CN107625127A - Collaboration anti-Fatigue Composition, capsule and the preparation method of antarctic krill oil and ubiquinone - Google Patents
Collaboration anti-Fatigue Composition, capsule and the preparation method of antarctic krill oil and ubiquinone Download PDFInfo
- Publication number
- CN107625127A CN107625127A CN201711118854.XA CN201711118854A CN107625127A CN 107625127 A CN107625127 A CN 107625127A CN 201711118854 A CN201711118854 A CN 201711118854A CN 107625127 A CN107625127 A CN 107625127A
- Authority
- CN
- China
- Prior art keywords
- parts
- ubiquinone
- capsule
- antarctic krill
- krill oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of antarctic krill oil and the collaboration anti-Fatigue Composition of ubiquinone, ubiquinone poorly water-soluble, it is difficult to low through biomembrane, bioavilability；Antarctic krill oil is combined with ubiquinone, improves the solubility of ubiquinone, has ensured the stability of reduced form ubiquinone, substantially increases the bioavilability of ubiquinone.The invention also discloses capsule prepared by a kind of collaboration anti-Fatigue Composition using antarctic krill oil and ubiquinone, by compounding anti-oxidation active substance ultra micro wheat germ powder and walnut oil, unrighted acid and vitamin V A, VD, VE etc. content are improved to a certain extent, the effective guarantee stability of reduced form ubiquinone, substantially increase the bioavilability of ubiquinone.The invention also discloses the preparation method of above-mentioned capsule, carry out three layers of light tight coating to the antarctic krill oil dissolved with ubiquinone, the effective guarantee stability of reduced form ubiquinone, preserved beneficial to long-time, extend its shelf-life.
Description
Technical field
The present invention relates to bioactive substance and functional food factory formula technical field, more particularly to a kind of South Pole
Collaboration anti-Fatigue Composition, capsule and the preparation method of krill oil and ubiquinone.
Background technology
Co-Q10 (Coenzyme Q10), also known as ubiquinone, structure are similar to vitamin K, belong to the derivative of fat-soluble benzene
Thing, it is the auxiliary enzyme material of the indispensable endogenous of human body.Co-Q10 is present in internal cell, is the igniting agent for generating energy.
Co-Q10 has oxidized form and reduced form, and in vivo, oxidized form can be converted into reduced form, and the ratio of reduced form with
The growth at age and the increase of pressure can be reduced.Clinical and experimental study shows that supplement Co-Q10 can effectively remove free radical, resist
Oxidation, anti-aging, strengthen immunologic function, improve cardiovascular circulation, set up rapidly, enhancing muscle power.Therefore Co-Q10 is made
It is applied to that there is good actual application value in food for a kind of addition of functional activity factor.But because Co-Q10 is water-soluble
Property it is extremely low, and molecular weight is larger, therefore the permeable membrane of whole molecule is very poor, and oral administration biaavailability is relatively low.And easily see light
Decompose, be easily oxidized.Emulsifying agent (lecithin), antioxidant (vitamin E/lycopene) etc. are needed to use in actual applications
Auxiliary substance improves its dissolubility/stability, and still, oral administration biaavailability is not still high.
The content of the invention
It is an object of the invention to solve at least the above, and provide the advantages of at least will be described later.
It is a still further object of the present invention to provide the antifatigue combination of collaboration of a kind of antarctic krill oil and ubiquinone (Co-Q10)
Thing, Co-Q10 poorly water-soluble, it is difficult to low through biomembrane, bioavilability；Antarctic krill oil is combined with Co-Q10, improved
The solubility of Co-Q10, has ensured the stability of reduced coenzyme Q 10, substantially increases the bioavilability of Co-Q10.
It is a still further object of the present invention to provide a kind of collaboration anti-Fatigue Composition system using antarctic krill oil and ubiquinone
Standby capsule, by compounding anti-oxidation active substance ultra micro wheat germ powder and walnut oil, insatiable hunger is improved to a certain extent
With aliphatic acid and vitamin V A, VD, VE etc. content, the effective guarantee stability of reduced coenzyme Q 10, substantially increase
The bioavilability of Co-Q10.
