CN105477369A - Anti-aging Chinese herbal medicinal health oral liquid containing seaweed protein and preparation method of anti-aging Chinese herbal medicinal health oral liquid - Google Patents
Anti-aging Chinese herbal medicinal health oral liquid containing seaweed protein and preparation method of anti-aging Chinese herbal medicinal health oral liquid Download PDFInfo
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Abstract
The invention discloses anti-aging Chinese herbal medicinal health oral liquid containing seaweed protein. Each 1000 parts of the health oral liquid is prepared from the following Chinese herbal medicinal materials in parts by weight: 40-60 parts of the seaweed protein, 10-15 parts of radix scutellariae, 8-12 parts of poria cocos, 10-15 parts of dendrobe, 15-20 parts of gynostemma pentaphylla, 10-13 parts of prepared rehmannia root, 8-12 parts of bighead atractylodes rhizome, 10-15 parts of gallnuts, 10-16 parts of the fruits of Chinese wolfberry, 10-18 parts of acanthopanax root, 5-10 parts of codonopsis pilosula, 5-10 parts of herba epimedii, 10-15 parts of licorice root, and 10-15 parts of stevia rebaudiana. The anti-aging Chinese herbal medicinal health oral liquid containing seaweed protein is prepared by adopting a technology comprising the steps including ultrasonic-assisted digestion, volatile oil distillation, water decoction and alcohol extraction. The product has the advantages of being good in anti-aging efficiency, being safe without side effects, and being convenient to drink.
Description
Technical field
The present invention relates to a kind of defying age Sargassum protein herbal health care oral liquid, particularly a kind of health care oral liquid made for raw material with Sargassum protein and vegetable Chinese herbal medicine, belong to field of health care food.
Background technology
Sargassum is because of its special composition and functionally have purposes widely.Containing a certain amount of protein and more polysaccharide fiber element, on a small quantity fat in Sargassum, abundant inorganic salt and vitamin.Mineral contained by Sargassum is calcium, ferrum, sodium, magnesium, phosphorus, iodine etc.Modern science is thought, normal food alga food can regulate blood pH effectively, avoids alkaline element in body (calcium, zinc) too much to be consumed because of acidity neutralization.Sargassum can optionally remove the heavy metal carcinogens such as hydrargyrum, cadmium, lead.Women, due to physiological reason, often causes iron deficiency anemia, and polyphagia Sargassum can effective iron supplement.Normal food alga food also can make dry skin gloss, and oily skin improves fat secretion.Vitamin abundant in Sargassum, can safeguard epithelial tissue healthy growth, reduces pigment spot.In addition, Sargassum belongs to low-calorie diet, is particularly suitable for old people and suffers from hypertension, heart disease, diabetic and constipation person eating.
Aging is that each organ of body engenders the progressive process that hypofunction and reserve capabillity decline along with the continuous increase at age, and with advancing age, the same miopragia of various organs of human body, produces various pathological changes, little by little enters ageing state.Therefore prevention and slow down aging have become current social medical research focus.Chinese herbal medicine resource is the rarity of Chinese traditional culture, because of its effect significantly, green, safely, have no side effect, the application in field of health care food is further extensive.Chinese medicine is thought: the main cause of human senility is deficient five internal organs, disorder of QI and blood etc., and by nourishing the five internal organs, QI and blood regulating is the important means of traditional Chinese medical science slow down aging.The research of Chinese medicine in defying age has the advantage of rich experience and uniqueness.Along with the continuous enhancing of people's prevention and health care consciousness, society increases day by day to the demand with function of delaying senility health food.Result of study shows, the health product utilizing Chinese herbal medicine to develop contain abundant nutritional labeling, be rich in trace element, the vitamin isoreactivity nutritional labelings such as polysaccharide, flavone, aminoacid, potassium calcium, there is adjustment function of human body, the effects such as enhancing immunity, nourishing and fit keeping function, life lengthening.
Summary of the invention
For overcoming the deficiency of existing product technology, the object of the present invention is to provide a kind of herbal health care oral liquid with senile-resistant efficacy.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The invention provides a kind of defying age Sargassum protein herbal health care oral liquid, it is characterized in that: in 1000 portions of oral liquids, raw material of Chinese medicine and quality proportioning are: Sargassum protein 40 ~ 60 parts, Radix Scutellariae 10 ~ 15 parts, 8 ~ 12 parts, Poria, Herba Dendrobii 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 15 ~ 20 parts, 10 ~ 13 parts, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae 8 ~ 12 parts, Galla Chinensis 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Radix Et Caulis Acanthopanacis Senticosi 10 ~ 18 parts, Radix Codonopsis 5 ~ 10 parts, Herba Epimedii 5 ~ 10 parts, 10 ~ 15 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 10 ~ 15 parts.
