CN104095984A - Traditional Chinese medicine combination for treating aleutian disease of mink - Google Patents
Traditional Chinese medicine combination for treating aleutian disease of mink Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating an aleutian disease of a mink, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35-45 parts of white peony roots, 5-15 parts of unprocessed rehmannia roots, 25-35 parts of cucumber stems, 5-15 parts of herba patriniae, and 5-15 parts of szechwan chinaberry fruits. The traditional Chinese medicine combination disclosed by the invention uses replenishing blood, cooling blood and dispersing stagnated liver qi for promoting bile flow as the principle of treatment, the formula is reasonable, the preparation technology is simple, and the application scope is broad. During application, the medicine disclosed by the invention is taken according to the principle that 0.5 g of the medicine is taken for per kilo of weight, clinical tests prove that the cure rate reaches more than 90%, and the traditional Chinese medicine combination has unique curative effects.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to particularly a kind of Chinese medicine composition for the treatment of Aleutian disease.
Background technology
AD (Aleution is sick) is the distinctive a kind of course advancement of mink infectious disease very slowly.Sick main manifestations is plasmacytosis, in serum gamma globulin increase, persistent virus mass formed by blood stasis, glomerulonephritis, with the raw bosom of female beast, significantly increase and large quantities of death of autumn and winter season.
This finds dry nineteen forty-six clearly the earliest, and the U.S., Canada, Sweden, Denmark, front West Germany, the former Soviet Union and Japan and other countries have confirmed that primary disease exists.Primary disease is considered to a kind of hereditary for a long time, within 1962, is proved to be viral infectious.
The cause of disease of l, cause of disease primary disease is a kind of virus.Mainly be present in blood, serum, bone marrow, spleen, fecaluria and the saliva of infecting mink.The cell-free filtrate of infected tissue and centrifugation sediment all have infectiousness, can resume generation at mink relaying, also can breeding in mink kidney and testicular cell cultivation.From infecting the DNA that the spleen of mink makes, there is infectiousness, and DNA enzyme can make it inactivation.Visible virus is a kind of DNA viruses.This virus is very strong to hot resistance, and conventional disinfectant will act on the long period just can be made it to lose activity, and at PH2.8--10, all can maintain vigour.With serological methods such as neutralization test, complement fixation test and precipitation tests, all can not prove in disease beast serum have the antibody reacting with this virus.With the reproducible primary disease of the healthy mink of the serum injection of sick beast, if but this kind of serum remove two kinds of globulin and lose infectiousness.In serum, virus and gamma globulin combine, so, even if there is antibody to exist, also combine with cause of disease.
2, epidemiology primary disease main infection mink, it be unclear that the infection conditions of other animals.Someone reports has similar disease exist in ferret, and ferret also can fall ill during artificial challenge.Mink susceptibility is without the difference of age and sex, but the hereditary form of mink with the susceptibility of primary disease is had to substantial connection, blue and yellow color ermine sickness rate is higher, the susceptibility of the mink that black and other colors are darker is much lower.This two classes mink not only sickness rate height is different, and incubation rate and grow up after the rate of being acyesis also have very big difference.Primary disease has obvious seasonality.The all increases greatly of autumn and winter season M & M.The main source of infection of primary disease is disease beast and is with malicious beast.Virus long-term existence, within suffering from ermine body, and is discharged and is polluted external environment from urine, excrement and saliva, through digestive tract and the healthy mink of respiratory tract infection.In addition, consider that primary disease has long persistent virus mass formed by blood stasis to exist, it is also possible by arthropod vector, propagating.When someone reports treatment and prophylactic immunization, syringe needle pollutes and can cause that primary disease is popular.In addition, also vertical transmission can occur, infecting female beast can be by disease transmission to young animal.Primary disease imports ermine group into and starts to be recessive popular more. the accumulation along with time lengthening and sick beast, show endemicity, and cause heavy losses.
3. the incubation period of symptom primary disease is long.Approach inoculation outside gastrointestinal tract, occurs in blood that the time average that gamma globulin raises is 21～30d, and the incubation period of natural infection is longer, and what have reaches more than 1 year.Clinical manifestation divides acute and chronic two kinds.Acutely show as poor appetite or lose one's husband, spirit is depressed, and exhaustion gradually occurs spasm before dead.The course of disease 2～3d.Chronic case main manifestations is extremely thirsty, and appetite declines, and poor growth, becomes thin gradually, and visual mucosal pallor, hemorrhage and ulcer are discharged tarry stool just.The serious anemia of sick ermine is cachexia shape, finally dies from uremia.The course of disease is several weeks.
