CN104958429A - Traditional Chinese medicinal composition for treating geriatric fracture and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating geriatric fracture and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention belongs to the technical field of traditional Chinese medicines and relates to a traditional Chinese medicinal composition for treating geriatric fracture and a preparation method thereof. The traditional Chinese medicinal composition for treating the geriatric fracture is prepared from the following raw materials: chickpea sprout extract, astragalus, codonopsis pilosula, safflower, ligusticum wallichii, Chinese angelica, prepared rehmannia root, cucumber seeds, pseudo-ginseng and liquorice. The traditional Chinese medicinal composition for treating the geriatric fracture has obvious treatment advantages of tonifying qi, promoting blood circulation, activating blood circulation to remove blood stasis, rejoining fractured bones, and strengthening tendons and bones in treatment of the geriatric fracture and also has the effects of supporting body resistance, reinforcing qi, nourishing blood, activating blood circulation to remove blood stasis, rejoining fractured bones and alleviating pain.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of senile fracture and preparation method thereof.
Background technology
Fracture, the bone parts that wound or disease are caused or the person that completely do not fracture, see that " medical secrets of official " rolls up 29, has another name called folding bone, injured, traumatics fracture, fracture complicated with infection.Fracture refers to a kind of disease because the reason such as wound or pathology causes bone parts or ruptures completely.Its main clinical manifestation is: fractures has localized pain and tenderness, local swelling and occur ecchymosis, limb function position or completely lose, and completeness sclerotin still can occur cacomelia and abnormal movement.Fracture is common disease clinically, how to cause by under External Force Acting, fracture not only brings pain to patient, also can occur a series of complication in clinical manifestation, as heating paresthesia, and patient because of soft tissue injury widely, bleed profusely, to have an intense pain etc. and the damaging surrounding tissue caused, important blood vessels is damaged, peripheral nerve injury, osteofascial compartment syndrome, traumatic arthritis etc., are common in child and old people.
Old people is due to legs and feet inconvenience, and the reasons such as health is dumb, usually easily fracture, and old people are due to organization healing ability, and often merge systemic disease etc., union of fracture ability is poor, and the time of healing is longer.The Chinese medicine formula being specifically designed to treatment senile fracture is in the market very few, using more is the Chinese medicine of blood circulation promoting and blood stasis dispelling, reunion of fractured tendons and bones, nourishing the liver and kidney, the non-blood of QI invigorating, and old people fails due to body function, hematopoietic potential declines, stasis etc. cause the time of union of fracture longer, therefore, find a kind of benefiting QI and nourishing blood, tonifying QI to promote blood circulation, promotes that the Chinese medicine formula of old people's vim and vigour running is even more important.
Chickpea is enjoyed a very good reputation and medical value widely, has continued to use more than 2500 year in the medical science of Uighur.It contains the nutrition of the abundant needed by human such as phytoprotein, lysine, crude fibre, linoleic acid, vitamin and magnesium, calcium, ferrum being easily absorbed by the body and digesting.There is the effects such as invigorating the spleen and replenishing QI, warming the kidney to invigorate YANG, nourishing the lung to arrest cough, building body, memory reinforcing, treatment diabetes and pneumonopathy.Especially original curative effect is had to chest pain, pleuritic treatment, and have removing toxic substances, antiinflammatory, skin care, antidotal effect, be the food of the edible for a long time a kind of high protein of applicable hyperglycemia, diabetics and middle-aged and elderly people, low starch, pure natural, be described as " king in the flower of nutrition, bean ".
Chickpea is more and more taken seriously at the medical value of medical domain, in order to improve chickpea value-added content of product further, Xinjiang physics and chemistry institute scientific research personnel by with foreign expert cooperation, the chemical analysis of chickpea is analyzed and researched.Result of study proves, full bean or the pars fibrosa composition of chickpea are well suited for manufacturing low-glycemic index food, and are expected to be developed into the chickpea medical product with function of polysaccharide.The also olecranon Semen Glycines powder function of polysaccharide zoopery with Shanghai new drug innovation center cooperation development of Xinjiang physics and chemistry institute plant resources chemical laboratory.Result shows, chickpea raises alloxan induced mice blood glucose certain blood sugar reducing function, and does not have bibliographical information chickpea and extract thereof the purposes in fracture so far.
