CN105477182A - Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid - Google Patents

Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid Download PDF

Info

Publication number
CN105477182A
CN105477182A CN201510951353.4A CN201510951353A CN105477182A CN 105477182 A CN105477182 A CN 105477182A CN 201510951353 A CN201510951353 A CN 201510951353A CN 105477182 A CN105477182 A CN 105477182A
Authority
CN
China
Prior art keywords
parts
oral liquid
chinese herbal
health care
add
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510951353.4A
Other languages
Chinese (zh)
Inventor
徐伦超
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Great Marine Health Food Co Ltd In Qingdao
Original Assignee
Great Marine Health Food Co Ltd In Qingdao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Great Marine Health Food Co Ltd In Qingdao filed Critical Great Marine Health Food Co Ltd In Qingdao
Priority to CN201510951353.4A priority Critical patent/CN105477182A/en
Publication of CN105477182A publication Critical patent/CN105477182A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/756—Phellodendron, e.g. corktree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity. In terms of 1000 parts, the health care oral liquid consists of the following Chinese herbal raw materials: 4-6 parts of ocellated puffer liver oil, 10-15 parts of fructus arctii, 8-12 parts of houttuynia cordata, 10-15 parts of radix puerariae, 15-20 parts of rhizoma ligustici wallichii, 10-13 parts of cortex phellodendri, 8-12 parts of herba andrographitis, 10-15 parts of dandelion, 10-16 parts of fruit of Chinese wolfberry, 10-18 parts of cyrtomium rhizome, 5-10 parts of rhizoma polygoni cuspidati, 5-10 parts of radix achyranthis bidentatae, 10-15 parts of liquorice root and 10-15 parts of chlorella vulgaris, and the health care oral liquid is prepared through combined technologies of ultrasonic-assisted extraction, volatile oil distillation, water decoction and alcohol extraction. The product has the advantages of being good in functions of resisting tumors and enhancing immunity, safe and free from side effects, convenient to drink and the like.

