CN106107978A - A kind of unknown mallow health care oral liquid of blood pressure lowering - Google Patents
A kind of unknown mallow health care oral liquid of blood pressure lowering Download PDFInfo
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- CN106107978A CN106107978A CN201610484612.1A CN201610484612A CN106107978A CN 106107978 A CN106107978 A CN 106107978A CN 201610484612 A CN201610484612 A CN 201610484612A CN 106107978 A CN106107978 A CN 106107978A
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- 230000036772 blood pressure Effects 0.000 title claims abstract description 22
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- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
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- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of unknown mallow health care oral liquid of blood pressure lowering, this products material formula is that in 1000 portions of oral liquids, raw material of Chinese medicine and quality proportioning are: unknown certain herbaceous plants with big flowers 40～60 parts, Semen Cassiae 10～15 parts, Radix Scutellariae 8～12 parts, Albizzia kalkora spend 10～15 parts, Herba Apocyni veneti 15～20 parts, Herba Epimedii 10～13 parts, Fructus Corni 8～12 parts, Herba Dendrobii 10～15 parts, Fructus Crataegi 10～16 parts, Radix Puerariae 10～18 parts, Spica Prunellae 5～10 parts, Radix Glycyrrhizae 10～15 parts, Folium Stevlae Rebaudianae 10～15 parts, uses " Ultrasonic Wave-Assisted Extraction+volatile matter distillation oil+decocting+alcohol extraction " technique to prepare.This product has that blood fat reducing function is good, safety has no side effect, drink the advantages such as convenient.
Description
Technical field
The present invention relates to a kind of unknown mallow health care oral liquid of blood pressure lowering, particularly one with unknown certain herbaceous plants with big flowers and vegetable Chinese herbal medicine is
The health care oral liquid that raw material is made, belongs to field of health care food.
Background technology
Unknown certain herbaceous plants with big flowers, Malvaceae, draft is annual, the most edible in more than 200 autumn chrysanthemum plants, medicinal, and health-care effect has
High value.In addition to viewing and admiring greening environment, treasure part and be none garbage of Herb, bud, Seedling, tender point, alabastrum, tender
Really rich in proteins, high polymerization virgin rubber, Ve, Vc and mineral, can as new varieties supply market, family and restaurant can cooking,
Crossing water cold and dressed with sauce, Baoshang etc., meat and vegetables is the most suitable.Taste flavor is unique, viscous sweet smooth, duplicates with its phase without any vegetable, and helping of food disappears
Changing, intestine moistening is regulated the flow of vital energy and is made the useless unobstructed discharge of thing of dispelling in gastrointestinal, and effective suppression toxin is absorbed, and controls low-density protein and improves,
Or the harm that athero is to human body；Especially treatment constipation of old people has the effect got instant result, and frees the hardship of difficult defecation, by force
Power is cleaned the intestines and stomach and is crossed the fat of Sheng, the beneficially physical and mental health of old people.
It is an important new discovery that the flower put at the beginning of unknown certain herbaceous plants with big flowers and seed core extract biological general flavone, and unknown certain herbaceous plants with big flowers flavones content occupies
All currently known containing first of flavone plant, the most universally acknowledged Semen Ginkgo and daidzein content are the highest, and newfound
Unknown certain herbaceous plants with big flowers but exceeds Semen Ginkgo and Semen sojae atricolor 500 times.The biological flavone importance to human body, is raised to very importantly already
Cancerous cell and hemostasis and anti-inflammation effect are killed in position, effectively suppression, can prevent comprehensively and wipe out and treat insect pests and plant diseases various " mixed-blood " disease, produce human body
Powerful profound influence, and there is significant efficacies of tonifying kidney and invigorating yang, because unknown certain herbaceous plants with big flowers is described as natural " viagra "；Meanwhile, VE's
Content is also won than other species, exceeds 2000 times of milk, fresh orange-juice 3000 times, comes out top；Additionally, Vc, albumen, polysaccharide
The necessary trace element of human body such as glue, Plant fiber, non-good fortune mineral selenium, ferrum, zinc are the abundantest.