Chinese invention patent 201210325056.5 discloses a kind of medicine for the treatment of fracture, this medicine comprises the raw material of following parts by weight: Radix Angelicae Sinensis 2-20 part, Herba Epimedii 2-20 part, Colla cornus cervi 2-20 part, Pheretima 2-20 part, Radix Dipsaci 10-30 part, Rhizoma Drynariae 2-20 part, Pyritum (calcined) 1-10 part, Ophisaurus 2-20 part, catechu 2-20 part, Eupolyphaga Seu Steleophaga 1-11 part, Os Draconis 5-25 part and Semen Coicis 5-25 part, the medicine of this invention plays certain curative effect in treatment fracture, but is not very good for treatment senile fracture aspect effect.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of senile fracture, and the effective vigorate qi and replenish the blood of this Chinese medicine composition energy, blood circulation promoting and blood stasis dispelling, promotes the vim and vigour running of old people.In addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use finished product preparation under the prerequisite ensureing curative effect by this Chinese medicine.
In order to solve this technical problem, inventor is while composition of prescription, the feature of fully take into account modern pharmaceutical process lot, producing fast, by the checking repeatedly of clinical practice, the amount of adjustment medical material and kind, the Chinese medicine composition that final invention one is brand-new and its preparation technology, perfectly solve above-mentioned technical problem.This Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 5-30 part, Radix Astragali 6-15 part, Radix Codonopsis 9-30 part, Flos Carthami 3-9 part, Rhizoma Chuanxiong 3-9 part, Radix Angelicae Sinensis 6-12 part, Radix Rehmanniae Preparata 9-15 part, Semen Cucumidis sativi 3-10 part, Radix Notoginseng 3-9 part and Radix Glycyrrhizae 1.5-15 part.
Further, this Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 20 parts, the Radix Astragali 10 parts, Radix Codonopsis 20 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 6 parts, Radix Angelicae Sinensis 9 parts, 12 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 7 parts, Radix Notoginseng 6 parts and 9 parts, Radix Glycyrrhizae.
Further, this Chinese medicine composition also comprises the raw materials of following parts by weight: Olibanum 3-10 part and Myrrha 3-10 part.
Further, this Chinese medicine composition also comprises the raw materials of following parts by weight: Resina Liquidambaris 1.5-5 part.
Further, this Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 20 parts, the Radix Astragali 10 parts, Radix Codonopsis 20 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 6 parts, Radix Angelicae Sinensis 9 parts, 12 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 7 parts, Radix Notoginseng 6 parts, 9 parts, Radix Glycyrrhizae, Olibanum 6 parts, Myrrha 6 parts and Resina Liquidambaris 3 parts.
Further, this Chinese medicine composition is made into instant particles as Chinese medicine, granule, powder, capsule, watered pill or tablet.
Accordingly, the preparation method of Chinese medicine composition of the present invention comprises following step:
S1: prepare chickpea bean sprout extract: germinateed through 3-4 days by chickpea, plucks bean sprout, dries, be ground into coarse powder, adding weight 20 times of concentration is the ethanol water of 70%, is dipped to the heart, is heated to 90 DEG C, reflux, extract, 3 times, each 1.5 hours, filter extracting solution, obtain filtrate; When being 5-20% decompression filtrate recycling ethanol to medicinal liquid containing determining alcohol, through macroporous adsorptive resins absorption 8h, with distilled water and ethanol elution to colourless, at 60 DEG C, concentrating under reduced pressure under-0.1Mpa condition, pulverize, cross 80-100 mesh sieve, obtain chickpea bean sprout extract;
S2: Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Astragali and Radix Codonopsis are extracted through ultrasonic conventional water extraction process, makes extractum fine powder;
S3: Radix Notoginseng, Olibanum, Flos Carthami, Rhizoma Chuanxiong, Myrrha, Resina Liquidambaris, Semen Cucumidis sativi and Radix Glycyrrhizae are ground into fine powder respectively, mixes with above-mentioned chickpea bean sprout extract, extractum fine powder, stirs, obtain Chinese medicine composition of the present invention;
Above-mentioned ultrasonic conventional water extraction process comprises the following steps:
S21: take raw material and soak and spend the night, room temperature supersound extraction 3 times, each 30 minutes;
S22: by the extracting solution sucking filtration of step S21 gained, obtains merging filtrate after filtrate, is eluted to colourless, reclaim under reduced pressure with water and 80% alcoholic solution, dries and obtains crude product;
S23: by the crude product of step S22 gained 95% alcoholic solution ultrasonic dissolution, sucking filtration, is recycled to filtrate decompression dry, obtains extractum fine powder after obtaining filtrate.
