CN106692758A - Double-layer medicinal and edible dual-purpose soft capsule capable of protecting liver and preparation method thereof - Google Patents
Double-layer medicinal and edible dual-purpose soft capsule capable of protecting liver and preparation method thereof Download PDFInfo
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- CN106692758A CN106692758A CN201710027594.9A CN201710027594A CN106692758A CN 106692758 A CN106692758 A CN 106692758A CN 201710027594 A CN201710027594 A CN 201710027594A CN 106692758 A CN106692758 A CN 106692758A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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Abstract
The invention relates to a double-layer medicinal and edible dual-purpose soft capsule capable of protecting liver and a preparation method of the double-layer medicinal and edible dual-purpose soft capsule capable of protecting liver, and solves the technical problems in the prior art that a squalene soft capsule is single in component, is higher in cost and is not easy to store. The invention provides the double-layer medicinal and edible dual-purpose soft capsule capable of protecting liver, a squalene soft capsule is arranged on the inner layer, a wheat germ flour capsule is arranged on the outer layer, the double-layer medicinal and edible dual-purpose soft capsule sequentially comprises squalene, the inner-layer soft capsule, wheat germ flour and the outer-layer capsule from inside to outside; and the weight ratio of the squalene to the wheat germ flour is 1:(1-4) at unit dose. A finished product of the capsule is prepared through the steps of preparing a glue solution, preparing the squalene soft capsule, preparing the wheat germ flour, installing the outer-layer capsule, polishing and the like. The double-layer medicinal and edible dual-purpose soft capsule is widely applied to a medicinal and edible dual-purpose healthcare food capable of protecting liver of the human body.
Description
Technical field
The present invention relates to a kind of liver protecting soft capsule and preparation method thereof, and in particular to one kind is with squalene, wheat
Bud powder is double-deck medicine-food two-purpose soft capsule of the liver protecting of primary raw material and preparation method thereof.
Background technology
Liver is the center of human metabolism, the aspect such as biosynthesis, bioconversion, removing toxic substances, immune is played important
Effect.While people's living standard is increased substantially, into human body and the factor of various hepatic injuries is caused with various foods
It is more and more, there are liver pathological changes up to the situation that liver cancer becomes is also more and more, liver pathological changes liver cancer has become harm human body
The primary killers of health.Effective liver protecting health food is increasingly valued by people and welcomes, and market is existing
Liver protection antitumor medicine, curative effect is preferably few, is badly in need of a kind of from the antineoplastic medicine food of liver protecting for repairing liver cell
Dual-purpose health food.
Squalene is a kind of lipid unsaponifiable matter, belongs to open chain triterpene, also known as Squalene.All contain in the liver of various sharks
There is squalene, content is high in deepwater shark liver.Squalene be distributed in plant it is very wide, but content in the markets not high squalene
It is the natural materials extracted from the large-scale shark liver perched in abyssal environment, its structure was established in 1931, its
Unique medical value is constantly subjected to concern extensively and profoundly.Through research, squalene mainly has five kinds of effects：One is that liver protection is made
With promotion liver cell regeneration simultaneously protects liver cell, so as to improve liver function；Two is antifatigue and the disease-resistant energy of enhancing body
Power, improves immune function of human body；Three is protection adrenal cortex function, improves the stress ability of body；Four be it is antitumor, especially
Used during in carcinectomy surgical site infections or using chemicotherapy, effect is significant, be to prevent cancer from turning to lung the characteristics of its is maximum
Move；Five is the effect of increasing leukocyte.In marine fish oils product, squalene is that unique confirmation has preventing and treating function of tumor, and
It is widely used in the medicine of tumour patient, but because of resource scarcity, and turn into the precious medicine food material of comparing.
Wheat embryo is the position that wheat seed breeds new life, and young root and cotyledon are constituted when growing, though only account for grain
The 1%~3% of weight, is a kind of high protein, height rich in proteins,vitamins,minerals and 8 kinds of amino acid needed by human
Vitamin E, low-heat, low fat, the nutriment of low cholesterol, contain vitamin B complex, vitamin D, unrighted acid, nucleic acid, leaf
Sour, n-octacosanol and calcium, iron, zinc, selenium etc. more than 10 plant mineral matters etc., are the supply sources of ideal minor metallic element,
It is " warehouse of natural VE ".The physiologically active efficiency of natural VE is synthesize VE nearly 30 times in wheat embryo, is prevented in vivo
The generation of oxidation lipid, protects cell membrane, suppresses free radical, promotes human metabolism, and anti-aging improves liver function.
Wheat embryo GSH-PX activity rich content, content is up to 98~107mg/100g in having document report wheat embryo, can help
Human body keeps the function of normal immune system, and with antioxidation and integrates detoxication, and its oxidation resistance is than dimension
Raw element E is strong 500 times.《Compendium of Materia Medica》Record：" wheat germ can control palpitation and insomnia, and mental-tranquilization, nourishing the liver gas, antidiarrheal, step-down is good for
Stomach ".