Chinese herbal medicine resource is the rarity of Chinese traditional culture, because its effect is notable, green, safely, have no side effect, in health care
Application in field of food is the most extensive.Result of study shows, utilizes the health product of Chinese herbal medicine development to contain abundant nutrition and becomes
Point, not only remain the trace element such as original polysaccharide in Chinese herbal medicine, flavone, aminoacid, potassium calcium, vitamin isoreactivity nutrition one-tenth
Point, and create the nutritional labelings such as substantial amounts of sugar, protein, essential amino acid in process of production, long-term rationally food
With regulating the effects such as function of human body, enhancing immunity, nourishing and fit keeping function, life lengthening.Chinese herbal medicine is got more and more in recent years
Be used for preventing and treating diabetes, but its application effect needs lifting further badly.At present, Chinese herbal medicine is in field of health care food
Application there is also more drawback, it is difficult to the real health-care effect playing Chinese herbal medicine.The present invention is directed to the problems referred to above, develop one
Plant the health care oral liquid with blood pressure reduction effect utilizing unknown certain herbaceous plants with big flowers and composite Chinese herbal, meet market to care food for reducing blood pressure
Demand.
Summary of the invention
For overcoming existing prevention and the deficiency for the treatment of hypertension product technology, it is an object of the invention to provide one and have
The herbal health care oral liquid of blood pressure reduction effect.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
The present invention provides a kind of unknown mallow health care oral liquid of blood pressure lowering, it is characterised in that: in 1000 portions of oral liquids raw material of Chinese medicine and
Quality proportioning is: unknown certain herbaceous plants with big flowers 40～60 parts, Semen Cassiae 10～15 parts, Radix Scutellariae 8～12 parts, Albizzia kalkora spend 10～15 parts, Herba Apocyni veneti 15
～20 parts, Herba Epimedii 10～13 parts, Fructus Corni 8～12 parts, Herba Dendrobii 10～15 parts, Fructus Crataegi 10～16 parts, Radix Puerariae 10～18 parts, summer
Hay 5～10 parts, Radix Glycyrrhizae 10～15 parts, Folium Stevlae Rebaudianae 10～15 parts.
The preferred technical solution of the present invention is: a kind of unknown mallow health care oral liquid of blood pressure lowering, it is characterised in that: its Chinese medicine is former
Material and quality proportioning be: unknown certain herbaceous plants with big flowers 50 parts, Semen Cassiae 13 parts, Radix Scutellariae 12 parts, Albizzia kalkora spend 12 parts, Herba Apocyni veneti 16 parts, Herba Epimedii 12
Part, Fructus Corni 10 parts, Herba Dendrobii 14 parts, Fructus Crataegi 15 parts, Radix Puerariae 15 parts, Spica Prunellae 7 parts, 12 parts of Radix Glycyrrhizae, Folium Stevlae Rebaudianae 13 parts.
The present invention provides a kind of unknown mallow health care oral liquid of blood pressure lowering, it is characterised in that prepared by following steps:
(1) sorting weighs: is sorted by Chinese herbal medicine used, goes the removal of impurity etc., weighs according to aforementioned proportion；
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. by Semen Cassiae, Radix Scutellariae, Albizzia kalkora flower, Herba Apocyni veneti, Fructus Corni, Herba Epimedii, Herba Dendrobii, Radix Puerariae, Spica Prunellae, Radix Glycyrrhizae, Folium Stevlae Rebaudianae
Carry out pulverization process after mixing, cross 40 mesh sieves；
2. in Fructus Crataegi, add 2～3 times of pure water, making beating, be subsequently adding 1～2% pectase, enzymolysis under the conditions of 40～50 DEG C
10～20min；
(3) ultrasound-assisted enzymolysis: after raw material mixing, addition raw materials quality is than 3～5 times of pure water, is subsequently adding raw materials quality ratio
2～3% cellulase, 1～2% non-starch polysaccharide enzyme, enzymolysis 30～60min under the conditions of ultrasonic assistant, hydrolysis temperature controls
At 40～50 DEG C；
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue；
(5) distillation: add the pure water of 3～5 times amount in Chinese herbal medicine residue, collects volatile oil 8～10h, and volatile oil is individually received
Collection is placed, and aqueous solution filters, and merges with lixiviating solution；
(6) volatile oil emulsifying: addition 1.5～the cosolvent tween 80 of 2.0%, heating emulsification in the volatile oil that will collect；
(7) decocting: by adding the water of 2～3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5～2h, decocting liquid
Merge with lixiviating solution；
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool；
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60～70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 4～6 times amount, heating extraction 2 times, extraction time in the Chinese herbal medicine residue after decocting
1～1.5h；
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract；
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste；
(13) mixing: add unknown certain herbaceous plants with big flowers and the good volatile oil of emulsifying while hot in concentrated solution, stir；
(14) adjuvant is added: addition 0.10～the potassium sorbate of 0.15% and 1～the sweeting agent of 2%, add water stirring constant volume；
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature；
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 5～10min；
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
What above-mentioned sweeting agent was selected is the mixture of one or more in xylitol, oligomeric isomaltose, Mel.