Source, the nature and flavor of the present invention's component used, return through and effect:
Flos Carthami
:this product is the flower of feverfew Flos Carthami; Acrid in the mouth, hardship, warm in nature; Return liver, heart spleen channel; Promoting blood circulation to restore menstrual flow, promoting the circulation of QI, stasis-dispelling and pain-killing.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.
Olibanum: this product is the oleo-gum-resin that Burseraceae Boswellia carterii platymiscium low temperature trunk skin zone wound oozes out; Acrid in the mouth, hardship, warm in nature; Enter the heart, liver, spleen channel; Promoting blood circulation and stopping pain.
Myrrha: this product is the oleo-gum-resin that the trunk skin zone of Burseraceae bdellium plant oozes out; Bitter in the mouth, property is put down; Enter Liver Channel; Eliminating stasis to stop pain, externally used detumescence granulation promoting.
Resina Liquidambaris: this product is the resin of Hamamelidaceae Plants sweetgum; Acrid in the mouth, hardship, property is put down; Invigorate blood circulation, removing heat from blood, removing toxic substances, pain relieving.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, pungent, warm in nature; Enrich blood invigorate blood circulation, menstruction regulating and pain relieving.
Radix Rehmanniae Preparata: this product is the Preparation process product of Radix Rehmanniae; Sweet in the mouth, slightly warm in nature; Return liver, kidney channel; Nourishing YIN and supplementing blood, beneficial essence fill out marrow.
Semen Cucumidis sativi: this product is the seed of cucurbitaceous plant Fructus Cucumidis sativi; Sweet in the mouth, cool, nontoxic; Replenish the calcium, synthetism, bone strengthening, to keep fit.
Radix Notoginseng: this product is the rhizome of plant Radix Notoginseng; Sweet and slightly bitter taste, property is put down; Return liver, stomach, large intestine channel; Hemostasis, blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain, strengthening by means of tonics.
The Radix Astragali: this product is the root of the leguminous plant Radix Astragali; Sweet in the mouth, tepor; Return lung, spleen, liver, kidney channel; Invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting.
Radix Codonopsis: this product is the dry root of Campanulaceae Radix Codonopsis; Sweet in the mouth, property is put down; Return spleen, lung meridian; Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is that spirit keeping and blood activating, enriches blood, invigorating the spleen and replenishing QI with the Radix Astragali, Radix Codonopsis, chickpea bean sprout extract for monarch drug; With Radix Angelicae Sinensis, Flos Carthami, Radix Notoginseng, Rhizoma Chuanxiong, Radix Rehmanniae Preparata for ministerial drug, invigorating QI to consolidate the body surface resistance, promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing, with Semen Cucumidis sativi, Olibanum, Myrrha, Resina Liquidambaris for adjuvant drug, removing pathogenic heat from blood and toxic substance from the body, replenishes the calcium and keeps fit, wind-expelling pain-stopping, detumescence and promoting granulation; With Radix Glycyrrhizae for making medicine, coordinating the actions of various ingredients in a prescription, all medicines are arranged in pairs or groups, and synergism, reaches benefiting QI and nourishing blood jointly, blood circulation promoting and blood stasis dispelling, and the effects such as bone-setting pain stopping, tonifying QI to promote blood circulation, promoting blood circulation to remove blood stasis, reunion of bone, bone and muscle strengthening, have very significant therapeutic effect to senile fracture.
In the present invention, the Radix Astragali and Radix Codonopsis all have the effect of invigorating vital QI, and result of use is better together for both; Chickpea bean sprout is rich in folic acid, potassium, magnesium, phosphorus, zinc, copper and vitamin B1, also containing the nicotinic acid of some, vitamin B6, pantothenic acid, calcium and fiber, enriching blood, to replenish the calcium etc. in effect obvious.
