A kind of Abelmoschus manihot (L.) Medic compound basic seed oil and its preparation method and application
Technical field
The invention belongs to pharmaceutical preparations technology field, be specifically related to a kind of Abelmoschus manihot (L.) Medic compound basic seed oil and its preparation method and application.
Background technology
Abelmoschus manihot (L.) Medic (Abelmoschus manihot(L.) Medic.) it is Malvaceae Abelmoschus plant, Abelmoschus manihot (L.) Medic all herbal medicine, there is effect of heat clearing away, removing heat from blood, removing toxic substances, yellow hollyhock seed contains abundant nutritional labeling, according to Lin Wenqun, Chen Zhong, Chen Jinling etc. are to research [J] research and development of natural products 2002 of yellow hollyhock seed form and chemical composition thereof, 14(3): the report of 41-44: yellow hollyhock seed contains crude protein 16.82%;Fatty oil 31.16%;Amino acid/11 3.56%;Reach 91.815% possibly together with unsaturated fatty acid contents various necessary to human body simultaneously, including linoleic acid (82.1179%), oleic acid (9.195%), Palmic acid (4.756%), stearic acid (2.681%), linolenic acid (0.1328%) etc., additionally, possibly together with 18 kinds of aminoacid and 24 kinds of mineral elements.Needed by human and have trace element Fe, Mn, Cu, Zn, Mo of valuable pharmacological activity, all contains in seed, but harmful element hydrargyrum, arsenic, cadmium content is less than food hygienic standard.
Therefore, yellow hollyhock seed and seed oil have higher nutritive value and medicinal health care function, have the value of potential exploitation.Linoleic acid (LA), linolenic acid (LNA) are all the fat oil of needed by human, and the content of its oil Linoleic acid is apparently higher than Vegetable Oils.But linolenic acid total amount is significantly lower than the linolenic acid content of general Vegetable Oils in its oil.High linoleic acid low linolenic is the feature of yellow hollyhock seed fatty acid oil composition.Therefore, yellow hollyhock seed fatty oil has the highest nutritive value.Linoleic acid is the essential fatty acid that body weight for humans is wanted, and has physiological action the most widely;There is certain treatment cardiovascular system diseases, reduce blood fat.Moreover, yellow hollyhock seed still has important medical value: have spleen reinforcing stomach invigorating, treatment dyspepsia, treatment effect such as traumatic injury and removing the necrotic tissue and promoting granulation.
The medical value of yellow hollyhock seed is mainly embodied by the seed oil obtained by seed.The patent of invention of Application No. 03105269.X discloses a kind of certain herbaceous plants with big flowers oil, be using yellow hollyhock seed squeeze after obtain certain herbaceous plants with big flowers oil the most medicinal as edible oil, Authorization Notice No. is that the patent of invention of CN 1057115C discloses producing and pressing method of a kind of Abelmoschus manihot (L.) Medic oils and fats, disclosing that Abelmoschus manihot (L.) Medic oils and fats is for oral administration can treat this medical value of malignant lymphoma in an embodiment, Authorization Notice No. is CN
The patent of invention of 1062896C discloses a kind of Wild cottonrose hibiscus oil, is to extract preparation from the seed of the wild Hibisci Mutabilis i.e. dry flower of Abelmoschus manihot (L.) Medic, flower, tender kind and maturation.Above-mentioned patent is all not disclosed Abelmoschus manihot (L.) Medic seed oil as this effect of topical agent.
Summary of the invention
It is an object of the invention to provide a kind of Abelmoschus manihot (L.) Medic compound basic seed oil and preparation method thereof, this Abelmoschus manihot (L.) Medic compound basic seed oil has antiinflammatory, hemostasis and analgesic effect, this Abelmoschus manihot (L.) Medic compound basic seed oil is made different dosage forms and has preferable medical functions.
For achieving the above object, the present invention is by the following technical solutions: a kind of Abelmoschus manihot (L.) Medic compound basic seed oil, it is characterised in that include that the raw material of following parts by weight is made: Abelmoschus manihot (L.) Medic basis seed oil 75 ~ 85 parts, Radix Notoginseng powder 3 ~ 8 parts, 3 ~ 8 parts of rutin powder.