It is a still further object of the present invention to provide a kind of preparation method of capsule, first by the krill dissolved with ubiquinone
Oil is coated in wheat germ powder, plays that drip shaping effect is good, and the effect that light-shading effect is good, preparation method are simple；Afterwards
Secondary capsulation is carried out using walnut oil carry out the coatings of capsule shells again, the effective guarantee stability of reduced coenzyme Q 10, be beneficial to
Preserve for a long time, extend its shelf-life.
In order to realize according to object of the present invention and further advantage, there is provided a kind of association of antarctic krill oil and ubiquinone
Same anti-Fatigue Composition, is counted in parts by weight, including following components：Antarctic krill oil 80-99 parts, ubiquinone 1-20 parts.
Preferably, count in parts by weight, including following components：99 parts of antarctic krill oil, ubiquinone 2-10 parts.
Preferably, count in parts by weight, including following components：99 parts of antarctic krill oil, ubiquinone 3-6 parts.
Capsule prepared by the collaboration anti-Fatigue Composition of antarctic krill oil and ubiquinone described in a kind of application, in parts by weight
Meter, in addition to following auxiliary material：
Walnut oil 5-15 parts, less than 100 nanometers ultra micro wheat germ powder 8-13 parts, chitosan 10-15 parts, organic monoacid
5-8 parts, algin 3-8 parts and pectin 1-3 parts, wherein, organic monoacid is propionic acid, maleic acid, tartaric acid, citric acid or amber
Acid.
Preferably, in addition to following auxiliary material：Walnut oil 5-10 parts, less than 100 nanometers of ultra micro wheat germ powder 8-10
Part, chitosan 10-12 parts, organic monoacid 5-6 parts, algin 3-5 parts and pectin 1-2 parts, wherein, organic monoacid be propionic acid,
Maleic acid, tartaric acid, citric acid or butanedioic acid.
Preferably, in addition to following auxiliary material：7 parts of walnut oil, less than 100 nanometers of 9 parts of ultra micro wheat germ powder, shell gather
2 parts of 11 parts of sugar, 5 parts of organic monoacid, 4 parts of algin and pectin, wherein, organic monoacid is propionic acid, maleic acid, tartaric acid, lemon
Lemon acid or butanedioic acid.
A kind of preparation method of capsule, comprises the following steps：
Step 1: counting in parts by weight, 10-15 parts chitosan is mixed simultaneously with 10-15 part water of the temperature not less than 70 DEG C
It is sufficiently stirred obtained mixed liquor I；
Transparent colloid shape is stirred well to Step 2: 5-6 part organic monoacids are dissolved into mixed liquor I, obtains mixture
Ⅱ；
Step 3: after the temperature of mixture II is down into 40-50 DEG C, count in parts by weight, by 3-8 part nanoscale ultra micros
Powder, 3-8 parts algin and 1-3 parts pectin, which dissolve in be well mixed in the mixture II successively, is prepared into capsule shells liquid, standby；
Step 4: counting in parts by weight, 1-20 part ubiquinone is dissolved into 80-99 part antarctic krill oils and obtains core agent I, it is standby
With；
Step 5: counting in parts by weight, core agent I is dropped into the step 2 in remaining nanoscale Ultramicro-powder and wrapped up
Uniformly prepare core agent II；
Step 6: the quick-frozen rear uniformly coating walnut oil of core agent II is prepared into core agent III；
Step 7: the core agent III is uniformly coated with into the capsule shells liquid, soft capsule is prepared into.
Preferably, the step 1~step 5 operates in an inert atmosphere.
Preferably, the temperature of the step 1 reclaimed water is 77-82 DEG C, and the temperature of mixture II is 45 in the step 3
℃。
Preferably, inflated with nitrogen is sealed the soft capsule within a package after low temperature drying and screening.