Compared with prior art, the present invention has following technical advantage:
1, Chinese medicine composition of the present invention have employed chickpea bean sprout extract, and by the synergism of chickpea bean sprout extract and other Chinese medicinal components, in vigorate qi and replenish the blood and replenishing the calcium is kept fit, effect is better;
2, Chinese medicine composition of the present invention has good effect in treatment fracture, and healing time waits soon and treats advantage significantly, especially for senile fracture aspect Be very effective;
3, the Chinese medicine composition of the present invention problem that causes bone fracture healing slow mainly for old people's insufficiency of vital energy and blood, has vigorate qi and replenish the blood, promoting blood circulation and stopping pain, promotes the remarkable result of old people's QI-blood circulation.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
The embodiment of the present invention 1 Chinese medicine composition comprises the raw material of following parts by weight: chickpea bean sprout extract 20 parts, the Radix Astragali 10 parts, Radix Codonopsis 20 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 6 parts, Radix Angelicae Sinensis 9 parts, 12 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 7 parts, Radix Notoginseng 6 parts, 9 parts, Radix Glycyrrhizae, Olibanum 6 parts, Myrrha 6 parts and Resina Liquidambaris 3 parts.
Preparation method is as follows:
S1: prepare chickpea bean sprout extract: germinateed through 3-4 days by chickpea, plucks bean sprout, dries, be ground into coarse powder, adding weight 20 times of concentration is the ethanol water of 70%, is dipped to the heart, is heated to 90 DEG C, reflux, extract, 3 times, each 1.5 hours, filter extracting solution, obtain filtrate; When being 5-20% decompression filtrate recycling ethanol to medicinal liquid containing determining alcohol, through macroporous adsorptive resins absorption 8h, with distilled water and ethanol elution to colourless, at 60 DEG C, concentrating under reduced pressure under-0.1Mpa condition, pulverize, cross 80-100 mesh sieve, obtain chickpea bean sprout extract;
S2: Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Astragali and Radix Codonopsis are extracted through ultrasonic conventional water extraction process, makes extractum fine powder;
S3: Radix Notoginseng, Olibanum, Flos Carthami, Rhizoma Chuanxiong, Myrrha, Resina Liquidambaris, Semen Cucumidis sativi and Radix Glycyrrhizae are ground into fine powder respectively, mixes with above-mentioned chickpea bean sprout extract, extractum fine powder, stirs, obtain Chinese medicine composition of the present invention;
Above-mentioned ultrasonic conventional water extraction process comprises following following steps:
S21: take raw material and soak and spend the night, room temperature supersound extraction 3 times, each 30 minutes;
S22: by the extracting solution sucking filtration of step S21 gained, obtains merging filtrate after filtrate, is eluted to colourless, reclaim under reduced pressure with water and 80% alcoholic solution, dries and obtains crude product;
S23: by the crude product of step S22 gained 95% alcoholic solution ultrasonic dissolution, sucking filtration, is recycled to filtrate decompression dry, obtains extractum fine powder after obtaining filtrate.
embodiment 2:
The embodiment of the present invention 2 Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 5 parts, the Radix Astragali 6 parts, Radix Codonopsis 9 parts, 3 parts, Flos Carthami, Rhizoma Chuanxiong 3 parts, Radix Angelicae Sinensis 6 parts, 9 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 3 parts, Radix Notoginseng 3 parts, 1.5 parts, Radix Glycyrrhizae, Olibanum 3 parts, Myrrha 3 parts and Resina Liquidambaris 1.5 parts.
Preparation method is with embodiment 1.
embodiment 3:
The embodiment of the present invention 3 Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 30 parts, the Radix Astragali 15 parts, Radix Codonopsis 30 parts, 9 parts, Flos Carthami, Rhizoma Chuanxiong 9 parts, Radix Angelicae Sinensis 12 parts, 15 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 10 parts, Radix Notoginseng 9 parts, 15 parts, Radix Glycyrrhizae, Olibanum 10 parts, Myrrha 10 parts and Resina Liquidambaris 5 parts.