Squalene product in the market is generally the soft gelatin capsules from Japanese import, composition is single, expensive,
Effect is not obvious enough, is not easy to popular popularization, and squalene is made the form of flexible glue in addition, easily by air during storage
Oxidation, effect decay.With the improvement of people ' s living standards with the development of food industry technology, grade flour, tailored flour are increasingly
Popularization, due to flour quality, unfavorable flour storage and reprocessing, major flour can be reduced if wheat germ is mixed into pulverizing process
Factory disposes wheat germ powder as the byproduct wheat bran of Machining Flour, forms the wasting of resources.It is disclosed in the prior art
There is squalene soft capsules health food, the public technology of squalene and wheat sprout compound is had no so far, also without disclosed by angle
The specific formulation of the compounding of MF59 and wheat embryo, considers above-mentioned factor, with squalene and wheat germ powder prescription, is made
A kind of health products of the medicine-food two-purpose with liver protection anti-aging antitumor efficacy of new model are that have good application prospect.
The content of the invention
The purpose of the present invention is exactly in order to overcome the above-mentioned deficiencies of the prior art, there is provided one kind is with squalene, wheat embryo
Powder is double-deck medicine-food two-purpose soft capsule of the liver protecting of primary raw material and preparation method thereof.
The technical proposal for solving the technical problem of the invention is：The present invention provides a kind of liver protecting bilayer medicine food two
With soft capsule, squalene, internal layer soft capsule, wheat germ powder and outer layer capsule are followed successively by from inside to outside；In UD, spiny dogfish
Alkene is 1: 1~4 with the weight ratio of wheat germ powder.
Preferably, in the UD of 500mg, squalene content is 100~300mg, and wheat embryo powder content is 200
~400mg.
Preferably, in the UD of 500mg, squalene content is 125~250mg, and wheat embryo powder content is 250
~375mg.
Preferably, in the UD of 500mg, squalene content is 165mg, and wheat embryo powder content is 335mg.
A kind of preparation method of liver protecting bilayer medicine-food two-purpose soft capsule described in any of the above-described, including following step
Suddenly：
(1) prepare glue
With natural plant gum as major ingredient, by natural plant gum: glycerine: purified water is molten in glue tank is changed with 100: 40: 100 part by weight
Glue, for preparing internal layer soft capsule, by following flow prepare glue.
Take in the purified water of ormal weight, glycerine being placed in glue tank, be well mixed, be heated to temperature for 70 DEG C~80 DEG C, then
The natural plant gum of ormal weight is added, stirring makes natural plant gum all dissolve；Decompression vacuum pumping, vacuum be -0.06Mpa~-
0.08MPa, bubble in glue is extracted out, is preserved at a temperature of 50~60 DEG C, standby.
(2) squalene soft capsules are prepared
Squalene is done into filling liquid, soft capsule is prepared by following scheme：
A) pelleting：Glue prepared by filling liquid and above-mentioned steps (1) is extruded through automatic rotary soft capsule pellet press and is closed
Lattice soft capsule, it is standby.
B) shape：Qualified soft capsule prepared by above-mentioned steps a) is 30%~40% in 18~26 DEG C, relative humidity
Cold air drying 4~6 hours, completes soft capsule sizing, standby.
C) ball is washed：By the edible wine seminal plasma that the soft capsule concentration of volume percent that above-mentioned steps b) completes sizing is 95%
Wash 3~4 times, wash away surface oil, it is standby.
D) capsule and pill is dried；The cleaned soft capsules of above-mentioned steps c) are put in drying pallet, in 18~30 DEG C of temperature, relatively
Dried 24 hours under conditions of humidity 10%~40%, it is standby.
E) ball is selected：Above-mentioned steps d) dried soft capsule is rejected into special-shaped ball, bubble ball, big piller, oil leak ball etc. no
Qualified soft capsule, obtains qualified squalene soft capsules, standby.
(3) wheat germ powder is prepared
Wheat embryo is crushed in 300,000 grades of clean areas, 80 mesh sieves are crossed, wheat germ powder is obtained, it is standby.
(4) outer layer capsule is filled
Qualified soft capsule, the wheat germ powder of step (3) preparation and outer layer capsule prepared by above-mentioned steps (2) adds respectively
Enter in respective hopper, operation capsule filling machine carries out capsule filling according to weight proportion, and the underproof capsule of outward appearance is rejected in time.
(5) polish
By in the populated capsule addition capsule polisher hopper of above-mentioned steps (4), operation capsule polisher carries out capsule
Polishing, rejects the underproof capsule of outward appearance in time, and qualified finished capsule product is obtained.
