CN1330296C - Propolis soft capsule and its preparation method - Google Patents
Propolis soft capsule and its preparation method Download PDFInfo
- Publication number
- CN1330296C CN1330296C CNB031413951A CN03141395A CN1330296C CN 1330296 C CN1330296 C CN 1330296C CN B031413951 A CNB031413951 A CN B031413951A CN 03141395 A CN03141395 A CN 03141395A CN 1330296 C CN1330296 C CN 1330296C
- Authority
- CN
- China
- Prior art keywords
- bee glue
- propolis
- water
- soft capsule
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Jellies, Jams, And Syrups (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a bee glue soft capsule and a preparation method thereof. Water soluble bee glue is quantitatively filled into empty gelatin by a capsule filling machine, the gelatin is polished, wherein each capsule contains 450 mg of water soluble bee glue. The water soluble bee glue is obtained by the method that raw material bee glue is primarily extracted by ethyl alcohol, lead is removed and impurities in the raw material bee glue are removed; then, the raw material bee glue is added to a compound solvent composed of polyethylene glycol and glycerol; the obtained mixture is heated to 80 DEG C, and the temperature is maintained for 2 to 3 hours to obtain the water soluble bee glue which is water soluble bee glue liquor which can be dissolved in water with arbitrary concentration. Duo to the water soluble bee glue, the bee glue soft capsule not only avoids the defects of anaphylactic reactions and stimulation to gastrointestinal tracts of wine soluble bee glue, but also successfully realizes the preparation of the bee glue soft capsules. The absorption effect of the bee glue soft capsule is enhanced, and thus, the bee glue soft capsule has good health care effect.
Description
Technical field
The present invention relates to a kind of bee glue soft capsule and preparation method thereof, it is water-soluble bee glue solution to be wrapped in the capsule material make.This capsule-type preparation is easy to people and takes, and can effectively improve pungent, the feeling of numbness of propolis, and importantly, it has avoided the anaphylaxis and the gastrointestinal tract stimulation of wine soluble bee glue, and has significantly improved assimilation effect.
Background technology
At present, continuous development along with science and technology, people are more and more deep to the understanding of bee products, be not only the effect that Mel, Lac regis apis, bee pollen have health care to human body and treat disease, and all almost relevant with Apis bee product raw materials all have different health-care effects and therapeutic effect.Propolis is exactly a kind of bee product that receives much attention in recent years, and it has unique biological effect and effect, is the honeybee product of a kind of " integration of edible and medicinal herbs ".
Along with improving constantly of people's living standard, health perception strengthens to some extent, and people no longer are satisfied with sick treatment again, but reduce the generation of disease in the mode of active prevention, and health food has formed an influential industry in China at present.Propolis be exactly in recent years in emerging health promoting product, its resin that to be Apis gather from positions such as the tree bud of plant, barks mixes the secretions of bodies of gland such as lingual gland with Apis, wax gland again, a kind of colloid substance that is transformed through Apis processing.Studies show that in a large number, contain numerous compositions in the propolis with biologic activity, immune system, respiratory system, digestive system, hormonal system, cardio-cerebrovascular, nervous system, blood circulation to human body all have medical function widely, and almost non-toxic side effect, be a kind of ideal health product.
Propolis has so many function, mainly is the complexity owing to its composition, the multifunctionality of single component, and synergism several or several constituents are formed.Modern chemical analysis is identified, propolis contains more than 70 kind of flavone compound, more than 50 kind of aromatic acid and aromatic esters compounds, more than 20 kind of phenols, alcohol compound, more than ten kind of aldehyde and ketone compounds, kind of terpenoid surplus in the of ten, more than 50 kind of fatty acid and fatty acid ester, the trace element of more than 30 kind of needed by human and 20 several amino acids.As the flavonoid of main component, it has the function of absorption oxygen-derived free radicals and good ultraviolet absorption ability, energy blood circulation promoting, delaying decrepitude of skin.
As everyone knows, propolis is water insoluble and be soluble in organic solvent, therefore when processing and dissolve, selects for use ethanol to make solvent usually.CN1323586A (open day: 2001.11.28) put down in writing a kind of prescription and technology for preparing bee glue soft capsule, system is earlier with the thick product process of propolis ethanol extraction, the glacial acetic acid deleading, under 0-4 ℃ of condition, stir, get supernatant after the placement, filter, reclaim ethanol at last through 400 order nylon mesh, obtained removing delead, unnecessary waxiness and the solid propolis of impurity thus, mixed forming again with medicinal oils and fats.Capsule through this method preparation contains ethanol, this easily causes the anaphylaxis of human body, studies show that in a large number, the incidence rate of this allergic phenomena reaches ten thousand/, and because alcoholic acid existence, also can produce stimulation to gastrointestinal tract, this has limited a part undoubtedly ethanol crowd hypersensitive has been taken this bee glue soft capsule.In addition, because propolis is in the past all extracted as solvent by ethanol, this must make in the propolis product after the extraction and contain a certain amount of ethanol, in view of gelatin has the certain absorption effect to ethanol, therefore make in the propolis of ethanol extraction can not be packed into by the soft capsule of gelatin as the capsule material.Occurring so have no precedent the bee glue soft capsule product, all is owing to this reason.