As the preferred technical solution of the present invention, also including at least one in Oleum Camelliae or Radix Oenotherae erythrosepalae oil, addition is 2 ~ 5 parts.
As the preferred technical solution of the present invention, a kind of Abelmoschus manihot (L.) Medic compound basic seed is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 75 ~ 85 parts, Radix Notoginseng powder 3 ~ 8 parts, 3 ~ 8 parts of rutin powder, Oleum Camelliae 2 ~ 5 parts.
As the preferred technical solution of the present invention, a kind of Abelmoschus manihot (L.) Medic compound basic seed is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 75 ~ 85 parts, Radix Notoginseng powder 3 ~ 8 parts, 3 ~ 8 parts of rutin powder, Radix Oenotherae erythrosepalae oil 2 ~ 5 parts.
As the preferred technical solution of the present invention, a kind of Abelmoschus manihot (L.) Medic compound basic seed is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 75 ~ 85 parts, Radix Notoginseng powder 3 ~ 8 parts, 3 ~ 8 parts of rutin powder, Oleum Camelliae 1 ~ 3 part, Radix Oenotherae erythrosepalae oil 1 ~ 2 part.
The preparation method of a kind of Abelmoschus manihot (L.) Medic compound basic seed oil, it is characterised in that step is as follows:
(1) yellow hollyhock seed pretreatment: Abelmoschus manihot (L.) Medic seed kind cleaned up, mechanical dehydration post-drying, then by broken apart for seed shell;
(2) Abelmoschus manihot (L.) Medic seed kind low temperature pressing: be 20 ~ 50 DEG C in temperature, under conditions of pressure is 600 ~ 700bar, uses level Four cold-rolling process to squeeze, obtains crude oil;
(3) precipitation filters: precipitated at normal temperatures by crude oil 48 ~ 72 hours, filters once with 80 mesh canvas, filters with 100 mesh canvas and once obtains edible vegetable oil, edible vegetable oil reprecipitation 48 ~ 60 hours, and upper strata edible vegetable oil is Abelmoschus manihot (L.) Medic basis seed oil;
(4) compounding: in the seed oil of Abelmoschus manihot (L.) Medic basis, add Oleum Helianthi, Radix Notoginseng powder and rutin powder, ultrasonic dissolution by formula proportion, i.e. obtain the Abelmoschus manihot (L.) Medic compound basic seed oil of stable homogeneous.
The application in terms of medicine of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present invention, can make unguentum, powder or spray.
Beneficial effects of the present invention: the Abelmoschus manihot (L.) Medic compound basic seed oil pure natural of the present invention, green, environmental protection;Containing abundant vitamin E, flavone and various aminoacid in Abelmoschus manihot (L.) Medic seed oil, flavone has antiinflammatory, analgesic effect, and vitamin E as natural antioxidant, can extend shelf-life and effect of Abelmoschus manihot (L.) Medic compound basic seed oil;Aminoacid has effect of antioxidation, stabilizing cell membrane and protein structure;Radix Notoginseng has effect of promoting blood circulation to remove blood stasis, hemostasis and pain-relieving;Rutin has treatment burn, hemostasia effect;Radix Oenotherae erythrosepalae oil has good anti-inflammatory efficacy;Oleum Camelliae has antiinflammatory, detumescence, the effect of pain relieving;Each component and effect complements each other, bring out the best in each other, good cooperative effect can be produced, wound is had well hemostasis, antiinflammatory, analgesia, wound healing and repair, Abelmoschus manihot (L.) Medic compound basic seed oil is made different dosage forms, such as medicine for external use such as unguentum, powder or sprays, add and toxic and side effects without any chemistry, there is promotion cell growth and delaying cell aging, the effect of skin care, preferably for oral ulcer, burn, scald or the patient of other skin injuries slows down pain, accelerate to restore, especially notable to the healing effect of diabetics wound.
Treatment case: Mr. Xie, Henan Jiaozuo City people, 75 years old, non-healing wounds caused by diabetic history for many years, through adhering to using for several times Abelmoschus manihot (L.) Medic compound basic seed oil to heal.
