CN105687264A - Hippophae rhamnoides linn fruit oral liquid for promoting growth and development and preparation method of hippophae rhamnoides linn fruit oral liquid - Google Patents

Abstract

The invention provides hippophae rhamnoides linn fruit oral liquid for promoting growth and development and a preparation method of the hippophae rhamnoides linn fruit oral liquid. The hippophae rhamnoides linn fruit oral liquid is prepared from the following active pharmaceutical ingredients in parts by weight: 30 to 50 parts of hippophae rhamnoides linn fruit stock solution, 0.1 to 1 part of taurine, 0.1 to 1 part of zinc lactate and 5 to 15 parts of honey. The hippophae rhamnoides linn fruit oral liquid can supplement various kinds of nutrient substances required by the human body; the growth and the development are promoted; the production process is simple; and the industrialization is easy to realize.

Description

A kind of Oral Liquid Fructus Hippophae of enhancing development and preparation method thereof

Technical field

The present invention relates to a kind of oral liquid, refer in particular to the Oral Liquid Fructus Hippophae of a kind of enhancing development。

Background technology

Fructus Hippophae (Classification system: HippophaerhamnoidesLinn.) is a kind of fallen leaves property shrub, and its characteristic is drought-enduring, anti-blown sand, it is possible to survives on wetland with saline-alkaline, is therefore widely used in water and soil conservation。Northwest China plants Fructus Hippophae in a large number, for desert afforestation。In sea buckthorn fruit, Vitamin C content is high, have the laudatory title of the king of vitamin C。

Fructus Hippophae has significantly high medical value, it is possible to decrease cholesterol, cures the effects such as angina pectoris, also has the effect preventing and treating coronary atherosclerotic heart disease；Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis；Gastric duodenal ulcer and dyspepsia etc. can be treated, the diseases such as chronic superficial gastritis, atrophic gastritis, colitis is evident in efficacy；To burn, scald, cutter burns, cold injury has good therapeutical effect；Cervical erosion is had good therapeutic effect。In recent years, research found that Fructus Hippophae also had the effect of enhancing development。

Taurine (Taurine), also known as beta-amino ethyl sulfonic acid, is separated by Calculus Bovis the earliest, therefore is gained the name。Sterling is colourless or white ramp-like crystal, odorless, and taurine stable chemical nature, insoluble in organic solvents such as ether, is the non-protein amino acid of a kind of sulfur-bearing, exists with free state in vivo, is not involved in the biosynthesis of vivo protein。Although taurine is not involved in protein synthesis, but it is closely related with the metabolism of cystine, cysteine。Cysteine sulfurous acid carboxylic acid (CSAD) activity of human body synthesizing taurine is relatively low, relies primarily on the taurine in pickuping food to meet body requirement。Research shows that it can improve animal brain cortex and Hippocampus beta-endorphin and Arginine Vasopressin Content, promote people's embryonic cerebral cell growth promoter and proliferation and differentiation effect, the acquisition being beneficial to animal learning memory ability is consolidated and reproduces, there is promotion brain development, nootropics, improves the ability of learning and memory。

Zinc lactate is a kind of well food zinc enhancer, and baby and teen-age intelligence and body development are had important effect, and assimilation effect is better than inorganic zinc。

Summary of the invention

It is an object of the invention to provide the oral liquid with enhancing development。

For reaching above-mentioned purpose, the present invention adopts the following technical scheme that

Fructus Hippophae stock solution: 30 ~ 50 parts；Taurine: 0.1 ~ 1 part；Zinc lactate: 0.1 ~ 1 part；Mel: 5 ~ 15 parts。

Optimum ratio of the present invention is the raw material containing following weight parts proportioning:

Fructus Hippophae stock solution: 38 parts；Taurine: 0.5 part；Zinc lactate: 0.5 part；Mel: 10 parts。

Above technical scheme can adopt following preparation method to prepare:

(1) by Fructus Hippophae stock solution, taurine, zinc lactate, Mel according to proportioning wiring solution-forming, add water 100 parts, enter mixing in agitator tank；

(2) deployed liquid, through filtering, enters sterilizing in instantaneous ultrahigh-temperature sterilization equipment；

(3) fill；

(4) pasteurization。

The preparation method of Fructus Hippophae stock solution described above is: choose fresh Fructus Hippophae, cleans, uses juice extractor squeezing juice, filter and get final product。

Detailed description of the invention:

The beneficial effect of of the present invention medicine is expanded on further below by way of pharmacodynamics test and contrast test。

Test example

(1) experimental technique

Select mice 80, male and female half and half, be randomly divided into dosage group and high dose group in blank group, medicine low dose group, medicine。Gavaging relative medicine or distilled water, every day 1 time respectively, growth test is 3 weeks, record daily inleting appetite and weekly body weight and height, observes mice behavior, hair color and mice health status every day period。Calculate each group of average weight gain and average efficiency of feed utilization。Put to death after above off-test and dissect mice, perusal pathological change, taking thymus, spleen, the heart, lung, liver, kidney are weighed, and calculate organ index [organ weights (mg)/body weight (g)]。