4. the variation of pathological change blood is mainly manifested in plasmacytosis and the increase of serum gamma globulin amount.Gamma globulin can, from the 1g/100ml serum of normal ermine, increase to 4～5g/100ml.While cuing open inspection, can see liver,kidney,spleen enlargement, kidney is petechial hemorrhage, or is dispersed in canescence speckle.All internal organs are obvious plasmocyte infiltrating, and the blood vessel of being everlasting forms oversleeve around.There is glomerulonephritis.Serious symptom liver has necrosis region.
5. diagnosis is because primary disease is mainly through slowly clinically, show weak, become thin, oral hemorrhage sometimes, is difficult for arousing attention, therefore, according to primary disease, in epidemiology, symptom and pathological change, can only make tentative diagnosis.Further making a definite diagnosis chamber by experiment checks.The most frequently used laboratory method is the hind leg toe occipital region blood sampling minute high serum ermine, gets 1 and bleeds and put clearly on microscope slide, and the beast Ge Shi iodine liquid that adds 1 new preparation mixes, observing response after 1 one 2min.As be AD, because changing, the ratio of Human Serum Albumin and globulin there is dun bulk flocculent aggregate.Though this test is not specific reaction, method is simple, and effect is infallible, a kind of good diagnostic method of still can yet be regarded as.
6. control, in order to control primary disease, should be done every year and exempt from the test of disease electrophoresis for twice, and conventional method is that disease electrophoresis method is exempted from convection current at present, once when selected kind of beast, once before breeding.The positive is suffered to beast isolated rearing, to beating the skin phase, eliminate.Only have the joey that parents are negative could be used as to plant.Because the band poison phase of primary disease is long, during introduced variety beast, should quarantine for a long time, negative patient can be gregarious.Morbidity beast can adopt the supporting treatments such as fluid infusion, vitimin supplement.Coordinate antibiotic to prevent secondary infection.
Use separately at present western medicine, effect is also imprecise, cannot remove the toxin in body.
Summary of the invention
The technical problem that will solve of the present invention provides a kind of Chinese medicine composition for the treatment of Aleutian disease, be to overcome above-mentioned weak point, the Chinese medicine composition that a kind of effective minimizing is residual, reduce toxic and side effects, reduce to pollute and treat safely and effectively Aleutian disease is provided.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for Aleutian disease, it is to be made by following raw materials by weight portion: Radix Paeoniae Alba 35-45 part, Radix Rehmanniae 5-15 part, Caulis Cucumidis sativiv 25-35 part, Herba Patriniae 5-15 part, Fructus Toosendan 5-15 part.
Described various raw material optimum ratio amount is: 40 parts of the Radix Paeoniae Albas, 10 parts of Radix Rehmanniae, 30 parts of Caulis Cucumidis sativivs, 10 parts of Herba Patriniae, 10 parts of Fructus Toosendans.
The granularity of the described Radix Paeoniae Alba, Radix Rehmanniae, Caulis Cucumidis sativiv, Herba Patriniae, Fructus Toosendan is 20-200 order.
The consumption of described traditional Chinese medicine composition for treating Aleutian disease is that the characteristic of 0.5g/ kg body weight medicine is as follows:
The Radix Paeoniae Alba: the Radix Paeoniae Alba is cool in nature, bitter in the mouth acid, is slightly cold, and has blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain.The effects such as astringing YIN to stop sweating, are applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction anxious, dysentery stomachache, spontaneous sweating, metrorrhagia, are with inferior disease.Modern study shows to contain paeoniflorin, paeonol, paeoniflorin, still containing benzoic acid, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes etc.
That paeoniflorin has is antibacterial, antipyretic, antiinflammatory, increase coronary flow, improve the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjusting blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.
Radix Rehmanniae: sweet-bitter flavor, cold in nature and enter blood system.Clearing away heat and cooling blood.Can clearing heat in YING system the heat of blood system and removing heat from blood., deep red tongue hot, thirsty for height of epidemic febrile disease, write out a prescription as qingying decoction.In addition, these product still have the effect of hemostasis by removing heat from blood, can be used for the various hemorrhages of heat in blood.YIN nourishing and the production of body fluid promoting.This quality is moistened the yin nourishing of many liquid energy, and sweet in the mouth is cold in nature can promote the production of body fluid, and has the nourishing YIN to relieve dryness effect of promoting the production of body fluid.For epidemic febrile disease later stage, pathogenic heat impairment of body fluid person.In addition, get this product nourishing YIN and clearing away heat effect, the xerostomia that is usually used in treating hyperactivity of fire caused by deficiency of YIN is thirsty.In Radix Rehmanniae, contain 20 several amino acids, wherein the highest with arginine content; In Radix Rehmanniae, have 15 seed amino acids, wherein alanine content is the highest.In Radix Rehmanniae, also contain 20 various trace elements such as ferrum, zinc, manganese, chromium.Modern study shows that Radix Rehmanniae has hemostasis and blood coagulation resisting function, antiinflammatory anti-allergic effects, etc.
