CN103156940B - A kind of extracting technique of Chinese medicine for garden balsam stem pain-relieving - Google Patents
A kind of extracting technique of Chinese medicine for garden balsam stem pain-relieving Download PDFInfo
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- CN103156940B CN103156940B CN201310015545.5A CN201310015545A CN103156940B CN 103156940 B CN103156940 B CN 103156940B CN 201310015545 A CN201310015545 A CN 201310015545A CN 103156940 B CN103156940 B CN 103156940B
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Abstract
Patent of the present invention forms garden balsam stem pain-relieving side according to a certain percentage with Radix Morindae Officinalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Sarcandrae 4 taste medical material, and clear and definite medical material dosage, reflux by adopting water extract-alcohol precipitation, acidity alcohol solution and after alcohol extraction, go up the Isolation and purification technique of each medical material in the method determination prescriptions such as macroporous adsorbent resin again, after the effective substance mixing obtained, as the principal agent raw material of garden balsam stem pain-relieving side, lay the foundation for preparing determined curative effect, safely controlled, the relevant dosage form of the little garden balsam stem pain-relieving good with compliance of dose.
Description
Technical field
Patent of the present invention belongs to medicine or field of health care products, relates to the content of a kind of formula for garden balsam stem pain-relieving composition and extraction process thereof.
Patent of the present invention to be offered in the institute of auspicious teaching inventive on preparation basis Liu, in conjunction with the pharmacodynamics test that antiinflammatory, analgesia and articular cartilage degeneration combine, the water extract-alcohol precipitation of reasonable, acid alcohol reflux is adopted to extract the method be separated with macroporous adsorbent resin, the active substance obtaining garden balsam stem pain-relieving side is thus basic, and obtained curative effect is more definite, taking dose reduces, quality controllable stable garden balsam stem pain-relieving side content.This content can be used as the medicine material of the dosage form such as capsule, granule, tablet, pill, powder, medicated wine of garden balsam stem pain-relieving side, the little principle of preparation three of " dosage is little, side effect is little, toxicity little " will be met, reach again the object of increase drug level and raising curative effect of medication, obtain the extraction process that formula forms and science is feasible optimized.
Background technology
Garden balsam stem pain-relieving side is as preparation in the institute of attached second the People's Hospital of Fujian University of Traditional Chinese Medicine, and prolonged application is in osteoarthritis (osteoarthritis, OA) clinically, obtains good result.The party is made up of 12 taste medical materials such as Radix Morindae Officinalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong and Herba Sarcandraes at first, by clinical experience and the research of serial pharmaceutical test of Liu Xianxiang professor, determine that the party is Radix Morindae Officinalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong and Herba Sarcandrae, there is effect of Bushenrougan and promoting blood circulation by removing wind.
Osteoarthritis, also known as degenerative osteoarthritis, is due to body aging and degeneration, the disease that the osteoarthrosis surrounding tissue inflammation making the adaptation of Joint mechanics and balance be damaged and cause becomes, and is the modal joint disease of middle-aged and elderly people.It increases gradually along with the growth at people's age, easy recurrent exerbation, show as the arthralgia of slowly development, stiff, enlargement companion limitation of activity, deformity, can secondary synovitis, and cause complication, cause very large financial burden and mental pressure to patient and family thereof, the serious physical and mental health affecting patient.In China, according to Epidemiological study, the OA prevalence of more than 60 years old crowd reaches 50%.Have nearly 2,700 ten thousand OA patients in the U.S., this numeral is compared nineteen ninety-five and is added 6,000,000.Along with the increase of social senilization's population, the sickness rate of OA rises year by year, has become the one of the main reasons of more than 50 years old crowd disability.Have scholar to point out, to the year two thousand twenty, OA causes greatly disabled disease by becoming the 4th.Therefore, treatment and prevention osteoarthritis disease, become medical task great now.
At present, the method of western medical treatment osteoarthritis OA is deepening continuously, the treatments such as antipyretic-antalgic, hormone and immunosuppressant are adopted more to the treatment of osteoarthritis both at home and abroad, but easily produce dependency, hepatorenal damage and toxic and side effects, general clinical symptoms of only alleviating but does not control it at all, and long-term effect is not ideal, and, major part drug price is expensive, and patient compliance is low, causes therapeutic effect to be affected.Compared with the local symptom can only alleviating OA with Western medicine, Chinese medicine OA has important clinical value and realistic meaning at curative effect, the Dominant Facies alleviated in drug side effect, price etc. to doctor trained in Western medicine.The traditional Chinese medical science is thought: after elder kidney asthenia, and medullization source is not enough, and articular cartilage and subchondral bone can not get effective nourishing, thus cause the regression of articular cartilage, cause the generation of osteoarthritis; Or because old, internal organs virtual loss, passages through which vital energy circulates loses supports, and normally can not run QI and blood, cause qi depression to blood stasis, numbness hinders passages through which vital energy circulates and causes kneed pain.