Krill aboundresources, growing environment is without industrial pollution.Antarctic krill oil is from krill (Euphausia
Superba the lipid of extraction, main component include in)：Glyceride, phosphatide, astaxanthin, sterol etc..Simultaneously in antarctic krill oil
Containing natural antioxidant astaxanthin, content significantly larger than ties up life up to 100mg/kg~300mg/kg, its oxidation resistance
The materials such as plain E, lycopene, it is referred to as the most strong natural materials of antioxidation activity.Existing research is proved antarctic krill oil richness
Containing a variety of unrighted acids, wherein long-chain omega-3 polyunsaturated fatty acids EPA and DHA content is up to 15.86%.Different from fish
Oil and cod-liver oil ω -3 triglycerides forms, the omega-fatty acid of antarctic krill oil are attached on phosphatide, this more insatiable hungers of long-chain
Small intestine can be directly entered after by stomach with the bioactivity compound molecule of Fatty acids Phospholipids to fully absorb, and add biological profit
Expenditure, and finally improve ω -3: ω -6 fatty acid proportion.And antarctic krill oil intrinsic natural powerful antioxidant shrimp
Blue or green element is also attached to phosphatide, so as to generate more stable lasting antioxidant effect.Shown according to experiment, antarctic krill oil
The compound sub bioavilability of bioactivity is 95%~98%, and the bioavilability of fish oil only 61%~64%, main former
Because be that antarctic krill oil contains is lipoid fatty acid, and almost 100% triglycerides that fish oil contains.Research shows：The South Pole
Krill oil (2g/d) can increase the concentration of EPA and DHA in obese people blood, positive effect higher than take herring oil (2g/d) and
Olive oil (2g/d) amplification is taken, illustrates that antarctic krill oil has good absorbability in human body；And after measured, the South Pole
Krill oil does not produce any toxic side effect.
The present invention comprises at least following beneficial effect：
In the collaboration anti-Fatigue Composition of antarctic krill oil and ubiquinone (Co-Q10) provided by the invention, Co-Q10 is water-soluble
Property is poor, it is difficult to low through biomembrane, bioavilability；And the omega-fatty acid of antarctic krill oil is attached on phosphatide, phosphatide sheet
Body just contains hydrophilic group and oleophylic group, is a kind of good emulsifying agent, improves the solubility of Co-Q10；It is and unsaturated
The oxidation resistance such as aliphatic acid and astaxanthin is strong, has ensured the stability of reduced coenzyme Q 10.Both active material groups
Close, there is bigger biocompatibility, and it is fat-soluble and water-soluble, and then substantially increase the bioavilability of Co-Q10.
In capsule prepared by the collaboration anti-Fatigue Composition provided by the invention using antarctic krill oil and ubiquinone, by multiple
With anti-oxidation active substance ultra micro wheat germ powder and walnut oil, unrighted acid and dimension life are improved to a certain extent
Plain VA, VD, VE etc. content, the effective guarantee stability of reduced coenzyme Q 10, substantially increase the biology profit of Co-Q10
Expenditure.
In the preparation method of capsule provided by the invention, the antarctic krill oil dissolved with ubiquinone is coated on wheat first
In bud powder, play that drip shaping effect is good, and the effect that light-shading effect is good, preparation method are simple；Carried out afterwards using walnut oil
Secondary capsulation carries out the coating of capsule shells again, the effective guarantee stability of reduced coenzyme Q 10, preserves, prolongs beneficial to long-time
Its long shelf-life.
Further advantage, target and the feature of the present invention embodies part by following explanation, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Embodiment
With reference to embodiment, the present invention is described in further detail, to make those skilled in the art with reference to specification
Word can be implemented according to this.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein do not allot one or more
The presence or addition of individual other elements or its combination.
Embodiment 1
A kind of collaboration anti-Fatigue Composition of antarctic krill oil and ubiquinone, is counted in parts by weight, including following components：The South Pole
1 part of krill oil 80-99 parts, ubiquinone.
Embodiment 2
A kind of collaboration anti-Fatigue Composition of antarctic krill oil and ubiquinone, is counted in parts by weight, including following components：The South Pole
99 parts of krill oil, 20 parts of ubiquinone.
Embodiment 3
A kind of collaboration anti-Fatigue Composition of antarctic krill oil and ubiquinone, is counted in parts by weight, including following components：The South Pole
99 parts of krill oil, 6 parts of ubiquinone.
Embodiment 4
Capsule prepared by the collaboration anti-Fatigue Composition of antarctic krill oil and ubiquinone described in a kind of application, including with the following group
Point and auxiliary material：
Component：80 parts of antarctic krill oil, 3 parts of ubiquinone；
Auxiliary material：5 parts of walnut oil, less than 100 nanometers of 8 parts of ultra micro wheat germ powder, 10 parts of chitosan, 5 parts of organic monoacid,
1 part of 3 parts of algin and pectin, wherein, organic monoacid is propionic acid.