Caulis Cucumidis sativiv: bitter in the mouth; Cool in nature; GUIXIN, lung meridian.Heat clearing away; Reduce phlegm; Dampness removing; Removing toxic substances.Main phlegm-heat cough; Epilepsy; Damp-heat dysentery; Multiple abscess caused by damp-phlegm; Sore and toxic; Hypertension.
Herba Patriniae: cool in nature, acrid in the mouth, hardship.Function cures mainly: heat-clearing and toxic substances removing, removing blood stasis and expelling pus.For appendicitis, dysentery, enteritis, hepatitis, eye conjunctivitis, postnatal blood stasis stomachache, carbuncle furuncle.Modern study shows to have resisting pathogenic microbes effect, sedation, hepatic cholagogic effect.
Fructus Toosendan: cold in nature, bitter in the mouth, is a kind of of qi-activating drug.There are soothing liver-QI promoting the circulation of QI to relieve pain, the drug effect of anthelmintic.For the breast side of body, abdominal distention, colic, abdominal pain due to worm stagnation.The sedimentation of Fructus Toosendan bitter cold, mainly enters Liver Channel, catharsis liver-heat, and promoting the circulation of QI to relieve pain, control the stagnation of QI and have the card of heat especially suitable.
The combination principle of Chinese medicine composition is " efficacy enhancing and toxicity reducing ", and therefore, the pharmacological action that the different medicine of compatibility embodies is also different.Said medicine compatibility, the Radix Paeoniae Alba, Radix Rehmanniae, the Caulis Cucumidis sativiv removing heat from blood of enriching blood, Herba Patriniae, Fructus Toosendan depressed liver-energy dispersing and function of gallbladder promoting, five medicines mutually 5, full side is able to treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, across-the-board regulation, Yin Yang balancing.
Each medicine mutually 5, reaches the removing heat from blood of enriching blood jointly, the effect of depressed liver-energy dispersing and function of gallbladder promoting, and adjust QI-blood circulation in body, can fast pain relief etc. symptom, recover appetite and digestive function.
The invention has the beneficial effects as follows: the present invention is with the removing heat from blood of enriching blood, and depressed liver-energy dispersing and function of gallbladder promoting is the rule for the treatment of, reasonable recipe, preparation technology is simple, applied widely.The present invention adopts pure Chinese medicinal herbs to make, wide material sources, cost are low, cure rate is high, medicine noresidue, have no side effect, particularly after micronizing, destroy to greatest extent plant cell wall, solved the deficiency that Chinese medicine powder crude fiber content is high, effective ingredient is difficult to stripping, be easier to mink and absorb.Have the removing heat from blood of enriching blood significantly, the effect of depressed liver-energy dispersing and function of gallbladder promoting and adjusting body function, effectively treats Aleutian disease, shortens the period of convalescence.Easy to use.Clinical trial proves, cure rate reaches more than 90%, has unique curative effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
By crossing 200 mesh sieves after the various raw material pulverizing in prescription, take Radix Paeoniae Alba 450g, Radix Rehmanniae 150g, Caulis Cucumidis sativiv 350g, Herba Patriniae 150g, Fructus Toosendan 150g, mix homogeneously.
Embodiment 2
By crossing 100 mesh sieves after the various raw material pulverizing in prescription, take Radix Paeoniae Alba 350g, Radix Rehmanniae 50g, Caulis Cucumidis sativiv 250g, Herba Patriniae 50g, Fructus Toosendan 50g, mix homogeneously.
Embodiment 3
By crossing 20 mesh sieves after the various raw material pulverizing in prescription, take Radix Paeoniae Alba 400g, Radix Rehmanniae 100g, Caulis Cucumidis sativiv 300g, Herba Patriniae 100g, Fructus Toosendan 100g, mix homogeneously.
Embodiment 4
By crossing 200 mesh sieves after the various raw material pulverizing in prescription, take Radix Paeoniae Alba 400g, Radix Rehmanniae 100g, Caulis Cucumidis sativiv 320g, Herba Patriniae 80g, Fructus Toosendan 100g, mix homogeneously.
Embodiment 5
By crossing 200 mesh sieves after the various raw material pulverizing in prescription, take Radix Paeoniae Alba 350g, Radix Rehmanniae 80g, Caulis Cucumidis sativiv 250g, Herba Patriniae 100g, Fructus Toosendan 100g, mix homogeneously.