Ms Zhang, Henan Jiaozuo City people, 70 years old, stomatocace for many years, through using Abelmoschus manihot (L.) Medic compound basic seed oil 3 times, heals completely.
Luyi County Liu so-and-so, man, 20 years old, whole face and neck all covered with comedo during freshman year winter vacation, through smearing with Abelmoschus manihot (L.) Medic compound basic seed oil, within 7 days, take a turn for the better.
Six town villager Wei Nvshi are pacified in city of Hui nationality, 60 years old, stomatitis with angular chilitis, through smearing with Abelmoschus manihot (L.) Medic compound basic seed oil, recovery from illness in 3 days.
Little Ji administrative village, Luyi County Beizhen City granddaughter villager scholar, 50 years old, redness and swelling of throat inflammation, slowly swallow sucking Abelmoschus manihot (L.) Medic compound basic seed oil, three times a day, recovery from illness in 3 days.
Luyi County Mr. Wang, 62 years old, is once scalded by deep fat and bubbles, and through smearing with Abelmoschus manihot (L.) Medic compound basic seed oil, pain relieving at once blister disappear.
Detailed description of the invention
Embodiment 1
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 85 parts, Radix Notoginseng powder 7 parts, 8 parts of rutin powder.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment, step is as follows:
(1) yellow hollyhock seed pretreatment: cleaned up by yellow hollyhock seed, is dehydrated post-drying, and the most sub-shell is broken apart;
(2) Abelmoschus manihot (L.) Medic seed low temperature pressing: be 50 DEG C in temperature, under conditions of pressure is 600bar, uses level Four cold-rolling process to squeeze, obtains crude oil;
(3) precipitation filters: precipitated at normal temperatures by crude oil 72 hours, with 80 mesh canvas filter once, 100 mesh canvas repeat to filter and once obtain edible vegetable oil, edible vegetable oil reprecipitation 60 hours, it is oily that upper strata edible vegetable oil is Abelmoschus manihot (L.) Medic basis seed;
(4) compounding: in the seed oil of Abelmoschus manihot (L.) Medic basis, to add other components, ultrasonic dissolution by formula proportion, i.e. obtain the Abelmoschus manihot (L.) Medic compound basic seed oil of stable homogeneous.
Embodiment 2
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 85 parts, Radix Notoginseng powder 3 parts, 8 parts of rutin powder, Oleum Camelliae 4 parts.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment, step is as follows:
(1) yellow hollyhock seed pretreatment: cleaned up by yellow hollyhock seed, is dehydrated post-drying, and the most sub-shell is broken apart;
(2) Abelmoschus manihot (L.) Medic seed low temperature pressing: be 20 DEG C in temperature, under conditions of pressure is 700bar, uses level Four cold-rolling process to squeeze, obtains crude oil;
(3) precipitation filters: precipitated at normal temperatures by crude oil 48 hours, with 80 mesh canvas filter once, 100 mesh canvas repeat to filter and once obtain edible vegetable oil, edible vegetable oil reprecipitation 48 hours, it is oily that upper strata edible vegetable oil is Abelmoschus manihot (L.) Medic basis seed;
(4) compounding: in the seed oil of Abelmoschus manihot (L.) Medic basis, to add other components, ultrasonic dissolution by formula proportion, i.e. obtain the Abelmoschus manihot (L.) Medic compound basic seed oil of stable homogeneous.
Embodiment 3
The Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment it be made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 79 parts, Radix Notoginseng powder 8 parts, 8 parts of rutin powder, Radix Oenotherae erythrosepalae oil 5 parts.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment, step is as follows:
(1) yellow hollyhock seed pretreatment: cleaned up by yellow hollyhock seed, is dehydrated post-drying, and the most sub-shell is broken apart;
(2) Abelmoschus manihot (L.) Medic seed low temperature pressing: be 30 DEG C in temperature, under conditions of pressure is 650bar, uses level Four cold-rolling process to squeeze, obtains crude oil;
(3) precipitation filters: precipitated at normal temperatures by crude oil 60 hours, with 80 mesh canvas filter once, 100 mesh canvas repeat to filter and once obtain edible vegetable oil, edible vegetable oil reprecipitation 50 hours, it is oily that upper strata edible vegetable oil is Abelmoschus manihot (L.) Medic basis seed;
(4) compounding: in the seed oil of Abelmoschus manihot (L.) Medic basis, to add other components, ultrasonic dissolution by formula proportion, i.e. obtain the Abelmoschus manihot (L.) Medic compound basic seed oil of stable homogeneous.