The preferred technical solution of the present invention is: a kind of defying age Sargassum protein herbal health care oral liquid, is characterized in that: its raw material of Chinese medicine and quality proportioning are: Sargassum protein 50 parts, Radix Scutellariae 13 parts, 12 parts, Poria, Herba Dendrobii 12 parts, Herb Gynostemmae Pentaphylli 16 parts, 12 parts, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae 10 parts, Galla Chinensis 14 parts, Fructus Lycii 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Radix Codonopsis 7 parts, Herba Epimedii 7 parts, 12 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 13 parts.
The invention provides a kind of defying age Sargassum protein herbal health care oral liquid, it is characterized in that being prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, removes impurity etc., weighs according to aforementioned proportion;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Scutellariae, Poria, Herba Dendrobii, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Herba Epimedii, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Sargassum protein and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
The mixture of one or more that what above-mentioned sweeting agent was selected is in xylitol, oligomeric isomaltose, Mel.
The invention provides a kind of defying age Sargassum protein herbal health care oral liquid, it is advantageous that: one is selected prescription under Traditional Chinese medical theory and practical advice, scientific compatibility Sargassum protein and multiple Chinese herbal medicine, and drug component is through dialectical compatibility, help using mutually assistant, can remarkable defying age; Two is the technique adopting " Ultrasonic Wave-Assisted Extraction+volatile matter distillation oil+decocting+alcohol extraction " in the preparation process of oral liquid, fully mixes the antidotal functional active components in Chinese herbal medicine, improves health-care effect; Three is that oral liquid has no side effect safely, drinks conveniently.
The invention provides a kind of defying age Sargassum protein herbal health care oral liquid, carried out toxicology test and the safety evaluatio of health care oral liquid by animal experiment.Chmice acute Oral toxicity result of the test shows, this health care oral liquid is greater than high dose group 75mg/kgbw to chmice acute per os maximum tolerated dose; Genetic toxicity test mouse marrow cell micro nuclear test and mouse inbred strain two result of the tests are feminine gender, show that this health care oral liquid is without mutagenic action; From rat 30d feeding trial, the behavior of rat sign is normal, figure is healthy, blood and blood parameters also change without exception, and therefore the dosage (150 times of human body recommended amounts) of 75mg/kgbw belongs to safe dose; Genetic toxicity test and rat 30d feeding trial result are feminine gender, therefore determine that this health beverage belongs to non-toxic type food, and people can be safe relieved edible.
The invention provides a kind of defying age Sargassum protein herbal health care oral liquid, different Chinese herbal medicine nature and flavor are different, effect also exists huge difference, complicated interaction relationship is there is after different Chinese herbal medicine combinations, and proportioning between Chinese herbal medicine is closer, different ratio also will make monarch relation that substantial change occurs, thus make the relation generation material alterations of composite Chinese herbal.Complicated interaction relationship is there is to each other in the application by Chinese herbal medicine such as Sargassum protein, Radix Scutellariae, Poria, Herba Dendrobii, Herb Gynostemmae Pentaphylli, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Galla Chinensis, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Herba Epimedii, Radix Glycyrrhizae, Folium Stevlae Rebaudianae, rational proportion, achieve unforeseeable technique effect, make the relation generation material alterations of defying age herbal health care oral liquid.According to " function of health food assessment process and the method for inspection ", Evaluation of Functional is carried out to the application's product, rat test is utilized to measure health care oral liquid to the impact on one of aging index-peroxidation lipid, after result shows to feed 3 months, experimental group serum MDA value is lower than matched group, liver homogenate MDA and brain homogenate MDA comparatively matched group reduces by 30.03% and 29.34%, comparatively matched group significant difference (p<0.01), illustrates that product has good activity of fighting against senium; In addition, result of the test shows, change Sargassum protein and the composition of Chinese herbal medicine and effect of reduction product more remarkable in regular meeting, result difference significantly (p<0.01), illustrates that the synergism between Sargassum protein and Chinese herbal medicine serves the effect of significantly lifting oral liquid functional activity.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
embodiment 1:
A kind of defying age Sargassum protein herbal health care oral liquid, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to Sargassum protein 50 parts, Radix Scutellariae 13 parts, 12 parts, Poria, Herba Dendrobii 12 parts, Herb Gynostemmae Pentaphylli 16 parts, 12 parts, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae 10 parts, Galla Chinensis 14 parts, Fructus Lycii 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Radix Codonopsis 7 parts, Herba Epimedii 7 parts, 12 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 13 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Scutellariae, Poria, Herba Dendrobii, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Rehmanniae Preparata, Radix Codonopsis, Herba Epimedii, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2.5 times of pure water, making beating, then adds 1.5% pectase, enzymolysis 15min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 4 times of pure water after raw material mixing, then add raw materials quality than 2.5% cellulase, 1.5% non-starch polysaccharide enzyme, enzymolysis 45min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 4 times amount in Chinese herbal medicine residue, collect volatile oil 9h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.8% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2.5 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.8h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 5 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.2h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Sargassum protein and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.12% and the xylitol of 1.5%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 8min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 2:
A kind of defying age Sargassum protein herbal health care oral liquid, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to Sargassum protein 60 parts, Radix Scutellariae 10 parts, 12 parts, Poria, Herba Dendrobii 10 parts, Herb Gynostemmae Pentaphylli 20 parts, 10 parts, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae 12 parts, Galla Chinensis 10 parts, Fructus Lycii 16 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts, Radix Codonopsis 5 parts, Herba Epimedii 10 parts, 15 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 10 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Scutellariae, Poria, Herba Dendrobii, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Rehmanniae Preparata, Radix Codonopsis, Herba Epimedii, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 3 times of pure water, making beating, then adds 2% pectase, enzymolysis 10min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 5 times of pure water after raw material mixing, then add raw materials quality than 3% cellulase, 2% non-starch polysaccharide enzyme, enzymolysis 30min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 5 times amount in Chinese herbal medicine residue, collect volatile oil 8h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Sargassum protein and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.15% and the oligomeric isomaltose of 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
embodiment 3:
A kind of defying age Sargassum protein herbal health care oral liquid, prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to Sargassum protein 40 parts, Radix Scutellariae 15 parts, 8 parts, Poria, Herba Dendrobii 15 parts, Herb Gynostemmae Pentaphylli 15 parts, 13 parts, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae 8 parts, Galla Chinensis 15 parts, Fructus Lycii 10 parts, Radix Et Caulis Acanthopanacis Senticosi 18 parts, Radix Codonopsis 10 parts, Herba Epimedii 5 parts, 10 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 15 parts of ratios in every 1000 portions of oral liquids;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Scutellariae, Poria, Herba Dendrobii, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Rehmanniae Preparata, Radix Codonopsis, Herba Epimedii, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2 times of pure water, making beating, then adds 1% pectase, enzymolysis 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 times of pure water after raw material mixing, then add raw materials quality than 2% cellulase, 1% non-starch polysaccharide enzyme, enzymolysis 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 times amount in Chinese herbal medicine residue, collect volatile oil 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Sargassum protein and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10% and the Mel of 1%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
Above embodiment only for illustration of technical scheme of the present invention, but not is limited; Although be described in detail by invention with reference to previous embodiment, for the person of ordinary skill of the art, still the technical scheme described in previous embodiment can be modified, or equivalent replacement has been carried out to wherein portion of techniques feature; And to these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of the present invention's technical scheme required for protection.
Claims (2)
1. a defying age Sargassum protein herbal health care oral liquid, is characterized in that being prepared by following steps:
(1) sorting weighs: sorted by Chinese herbal medicine used, remove impurity etc., weigh according to every 1000 parts of oral liquid Raw quality proportioning Sargassum proteins 40 ~ 60 parts, Radix Scutellariae 10 ~ 15 parts, 8 ~ 12 parts, Poria, Herba Dendrobii 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 15 ~ 20 parts, 10 ~ 13 parts, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae 8 ~ 12 parts, Galla Chinensis 10 ~ 15 parts, Fructus Lycii 10 ~ 16 parts, Radix Et Caulis Acanthopanacis Senticosi 10 ~ 18 parts, Radix Codonopsis 5 ~ 10 parts, Herba Epimedii 5 ~ 10 parts, 10 ~ 15 parts, Radix Glycyrrhizae, Folium Stevlae Rebaudianae 10 ~ 15 parts;