Description

A kind of antitumor improves immunity Fugu ocellatus fish oil herbal health care oral liquid and preparation method
Technical field
The present invention relates to a kind of antitumor and improve immunity Fugu ocellatus fish oil herbal health care oral liquid, particularly a kind of health care oral liquid made for raw material with Fugu ocellatus fish oil and vegetable Chinese herbal medicine, belong to healthcare field.
Background technology
Globe fish ( fugurubripes) in containing extremely toxic substance tetrodotoxin, this toxin has high economic worth and medical value.People comparatively go deep into %, careful to the research of tetrodotoxin, but have ignored the value of globe fish other side.Along with non-toxic globefish cultivation and the development of processing detoxification technology, the output of China's non-toxic globefish rises year by year, year outlet rate more than 90%, has now become the main source of external globe fish supply.Fugu ocellatus is of high nutritive value, and is a kind of extremely famous and precious high-grade aquatic products.Identify through State Aquatic Product Quality Monitoring Test Centre: the protein content of Fugu ocellatus is up to 17.71%, and fat content is only 0.62%, unsaturated fatty acid content more than 20%, the wherein main component of DHA(NAOHUANGJIN) to account for 15.36%, EPA be 6.19%.Fugu ocellatus fish oil mainly refers to the extract from the leftover bits and pieces such as Fugu ocellatus liver, ovary after detoxification, has tumor suppression, enhancing immunity, the various addictive function of withdrawal, is usually used in food, health product, medicine etc. at present, has good application and development and is worth.
Summary of the invention
Improving the deficiency of immunity health promoting product technology for overcoming existing antitumor, the object of the present invention is to provide a kind of herbal health care oral liquid with antitumor raising efficacy of immunity.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The invention provides a kind of antitumor and improve immunity Fugu ocellatus fish oil herbal health care oral liquid, it is characterized in that: in 1000 portions of oral liquids, raw material of Chinese medicine and quality proportioning are: 4 ~ 6 parts, Fugu ocellatus fish oil, Fructus Arctii 10 ~ 15 parts, Herba Houttuyniae 8 ~ 12 parts, Radix Puerariae 10 ~ 15 parts, Rhizoma Chuanxiong 15 ~ 20 parts, Cortex Phellodendri 10 ~ 13 parts, Herba Andrographis 8 ~ 12 parts, Herba Taraxaci 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Rhizoma Osmundae 10 ~ 18 parts, Rhizoma Polygoni Cuspidati 5 ~ 10 parts, Radix Achyranthis Bidentatae 5 ~ 10 parts, 10 ~ 15 parts, Radix Glycyrrhizae, chlorella 10 ~ 15 parts.
The preferred technical solution of the present invention is: a kind of antitumor improves immunity Fugu ocellatus fish oil herbal health care oral liquid, it is characterized in that: its raw material of Chinese medicine and quality proportioning are: 5 parts, Fugu ocellatus fish oil, Fructus Arctii 13 parts, Herba Houttuyniae 12 parts, Radix Puerariae 12 parts, Rhizoma Chuanxiong 16 parts, Cortex Phellodendri 12 parts, Herba Andrographis 10 parts, Herba Taraxaci 14 parts, Fructus Lycii 15 parts, Rhizoma Osmundae 15 parts, Rhizoma Polygoni Cuspidati 7 parts, Radix Achyranthis Bidentatae 7 parts, 12 parts, Radix Glycyrrhizae, chlorella 13 parts.
The invention provides a kind of antitumor and improve immunity Fugu ocellatus fish oil herbal health care oral liquid, it is characterized in that being prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, removes impurity etc., weighs according to aforementioned proportion;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Fructus Arctii, Herba Houttuyniae, Radix Puerariae, Rhizoma Chuanxiong, Herba Andrographis, Cortex Phellodendri, Herba Taraxaci, Rhizoma Osmundae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, chlorella mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Fugu ocellatus fish oil and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
The mixture of one or more that what above-mentioned sweeting agent was selected is in xylitol, oligomeric isomaltose, Mel.
The invention provides a kind of antitumor and improve immunity Fugu ocellatus fish oil herbal health care oral liquid, it is advantageous that: one is selected prescription under Traditional Chinese medical theory and practical advice, scientific compatibility Fugu ocellatus fish oil and multiple Chinese herbal medicine, drug component is through dialectical compatibility, help using mutually assistant, significantly can improve immunity by antitumor; Two is the technique adopting " Ultrasonic Wave-Assisted Extraction+volatile matter distillation oil+decocting+alcohol extraction " in the preparation process of oral liquid, and the antitumor fully mixed in Chinese herbal medicine improves the functional active components of immunity, improves health-care effect; Three is that oral liquid has no side effect safely, drinks conveniently.
The invention provides a kind of antitumor and improve immunity Fugu ocellatus fish oil herbal health care oral liquid, carried out toxicology test and the safety evaluatio of health care oral liquid by animal experiment.Chmice acute Oral toxicity result of the test shows, this health care oral liquid is greater than high dose group 75mg/kgbw to chmice acute per os maximum tolerated dose; Genetic toxicity test mouse marrow cell micro nuclear test and mouse inbred strain two result of the tests are feminine gender, show that this health care oral liquid is without mutagenic action; From rat 30d feeding trial, the behavior of rat sign is normal, figure is healthy, blood and blood parameters also change without exception, and therefore the dosage (150 times of human body recommended amounts) of 75mg/kgbw belongs to safe dose; Genetic toxicity test and rat 30d feeding trial result are feminine gender, therefore determine that this health beverage belongs to non-toxic type food, and people can be safe relieved edible.