(6) dispense
Packaging formwork is assembled by packing specification and through the qualified plastic bottle of quality inspection, prepared by above-mentioned steps (5) closed
The finished capsule product of lattice is added in hopper, and the plastic bottle packing of capsule is completed by the operational procedure of packing machine.
Preferably, natural plant gum used by step (1) prepare glue be konjac glucomannan, mannosan glue, carragheen in one kind or
Two kinds or two or more mixtures.
Preferably, natural plant gum is konjac glucomannan.
Preferably, the qualified soft capsule rubber thickness that step (2) prepares that step a) in squalene soft capsules extrudes is
0.85~0.95mm.
Beneficial effects of the present invention：The present invention provides a kind of liver protecting bilayer medicine-food two-purpose soft capsule and its preparation side
Method, has the advantages that：
(1), from traditional wheat processing substandard goods, compared to squalene, aboundresources is with low cost for wheat germ powder；
(2) squalene compounding wheat germ powder, the extremely strong oxidation resistance of reduced glutathione can be abundant in germ flour
Protect active component is not oxidized, effect the does not wane drop of squalene or reduce the drop that declines, the product preparation method can effectively be reduced or prevented
The oxidation deterioration of core functional component, effect decay, product form instant edible, and being capable of long term guarantee quality storage；
(3) after taking squalene and wheat germ powder together, in the open chain triterpene structure of squalene and wheat embryo
Active group collaboration removing toxic substances, free radical is eliminated, with synergistic function, squalene, two kinds of component Synergistics of wheat germ powder,
Liver protecting has a significant effect with antitumor.
Compatibility science of the present invention, Synergistic can promote liver cell regeneration and protect liver cell, improve liver function, together
When used in carcinectomy surgical site infections or chemicotherapy, can prevent cancer to lung shift, effect is significant, storage of guaranteeing the quality.
Brief description of the drawings
Fig. 1 is structural representation of the invention.
Marked in figure：1. squalene, 2. internal layer soft capsule, 3. wheat germ powder, 4. outer layer capsule.
Specific embodiment
The invention will be further described with specific embodiment below in conjunction with the accompanying drawings, to help understanding present disclosure.
The present invention provides a kind of liver protecting bilayer medicine-food two-purpose soft capsule, squalene 1, internal layer is followed successively by from inside to outside soft
Capsule 2, wheat germ powder 3 and outer layer capsule 4；In UD, squalene is 1: 1~4 with the weight ratio of wheat germ powder.
Embodiment 1
A kind of liver protecting bilayer medicine-food two-purpose soft capsule is prepared, is comprised the following steps：
(1) prepare glue
With konjac glucomannan as major ingredient, by konjac glucomannan: glycerine: purified water is molten in glue tank is changed with 100: 40: 100 part by weight
Glue, for preparing internal layer soft capsule, by following flow prepare glue：
Take in the purified water of ormal weight, glycerine being placed in glue tank, be well mixed, be heated to temperature for 75 DEG C, add rule
Quantitative konjac glucomannan, stirring makes konjac glucomannan all dissolve；Decompression vacuum pumping, vacuum is -0.06MPa, and bubble in glue is taken out
Go out, preserved at a temperature of 55~60 DEG C, it is standby.
(2) squalene soft capsules are prepared
Squalene is done into filling liquid, soft capsule is prepared by following scheme：
A) pelleting：Glue prepared by filling liquid and above-mentioned steps (1) is extruded through automatic rotary soft capsule pellet press and is closed
Lattice soft capsule, rubber thickness control is in 0.85~0.95mm, and squalene weight is every 250mg, standby.
B) shape：Qualified soft capsule prepared by above-mentioned steps a) is 30%~35% in 20~25 DEG C, relative humidity
Cold air drying 4 hours, completes soft capsule sizing, standby.
C) ball is washed：By the edible wine seminal plasma that the soft capsule concentration of volume percent that above-mentioned steps b) completes sizing is 95%
Wash 3 times, wash away surface oil, it is standby.
D) capsule and pill is dried；The cleaned soft capsules of above-mentioned steps c) are put in drying pallet, in 20~25 DEG C of temperature, relatively
Dried 24 hours under conditions of humidity 20%~30%, it is standby.
E) ball is selected：Above-mentioned steps d) dried soft capsule is rejected on lamp inspection desk special-shaped ball, bubble ball, big piller,
The underproof soft capsule such as oil leak ball, obtains qualified squalene soft capsules, standby.
(3) wheat germ powder is prepared
Good quality wheat plumule is crushed in 300,000 grades of clean areas, 80 mesh sieves are crossed, wheat germ powder is obtained, it is standby.