Embodiment 5
Capsule prepared by the collaboration anti-Fatigue Composition of antarctic krill oil and ubiquinone described in a kind of application, in parts by weight
Meter, including following components and auxiliary material：
Component：85 parts of antarctic krill oil, 20 parts of ubiquinone；
Auxiliary material：7 parts of walnut oil, less than 100 nanometers of 10 parts of ultra micro wheat germ powder, 12 parts of chitosan, organic monoacid 6
2 parts of part, 5 parts of algin and pectin, wherein, organic monoacid is tartaric acid.
Embodiment 6
Capsule prepared by the collaboration anti-Fatigue Composition of antarctic krill oil and ubiquinone described in a kind of application, in parts by weight
Meter, including following components and auxiliary material：
Component：99 parts of antarctic krill oil, 6 parts of ubiquinone；
Auxiliary material：10 parts of walnut oil, less than 100 nanometers of 9 parts of ultra micro wheat germ powder, 11 parts of chitosan, organic monoacid 5
2 parts of part, 4 parts of algin and pectin, wherein, organic monoacid is citric acid.
Embodiment 7
A kind of preparation method of capsule, comprises the following steps：
Step 1: counting in parts by weight, 10 parts of chitosans are mixed with 10 parts of water of the temperature not less than 70 DEG C and fully stirred
Mixing obtains mixed liquor I；
Transparent colloid shape is stirred well to Step 2: 5 parts of organic monoacids are dissolved into mixed liquor I, obtains mixture II；
Step 3: after the temperature of mixture II is down into 40 DEG C, count in parts by weight, by 3 parts of nanoscale Ultramicro-powders, 3 parts
Algin and 1 part of pectin, which dissolve in be well mixed in the mixture II successively, is prepared into capsule shells liquid, standby；
Step 4: counting in parts by weight, 1 part of ubiquinone is dissolved into 80 parts of antarctic krill oils and obtains core agent I, it is standby；
Step 5: counting in parts by weight, core agent I is dropped into the step 2 in remaining nanoscale Ultramicro-powder and wrapped up
Uniformly prepare core agent II；
Step 6: the quick-frozen rear uniformly coating walnut oil of core agent II is prepared into core agent III；
Step 7: the core agent III is uniformly coated with into the capsule shells liquid, soft capsule is prepared into.
Wherein, the step 1~step 5 operates in an inert atmosphere.
Wherein, inflated with nitrogen is sealed the soft capsule within a package after low temperature drying and screening.
Wherein, the temperature of the step 1 reclaimed water is 77 DEG C, and the temperature of mixture II is 45 DEG C in the step 3.
Embodiment 8
A kind of preparation method of capsule, comprises the following steps：
Step 1: counting in parts by weight, 15 parts of chitosans are mixed with 15 parts of water of the temperature not less than 70 DEG C and fully stirred
Mixing obtains mixed liquor I；
Transparent colloid shape is stirred well to Step 2: 6 parts of organic monoacids are dissolved into mixed liquor I, obtains mixture II；
Step 3: after the temperature of mixture II is down into 50 DEG C, count in parts by weight, by 8 parts of nanoscale Ultramicro-powders, 8 parts
Algin and 3 parts of pectin, which dissolve in be well mixed in the mixture II successively, is prepared into capsule shells liquid, standby；
Step 4: counting in parts by weight, 20 parts of ubiquinone are dissolved into 99 parts of antarctic krill oils and obtain core agent I, it is standby；
Step 5: counting in parts by weight, core agent I is dropped into the step 2 in remaining nanoscale Ultramicro-powder and wrapped up
Uniformly prepare core agent II；
Step 6: the quick-frozen rear uniformly coating walnut oil of core agent II is prepared into core agent III；
Step 7: the core agent III is uniformly coated with into the capsule shells liquid, soft capsule is prepared into.
Wherein, the step 1~step 5 operates in an inert atmosphere.
Wherein, inflated with nitrogen is sealed the soft capsule within a package after low temperature drying and screening.