The present invention provides a kind of unknown mallow health care oral liquid of blood pressure lowering, and what described unknown certain herbaceous plants with big flowers raw material was selected is the leaf of unknown certain herbaceous plants with big flowers
Son, stem etc..
The present invention provides a kind of unknown mallow health care oral liquid of blood pressure lowering, it is advantageous that: one be in Traditional Chinese medical theory and
Selected prescription under practical advice, the unknown certain herbaceous plants with big flowers of scientific compatibility and multiple Chinese herbal medicine, drug component, through dialectical compatibility, is being used mutually
Assistant helps, can notable blood pressure lowering；Two is employing " Ultrasonic Wave-Assisted Extraction+volatile matter distillation oil+decocting in the preparation process of oral liquid
+ alcohol extraction " technique, fully mix the functional active components of the prevention in Chinese herbal medicine and blood pressure lowering, improve health-care effect；Three is mouth
Take liquid to have no side effect safely, drink conveniently.
The present invention provides a kind of unknown mallow health care oral liquid of blood pressure lowering, is carried out the toxicity of health care oral liquid by animal experiment
Learn test and safety evaluatio.Chmice acute Oral toxicity result of the test shows, this health care oral liquid is to chmice acute per os
Big tolerance dose is more than high dose group 75mg/kg bw；Genetic toxicity test mouse marrow cell micro nuclear test and mouse sperm
Two result of the tests of deformity test are feminine gender, show that this health care oral liquid is without mutagenic action；Can by rat 30d feeding trial
Know, rat sign behavior is normal, figure is healthy, blood and blood parameters change the most without exception, therefore 75mg/kg bw
Dosage (150 times of human body recommended amounts) belongs to safe dose；Genetic toxicity test and rat 30d feeding trial result are the moon
Property, it is thus determined that this health beverage belongs to non-toxic type food, people can be safe relieved edible.
The present invention provides a kind of unknown mallow health care oral liquid of blood pressure lowering, and different Chinese herbal medicine nature and flavor are different, and effect also exists
, there is the interaction relationship of complexity after different Chinese herbal medicine combinations, and the proportioning between Chinese herbal medicine be closeer in huge difference
Cutting, different ratio also will make monarch relation that substantial change occurs, so that the relation generation essence of composite Chinese herbal
Sexually revise.The application passes through unknown certain herbaceous plants with big flowers, Semen Cassiae, Radix Scutellariae, Albizzia kalkora flower, Herba Apocyni veneti, Herba Epimedii, Fructus Corni, Herba Dendrobii, Fructus Crataegi, Pueraria lobota
There is the interaction relationship of complexity, rational proportion in the Chinese herbal medicine such as root, Spica Prunellae, Radix Glycyrrhizae, Folium Stevlae Rebaudianae, achieves expectation to each other
Less than technique effect, make the relation generation material alterations of blood pressure lowering herbal health care oral liquid.According to " function of health food
Learn assessment process and the method for inspection " the application product has been carried out Evaluation of Functional, utilize Hypertensive Rats experiment continuously
Surrounding measures blood markers with tail pulsation method, feeds the modeling test group pressure value compared with matched group after this health beverage surrounding
Decline 24.18%, relatively matched group significant difference (p < 0.01), and feed Nifedipine sustained release tablets matched group without significant difference, explanation
Product has preferable hypotensive activity；Additionally, result of the test shows, change unknown certain herbaceous plants with big flowers and the composition of Chinese herbal medicine and show than regular meeting
Writing the effect reducing product, result difference is notable (p < 0.01), illustrates that the synergism between unknown certain herbaceous plants with big flowers and Chinese herbal medicine serves
It is obviously improved the effect of oral liquid functional activity.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1:
A kind of unknown mallow health care oral liquid of blood pressure lowering, is prepared by following steps:
(1) sorting weighs: is sorted by Chinese herbal medicine used, goes the removal of impurity etc., according to unknown certain herbaceous plants with big flowers 50 parts in every 1000 portions of oral liquids, certainly
Pine torch 13 parts, Radix Scutellariae 12 parts, Albizzia kalkora spend 12 parts, Herba Apocyni veneti 16 parts, Herba Epimedii 12 parts, Fructus Corni 10 parts, Herba Dendrobii 14 parts, Fructus Crataegi 15
Part, Radix Puerariae 15 parts, Spica Prunellae 7 parts, 12 parts of Radix Glycyrrhizae, 13 parts of ratios of Folium Stevlae Rebaudianae are weighed；
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. by Semen Cassiae, Radix Scutellariae, Albizzia kalkora flower, Herba Apocyni veneti, Fructus Corni, Herba Dendrobii, Radix Puerariae, Herba Epimedii, Spica Prunellae, Radix Glycyrrhizae, Folium Stevlae Rebaudianae
Carry out pulverization process after mixing, cross 40 mesh sieves；
2. in Fructus Crataegi, add 2.5 times of pure water, making beating, be subsequently adding 1.5% pectase, enzymolysis under the conditions of 40～50 DEG C
15min；
(3) ultrasound-assisted enzymolysis: after raw material mixing, addition raw materials quality is than 4 times of pure water, is subsequently adding raw materials quality ratio
2.5% cellulase, 1.5% non-starch polysaccharide enzyme, enzymolysis 45min under the conditions of ultrasonic assistant, hydrolysis temperature control 40～
50℃；
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue；
(5) distillation: add the pure water of 4 times amount in Chinese herbal medicine residue, collects volatile oil 9h, and volatile oil is collected separately placement,
Aqueous solution filters, and merges with lixiviating solution；
(6) volatile oil emulsifying: add the cosolvent tween 80 of 1.8%, heating emulsification in the volatile oil that will collect；
(7) decocting: by adding the water of 2.5 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.8h, decocting liquid and leaching
Extract merges；
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool；
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60～70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 5 times amount, heating extraction 2 times, extraction time in the Chinese herbal medicine residue after decocting
1.2h；
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract；
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste；
(13) mixing: add unknown certain herbaceous plants with big flowers and the good volatile oil of emulsifying while hot in concentrated solution, stir；
(14) adjuvant is added: adding potassium sorbate and the xylitol of 1.5% of 0.12%, add water stirring constant volume；
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature；
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 8min；
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
Embodiment 2:
A kind of unknown mallow health care oral liquid of blood pressure lowering, is prepared by following steps:
(1) sorting weighs: is sorted by Chinese herbal medicine used, goes the removal of impurity etc., according to unknown certain herbaceous plants with big flowers 60 parts in every 1000 portions of oral liquids, certainly
Pine torch 10 parts, Radix Scutellariae 12 parts, Albizzia kalkora spend 10 parts, Herba Apocyni veneti 20 parts, Herba Epimedii 10 parts, Fructus Corni 12 parts, Herba Dendrobii 10 parts, Fructus Crataegi 16
Part, Radix Puerariae 10 parts, Spica Prunellae 5 parts, 15 parts of Radix Glycyrrhizae, 10 parts of ratios of Folium Stevlae Rebaudianae are weighed；
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. by Semen Cassiae, Radix Scutellariae, Albizzia kalkora flower, Herba Apocyni veneti, Fructus Corni, Herba Dendrobii, Radix Puerariae, Herba Epimedii, Spica Prunellae, Radix Glycyrrhizae, Folium Stevlae Rebaudianae
Carry out pulverization process after mixing, cross 40 mesh sieves；
2. in Fructus Crataegi, add 3 times of pure water, making beating, be subsequently adding 2% pectase, enzymolysis 10min under the conditions of 40～50 DEG C；
(3) ultrasound-assisted enzymolysis: after raw material mixing, addition raw materials quality is than 5 times of pure water, is subsequently adding raw materials quality ratio 3%
Cellulase, 2% non-starch polysaccharide enzyme, enzymolysis 30min under the conditions of ultrasonic assistant, hydrolysis temperature controls at 40～50 DEG C；
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue；
(5) distillation: add the pure water of 5 times amount in Chinese herbal medicine residue, collects volatile oil 8h, and volatile oil is collected separately placement,
Aqueous solution filters, and merges with lixiviating solution；