(4) outer layer capsule is filled
Qualified soft capsule, the wheat germ powder of step (3) preparation and outer layer capsule prepared by above-mentioned steps (2) adds respectively
Enter in respective hopper, operation capsule filling machine carries out capsule filling according to weight proportion, in the UD of 500mg, spiny dogfish
Alkene is 1: 1 with the weight ratio of wheat germ powder, and the weight of wheat germ powder is every 250mg, during operation capsule filling machine, at any time
Note regulation wheat germ powder and soft capsule hopper discharging situation, be allowed to each actuation cycle and release a soft capsule, quantify
Wheat germ powder, load capsule in, and in time reject the underproof capsule of outward appearance.
(5) polish
By in the populated capsule addition capsule polisher hopper of above-mentioned steps (4), operation capsule polisher carries out capsule
Polishing, rejects the underproof capsule of outward appearance in time, and qualified finished capsule product is obtained.
(6) dispense
Packaging formwork is assembled by packing specification and through the qualified plastic bottle of quality inspection, prepared by above-mentioned steps (5) closed
The finished capsule product of lattice is added in hopper, and the plastic bottle packing of capsule is completed by the operational procedure of packing machine.
The test of pesticide effectiveness：The soft capsule that will be prepared according to the method described in embodiment 1 gives paddy third turn of exceeded (meaning of peace enzyme respectively
Liver has damage) person takes, one full year of life at age 25-35,20 one group of people；One full year of life at age 36-45,20 one group of people；Age 46-55
One full year of life, 20 one group of people；Three times a day, every time oral two before feed, period, without other drugs, takes 2 weeks and detects paddy again
Pyruvic transaminase, the glutamic-pyruvic transaminase index that discovery has hepatic injury person has substantially reduction, and (range of decrease more than 20% is down to reasonable value model
Enclose) up to 86%, the effective percentage of wherein age 25-35 one full year of life reaches 98%；One full year of life at age 36-45, effective percentage reaches 87%；
One full year of life at age 46-55, effective percentage reaches 73%.
Product core functional component attenuation is monitored：Respectively Example 1 semi-finished product squalene soft capsules 200, into
Product capsule 200, in identical health food bottle generally, places indoor under room temperature condition, place 1,3,6 months points
Qu Yangceding not squalene content.Result see the table below one：
Table one：Product core functional component attenuation monitoring result
Be can be seen that from upper table testing result, place 1,3,6 month finished capsule products in squalene content decreasing value well below
The decreasing value of squalene content in semi-finished product soft capsule, illustrates that product structure of the present invention and the wheat germ powder of filling can have
Effect reduces the decay of squalene composition.
Embodiment 2
A kind of liver protecting bilayer medicine-food two-purpose soft capsule is prepared, is comprised the following steps：
(1) prepare glue
With mannosan glue as major ingredient, by mannosan glue: glycerine: purified water is being changed with 100: 40: 100 part by weight
Colloidal sol in glue tank, for preparing internal layer soft capsule, by following flow prepare glue：
Take in the purified water of ormal weight, glycerine being placed in glue tank, be well mixed, be heated to temperature for 75 DEG C, add rule
Quantitative mannosan glue, stirring makes mannosan glue all dissolve；Decompression vacuum pumping, vacuum is -0.07MPa, by glue
Interior bubble is extracted out, is preserved at a temperature of 50~55 DEG C, standby.
(2) squalene soft capsules are prepared
Squalene is done into filling liquid, soft capsule is prepared by following scheme：
A) pelleting：Glue prepared by filling liquid and above-mentioned steps (1) is extruded through automatic rotary soft capsule pellet press and is closed
Lattice soft capsule, rubber thickness control is in 0.85~0.95mm, and squalene weight is every 165mg, standby.
B) shape：Qualified soft capsule prepared by above-mentioned steps a) is 35%~40% in 18~26 DEG C, relative humidity
Cold air drying 5 hours, completes soft capsule sizing, standby.
C) ball is washed：By the edible wine seminal plasma that the soft capsule concentration of volume percent that above-mentioned steps b) completes sizing is 95%
Wash 3 times, wash away surface oil, it is standby.
D) capsule and pill is dried；The cleaned soft capsules of above-mentioned steps c) are put in drying pallet, in 25~30 DEG C of temperature, relatively
Dried 26 hours under conditions of humidity 10%~20%, it is standby.
E) ball is selected：Above-mentioned steps d) dried soft capsule is rejected on lamp inspection desk special-shaped ball, bubble ball, big piller,
The underproof soft capsule such as oil leak ball, obtains qualified squalene soft capsules, standby.
(3) wheat germ powder is prepared
Wheat embryo is crushed in 300,000 grades of clean areas, 80 mesh sieves are crossed, wheat germ powder is obtained, it is standby.