(2) statistical method

SPSSl2.0forWindows software is adopted to complete。Comparing with variance analysis LSD-t inspection between measurement data group, experimental result represents with ± s, and P < 0.05 thinks statistically significant。

(3) result

1. comparing with blank group, middle and high dosage group children female, male Mus body weight increases notable (P < 0.05 and P < 0.01), and low dose group body weight when 2ld dramatically increases (P < 0.05), and detailed results is in Table 1 ~ 2；Compare with blank group, high dose group male juvenile mouse 7,14,21d time height increase notable, young female rat 14,21d time height increase notable, middle dosage group male juvenile mouse height when 2ld increases notable (P < 0.05), young female rat 14,21d time height increase notable (P < 0.05), detailed results is in Table 3 ~ 4；Compare with blank group, appetite increase of spouting male juvenile mouse basic, normal, high dosage group day all has significant difference (P < O.05 with P < 0.01), the middle and high dosage group daily inleting appetite of young female rat increases notable (P < 0.05), and detailed results is in Table 5。

The impact (g) on male juvenile mouse body weight of table 1 Oral Liquid Fructus Hippophae

Note: with blank ratio, < O.05, * * P is < O.01 for * P

The impact (g) on young female rat body weight of table 2 Oral Liquid Fructus Hippophae

Note: with blank ratio, < O.05, * * P is < O.01 for * P

The impact (cm) on male juvenile mouse height of table 3 Oral Liquid Fructus Hippophae

Note: with blank ratio, * P is < O.05

The impact (cm) on young female rat height of table 4 Oral Liquid Fructus Hippophae

Note: with blank ratio, < O.05, * * P is < O.01 for * P

The impact (g/ sky) on children's Mus food-intake of table 5 Oral Liquid Fructus Hippophae

Note: with blank ratio, < O.05, * * P is < O.01 for * P

2. organ index

Compare with blank group, basic, normal, high dosage group male, female children the Mus heart, liver, spleen, lung, kidney, thymus organ index there was no significant difference, detailed results is in Table 6 ~ 7。

The impact (mg) on male juvenile mouse organ index of table 6 Oral Liquid Fructus Hippophae

The impact (mg) on male juvenile mouse organ index of table 7 Oral Liquid Fructus Hippophae

This experimental studies results shows, the Oral Liquid Fructus Hippophae being Main Ingredients and Appearance with Fructus Hippophae stock solution, and especially middle and high dosage group can promote the growth of mice height female, male, body weight。The growth of internal organs and body weight grow into direct ratio, and point out Oral Liquid Fructus Hippophae high dose group that the impact of Liver and kidney is smaller, and safety is higher。

Below by specific embodiment, technical scheme is described in further detail, but the present invention is not limited to these embodiments。

Embodiment one:

It is made up of the crude drug of following weight part ratio:

Fructus Hippophae stock solution: 30 parts；Taurine: 0.4 part；Zinc lactate: 0.8 part；Mel: 8 parts。

Embodiment two:

It is made up of the crude drug of following weight part ratio:

Fructus Hippophae stock solution: 45 parts；Taurine: 0.1 part；Zinc lactate: 1 part；Mel: 5 parts。

Embodiment three:

It is made up of the crude drug of following weight part ratio:

Fructus Hippophae stock solution: 50 parts；Taurine: 1 part；Zinc lactate: 0.1 part；Mel: 5 parts。

Embodiment four:

It is made up of the crude drug of following weight part ratio:

Fructus Hippophae stock solution: 35 parts；Taurine: 0.5 part；Zinc lactate: 0.5 part；Mel: 15 parts。

Embodiment five:

It is made up of the crude drug of following weight part ratio:

Fructus Hippophae stock solution: 38 parts；Taurine: 0.5 part；Zinc lactate: 0.5 part；Mel: 10 parts。

Claims (4)

1. the Oral Liquid Fructus Hippophae of an enhancing development, it is characterised in that be made up of the crude drug of following weight part ratio:

Fructus Hippophae stock solution: 30 ~ 50 parts；Taurine: 0.1 ~ 1 part；Zinc lactate: 0.1 ~ 1 part；Mel: 5 ~ 15 parts。

2. the Oral Liquid Fructus Hippophae of a kind of enhancing development according to claim 1, it is characterised in that be made up of the crude drug of following weight part ratio:

Fructus Hippophae stock solution: 38 parts；Taurine: 0.5 part；Zinc lactate: 0.5 part；Mel: 10 parts。

3. the preparation method of the Oral Liquid Fructus Hippophae of an enhancing development, it is characterised in that comprise the following steps:

(1) by Fructus Hippophae stock solution, taurine, zinc lactate, Mel according to proportioning wiring solution-forming, add water 100 parts, enter mixing in agitator tank；

(2) deployed liquid, through filtering, enters sterilizing in instantaneous ultrahigh-temperature sterilization equipment；

(3) fill；

(4) pasteurization。

4. the preparation method of the Oral Liquid Fructus Hippophae of a kind of enhancing development according to claim 3, it is characterised in that: the preparation method of described Fructus Hippophae stock solution is: choose fresh Fructus Hippophae, cleans, uses juice extractor squeezing juice, filter and get final product。