Preparation method is with embodiment 1.
embodiment 4:
The embodiment of the present invention 4 Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 25 parts, the Radix Astragali 12 parts, Radix Codonopsis 18 parts, 8 parts, Flos Carthami, Rhizoma Chuanxiong 8 parts, Radix Angelicae Sinensis 10 parts, 11 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 8 parts, Radix Notoginseng 5 parts, 10 parts, Radix Glycyrrhizae, Olibanum 9 parts, Myrrha 9 parts and Resina Liquidambaris 4 parts.
Preparation method is with embodiment 1.
embodiment 5:
The embodiment of the present invention 5 Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 22 parts, the Radix Astragali 11 parts, Radix Codonopsis 22 parts, 5 parts, Flos Carthami, Rhizoma Chuanxiong 7 parts, Radix Angelicae Sinensis 7 parts, 10 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 6 parts, Radix Notoginseng 8 parts, 9 parts, Radix Glycyrrhizae, Olibanum 8 parts, Myrrha 8 parts and Resina Liquidambaris 2 parts.
Preparation method is with embodiment 1.
chinese medicine composition pharmacodynamic study of the present invention
test example one Chinese medicine composition of the present invention is to the clinical observation on the therapeutic effect of fracture clinical volunteers patient
One, data and method
1. physical data: this organizes 130 routine closed fracture clinical volunteers, wherein man 78 example, female 52 example, 52-79 year, 68.5 years old mean age.
2. criterion of therapeutical effect:
2.1 is effective: pain obtains larger alleviation, and fracture site is red, swollen, heat all alleviates;
2.2 is invalid: pain does not have alleviation, and fracture site is red, swollen, heat does not all obtain and obviously alleviates.
3. grouping and Therapeutic Method
Select fracture patient 90 example, be divided into 6 groups at random, often organize 15 people, concrete grouping is as follows with administration:
Radix Lamiophlomidis Rotatae group: oral Radix Lamiophlomidis Rotatae capsule (Gansu Duyiwei Biological Pharmaceutical Co., Ltd, 0.3g*50 grain/bottle), every day 3 times, each 3;
Chinese medicine composition A group: capsule (0.4g*100 grain/bottle) prepared by the administration embodiment of the present invention 1, every day 3 times, each 4;
Chinese medicine composition B group: capsule (0.4g*100 grain/bottle) prepared by the administration embodiment of the present invention 2, every day 3 times, each 4;
Chinese medicine composition C group: capsule (0.4g*100 grain/bottle) prepared by the administration embodiment of the present invention 3, every day 3 times, each 4;
Chinese medicine composition D group: capsule (0.4g*100 grain/bottle) prepared by the administration embodiment of the present invention 4, every day 3 times, each 4;
Chinese medicine composition E group: capsule (0.4g*100 grain/bottle) prepared by the administration embodiment of the present invention 5, every day 3 times, each 4.
The Chinese medicine composition of remarks: embodiment of the present invention 1-5 conveniently technique is closed in capsule shells and obtains capsule described in embodiment 1-5.
4. date processing
Efficiently individual quantity in half a year, recovery from illness number and healing time is recorded after medication.Calculate effective percentage=efficiently individual quantity/case total number of persons × 100%.Applied statistics software SPSS 15.0 carries out each treatment group cure rate and efficient χ
2inspection.If χ
2> χ
2 0.05,1=3.84, with p<0.05, there is significant difference.And to healing time carry out t inspection compare, the results are shown in Table 1.
Two, result of the test
Clinical test results (see table 1) shows:
(1) for the treatment of fracture, compared with Radix Lamiophlomidis Rotatae group, each treatment group is higher in effective percentage, especially best with the curative effect of embodiment 1;
(2) for fracture treatment, the Chinese medicine composition that the present invention has investigated Different Weight number proportioning, to the curative effect of fracture, found that, the Chinese medicinal composition capsules healing time wherein especially provided with the embodiment of the present invention 1 is the shortest.That is when the raw materials of Chinese medicine composition of the present invention comprise chickpea bean sprout extract 20 parts, the Radix Astragali 10 parts, Radix Codonopsis 20 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 6 parts, Radix Angelicae Sinensis 9 parts, 12 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 7 parts, Radix Notoginseng 6 parts, 9 parts, Radix Glycyrrhizae, Olibanum 6 parts, Myrrha 6 parts and Resina Liquidambaris 3 parts time, traditional Chinese medicine composition for treating fracture effect of the present invention is best.