Wherein, the temperature of the step 1 reclaimed water is 82 DEG C, and the temperature of mixture II is 45 DEG C in the step 3.
Embodiment 9
A kind of preparation method of capsule, comprises the following steps：
Step 1: counting in parts by weight, 13 parts of chitosans are mixed with 12 parts of water of the temperature not less than 70 DEG C and fully stirred
Mixing obtains mixed liquor I；
Transparent colloid shape is stirred well to Step 2: 5 parts of organic monoacids are dissolved into mixed liquor I, obtains mixture II；
Step 3: after the temperature of mixture II is down into 45 DEG C, count in parts by weight, by 6 parts of nanoscale Ultramicro-powders, 3-8
Part algin and 1-3 parts pectin, which dissolve in be well mixed in the mixture II successively, is prepared into capsule shells liquid, standby；
Step 4: counting in parts by weight, 10 parts of ubiquinone are dissolved into 85 parts of antarctic krill oils and obtain core agent I, it is standby；
Step 5: counting in parts by weight, core agent I is dropped into the step 2 in remaining nanoscale Ultramicro-powder and wrapped up
Uniformly prepare core agent II；
Step 6: the quick-frozen rear uniformly coating walnut oil of core agent II is prepared into core agent III；
Step 7: the core agent III is uniformly coated with into the capsule shells liquid, soft capsule is prepared into.
Wherein, the step 1~step 5 operates in an inert atmosphere.
Wherein, inflated with nitrogen is sealed the soft capsule within a package after low temperature drying and screening.
Preferably, the temperature of the step 1 reclaimed water is 80 DEG C, and the temperature of mixture II is 45 DEG C in the step 3.
Experimental example 1
Using the allocation ratio configuration collaboration anti-Fatigue Composition of embodiment 1~3 as experimental group 1, experimental group 2 and experiment
Group 3.
Comparative example 1
Compareed with embodiment 1~3, three groups of control groups 1, control group 2 and control group 3 are set, counted in parts by weight, using jade
Rice bran oil replaces antarctic krill oil dissolving equivalent ubiquinone, daily feeding rat, and detect rat swimming time at regular time and quantity.
Experimental example 2
Capsule is configured as experimental group 4, experimental group 5 and experimental group 6 using the allocation ratio of embodiment 7~9.
Comparative example 2
Compareed with embodiment 7~9, three groups of control groups 4, control group 5 and control group 6 are set, counted in parts by weight, using jade
Rice bran oil replaces antarctic krill oil dissolving equivalent ubiquinone, and corn oil system of the application existing soft capsule shell coating dissolved with equivalent ubiquinone
It is standby into capsule；Daily feeding rat, and detect rat swimming time at regular time and quantity.
Experimentation specifically includes：
The 1.1 experiment material rats being related to：Male Wistar rat (institute of lab animals of Guangdong Province) 156, mouse age 6
Week, 110~130g of body weight, standard rodent animal feed conventinal breeding.
Co-Q10 (coenzyme-Q10, purity 98%)；Antarctic krill oil picks up by oneself.
1.2 method
After Wistar rats are adapted into raising one week, 13 groups are randomly divided into, every group 12, respectively blank control group A, reality
Test group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, experimental group 6, control group 1, control group, control group 3, control group 4,
Control group 5 and control group 6；Wherein, Co-Q10 dosage is 10mg/ (kgbwd).The oral gavage of tested material is given, even
Continuous gavage 3 months, weighs in weekly, adjusts gavage amount.It is (straight in transparent swimming pool to 4 groups of experimental rats after last dose 30min
Footpath 100cm, 30 ± 2 DEG C of water temperature, depth of water 50cm) locomitivity test is carried out, swum using the galvanized wire load of 5% body weight to power
Exhaust.Power exhausts standard and not risen for the obvious imbalance of rats'swimming action, head submerged 8s.Record what every rats'swimming exhausted to power
Time, testing result see the table below 1.
After power exhausts swimming 24h recoveries, urethane is anaesthetized under rest state, and broken end takes blood, takes liver, brain tissue, is placed in ice
Blood is cleaned in physiological saline, is blotted, weighed with filter paper, respectively with phosphate buffer (pH=7.2) low-temperature homogenate.According to reagent
Box operating guidance (kit is built up in Nanjing), using 721 spectrophotometric determination brain homogenate MDA values and liver homogenate MDA values, detection
As a result 2 be see the table below.