Summary of the invention
Purpose of the present invention just is to provide a kind of water miscible propolis, anaphylaxis not only never took place in it, and gastrointestinal tract had no stimulation, the more important thing is, because water-soluble bee glue obtains by a kind of plyability solvent extraction, thus can not make gelatin that it is produced Absorption, so successful preparation bee glue soft capsule, filled up the blank of this respect, having overcome traditional propolis can only be with pack into defective in the hard capsule of pressed powder form.And this water-soluble bee glue can improve the absorption of propolis in human body greatly, makes its effect more remarkable, is a kind of ideal propolis product.
Through long-term exploration and discovering, propolis is extracted as solvent with water miscible low cluster carbohydrate, can be so that the propolis that arrives be soluble in water with any concentration, thus realized the production of propolis solution.This has not only been avoided the anaphylaxis and the gastrointestinal tract stimulation of wine soluble bee glue, and has successfully realized the preparation of bee glue soft capsule,
Purpose of the present invention mainly is to provide a kind of low cluster carbohydrate, and as the solvent that extracts propolis, this solvent is a kind of double solvents, mainly is made up of Polyethylene Glycol and glycerol.This solvent is heated to 60-80 ℃, under mechanical agitation, adds propolis then, mixing.Through secular, a large amount of laboratory researches, and factory's trial production proof, concentration is soluble in water arbitrarily by the propolis of this method preparation, thereby has solved the water solublity problem of propolis, avoided by ethanol extraction propolis brought takes problem such as inconvenience.
The invention provides a kind of bee glue soft capsule, form by water-soluble bee glue and gelatine capsule, wherein water-soluble bee glue is the Polyethylene Glycol of propolis and the extract of glycerol double solvents, wherein the propolis weight percentage is 30%, the Polyethylene Glycol weight percentage is 60%-65%, the glycerol weight percentage is 5%-10%, and wherein Polyethylene Glycol is Macrogol 200, PEG400 or its mixture, and both weight ratios are 1: 2 or 6: 7 when for mixture.
The propolis that the present invention relates to, can be that the raw material propolis is just carried with ethanol, then by independently deleading reagent and cation exchange technology have reduced the lead content in the propolis, reach 2.87ppm, this just can make, and lead content is lower than 0.5ppm in liquid propolis food, thereby has realized the extensive use of propolis in the food and medicine industry, but the propolis that the present invention relates to is not limited in the method and prepares, also comprise through preparations such as deleading reagent commonly used such as lead acetates, and other method of purification preparation commonly used.
The bee glue soft capsule that the invention provides a kind of water-soluble bee glue and make thus, and this preparation of soft capsule technology.Concrete grammar is as follows:
The preparation of water-soluble bee glue:
Polyethylene Glycol is heated to 80 ℃, add glycerol then gradually and be heated to 80 ℃, obtain composite solution, propolis is joined in this composite solution gradually, be heated to 80 ℃, and remained on this temperature 2-3 hour, propolis is fully dissolved, wherein Polyethylene Glycol is Macrogol 200, PEG400 or its mixture, and both weight ratios are 1: 2 or 6: 7 when for mixture.Promptly concentration is soluble in water arbitrarily for the solution that obtains, and becomes water-soluble bee glue liquid.
The preparation of bee glue soft capsule:
With the pharmagel is that packaging material prepares soft capsule, and wherein every capsules contains water-soluble bee glue 450mg.
The specific embodiment
The preparation of embodiment 1 propolis:
With the refrigerated storage of raw material propolis, pulverize at low temperature adds the dissolving of 75% alcohol solution dipping in 1: 4 ratio, adds an amount of Na
2SO
3And Na
2S
2O
4As deleading agent, left standstill 24 hours, adopt 400 order import nylon net filters then, get supernatant, through testing identity, obtain the propolis of lead tolerance below 3ppm, it has reached the standard of international food health legislation.
The preparation of embodiment 2 water-soluble bee glues:
Propolis 30% (weight ratio)
Glycerol 10% (weight ratio)
Macrogol 200 20% (weight ratio)
PEG400 40% (weight ratio)
With Macrogol 200 20kg and the abundant mix homogeneously of PEG400 40kg, be heated to 80 ℃, add glycerol 10kg gradually, be heated to 80 ℃, join propolis 30kg gradually in the mixed solution of Macrogol 200, PEG400 and glycerol this moment, be heated to 80 ℃, and remained on this temperature 2-3 hour, propolis is fully dissolved.Can obtain thus can be with the water-soluble water-soluble bee glue of any concentration.