table 1 Chinese medicine composition of the present invention is to the clinical efficacy of fracture patient
Note:
▲compare with Radix Lamiophlomidis Rotatae group, p < 0.05.
test example two Chinese medicine composition of the present invention is on the impact of rabbit fracture model bone density
One, test material
1, instrument: Hitachi 7020 automatic clinical chemistry analyzer, Japanese Hitachi company; Absorptiometry (Piximus bone densito-meter, LUNAR company of the U.S.);
2, experimental animal: White Rabbit, male and female half and half, 1.5-3.0kg, are provided by Zhongshan University center;
3, trial drug: Chinese medicine composition prepared by the embodiment of the present invention 1; Radix Lamiophlomidis Rotatae capsule, Gansu Duyiwei Biological Pharmaceutical Co., Ltd, 0.3g*50 grain/bottle.
Two, test method:
1, animal grouping: get white rabbit 70, be divided into 5 groups at random, often organize 14, be respectively model group (equal-volume distilled water), Radix Lamiophlomidis Rotatae group (1.0 g/kg ﹒ d), Chinese medicine composition low dose group of the present invention (0.3 g/kg ﹒ d), middle dosage group (0.9 g/kg ﹒ d) and high dose group (1.8 g/kg ﹒ d); Chinese medicine composition preparation of the present invention is with embodiment 1.
2, the preparation of animal model: after rabbit adaptability raises a week, after rabbit is anaesthetized according to 1ml/kg dose intravenous with 3% Nembutal sodium solution, both sides forelimb cropping, 75% alcohol disinfecting, is aseptically widely about 3mm with horizontal being drilled to of medical operation dental burr epimere 1/3 intersection in the radius of both sides, go deep into medullary cavity and form bone injury, skin suture, Post operation starts gastric infusion, successive administration next day, within after administration one week to five weeks, get 7 in each group of rabbit, measure indices.
3, bone densitometry: intercepted both sides radius respectively at after administration the 3rd week, the 5th week, its length comprises damage and each normal reach sclerotin up and down, measure bone density with LUNAR company of U.S. Piximus bone densito-meter analyzer, observe union of fracture situation.
three, result of the test
Result of the test (specifically in table 2) shows: give Chinese medicine composition of the present invention continuously after three weeks, the bone density of Radix Lamiophlomidis Rotatae group and low middle high three the dosage groups of Chinese medicine composition of the present invention increases, and has significant difference (p < 0.05) compared with model group.Administration is after five weeks, Radix Lamiophlomidis Rotatae group has pole significant difference (p < 0.01) compared with model group, Chinese medicine composition low dose group of the present invention, middle dosage group and high dose group have significant difference (p < 0.05) compared with model group, and the bone density after five weeks than three weeks after bone density increase, the rising effect of middle high dose group to bone density of Chinese medicine composition of the present invention is suitable with Radix Lamiophlomidis Rotatae group.Result shows that Chinese medicine composition of the present invention has and accelerates bone ore deposit sedimentation rate, improves bone density, promotes the function of fracture site healing.
table 2 Chinese medicine composition of the present invention is on the impact of rabbit fracture model bone density
▲compared with model group, p < 0.05;
▲ ▲compared with model group, p < 0.01.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.
Claims (8)
1. treat the Chinese medicine composition of senile fracture for one kind, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 5-30 part, Radix Astragali 6-15 part, Radix Codonopsis 9-30 part, Flos Carthami 3-9 part, Rhizoma Chuanxiong 3-9 part, Radix Angelicae Sinensis 6-12 part, Radix Rehmanniae Preparata 9-15 part, Semen Cucumidis sativi 3-10 part, Radix Notoginseng 3-9 part and Radix Glycyrrhizae 1.5-15 part.