The statistical procedures of 1.3 data
All numerical value represent that statistical analysis uses SPSS for Windows17 with mean ± standard deviation (mean ± SD)
Version statistical analysis software is completed.P<Statistics has significant when 0.05, and statistical result see the table below 1.
Each group rat swimming time of table 1
Note：Compared with blank control group, * represents P<0.05, there is significant difference；* represents P<0.01, there is pole conspicuousness
Difference
It was found from upper table 1, the power that experimental example 1, experimental example 2, comparative example 1, comparative example 2 can significantly extend rat exhausts trip
Swim the time, there is antifatigue effect, still, experimental example 1 and experimental example 2 have pole significant difference respectively compared with blank control
(P<0.01), effect is better than comparative example 1 or comparative example 2.Illustrate antarctic krill oil and ubiquinone provided by the invention collaboration resist it is tired
Labor composition and the capsule of preparation are respectively provided with preferable anti-fatigue active.Illustrate the collaboration between antarctic krill oil and Co-Q10
Effect serves the effect for being obviously improved Co-Q10 functional activity, and capsule structure and auxiliary material help further to improve Co-Q10
Stability and bioavilability.
Each group rat power of table 2 exhausts liver homogenate MDA values and brain homogenate MDA values after swimming recovers
Note：Compared with blank control group, * represents P<0.05, there is significant difference；* represents P<0.01, there is pole conspicuousness
Difference
It was found from upper table 2, after feeding 3 months, serum MDA value is less than reference examples 1, reference examples in experimental example 1 and experimental example 2
2 and blank control, experimental example 1 and the liver homogenate MDA values of experimental example 2 and brain homogenate MDA values reduced respectively compared with control group 1, control group 2
39.5%-41.2% and 46.2%-47.1%, compared with blank control group significant difference (P<0.01).Illustrate south provided by the invention
The capsule of the collaboration anti-Fatigue Composition and preparation of pole krill oil and ubiquinone is respectively provided with preferable anti-fatigue active, also furtherly
Synergy between bright antarctic krill oil and Co-Q10 serves the effect for being obviously improved Co-Q10 functional activity.
Although embodiment of the present invention is disclosed as above, it is not restricted in specification and embodiment listed
With it can be applied to various suitable the field of the invention completely, can be easily for those skilled in the art
Other modification is realized, therefore under the universal limited without departing substantially from claim and equivalency range, it is of the invention and unlimited
In specific details and shown here as the embodiment with description.
Claims (10)
- A kind of 1. collaboration anti-Fatigue Composition of antarctic krill oil and ubiquinone, it is characterised in that count in parts by weight, including it is following Component：Antarctic krill oil 80-99 parts, ubiquinone 1-20 parts.
- 2. the collaboration anti-Fatigue Composition of antarctic krill oil as claimed in claim 1 and ubiquinone, it is characterised in that by weight Number meter, including following components：99 parts of antarctic krill oil, ubiquinone 2-10 parts.
- 3. the collaboration anti-Fatigue Composition of antarctic krill oil as claimed in claim 1 and ubiquinone, it is characterised in that by weight Number meter, including following components：99 parts of antarctic krill oil, ubiquinone 3-6 parts.
- A kind of 4. collaboration anti-Fatigue Composition system of antarctic krill oil applied as any one of claim 1-3 and ubiquinone Standby capsule, it is characterised in that count in parts by weight, in addition to following auxiliary material：Walnut oil 5-15 parts, less than 100 nanometers ultra micro wheat germ powder 8-13 parts, chitosan 10-15 parts, organic monoacid 5-8 Part, algin 3-8 parts and pectin 1-3 parts, wherein, organic monoacid is propionic acid, maleic acid, tartaric acid, citric acid or butanedioic acid.
- 5. capsule as claimed in claim 4, it is characterised in that also including following auxiliary material：Walnut oil 5-10 parts, less than 100 nanometers ultra micro wheat germ powder 8-10 parts, chitosan 10-12 parts, organic monoacid 5-6 Part, algin 3-5 parts and pectin 1-2 parts, wherein, organic monoacid is propionic acid, maleic acid, tartaric acid, citric acid or butanedioic acid.