(6) volatile oil emulsifying: add the cosolvent tween 80 of 2.0%, heating emulsification in the volatile oil that will collect；
(7) decocting: by adding the water of 3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5h, decocting liquid and extraction
Liquid merges；
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool；
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60～70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 6 times amount, heating extraction 2 times, extraction time 1h in the Chinese herbal medicine residue after decocting；
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract；
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste；
(13) mixing: add unknown certain herbaceous plants with big flowers and the good volatile oil of emulsifying while hot in concentrated solution, stir；
(14) adjuvant is added: adding potassium sorbate and the oligomeric isomaltose of 2% of 0.15%, add water stirring constant volume；
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature；
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 10min；
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
Embodiment 3:
A kind of unknown mallow health care oral liquid of blood pressure lowering, is prepared by following steps:
(1) sorting weighs: is sorted by Chinese herbal medicine used, goes the removal of impurity etc., according to unknown certain herbaceous plants with big flowers 40 parts in every 1000 portions of oral liquids, certainly
Pine torch 15 parts, Radix Scutellariae 8 parts, Albizzia kalkora spend 15 parts, Herba Apocyni veneti 15 parts, Herba Epimedii 13 parts, Fructus Corni 8 parts, Herba Dendrobii 15 parts, Fructus Crataegi 10
Part, Radix Puerariae 18 parts, Spica Prunellae 10 parts, 10 parts of Radix Glycyrrhizae, 15 parts of ratios of Folium Stevlae Rebaudianae are weighed；
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. by Semen Cassiae, Radix Scutellariae, Albizzia kalkora flower, Herba Apocyni veneti, Fructus Corni, Herba Dendrobii, Radix Puerariae, Herba Epimedii, Spica Prunellae, Radix Glycyrrhizae, Folium Stevlae Rebaudianae
Carry out pulverization process after mixing, cross 40 mesh sieves；
2. in Fructus Crataegi, add 2 times of pure water, making beating, be subsequently adding 1% pectase, enzymolysis 20min under the conditions of 40～50 DEG C；
(3) ultrasound-assisted enzymolysis: after raw material mixing, addition raw materials quality is than 3 times of pure water, is subsequently adding raw materials quality ratio 2%
Cellulase, 1% non-starch polysaccharide enzyme, enzymolysis 60min under the conditions of ultrasonic assistant, hydrolysis temperature controls at 40～50 DEG C；
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue；
(5) distillation: add the pure water of 3 times amount in Chinese herbal medicine residue, collects volatile oil 10h, and volatile oil is collected separately placement,
Aqueous solution filters, and merges with lixiviating solution；
(6) volatile oil emulsifying: add the cosolvent tween 80 of 1.5%, heating emulsification in the volatile oil that will collect；
(7) decocting: by adding the water of 2 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 2h, decocting liquid and lixiviating solution
Merge；
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool；
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60～70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 4 times amount, heating extraction 2 times, extraction time in the Chinese herbal medicine residue after decocting
1.5h；
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract；
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste；
(13) mixing: add unknown certain herbaceous plants with big flowers and the good volatile oil of emulsifying while hot in concentrated solution, stir；
(14) adjuvant is added: adding potassium sorbate and the Mel of 1% of 0.10%, add water stirring constant volume；
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature；
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 5～10min；
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
Above example is merely to illustrate technical scheme, rather than is limited；Although with reference to aforementioned reality
Execute example to be described in detail by invention, but for the person of ordinary skill of the art, still can be to aforementioned reality
Execute the technical scheme described in example to modify, or wherein portion of techniques feature is carried out equivalent；And these are revised
Or replace, do not make the essence of appropriate technical solution depart from the spirit and scope of claimed technical solution of the invention.