(4) outer layer capsule is filled
Qualified soft capsule, the wheat germ powder of step (3) preparation and outer layer capsule prepared by above-mentioned steps (2) adds respectively
Enter in respective hopper, operation capsule filling machine carries out capsule filling according to weight proportion, in the UD of 500mg, spiny dogfish
The weight ratio about 1: 2 of alkene and wheat germ powder, the weight of wheat germ powder is every 335mg, during operation capsule filling machine, with
When note regulation wheat germ powder and soft capsule hopper discharging situation, be allowed to each actuation cycle and release soft capsule, fixed
The wheat germ powder of amount, loads in capsule, and rejects the underproof capsule of outward appearance in time.
(5) polish
By in the populated capsule addition capsule polisher hopper of above-mentioned steps (4), operation capsule polisher carries out capsule
Polishing, rejects the underproof capsule of outward appearance in time, and qualified finished capsule product is obtained.
(6) dispense
Packaging formwork is assembled by packing specification and through the qualified plastic bottle of quality inspection, prepared by above-mentioned steps (5) closed
The finished capsule product of lattice is added in hopper, and the plastic bottle packing of capsule is completed by the operational procedure of packing machine.
The test of pesticide effectiveness：The soft capsule that will be prepared according to the method described in embodiment 2 gives paddy third turn of exceeded (meaning of peace enzyme respectively
Liver has damage) person takes, one full year of life at age 25-35,20 one group of people；One full year of life at age 36-45,20 one group of people；Age 46-55
One full year of life, 20 one group of people；Three times a day, every time oral two before feed, period, without other drugs, takes 2 weeks and detects paddy again
Pyruvic transaminase, the glutamic-pyruvic transaminase index that discovery has hepatic injury person has substantially reduction, and (range of decrease more than 20% is down to reasonable value model
Enclose) up to 83%, the effective percentage of wherein age 25-35 one full year of life reaches 95%；One full year of life at age 36-45, effective percentage reaches 84%；
One full year of life at age 46-55, effective percentage reaches 70%.
Product core functional component attenuation is monitored：Respectively Example 2 semi-finished product squalene soft capsules 200, into
Product capsule 200, in identical health food bottle generally, places indoor under room temperature condition, place 1,3,6 months points
Qu Yangceding not squalene content.Result see the table below two：
Table two：Product core functional component attenuation monitoring result
Be can be seen that from upper table testing result, place 1,3,6 month finished capsule products in squalene content decreasing value well below
The decreasing value of squalene content in semi-finished product soft capsule, illustrates that product structure of the present invention and the wheat germ powder of filling can have
Effect reduces the decay of squalene composition.
Embodiment 3
A kind of liver protecting bilayer medicine-food two-purpose soft capsule is prepared, is comprised the following steps：
(1) prepare glue
With carragheen as major ingredient, by carragheen: glycerine: purified water is molten in glue tank is changed with 100: 40: 100 part by weight
Glue, for preparing internal layer soft capsule, by following flow prepare glue：
Take in the purified water of ormal weight, glycerine being placed in glue tank, be well mixed, be heated to temperature for 70 DEG C, add rule
Quantitative carragheen, stirring makes carragheen all dissolve；Decompression vacuum pumping, vacuum is -0.06Mpa, and bubble in glue is taken out
Go out, preserved at a temperature of 50~60 DEG C, it is standby.
(2) squalene soft capsules are prepared
Squalene is done into filling liquid, soft capsule is prepared by following scheme：
A) pelleting：Glue prepared by filling liquid and above-mentioned steps (1) is extruded through automatic rotary soft capsule pellet press and is closed
Lattice soft capsule, rubber thickness control is in 0.85~0.95mm, and squalene weight is every 125mg, standby.
B) shape：Qualified soft capsule prepared by above-mentioned steps a) is 30%~40% in 18~26 DEG C, relative humidity
Cold air drying 4 hours, completes soft capsule sizing, standby.
C) ball is washed：By the edible wine seminal plasma that the soft capsule concentration of volume percent that above-mentioned steps b) completes sizing is 95%
Wash 3 times, wash away surface oil, it is standby.
D) capsule and pill is dried；The cleaned soft capsules of above-mentioned steps c) are put in drying pallet, in 18~30 DEG C of temperature, relatively
Dried 28 hours under conditions of humidity 10%~40%, it is standby.
E) ball is selected：Above-mentioned steps d) dried soft capsule is rejected on lamp inspection desk special-shaped ball, bubble ball, big piller,
The underproof soft capsule such as oil leak ball, obtains qualified squalene soft capsules, standby.
(3) wheat germ powder is prepared
Good quality wheat plumule is crushed in 300,000 grades of clean areas, 80 mesh sieves are crossed, wheat germ powder is obtained, it is standby.