2. the Chinese medicine composition for the treatment of senile fracture as claimed in claim 1, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 20 parts, the Radix Astragali 10 parts, Radix Codonopsis 20 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 6 parts, Radix Angelicae Sinensis 9 parts, 12 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 7 parts, Radix Notoginseng 6 parts and 9 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of senile fracture as claimed in claim 1, it is characterized in that, described Chinese medicine composition also comprises the raw materials of following parts by weight: Olibanum 3-10 part and Myrrha 3-10 part.
4. the Chinese medicine composition for the treatment of senile fracture as claimed in claim 3, it is characterized in that, described Chinese medicine composition also comprises the raw materials of following parts by weight: Resina Liquidambaris 1.5-5 part.
5. the Chinese medicine composition for the treatment of senile fracture as claimed in claim 4, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: chickpea bean sprout extract 20 parts, the Radix Astragali 10 parts, Radix Codonopsis 20 parts, 6 parts, Flos Carthami, Rhizoma Chuanxiong 6 parts, Radix Angelicae Sinensis 9 parts, 12 parts, Radix Rehmanniae Preparata, Semen Cucumidis sativi 7 parts, Radix Notoginseng 6 parts, 9 parts, Radix Glycyrrhizae, Olibanum 6 parts, Myrrha 6 parts and Resina Liquidambaris 3 parts.
6. the Chinese medicine composition of the treatment senile fracture as described in as arbitrary in claim 1-5, is characterized in that: described Chinese medicine composition is made into instant particles as Chinese medicine, granule, powder, capsule, watered pill or tablet.
7. prepare as arbitrary in claim 1-6 as described in the method for Chinese medicine composition for the treatment of senile fracture, it is characterized in that comprising the steps:
S1: prepare chickpea bean sprout extract: germinateed through 3-4 days by chickpea, plucks bean sprout, dries, be ground into coarse powder, adding weight 20 times of concentration is the ethanol water of 70%, is dipped to the heart, is heated to 90 DEG C, reflux, extract, 3 times, each 1.5 hours, filter extracting solution, obtain filtrate; When being 5-20% decompression filtrate recycling ethanol to medicinal liquid containing determining alcohol, through macroporous adsorptive resins absorption 8h, with distilled water and ethanol elution to colourless, at 60 DEG C, concentrating under reduced pressure under-0.1Mpa condition, pulverize, cross 80-100 mesh sieve, obtain chickpea bean sprout extract;
S2: Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Astragali and Radix Codonopsis are extracted through ultrasonic conventional water extraction process, makes extractum fine powder;
S3: Radix Notoginseng, Olibanum, Flos Carthami, Rhizoma Chuanxiong, Myrrha, Resina Liquidambaris, Semen Cucumidis sativi and Radix Glycyrrhizae are ground into fine powder respectively, mixes with above-mentioned chickpea bean sprout extract, extractum fine powder, stirs, obtain Chinese medicine composition of the present invention.
8. the preparation method of the Chinese medicine composition for the treatment of senile fracture as claimed in claim 7, it is characterized in that, described ultrasonic conventional water extraction process comprises the following steps:
S21: take raw material and soak and spend the night, room temperature supersound extraction 3 times, each 30 minutes;
S22: by the extracting solution sucking filtration of step S21 gained, obtains merging filtrate after filtrate, is eluted to colourless, reclaim under reduced pressure with water and 80% alcoholic solution, dries and obtains crude product;
S23: by the crude product of step S22 gained 95% alcoholic solution ultrasonic dissolution, sucking filtration, is recycled to filtrate decompression dry, obtains extractum fine powder after obtaining filtrate.
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| CN201510469891.XA CN104958429A (en) | 2015-08-04 | 2015-08-04 | Traditional Chinese medicinal composition for treating geriatric fracture and preparation method thereof |
| CN201610338416.3A CN105796739A (en) | 2015-08-04 | 2015-08-04 | Method for preparing traditional Chinese medicinal composition for treating geriatric fracture |
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Cited By (3)
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| CN105434800A (en) * | 2015-12-29 | 2016-03-30 | 青岛华之草医药科技有限公司 | Traditional Chinese medicine composition for treating geriatric fracture |
| CN105434799A (en) * | 2015-12-29 | 2016-03-30 | 青岛华之草医药科技有限公司 | Method for preparing traditional Chinese medicine composition for treating geriatric fracture |
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Application publication date: 20151007 |