Be core based on osteoarthritis with articular cartilage degeneration, hyperosteogeny is formed as the pathological characteristic of feature, we think that the pathogenesis of osteoarthritis is for this flaccidity mark numbness, kidney governing bones, liver governing tendons, proposing Bushenrougan is osteoarthritis treatment fundamental law (controlling flaccidity), is aided with promoting blood circulation by removing wind (controlling numbness).Medicine effects a permanent cure as monarch drug with the product of Radix Morindae Officinalis the kidney invigorating; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver consolidates as ministerial drug to help; Rhizoma Chuanxiong invigorates blood circulation promoting the circulation of blood, blood wind from going out, and Herba Sarcandrae expelling wind and removing dampness, wind only dispel arthralgia pain, are adjuvant.Therefore, garden balsam stem pain-relieving side's compatibility science that Radix Morindae Officinalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong and Herba Sarcandrae form, has solid guidance of traditional Chinese medicine theory.In addition, garden balsam stem pain-relieving side serves the object for the treatment of both the principal and secondary aspects of a disease, this also just said preparation obtain the reason of curative effect clinically.
Therefore, if the pharmaceutical formulation of this garden balsam stem pain-relieving can be produced by said extracted preparation technology, being prepared into related preparations, after putting goods on the market, by obtaining considerable Social benefit and economic benefit, having a good application prospect.
Summary of the invention
The invention provides a kind of formula for garden balsam stem pain-relieving composition and extraction process thereof.This pharmaceutical formulation consist of Radix Morindae Officinalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong and Herba Sarcandrae 4 taste medicine, to adopt after water extraction alcohol precipitation, acidity alcohol solution backflow and alcohol extraction the methods such as upper macroporous resin to its extraction purification respectively, mixing, obtain the active substance basis of garden balsam stem pain-relieving side, garden balsam stem pain-relieving side's content that obtained curative effect is more definite, taking dose reduces, can be used as the medicine material of the dosage forms such as the capsule of garden balsam stem pain-relieving side, granule, tablet, pill, powder, medicated wine.
A kind of composition of the formula for garden balsam stem pain-relieving of the present invention and extraction process thereof, it is characterized in that: the ampoule of 4 taste medical materials is substantially just Radix Morindae Officinalis 12g, Radix Paeoniae Alba 12g, Rhizoma Chuanxiong 6g, Herba Sarcandrae 6g, according to the difference of patient's card, formula ratio can be added and subtracted as one sees fit, determines that 4 taste medical materials of garden balsam stem pain-relieving formula mainly consist of Radix Morindae Officinalis 5-60g, Radix Paeoniae Alba 5-60g, Rhizoma Chuanxiong 1-36g and Herba Sarcandrae 1-36g.If there are special circumstances, can be quantitative separately.
A kind of composition of the formula for garden balsam stem pain-relieving of the present invention and extraction process thereof, is characterized in that: extraction process shows as carries out Isolation and purification respectively to Radix Morindae Officinalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Sarcandrae, specific as follows: Radix Morindae Officinalis and the Radix Paeoniae Alba merge, with 70% alcohol reflux 2 times, each 2h, filters, merging filtrate, reclaim ethanol to appropriate amount, upper macroporous adsorptive resins, collects 30% ethanol and 70% ethanol elution, merges, reclaim ethanol, obtain concentrate 1; Herba Sarcandrae soak by water 2 times, each 2h, collecting decoction, filters, it is 1.33 (60 DEG C) left and right that filtrate is concentrated into relative density, adds alcohol settling 2 times, and alcohol content is 70% for the first time, and second time alcohol content is 80%, each standing 12 hours, filter, filtrate recycling ethanol, obtained concentrate 2; Rhizoma Chuanxiong 30% ethanol acid adding adjusts pH4 ~ 5, refluxes 2 times, and each 1.5h filters, merging filtrate, reclaims ethanol, obtains concentrate 3.Merge to obtain concentrate 1,2 and 3, mix homogeneously, dry, gained medicated powder is principal agent raw material.Meanwhile, the extract raw material that this 4 taste medical material adopts other extraction process to obtain also is comprised.
A kind of composition of the formula for garden balsam stem pain-relieving of the present invention and extraction process thereof, it is characterized in that: extraction purification obtains principal agent raw material, can be used for the various clinical dosage forms for the preparation of garden balsam stem pain-relieving, as conventional capsule agent, granule, tablet, pill, powder etc. and relevant sustained-release preparation etc., the novel form etc. that may produce with era development after also comprising.
A kind of composition of the formula for garden balsam stem pain-relieving of the present invention and extraction process thereof, it is characterized in that: the preparation related to has garden balsam stem pain-relieving effect, to reach the object of the rheumatic arthralgia such as treatment osteoarthritis, disease of controlling relates generally to osteoarthritis, also other disease of human body can be comprised, as rheumatism immunity class disease etc.
A kind of composition of the formula for garden balsam stem pain-relieving of the present invention and extraction process thereof, it is characterized in that: the formula composition of garden balsam stem pain-relieving, except refer to Radix Morindae Officinalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Sarcandrae 4 taste medical material or 4 taste medical materials extract raw material as except basic composition, also comprise the tcm components formula etc. obtained in the side's of adding formula on this formula basis and extract raw material (as Radix Morindae Officinalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Sarcandrae and Herba Epimedii formula etc.) thereof and this formula or the side's of adding formula.