(4) outer layer capsule is filled
Qualified soft capsule, the wheat germ powder of step (3) preparation and outer layer capsule prepared by above-mentioned steps (2) adds respectively
Enter in respective hopper, operation capsule filling machine carries out capsule filling according to weight proportion, in the UD of 500mg, spiny dogfish
Alkene is 1: 3 with the weight ratio of wheat germ powder, and the weight of wheat germ powder is every 375mg, during operation capsule filling machine, at any time
Note regulation wheat germ powder and soft capsule hopper discharging situation, be allowed to each actuation cycle and release a soft capsule, quantify
Wheat germ powder, load capsule in, and in time reject the underproof capsule of outward appearance.
(5) polish
By in the populated capsule addition capsule polisher hopper of above-mentioned steps (4), operation capsule polisher carries out capsule
Polishing, rejects the underproof capsule of outward appearance in time, and qualified finished capsule product is obtained.
(6) dispense
Packaging formwork is assembled by packing specification and through the qualified plastic bottle of quality inspection, prepared by above-mentioned steps (5) closed
The finished capsule product of lattice is added in hopper, and the plastic bottle packing of capsule is completed by the operational procedure of packing machine.
The test of pesticide effectiveness：The soft capsule that will be prepared according to the method described in embodiment 3 gives paddy third turn of exceeded (meaning of peace enzyme respectively
Liver has damage) person takes, one full year of life at age 25-35,20 one group of people；One full year of life at age 36-45,20 one group of people；Age 46-55
One full year of life, 20 one group of people；Three times a day, every time oral two before feed, period, without other drugs, takes 2 weeks and detects paddy again
Pyruvic transaminase, the glutamic-pyruvic transaminase index that discovery has hepatic injury person has substantially reduction, and (range of decrease more than 20% is down to reasonable value model
Enclose) up to 78%, the effective percentage of wherein age 25-35 one full year of life reaches 90%；One full year of life at age 36-45, effective percentage reaches 80%；
One full year of life at age 46-55, effective percentage reaches 65%.
Product core functional component attenuation is monitored：Respectively Example 3 semi-finished product squalene soft capsules 200, into
Product capsule 200, in identical health food bottle generally, places indoor under room temperature condition, place 1,3,6 months points
Qu Yangceding not squalene content.Result see the table below three：
Table three：Product core functional component attenuation monitoring result
Be can be seen that from upper table testing result, place 1,3,6 month finished capsule products in squalene content decreasing value well below
The decreasing value of squalene content in semi-finished product soft capsule, illustrates that product structure of the present invention and the wheat germ powder of filling can have
Effect reduces the decay of squalene composition.
Embodiment 4
A kind of liver protecting bilayer medicine-food two-purpose soft capsule is prepared, is comprised the following steps：
(1) prepare glue
With konjac glucomannan, mannosan glue as major ingredient, by (konjac glucomannan, mannosan glue): glycerine: purified water is with 100: 40:
100 part by weight colloidal sol in glue tank is changed, for preparing internal layer soft capsule, wherein konjac glucomannan, mannosan glue weight ratio is 1
: 1, by following flow prepare glue.
Take in the purified water of ormal weight, glycerine being placed in glue tank, be well mixed, be heated to temperature for 70 DEG C~80 DEG C, then
Konjac glucomannan, the mannosan glue of ormal weight are added, stirring makes konjac glucomannan, mannosan glue all dissolve；Decompression vacuum pumping, very
Reciprocal of duty cycle is -0.08MPa, and bubble in glue is extracted out, is preserved at a temperature of 50~60 DEG C, standby.
(2) squalene soft capsules are prepared
Squalene is done into filling liquid, soft capsule is prepared by following scheme：
A) pelleting：Glue prepared by filling liquid and above-mentioned steps (1) is extruded through automatic rotary soft capsule pellet press and is closed
Lattice soft capsule, rubber thickness control is in 0.85~0.95mm, and squalene weight is every 100mg, standby.
B) shape：Qualified soft capsule prepared by above-mentioned steps a) is 30%~40% in 18~26 DEG C, relative humidity
Cold air drying 6 hours, completes soft capsule sizing, standby.
C) ball is washed：By the edible wine seminal plasma that the soft capsule concentration of volume percent that above-mentioned steps b) completes sizing is 95%
Wash 4 times, wash away surface oil, it is standby.
D) capsule and pill is dried；The cleaned soft capsules of above-mentioned steps c) are put in drying pallet, in 18~30 DEG C of temperature, relatively
Dried 24 hours under conditions of humidity 10%~40%, it is standby.
E) ball is selected：Above-mentioned steps d) dried soft capsule is rejected on lamp inspection desk special-shaped ball, bubble ball, big piller,
The underproof soft capsule such as oil leak ball, obtains qualified squalene soft capsules, standby.
(3) wheat germ powder is prepared
Wheat embryo is crushed in 300,000 grades of clean areas, 80 mesh sieves are crossed, wheat germ powder is obtained, it is standby.
