 2017-05-24 | 威海百合生物技术股份有限公司 | Double-layer medicinal and edible dual-purpose soft capsule capable of protecting liver and preparation method thereof |
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Application publication date: 20160316 |