(2) pretreatment of raw material: carry out pretreatment of raw material respectively according to property of raw material difference:
1. carry out pulverization process by after Radix Scutellariae, Poria, Herba Dendrobii, Herb Gynostemmae Pentaphylli, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Galla Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Radix Codonopsis, Herba Epimedii, Radix Glycyrrhizae, Folium Stevlae Rebaudianae mixing, cross 40 mesh sieves;
2. in Fructus Lycii, add 2 ~ 3 times of pure water, making beating, then adds 1 ~ 2% pectase, enzymolysis 10 ~ 20min under 40 ~ 50 DEG C of conditions;
(3) ultrasound-assisted enzymolysis: add raw materials quality than 3 ~ 5 times of pure water after raw material mixing, then raw materials quality is added than 2 ~ 3% cellulase, 1 ~ 2% non-starch polysaccharide enzyme, enzymolysis 30 ~ 60min under ultrasonic assistant condition, hydrolysis temperature controls at 40 ~ 50 DEG C;
(4) centrifugal: centrifugalize lixiviating solution and middle medicinal herbs residue;
(5) distill: the pure water adding 3 ~ 5 times amount in Chinese herbal medicine residue, collect volatile oil 8 ~ 10h, volatile oil collects placement separately, and aqueous solution filters, and merges with lixiviating solution;
(6) volatile oil emulsifying: the cosolvent tween 80 of 1.5 ~ 2.0% will be added in the volatile oil of collection, heating emulsification;
(7) decocting: will add the water of 2 ~ 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5 ~ 2h, decocting liquid and lixiviating solution merge;
(8) concentrating under reduced pressure: the clear paste aqueous solution after merging being concentrated into 1g/ml, lets cool;
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60 ~ 70%, places more than 48h under 4 DEG C of conditions
(10) alcohol extraction: 50% ethanol adding 4 ~ 6 times amount in the Chinese herbal medicine residue after decocting, heating extraction 2 times, extraction time 1 ~ 1.5h;
(11) sucking filtration is merged: the liquid after precipitate with ethanol and alcohol extract are merged sucking filtration;
(12) reclaim under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol extremely without alcohol taste;
(13) mix: in concentrated solution, add Sargassum protein and the good volatile oil of emulsifying while hot, stir;
(14) adjuvant is added: add the potassium sorbate of 0.10 ~ 0.15% and the sweeting agent of 1 ~ 2%, add water stirring standardize solution;
(15) leave standstill: leave standstill more than 48h by under oral liquid semi-finished product room temperature;
(16) centrifugal: by the centrifugal 5 ~ 10min of oral liquid semi-finished product 3000r/min;
(17) standardize solution subpackage: namely the oral liquid standardize solution after centrifugal, subpackage are obtained oral liquid finished product.
2. the herbal health care oral liquid of a kind of prevention and therapy diabetic retinopathy according to claim 1, what it is characterized in that described sweeting agent selects is the mixture of one or more in xylitol, oligomeric isomaltose, Mel.
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Cited By (7)
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| CN105878840A (en) * | 2016-06-23 | 2016-08-24 | 青岛浩大海洋保健食品有限公司 | Euphausia superba oil healthy oral liquid capable of preventing and improving diabetes |
| CN105943879A (en) * | 2016-06-23 | 2016-09-21 | 青岛浩大海洋保健食品有限公司 | Anti-ageing euphausia superba oil health oral solution |
| CN105998732A (en) * | 2016-06-27 | 2016-10-12 | 青岛铭晨信息技术有限公司 | Anti-aging Chinese herb healthcare oral liquid and preparation method |
| CN105995357A (en) * | 2016-06-28 | 2016-10-12 | 青岛浩大海洋保健食品有限公司 | Innominatam kwai herb healthcare oral liquid for slowing aging |
| CN106072641A (en) * | 2016-06-28 | 2016-11-09 | 青岛浩大海洋保健食品有限公司 | A kind of unknown mallow health care oral liquid contributing to blood fat reducing |
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| CN106509903A (en) * | 2016-12-13 | 2017-03-22 | 青岛嘉瑞生物技术有限公司 | Salicornia europaea health-care oral liquid having effects of treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105878840A (en) * | 2016-06-23 | 2016-08-24 | 青岛浩大海洋保健食品有限公司 | Euphausia superba oil healthy oral liquid capable of preventing and improving diabetes |
| CN105943879A (en) * | 2016-06-23 | 2016-09-21 | 青岛浩大海洋保健食品有限公司 | Anti-ageing euphausia superba oil health oral solution |
| CN105998732A (en) * | 2016-06-27 | 2016-10-12 | 青岛铭晨信息技术有限公司 | Anti-aging Chinese herb healthcare oral liquid and preparation method |
| CN105995357A (en) * | 2016-06-28 | 2016-10-12 | 青岛浩大海洋保健食品有限公司 | Innominatam kwai herb healthcare oral liquid for slowing aging |
| CN106072641A (en) * | 2016-06-28 | 2016-11-09 | 青岛浩大海洋保健食品有限公司 | A kind of unknown mallow health care oral liquid contributing to blood fat reducing |
| CN106107978A (en) * | 2016-06-28 | 2016-11-16 | 青岛浩大海洋保健食品有限公司 | A kind of unknown mallow health care oral liquid of blood pressure lowering |
| CN106509903A (en) * | 2016-12-13 | 2017-03-22 | 青岛嘉瑞生物技术有限公司 | Salicornia europaea health-care oral liquid having effects of treating diabetes |
| CN106509903B (en) * | 2016-12-13 | 2019-12-06 | 青岛嘉瑞生物技术有限公司 | salicornia herbacea oral liquid with effect of treating diabetes |
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