The invention provides a kind of antitumor and improve immunity Fugu ocellatus fish oil herbal health care oral liquid, different Chinese herbal medicine nature and flavor are different, effect also exists huge difference, complicated interaction relationship is there is after different Chinese herbal medicine combinations, and proportioning between Chinese herbal medicine is closer, different ratio also will make monarch relation that substantial change occurs, thus make the relation generation material alterations of composite Chinese herbal.Complicated interaction relationship is there is to each other in the application by Chinese herbal medicine such as Fugu ocellatus fish oil, Fructus Arctii, Herba Houttuyniae, Radix Puerariae, Rhizoma Chuanxiong, Cortex Phellodendri, Herba Andrographis, Herba Taraxaci, Fructus Lycii, Rhizoma Osmundae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, chlorellas, rational proportion, achieve unforeseeable technique effect, make antitumor improve the relation generation material alterations of immunity herbal health care oral liquid.Carried out Evaluation of Functional according to " function of health food assessment process and the method for inspection " to the application's product, research health care oral liquid is to S 180the impact of tumor-bearing mice spleen lymphocyte proliferation function, result shows that health care oral liquid can significantly improve lymphocytic proliferation activity (amplification 91.32%), also the lymphopoiesis (amplification 52.84%) that ConA stimulates can obviously be strengthened, comparatively matched group significant difference (p<0.01); Research health care oral liquid is to S 180the impact of tumor-bearing mice phagocyte activate the phagocytic capacity, result shows that health care oral liquid experimental group activate the phagocytic capacity is all significantly increased (amplification 93.25%), comparatively matched group significant difference (p<0.01), thus improve the non-specific immunity of mice; Relatively S 180tumor-bearing mice gross tumor volume, health care oral liquid experimental group is significantly less; Illustrate that product has good antitumor and improves immunity activity; In addition, result of the test shows, change Fugu ocellatus fish oil and the composition of Chinese herbal medicine and effect of reduction product more remarkable in regular meeting, result difference significantly (p<0.01), illustrates that the synergism between Fugu ocellatus fish oil and Chinese herbal medicine serves the effect of significantly lifting oral liquid functional activity.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
embodiment 1:
A kind of antitumor improves immunity Fugu ocellatus fish oil herbal health care oral liquid, is prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to 5 parts, Fugu ocellatus fish oil, Fructus Arctii 13 parts, Herba Houttuyniae 12 parts, Radix Puerariae 12 parts, Rhizoma Chuanxiong 16 parts, Cortex Phellodendri 12 parts, Herba Andrographis 10 parts, Herba Taraxaci 14 parts, Fructus Lycii 15 parts, Rhizoma Osmundae 15 parts, Rhizoma Polygoni Cuspidati 7 parts, Radix Achyranthis Bidentatae 7 parts, 12 parts, Radix Glycyrrhizae, chlorella 13 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Fructus Arctii, Herba Houttuyniae, Radix Puerariae, Rhizoma Chuanxiong, Herba Andrographis, Herba Taraxaci, Rhizoma Osmundae, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, chlorella mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2.5 times of pure water, making beating, then adds 1.5% pectase, enzymolysis 15min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 4 times of pure water after raw material mixing, then add raw materials quality than 2.5% cellulase, 1.5% non-starch polysaccharide enzyme, enzymolysis 45min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 4 times amount in Chinese herbal medicine residue, collect volatile oil 9h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.8% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2.5 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.8h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 5 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.2h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Fugu ocellatus fish oil and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.12% and the xylitol of 1.5%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 8min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 2:
A kind of antitumor improves immunity Fugu ocellatus fish oil herbal health care oral liquid, is prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to 6 parts, Fugu ocellatus fish oil, Fructus Arctii 10 parts, Herba Houttuyniae 12 parts, Radix Puerariae 10 parts, Rhizoma Chuanxiong 20 parts, Cortex Phellodendri 10 parts, Herba Andrographis 12 parts, Herba Taraxaci 10 parts, Fructus Lycii 16 parts, Rhizoma Osmundae 10 parts, Rhizoma Polygoni Cuspidati 5 parts, Radix Achyranthis Bidentatae 10 parts, 15 parts, Radix Glycyrrhizae, chlorella 10 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Fructus Arctii, Herba Houttuyniae, Radix Puerariae, Rhizoma Chuanxiong, Herba Andrographis, Herba Taraxaci, Rhizoma Osmundae, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, chlorella mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 3 times of pure water, making beating, then adds 2% pectase, enzymolysis 10min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 5 times of pure water after raw material mixing, then add raw materials quality than 3% cellulase, 2% non-starch polysaccharide enzyme, enzymolysis 30min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 5 times amount in Chinese herbal medicine residue, collect volatile oil 8h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Fugu ocellatus fish oil and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.15% and the oligomeric isomaltose of 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 3:
A kind of antitumor improves immunity Fugu ocellatus fish oil herbal health care oral liquid, is prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to 4 parts, Fugu ocellatus fish oil, Fructus Arctii 15 parts, Herba Houttuyniae 8 parts, Radix Puerariae 15 parts, Rhizoma Chuanxiong 15 parts, Cortex Phellodendri 13 parts, Herba Andrographis 8 parts, Herba Taraxaci 15 parts, Fructus Lycii 10 parts, Rhizoma Osmundae 18 parts, Rhizoma Polygoni Cuspidati 10 parts, Radix Achyranthis Bidentatae 5 parts, 10 parts, Radix Glycyrrhizae, chlorella 15 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Fructus Arctii, Herba Houttuyniae, Radix Puerariae, Rhizoma Chuanxiong, Herba Andrographis, Herba Taraxaci, Rhizoma Osmundae, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, chlorella mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2 times of pure water, making beating, then adds 1% pectase, enzymolysis 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 times of pure water after raw material mixing, then add raw materials quality than 2% cellulase, 1% non-starch polysaccharide enzyme, enzymolysis 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 times amount in Chinese herbal medicine residue, collect volatile oil 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Fugu ocellatus fish oil and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10% and the Mel of 1%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
Above embodiment only for illustration of technical scheme of the present invention, but not is limited; Although be described in detail by invention with reference to previous embodiment, for the person of ordinary skill of the art, still the technical scheme described in previous embodiment can be modified, or equivalent replacement has been carried out to wherein portion of techniques feature; And to these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.