(4) outer layer capsule is filled
Qualified soft capsule, the wheat germ powder of step (3) preparation and outer layer capsule prepared by above-mentioned steps (2) adds respectively
Enter in respective hopper, operation capsule filling machine carries out capsule filling according to weight proportion, in the UD of 500mg, spiny dogfish
Alkene is 1: 4 with the weight ratio of wheat germ powder, and the weight of wheat germ powder is every 400mg, during operation capsule filling machine, at any time
Note regulation wheat germ powder and soft capsule hopper discharging situation, be allowed to each actuation cycle and release a soft capsule, quantify
Wheat germ powder, load capsule in, and in time reject the underproof capsule of outward appearance.
(5) polish
By in the populated capsule addition capsule polisher hopper of above-mentioned steps (4), operation capsule polisher carries out capsule
Polishing, rejects the underproof capsule of outward appearance in time, and qualified finished capsule product is obtained.
(6) dispense
Packaging formwork is assembled by packing specification and through the qualified plastic bottle of quality inspection, prepared by above-mentioned steps (5) closed
The finished capsule product of lattice is added in hopper, and the plastic bottle packing of capsule is completed by the operational procedure of packing machine.
The test of pesticide effectiveness：The soft capsule that will be prepared according to the method described in embodiment 4 gives paddy third turn of exceeded (meaning of peace enzyme respectively
Liver has damage) person takes, one full year of life at age 25-35,20 one group of people；One full year of life at age 36-45,20 one group of people；Age 46-55
One full year of life, 20 one group of people；Three times a day, every time oral two before feed, period, without other drugs, takes 2 weeks and detects paddy again
Pyruvic transaminase, the glutamic-pyruvic transaminase index that discovery has hepatic injury person has substantially reduction, and (range of decrease more than 20% is down to reasonable value model
Enclose) up to 72%, the effective percentage of wherein age 25-35 one full year of life reaches 85%；One full year of life at age 36-45, effective percentage reaches 72%；
One full year of life at age 46-55, effective percentage reaches 60%.
Product core functional component attenuation is monitored：Respectively Example 4 semi-finished product squalene soft capsules 200, into
Product capsule 200, in identical health food bottle generally, places indoor under room temperature condition, place 1,3,6 months points
Qu Yangceding not squalene content.Result see the table below four：
Table four：Product core functional component attenuation monitoring result
Be can be seen that from upper table testing result, place 1,3,6 month finished capsule products in squalene content decreasing value well below
The decreasing value of squalene content in semi-finished product soft capsule, illustrates that product structure of the present invention and the wheat germ powder of filling can have
Effect reduces the decay of squalene composition.
Above-described embodiment 1- embodiments 4, in step (1) prepare glue major ingredient be konjac glucomannan, mannosan glue, carragheen,
Belong to natural plant gum, extracted from plant, belong to natural food, it is without any side effects, break the industry and made with animal glue
It is the tradition of prepare glue major ingredient.It should be noted that prepare glue major ingredient is not limited to konjac glucomannan, mannosan glue, carragheen,
Or two kinds, two or more mixtures, other plant glue is can also be, more common is konjac glucomannan.From effect experiment and inspection
Survey from the point of view of result, preferably, the decay of the finished capsule product core functional component of embodiment 4 is minimum, comprehensive for the finished capsule product pharmacodynamic results of embodiment 1
From the point of view of closing, the finished capsule product drug effect of embodiment 2 and core functional component attenuating are ideal.
The present invention uses new model, and the squalene of easy oxidation by air is first made into soft capsule, soft capsule again with to it
There is the wheat germ powder of protection and synergistic effect in medicinal/edible capsule, on the one hand, wheat germ powder is compared to spiny dogfish
Alkene, aboundresources is with low cost；On the other hand, the glutathione in wheat embryo can be with anti-lipid peroxidation, with squalene
Compound can effectively protect the characteristic of the functional active components of squalene, and realization has dual oxygen barrier oxygen to effect nucleus
Chemoprevention effect attenuation function, can effectively reduce or prevent the oxidation deterioration of core functional component, effect decay, being capable of long term guarantee quality
Storage；3rd, it is ensured that effect of squalene obtains fully efficiently playing a role, two kinds of component compatibilities of squalene and wheat germ powder
Science, Synergistic can promote liver cell regeneration and protect liver cell, improve liver function, while in carcinectomy surgical operation
Use afterwards or during chemicotherapy, can prevent cancer from being shifted to lung, effect is significant.
Only as described above, specific embodiment only of the invention, when can not with this limit the present invention implementation model
Enclose, such as capsule can also be three layers, the sandwich constructions such as four layers, all impartial changes done according to scope of the present invention patent with
Modification, should all belong to covering scope of the invention.