Claims (2)
1. the unknown mallow health care oral liquid of blood pressure lowering, it is characterised in that prepared by following steps:
(1) sorting weighs: is sorted by Chinese herbal medicine used, goes the removal of impurity, joins according to raw material of Chinese medicine and quality in 1000 portions of oral liquids
Ratio is: unknown certain herbaceous plants with big flowers 40～60 parts, Semen Cassiae 10～15 parts, Radix Scutellariae 8～12 parts, Albizzia kalkora spend 10～15 parts, Herba Apocyni veneti 15～20 parts,
Herba Epimedii 10～13 parts, Fructus Corni 8～12 parts, Herba Dendrobii 10～15 parts, Fructus Crataegi 10～16 parts, Radix Puerariae 10～18 parts, Spica Prunellae 5～
10 parts, Radix Glycyrrhizae 10～15 parts, Folium Stevlae Rebaudianae 10～15 parts of ratios are weighed；
(2) pretreatment of raw material: carry out pretreatment of raw material according to property of raw material difference respectively:
1. by Semen Cassiae, Radix Scutellariae, Albizzia kalkora flower, Herba Apocyni veneti, Fructus Corni, Herba Epimedii, Herba Dendrobii, Radix Puerariae, Spica Prunellae, Radix Glycyrrhizae, Folium Stevlae Rebaudianae
Carry out pulverization process after mixing, cross 40 mesh sieves；
2. in Fructus Crataegi, add 2～3 times of pure water, making beating, be subsequently adding 1～2% pectase, enzymolysis under the conditions of 40～50 DEG C
10～20min；
(3) ultrasound-assisted enzymolysis: after raw material mixing, addition raw materials quality is than 3～5 times of pure water, is subsequently adding raw materials quality ratio
2～3% cellulase, 1～2% non-starch polysaccharide enzyme, enzymolysis 30～60min under the conditions of ultrasonic assistant, hydrolysis temperature controls
At 40～50 DEG C；
(4) centrifugal: centrifugation lixiviating solution and middle medicinal herbs residue；
(5) distillation: add the pure water of 3～5 times amount in Chinese herbal medicine residue, collects volatile oil 8～10h, and volatile oil is individually received
Collection is placed, and aqueous solution filters, and merges with lixiviating solution；
(6) volatile oil emulsifying: addition 1.5～the cosolvent tween 80 of 2.0%, heating emulsification in the volatile oil that will collect；
(7) decocting: by adding the water of 2～3 times amount in the Chinese herbal medicine residue after distillation, decoct 3 times, each 1.5～2h, decocting liquid
Merge with lixiviating solution；
(8) concentrating under reduced pressure: the aqueous solution after merging is concentrated into the clear paste of 1g/ml, lets cool；
(9) precipitate with ethanol: the ethanol adding 95% in clear paste makes alcohol content reach 60～70%, places more than 48h under the conditions of 4 DEG C
(10) alcohol extraction: add 50% ethanol of 4～6 times amount, heating extraction 2 times, extraction time in the Chinese herbal medicine residue after decocting
1～1.5h；
(11) sucking filtration is merged: the liquid after precipitate with ethanol is merged sucking filtration with alcohol extract；
(12) recovered under reduced pressure: sucking filtration liquid is carried out decompression recycling ethanol to without alcohol taste；
(13) mixing: add unknown certain herbaceous plants with big flowers and the good volatile oil of emulsifying while hot in concentrated solution, stir；
(14) adjuvant is added: addition 0.10～the potassium sorbate of 0.15% and 1～the sweeting agent of 2%, add water stirring constant volume；
(15) stand: more than 48h will be stood under oral liquid semi-finished product room temperature；
(16) centrifugal: oral liquid semi-finished product 3000r/min is centrifuged 5～10min；
(17) constant volume subpackage: oral liquid constant volume, subpackage after being centrifuged i.e. obtain oral liquid finished product.
A kind of unknown mallow health care oral liquid of blood pressure lowering the most according to claim 1, it is characterised in that described sweeting agent is selected
Be the mixture of one or more in xylitol, oligomeric isomaltose, Mel.
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| CN106578212A (en) * | 2016-12-10 | 2017-04-26 | 青岛嘉瑞生物技术有限公司 | Salicornia Bigelovii Torr. healthcare beverage helpful for reducing blood pressure |
| WO2019059751A1 (en) * | 2017-09-25 | 2019-03-28 | Université Sidi Mohammed Ben Abdellah | Novel locust bean dehulling method |
| CN110982652A (en) * | 2019-01-25 | 2020-04-10 | 山东跃腾生态农业有限公司 | Health-care wine containing innominate sunflower |
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| CN101181445A (en) * | 2007-11-12 | 2008-05-21 | 徐朝阳 | Antihypertensive Chinese medicine |
| CN101274084A (en) * | 2007-12-18 | 2008-10-01 | 秦庆吉 | Medicament for curing hypertension, hyperlipemia and complication thereof |
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| CN106578212A (en) * | 2016-12-10 | 2017-04-26 | 青岛嘉瑞生物技术有限公司 | Salicornia Bigelovii Torr. healthcare beverage helpful for reducing blood pressure |
| WO2019059751A1 (en) * | 2017-09-25 | 2019-03-28 | Université Sidi Mohammed Ben Abdellah | Novel locust bean dehulling method |
| CN110982652A (en) * | 2019-01-25 | 2020-04-10 | 山东跃腾生态农业有限公司 | Health-care wine containing innominate sunflower |
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