Clinical trial:
Application example 1:
Undercoat Heisui River, ermine field, Laishan District, Yantai ermine
This priority has 15 minks to suffer from this disease, sick just show as poor appetite or loses one's husband, and spirit is depressed, and exhaustion gradually occurs spasm before dead.Blood variation is mainly manifested in plasmacytosis and serum gamma globulin amount increases.Gamma globulin can, from the 1g/100ml serum of normal ermine, increase to 4～5g/100ml.While cuing open inspection, can see liver,kidney,spleen enlargement, kidney is petechial hemorrhage, or is dispersed in canescence speckle.All internal organs are obvious plasmocyte infiltrating, and the blood vessel of being everlasting forms oversleeve around.There is glomerulonephritis.Serious symptom liver has necrosis region.The medicine of application above-described embodiment 1 is given ill mink dispensing by per kilogram of body weight 0.5g, admixes in feedstuff administration every day 1 time, is used in conjunction 5 days, the mink of take searches for food normally, gamma globulin is normally criterion of cure in blood, 15 minks are cured 14, and 1 invalid, and cure rate is 93%.
Application example 2:
Undercoat Heisui River, ermine field, Wendeng City, Weihai ermine
This priority has 30 sick just show as poor appetite or lose one's husband, and spirit is depressed, and exhaustion gradually occurs spasm before dead.Blood variation is mainly manifested in plasmacytosis and serum gamma globulin amount increases.Gamma globulin can, from the 1g/100ml serum of normal ermine, increase to 4～5g/100ml.While cuing open inspection, can see liver,kidney,spleen enlargement, kidney is petechial hemorrhage, or is dispersed in canescence speckle.All internal organs are obvious plasmocyte infiltrating, and the blood vessel of being everlasting forms oversleeve around.There is glomerulonephritis.Serious symptom liver has necrosis region.The medicine of application above-described embodiment 1 is given ill mink dispensing by per kilogram of body weight 0.5g, decocts soup administration every day 1 time, is used in conjunction 5 days, the mink of take searches for food normally, gamma globulin is normally criterion of cure in blood, 30 minks are cured 27, and 3 invalid, and cure rate is 90%.
Medicine of the present invention has no side effect, easy to use.During application, medicine of the present invention is offerd medicine to mink by per kilogram of body weight 0.5g, and administration every day 1 time, is used in conjunction 5 days, the mink of take searches for food normally, gamma globulin is normally criterion of cure in blood, and clinical trial proves, totally 45 ill minks are cured 41,4 invalid, and cure rate is 91%, has unique curative effect.
Above-mentioned detailed description of the Chinese medicine composition for the treatment of Aleutian disease being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a Chinese medicine composition for Aleutian disease, it is characterized in that it is to be made by following raw materials by weight portion: Radix Paeoniae Alba 35-45 part, Radix Rehmanniae 5-15 part, Caulis Cucumidis sativiv 25-35 part, Herba Patriniae 5-15 part, Fructus Toosendan 5-15 part.
2. a kind of Chinese medicine composition for the treatment of Aleutian disease according to claim 1, is characterized in that the parts by weight of described various raw materials: 40 parts of the Radix Paeoniae Albas, 10 parts of Radix Rehmanniae, 30 parts of Caulis Cucumidis sativivs, 10 parts of Herba Patriniae, 10 parts of Fructus Toosendans.
3. a kind of Chinese medicine composition for the treatment of Aleutian disease according to claim 1 and 2, the granularity that it is characterized in that the described Radix Paeoniae Alba, Radix Rehmanniae, Caulis Cucumidis sativiv, Herba Patriniae, Fructus Toosendan is 20-200 order.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036133A (en) * | 2016-05-30 | 2016-10-26 | 青岛海之源智能技术有限公司 | Feed additive capable of preventing and treating chronic aleutian disease of minks and preparation method of feed additive |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1688320A (en) * | 2002-08-13 | 2005-10-26 | 蒙纳什大学 | Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof |
| CN103520227A (en) * | 2013-10-09 | 2014-01-22 | 南京农业大学 | Injectable Isatis Root in-situ gel, and preparation method thereof |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1688320A (en) * | 2002-08-13 | 2005-10-26 | 蒙纳什大学 | Antimicrobial charged polymers that exhibit resistance to lysosomal degradation during kidney filtration and renal passage, compositions and method of use thereof |
| CN103520227A (en) * | 2013-10-09 | 2014-01-22 | 南京农业大学 | Injectable Isatis Root in-situ gel, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 钱爱东，李影: "《毛皮动物疾病》", 31 August 2009, 中国农业出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106036133A (en) * | 2016-05-30 | 2016-10-26 | 青岛海之源智能技术有限公司 | Feed additive capable of preventing and treating chronic aleutian disease of minks and preparation method of feed additive |
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