Claims (9)
1. a kind of liver protecting bilayer medicine-food two-purpose soft capsule, it is characterised in that be followed successively by squalene, internal layer flexible glue from inside to outside
Capsule, wheat germ powder and outer layer capsule；In UD, squalene is 1: 1~4 with the weight ratio of wheat germ powder.
2. a kind of liver protecting bilayer medicine-food two-purpose soft capsule according to claim 1, it is characterised in that 500mg's
In UD, squalene content is 100~300mg, and wheat embryo powder content is 200~400mg.
3. a kind of liver protecting bilayer medicine-food two-purpose soft capsule according to claim 1, it is characterised in that 500mg's
In UD, squalene content is 125~250mg, and wheat embryo powder content is 250~375mg.
4. a kind of liver protecting bilayer medicine-food two-purpose soft capsule according to claim 1, it is characterised in that 500mg's
In UD, squalene content is 165mg, and wheat embryo powder content is 335mg.
5. a kind of preparation method of the double-deck medicine-food two-purpose soft capsule of liver protecting according to claim any one of 1-4, its
It is characterised by, comprises the following steps：
(1) prepare glue
With natural plant gum as major ingredient, by natural plant gum: glycerine: purified water colloidal sol in glue tank is changed with 100: 40: 100 part by weight,
For preparing internal layer soft capsule, by following flow prepare glue：
Take in the purified water of ormal weight, glycerine being placed in glue tank, be well mixed, be heated to temperature for 70 DEG C~80 DEG C, add
The natural plant gum of ormal weight, stirring makes natural plant gum all dissolve；Decompression vacuum pumping, vacuum is -0.06Mpa~-0.08MPa, will
Bubble is extracted out in glue, is preserved at a temperature of 50~60 DEG C, standby；
(2) squalene soft capsules are prepared
Squalene is done into filling liquid, soft capsule is prepared by following scheme：
A) pelleting：Glue prepared by filling liquid and above-mentioned steps (1) extrudes qualified soft through automatic rotary soft capsule pellet press
Capsule, it is standby；
B) shape：Qualified soft capsule prepared by above-mentioned steps a) is in the cold wind that 18~26 DEG C, relative humidity are 30%~40%
Dry 4~6 hours, complete soft capsule sizing, it is standby；
C) ball is washed：The soft capsule that above-mentioned steps b) completes sizing is cleaned 3 with the edible alcohol that concentration of volume percent is 95%
~4 times, surface oil is washed away, it is standby；
D) capsule and pill is dried；The cleaned soft capsules of above-mentioned steps c) are put in drying pallet, in 18~30 DEG C of temperature, relative humidity
Dried 20~30 hours under conditions of 10%~40%, it is standby；
E) ball is selected：Above-mentioned steps d) dried soft capsule is rejected into special-shaped ball, bubble ball, big piller, oil leak ball etc. unqualified
Soft capsule, obtain qualified squalene soft capsules, it is standby；
(3) wheat germ powder is prepared
Wheat embryo is crushed in 300,000 grades of clean areas, 80 mesh sieves are crossed, wheat germ powder is obtained, it is standby；
(4) outer layer capsule is filled
Qualified soft capsule, the wheat germ powder of step (3) preparation and outer layer capsule prepared by above-mentioned steps (2) is separately added into respectively
From in hopper, operation capsule filling machine carries out capsule filling according to weight proportion, and the underproof capsule of outward appearance is rejected in time；
(5) polish
By in the populated capsule addition capsule polisher hopper of above-mentioned steps (4), operation capsule polisher carries out capsule polishing,
The underproof capsule of outward appearance is rejected in time, and qualified finished capsule product is obtained.
6. the preparation method of a kind of liver protecting bilayer medicine-food two-purpose soft capsule according to claim 5, it is characterised in that
The preparation method is also dispensed including step (6)：Packaging formwork is assembled by packing specification and through the qualified plastics of quality inspection
Bottle, the step (5) is prepared during qualified finished capsule product adds hopper, by the plastics of the operational procedure completion capsule of packing machine
Bottle packaging.
7. the preparation method of a kind of liver protecting bilayer medicine-food two-purpose soft capsule according to claim 5, it is characterised in that
Natural plant gum used by step (1) prepare glue is one or two or two kinds in konjac glucomannan, mannosan glue, carragheen
Mixture above.
8. the preparation method of a kind of liver protecting bilayer medicine-food two-purpose soft capsule according to claim 7, it is characterised in that
The natural plant gum is konjac glucomannan.
9. the preparation method of a kind of liver protecting bilayer medicine-food two-purpose soft capsule according to claim 5, it is characterised in that
The qualified soft capsule rubber thickness that the step (2) prepares the step a) extrusion in squalene soft capsules is 0.85~0.95mm.
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