Claims (2)

1. antitumor improves an immunity Fugu ocellatus fish oil herbal health care oral liquid, it is characterized in that being prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to every 4 ~ 6 parts, 1000 parts of oral liquid Raw quality proportioning Fugu ocellatus fish oil, Fructus Arctii 10 ~ 15 parts, Herba Houttuyniae 8 ~ 12 parts, Radix Puerariae 10 ~ 15 parts, Rhizoma Chuanxiong 15 ~ 20 parts, Cortex Phellodendri 10 ~ 13 parts, Herba Andrographis 8 ~ 12 parts, Herba Taraxaci 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Rhizoma Osmundae 10 ~ 18 parts, Rhizoma Polygoni Cuspidati 5 ~ 10 parts, Radix Achyranthis Bidentatae 5 ~ 10 parts, 10 ~ 15 parts, Radix Glycyrrhizae, chlorella 10 ~ 15 parts;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Fructus Arctii, Radix Bupleuri, Radix Puerariae, Spica Prunellae, Herba Andrographis, Radix Scutellariae, Herba Taraxaci, Rhizoma Osmundae, Rhizoma Polygoni Cuspidati, Radix Achyranthis Bidentatae, Radix Glycyrrhizae, spirulina mixing, cross 40 mesh sieves;
2. in Fructus Crataegi, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Fugu ocellatus fish oil and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
2. a kind of antitumor improves immunity Fugu ocellatus fish oil herbal health care oral liquid according to claim 1, and what it is characterized in that described sweeting agent selects is the mixture of one or more in xylitol, oligomeric isomaltose, Mel.
CN201510951353.4A 2015-12-19 2015-12-19 Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid Pending CN105477182A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510951353.4A CN105477182A (en) 2015-12-19 2015-12-19 Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201510951353.4A CN105477182A (en) 2015-12-19 2015-12-19 Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid

Publications (1)

Publication Number Publication Date
CN105477182A true CN105477182A (en) 2016-04-13

Family

ID=55664696

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201510951353.4A Pending CN105477182A (en) 2015-12-19 2015-12-19 Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid

Country Status (1)