- 6. capsule as claimed in claim 4, it is characterised in that also including following auxiliary material：7 parts of walnut oil, less than 100 nanometers of 9 parts of ultra micro wheat germ powder, 11 parts of chitosan, 5 parts of organic monoacid, 4 parts of algin And 2 parts of pectin, wherein, organic monoacid is propionic acid, maleic acid, tartaric acid, citric acid or butanedioic acid.
- 7. the preparation method of a kind of capsule as any one of claim 4-6, it is characterised in that comprise the following steps：Step 1: count in parts by weight, 10-15 parts chitosan is mixed and abundant with 10-15 part water of the temperature not less than 70 DEG C Mixed liquor I is made in stirring；Transparent colloid shape is stirred well to Step 2: 5-6 part organic monoacids are dissolved into mixed liquor I, obtains mixture II；Step 3: after the temperature of mixture II is down into 40-50 DEG C, count in parts by weight, by 3-8 part nanoscale ultra micro wheats Bud powder, 3-8 parts algin and 1-3 parts pectin, which dissolve in be well mixed in the mixture II successively, is prepared into capsule shells liquid, standby；Step 4: counting in parts by weight, 1-20 part ubiquinone is dissolved into 80-99 part antarctic krill oils and obtains core agent I, it is standby；Step 5: counting in parts by weight, core agent I is dropped into the step 2 in remaining nanoscale Ultramicro-powder and wrapped up uniformly Prepare core agent II；Step 6: the quick-frozen rear uniformly coating walnut oil of core agent II is prepared into core agent III；Step 7: the core agent III is uniformly coated with into the capsule shells liquid, soft capsule is prepared into.
- 8. the preparation method of capsule as claimed in claim 7, it is characterised in that the step 1~step 5 is in indifferent gas Operated under body environment.
- 9. the preparation method of capsule as claimed in claim 7, it is characterised in that the temperature of the step 1 reclaimed water is 77-82 DEG C, the temperature of mixture II is 45 DEG C in the step 3.
- 10. the preparation method of capsule as claimed in claim 1, it is characterised in that the soft capsule is through low temperature drying and screening Inflated with nitrogen is sealed within a package afterwards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711118854.XA CN107625127B (en) | 2017-11-14 | 2017-11-14 | Euphausia superba oil and ubiquinone synergistic anti-fatigue composition, capsule and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711118854.XA CN107625127B (en) | 2017-11-14 | 2017-11-14 | Euphausia superba oil and ubiquinone synergistic anti-fatigue composition, capsule and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107625127A true CN107625127A (en) | 2018-01-26 |
| CN107625127B CN107625127B (en) | 2020-09-29 |
Family
ID=61107741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711118854.XA Active CN107625127B (en) | 2017-11-14 | 2017-11-14 | Euphausia superba oil and ubiquinone synergistic anti-fatigue composition, capsule and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107625127B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114304285A (en) * | 2021-12-18 | 2022-04-12 | 青岛市远洋捕捞有限公司 | Euphausia superba oil composition and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102754829A (en) * | 2012-07-03 | 2012-10-31 | 广东仙乐制药有限公司 | Healthcare composition containing coenzyme Q10, capsule preparation and preparation method |
| CN104189553A (en) * | 2014-07-26 | 2014-12-10 | 广东医学院 | Application of composition containing coenzyme Q10 and vegetable oil to preparation of health foods and medicines for preventing osteoporosis |
| KR20160122110A (en) * | 2015-01-21 | 2016-10-21 | 주식회사 엘지생활건강 | A composition for reinforcing immune function and anti-fatigue comprising fermented placenta and its use |
| CN106692758A (en) * | 2017-01-10 | 2017-05-24 | 威海百合生物技术股份有限公司 | Double-layer medicinal and edible dual-purpose soft capsule capable of protecting liver and preparation method thereof |
-
2017