Below in conjunction with embodiment, patent of the present invention is described further.
Embodiment 1:
Radix Morindae Officinalis 60g Radix Paeoniae Alba 60g Rhizoma Chuanxiong 30g Herba Sarcandrae 30g starch, appropriate amount of ethanol
Radix Morindae Officinalis and the Radix Paeoniae Alba merge, with 70% alcohol reflux 2 times, and each 2h, merging filtrate, reclaim ethanol to appropriate amount, upper macroporous adsorptive resins, collects 30% ethanol and 70% ethanol elution, merges, and reclaims ethanol, obtains concentrate 1; Herba Sarcandrae soak by water 2 times, each 2h, collecting decoction, it is 1.33 (60 DEG C) left and right that filtrate is concentrated into relative density, add alcohol settling 2 times, alcohol content is 70% for the first time, and second time alcohol content is 80%, each standing 12 hours, filter, filtrate recycling ethanol, obtains concentrate 2; Rhizoma Chuanxiong 30% ethanol acid adding adjusts pH4 ~ 5, refluxes 2 times, and each 1.5h filters, merging filtrate, reclaims ethanol, obtains concentrate 3.Merge concentrate 1,2 and 3, add starch in right amount, equivalent is progressively increased after method mixing, and with 70% ethanol soft material, granulate, 60 DEG C of dryings, granulate, obtains Tougu Xiaotong Granule agent.
Embodiment 2:
Radix Morindae Officinalis 60g Radix Paeoniae Alba 48g Rhizoma Chuanxiong 36g Herba Sarcandrae 36g starch is appropriate
Take the extraction process in embodiment 1, extract the extract raw material obtaining Radix Morindae Officinalis, the Radix Paeoniae Alba, Rhizoma Chuanxiong and Herba Sarcandrae respectively, mix homogeneously, adopt the technology of one-step palletizing fluid bed, spray adds 5% starch slurry, the granule of obtained suitable size, be packed into capsule, obtain garden balsam stem pain-relieving capsule.
Claims (2)
1. for an extracting technique of Chinese medicine for garden balsam stem pain-relieving, it is characterized in that: the raw material of described Chinese medicine is Radix Morindae Officinalis 12g, Radix Paeoniae Alba 12g, Rhizoma Chuanxiong 6g, Herba Sarcandrae 6g, and extraction process shows as: Radix Morindae Officinalis and the Radix Paeoniae Alba merge, with 70% alcohol reflux 2 times, each 2h, filters, merging filtrate, reclaim ethanol to appropriate amount, upper macroporous adsorptive resins, collects 30% ethanol and 70% ethanol elution, merges, reclaim ethanol, obtain concentrate 1; Herba Sarcandrae soak by water 2 times, each 2h, collecting decoction, filter, it is 1.33 that filtrate is concentrated into relative density, adds alcohol settling 2 times, and alcohol content is 70% for the first time, and second time alcohol content is 80%, and each standing 12 hours, filter, filtrate recycling ethanol, obtained concentrate 2; Rhizoma Chuanxiong 30% ethanol acid adding adjusts pH4 ~ 5, refluxes 2 times, and each 1.5h filters, merging filtrate, reclaims ethanol, obtains concentrate 3, merge to obtain concentrate 1,2 and 3, mix homogeneously, and drying is for medicated powder and get final product.
2. a kind of extracting technique of Chinese medicine for garden balsam stem pain-relieving according to claim 1, is characterized in that: described garden balsam stem pain-relieving is osteoarthritis.
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| CN201310015545.5A CN103156940B (en) | 2013-01-16 | 2013-01-16 | A kind of extracting technique of Chinese medicine for garden balsam stem pain-relieving |
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| CN102727541A (en) * | 2012-07-17 | 2012-10-17 | 福建中医药大学 | External sarcandra glabra ointment and preparation method thereof |
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2013
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1524528A (en) * | 2003-02-28 | 2004-09-01 | 谢秀琼 | Medicament composition for treating coronary heart disease |
| WO2005012507A1 (en) * | 2003-07-25 | 2005-02-10 | The University Of Melbourne | Production of plant secondary metabolites using adsorption and elicitation in cell suspension culture |
| CN1742762A (en) * | 2005-09-19 | 2006-03-08 | 江西天施康中药股份有限公司 | New use of Zhongjiefeng for treating chronic gastritis and stomach and duodenal ulcer |
| CN102727541A (en) * | 2012-07-17 | 2012-10-17 | 福建中医药大学 | External sarcandra glabra ointment and preparation method thereof |
Non-Patent Citations (3)
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| HPLC测定不同产地和批次巴戟天中主要环烯醚萜苷含量;王玉磊等;《中药材》;20110831;第34卷(第8期);第1187-1190页，尤其是第2.1节 * |
| 大孔树脂纯化白芍总苷的研究;蔡一杰等;《安徽医药》;20090331;第13卷(第3期);第245-246页，尤其是第246页第3部分 * |
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