Country Link
CN (1) CN105477182A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753929A (en) * 2017-11-10 2018-03-06 河南工业大学 A kind of health care oral liquid of the globulin containing wheat germ and preparation method thereof
CN109331042A (en) * 2018-08-03 2019-02-15 泰州市康特生物工程有限公司 A kind of compound filefish liver oil composition and the preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102283883A (en) * 2011-08-04 2011-12-21 湖南森康生物技术有限公司 Health-care oral liquid for enhancing immunity and relieving physical fatigue and preparation method thereof
CN104434982A (en) * 2015-01-06 2015-03-25 刘学民 Medicinal globefish oil making method
CN105055569A (en) * 2015-07-22 2015-11-18 青岛浩大海洋保健食品有限公司 Anti-tumor shark fin bone meal Chinese herbal medicine health oral liquid capable of improving immunity and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102283883A (en) * 2011-08-04 2011-12-21 湖南森康生物技术有限公司 Health-care oral liquid for enhancing immunity and relieving physical fatigue and preparation method thereof
CN104434982A (en) * 2015-01-06 2015-03-25 刘学民 Medicinal globefish oil making method
CN105055569A (en) * 2015-07-22 2015-11-18 青岛浩大海洋保健食品有限公司 Anti-tumor shark fin bone meal Chinese herbal medicine health oral liquid capable of improving immunity and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753929A (en) * 2017-11-10 2018-03-06 河南工业大学 A kind of health care oral liquid of the globulin containing wheat germ and preparation method thereof
CN109331042A (en) * 2018-08-03 2019-02-15 泰州市康特生物工程有限公司 A kind of compound filefish liver oil composition and the preparation method and application thereof
CN113577229A (en) * 2018-08-03 2021-11-02 泰州市康特生物工程有限公司 Compound globefish liver oil composition and preparation method and application thereof
CN113694165A (en) * 2018-08-03 2021-11-26 泰州市康特生物工程有限公司 Compound globefish liver oil composition and preparation method and application thereof

Similar Documents

Publication Publication Date Title
CN104957313A (en) Green tea beverage beneficial for reducing blood fat and reducing blood press
CN101856430A (en) Green tonic lucid ganoderma (three immortals) cream for preventing sub-health and preparation method thereof
CN104547534A (en) Chinese herbal medicine health oral liquid with efficacy of relieving visual fatigue
CN106237075B (en) Food, health-care product or pharmaceutical composition with anti-fatigue and attention-improving functions as well as preparation method and application thereof
CN105477369A (en) Anti-aging Chinese herbal medicinal health oral liquid containing seaweed protein and preparation method of anti-aging Chinese herbal medicinal health oral liquid
CN105055648A (en) Anti-aging Chinese herbal medicinal health oral liquid containing shark cartilage powder and preparation method of oral liquid
CN102178867A (en) Chinese medicine preparation for replenishing qi to invigorate spleen and tonifying kidney and products thereof
CN103341039A (en) Nourishing formula for enhancing human body immunity and production method of soup thereof
CN104757540A (en) Health-care product assisted to reduce blood glucose and preparation method thereof
CN106135527A (en) A kind of health-care tea for taking good care of health
CN105055569A (en) Anti-tumor shark fin bone meal Chinese herbal medicine health oral liquid capable of improving immunity and preparation method thereof
CN102579836B (en) Traditional Chinese medical dendrobium huoshanense composition and preparation method thereof
CN105055707A (en) Lipid-lowering Chinese herbal medicinal health oral liquid containing shark cartilage powder and preparation method of oral liquid
CN105477182A (en) Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid
CN104138468A (en) Application of traditional Chinese medicine compound in preparing of lipid-lowering drugs
CN104922299A (en) Traditional Chinese medicine healthcare oral liquid used for preventing and treating diabetic retinopathy
CN104888046A (en) Chinese medicinal herbal healthcare oral liquid with anemia improvement function
CN105327238A (en) Traditional Chinese medicinal composition for tonifying spleen and stomach as well as preparation method and application of traditional Chinese medicinal composition
CN105998733A (en) Preparing method for pear flower and lily honey ointment
CN106072641A (en) A kind of unknown mallow health care oral liquid contributing to blood fat reducing
CN105998732A (en) Anti-aging Chinese herb healthcare oral liquid and preparation method
CN105497277A (en) Fugu-rubripe-oil oral solution for improving sexual hypofunction
CN105475798A (en) Shark fin bone meal solid beverage with blood fat lowering efficacy, and preparation technology thereof
CN100428897C (en) Health care food for antifatigue and improving subhealthy and its preparation method
CN105943836A (en) Lily honey paste for preventing and treating respiratory diseases caused by haze

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160413

WD01 Invention patent application deemed withdrawn after publication