- 2017-11-14 CN CN201711118854.XA patent/CN107625127B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102754829A (en) * | 2012-07-03 | 2012-10-31 | 广东仙乐制药有限公司 | Healthcare composition containing coenzyme Q10, capsule preparation and preparation method |
| CN104189553A (en) * | 2014-07-26 | 2014-12-10 | 广东医学院 | Application of composition containing coenzyme Q10 and vegetable oil to preparation of health foods and medicines for preventing osteoporosis |
| KR20160122110A (en) * | 2015-01-21 | 2016-10-21 | 주식회사 엘지생활건강 | A composition for reinforcing immune function and anti-fatigue comprising fermented placenta and its use |
| CN106692758A (en) * | 2017-01-10 | 2017-05-24 | 威海百合生物技术股份有限公司 | Double-layer medicinal and edible dual-purpose soft capsule capable of protecting liver and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郑琳等: "南极磷虾油对负重游泳小鼠的抗疲劳作用", 《大连工业大学学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114304285A (en) * | 2021-12-18 | 2022-04-12 | 青岛市远洋捕捞有限公司 | Euphausia superba oil composition and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107625127B (en) | 2020-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6995620B2 (en) | Multi-supplement composition | |
| JP4758898B2 (en) | Solubilized CoQ-10 | |
| Wang et al. | Enhancing stability and anti-inflammatory properties of curcumin in ulcerative colitis therapy using liposomes mediated colon-specific drug delivery system | |
| JP6153922B2 (en) | Synergistic compositions and methods | |
| US20120195871A1 (en) | Stable aqueous suspension | |
| Ahmed et al. | Chitosan vitamin E nanocomposite ameliorates the growth, redox, and immune status of Nile tilapia (Oreochromis niloticus) reared under different stocking densities | |
| JPWO2005061684A1 (en) | Oil composition | |
| JP2012180337A (en) | Self-emulsifying preparation | |
| JP2005535339A (en) | Dietary fortification composition | |
| CN105079009A (en) | Composition for preventing and /or treating cardiovascular and cerebrovascular diseases | |
| Qiu et al. | Tracking in vitro digestion and in vivo metabolism of water-in-oil-in-water microemulsion as a delivery carrier for α-linolenic acid | |
| CN107625127A (en) | Collaboration anti-Fatigue Composition, capsule and the preparation method of antarctic krill oil and ubiquinone | |
| US20070009590A1 (en) | Physiologically active composition based on phosphatidylserine | |
| JP5096658B2 (en) | Soft capsule with improved bioavailability | |
| US20230115099A1 (en) | Combination of curcuminoids with krill oil for improved delivery and efficacy | |
| JP6794490B2 (en) | Anaerobic antioxidant composition | |
| TW200904456A (en) | Organic compounds | |
| JP3131917U (en) | Soft capsule | |
| RU2419446C1 (en) | Composition of dense extract of conifer needles for capsulation | |
| EP1725121A1 (en) | Novel dietary supplements or foodstuff based on unsaturated fatty acids and uses thereof | |
| KR102486088B1 (en) | Smoothie Having Omega-3 | |
| JPS63133969A (en) | Auxiliary nourishing food | |
| US20230381207A1 (en) | Oral cannabinoid formulation comprising tocopheryl phosphates and long chain triglycerides or long chain fatty acids | |
| JP2006050933A (en) | Chlorella dietary supplement | |
| JP2024125191A (en) | Anti-anisakiasis composition containing carvacrol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230627 Address after: 710000 No. B49, Xinda Zhongchuang space, 26th Street, block C, No. 2 Trading Plaza, South China City, international port district, Xi'an, Shaanxi Province Patentee after: Xi'an Huaqi Zhongxin Technology Development Co.,Ltd. Address before: 528216 No.98, Guidan West Road, Danzao Town, Foshan City, Guangdong Province Patentee before: GUANGDONG POLYTECHNIC OF ENVIRONMENTAL PROTECTION ENGINEERING Effective date of registration: 20230627 Address after: Room 305, Floor 3, Building 30, Yard 1, Disheng North Street, Daxing District, Beijing Economic-Technological Development Area, 100176 Patentee after: Beijing Nuokanglai Biotechnology Co.,Ltd. Address before: 710000 No. B49, Xinda Zhongchuang space, 26th Street, block C, No. 2 Trading Plaza, South China City, international port district, Xi'an, Shaanxi Province Patentee before: Xi'an Huaqi Zhongxin Technology Development Co.,Ltd. |