Embodiment 4
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 82 parts, Radix Notoginseng powder 5 parts, 8 parts of rutin powder, Oleum Camelliae 3 parts, Radix Oenotherae erythrosepalae oil 2 parts.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment, step is as follows:
(1) yellow hollyhock seed pretreatment: cleaned up by yellow hollyhock seed, is dehydrated post-drying, and the most sub-shell is broken apart;
(2) Abelmoschus manihot (L.) Medic seed low temperature pressing: be 40 DEG C in temperature, under conditions of pressure is 680bar, uses level Four cold-rolling process to squeeze, obtains crude oil;
(3) precipitation filters: precipitated at normal temperatures by crude oil 50 hours, with 80 mesh canvas filter once, 100 mesh canvas repeat to filter and once obtain edible vegetable oil, edible vegetable oil reprecipitation 55 hours, it is oily that upper strata edible vegetable oil is Abelmoschus manihot (L.) Medic basis seed;
(4) compounding: in the seed oil of Abelmoschus manihot (L.) Medic basis, to add other components, ultrasonic dissolution by formula proportion, i.e. obtain the Abelmoschus manihot (L.) Medic compound basic seed oil of stable homogeneous.
Embodiment 5
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 82 parts, Radix Notoginseng powder 5 parts, 8 parts of rutin powder, Oleum Camelliae 3 parts, Radix Oenotherae erythrosepalae oil 2 parts.
The Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment and the preparation method of oil gauze are with embodiment 4.
Embodiment 6
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 75 parts, Radix Notoginseng powder 8 parts, 8 parts of rutin powder, Oleum Camelliae 3 parts, Radix Oenotherae erythrosepalae oil 2 parts.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 4.
Embodiment 7
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 85 parts, Radix Notoginseng powder 3 parts, 3 parts of rutin powder, Oleum Camelliae 1 part, Radix Oenotherae erythrosepalae oil 1 part.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 4.
Embodiment 8
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 75 parts, Radix Notoginseng powder 8 parts, 8 parts of rutin powder, Oleum Camelliae 5 parts.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 2.
Embodiment 9
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 85 parts, Radix Notoginseng powder 3 parts, 3 parts of rutin powder, Oleum Camelliae 5 parts.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 2.
Embodiment 10
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 80 parts, Radix Notoginseng powder 7 parts, 7 parts of rutin powder, Oleum Camelliae 2 parts.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 2.
Embodiment 11
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 80 parts, Radix Notoginseng powder 5 parts, 5 parts of rutin powder, Oleum Camelliae 4 parts.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 2.
Embodiment 12
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 80 parts, Radix Notoginseng powder 5 parts, 4 parts of rutin powder, Radix Oenotherae erythrosepalae oil 3 parts.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 3.
Embodiment 13
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 85 parts, Radix Notoginseng powder 3 parts, 7 parts of rutin powder.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 1.
Embodiment 14
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 75 parts, Radix Notoginseng powder 8 parts, 3 parts of rutin powder.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 1.
Embodiment 15
The Abelmoschus manihot (L.) Medic compound basic seed of the present embodiment is oily, and it is made up of the raw material of following portions by weight: Abelmoschus manihot (L.) Medic basis seed oil 80 parts, Radix Notoginseng powder 5 parts, 5 parts of rutin powder.
The preparation method of the Abelmoschus manihot (L.) Medic compound basic seed oil of the present embodiment is with embodiment 1.
The explanation of above example is only intended to help to understand method and the core concept thereof of the present invention.It should be pointed out that, for the ordinary skill in the art, on the premise of not changing the principle of the invention, it is also possible to be suitably modified the present invention, these are suitably modified also should be within the scope of the invention as claimed.