The preparation of embodiment 3 water-soluble bee glues:
Propolis 30% (weight ratio)
Glycerol 5% (weight ratio)
Macrogol 200 65% (weight ratio)
Macrogol 200 65kg is heated to 80 ℃, adds glycerol 5kg gradually, be heated to 80 ℃,, join propolis 30kg gradually in the mixed solution of Macrogol 200 and glycerol this moment, is heated to 80 ℃, and remained on this temperature 2-3 hour, propolis is fully dissolved.Can obtain thus can be with the water-soluble water-soluble bee glue of any concentration.
The preparation of embodiment 4 water-soluble bee glues:
Propolis 30% (weight ratio)
Glycerol 5% (weight ratio)
PEG400 65% (weight ratio)
According to the preparation of embodiment 3 methods, can obtain water-soluble bee glue.
The preparation of embodiment 5 water-soluble bee glues:
Propolis 30% (weight ratio)
Glycerol 10% (weight ratio)
Macrogol 200 25% (weight ratio)
PEG400 35% (weight ratio)
According to the preparation of embodiment 2 methods, can obtain water-soluble bee glue.
The preparation of embodiment 6 water-soluble bee glues:
Propolis 30% (weight ratio)
Glycerol 5% (weight ratio)
Macrogol 200 30% (weight ratio)
PEG400 35% (weight ratio)
According to the preparation of embodiment 2 methods, can obtain water-soluble bee glue.
The preparation of embodiment 7 bee glue soft capsules
Water-soluble bee glue is inspected by random samples, met the reuse capsule filling machine quantitative filling that food hygienic standard requires, polishing, bottling, wherein every capsules contains water-soluble bee glue 450mg.
Claims (6)
1. bee glue soft capsule, form by water-soluble bee glue and gelatine capsule, wherein water-soluble bee glue is the Polyethylene Glycol of propolis and the extract of glycerol double solvents, wherein this water-soluble bee glue is that this double solvents is heated to 60-80 ℃, add propolis then and obtain, wherein the weight percentage of propolis, Polyethylene Glycol and glycerol be respectively 30%, 60%-65% and 5%-10%.
2. bee glue soft capsule as claimed in claim 1, wherein the propolis weight percentage is 30%, and the Polyethylene Glycol weight percentage is 60%, and the glycerol weight percentage is 10%.
3. bee glue soft capsule as claimed in claim 1, wherein the propolis weight percentage is 30%, and the Polyethylene Glycol weight percentage is 65%, and the glycerol weight percentage is 5%.
4. as each described bee glue soft capsule of claim 1 to 3, wherein Polyethylene Glycol is Macrogol 200, PEG400 or its mixture, and when being mixture, both weight ratios are 1: 2 or 6: 7.
5. method for preparing as each described bee glue soft capsule in the claim 1 to 3, with water-soluble bee glue capsule filling machine quantitative filling, polishing, bottling, make wherein every capsules contain water-soluble bee glue 450mg, wherein the preparation method of water-soluble bee glue is as follows: Polyethylene Glycol is heated to 80 ℃, add glycerol then gradually and be heated to 80 ℃, obtain composite solution, propolis is joined in this composite solution gradually, be heated to 80 ℃, and remained on this temperature 2-3 hour, propolis is fully dissolved.
6. method as claimed in claim 5, wherein Polyethylene Glycol is Macrogol 200, PEG400 or its mixture, when being mixture, both weight ratios are 1: 2 or 6: 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031413951A CN1330296C (en) | 2003-06-08 | 2003-06-08 | Propolis soft capsule and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031413951A CN1330296C (en) | 2003-06-08 | 2003-06-08 | Propolis soft capsule and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1460487A CN1460487A (en) | 2003-12-10 |
| CN1330296C true CN1330296C (en) | 2007-08-08 |
Family
ID=29591365
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031413951A Expired - Fee Related CN1330296C (en) | 2003-06-08 | 2003-06-08 | Propolis soft capsule and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1330296C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100369603C (en) * | 2005-08-30 | 2008-02-20 | 浙江蜂之语蜂业集团有限公司 | Product recipe for bee glue soft capsule inclusion |
| CN106619736A (en) * | 2017-02-17 | 2017-05-10 | 王左良 | Gingko propolis hard capsule and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1162613A (en) * | 1996-04-16 | 1997-10-22 | 边成均 | Process for refining bee propolis |
| CN1323586A (en) * | 2000-05-12 | 2001-11-28 | 中国农业科学院蜜蜂研究所 | Formulation and production process of bee glue capsule |
| CN1360897A (en) * | 2000-12-28 | 2002-07-31 | 上海大承生物制品有限公司 | Bee glue purifying technological process |
-
2003
- 2003-06-08 CN CNB031413951A patent/CN1330296C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1162613A (en) * | 1996-04-16 | 1997-10-22 | 边成均 | Process for refining bee propolis |
| CN1323586A (en) * | 2000-05-12 | 2001-11-28 | 中国农业科学院蜜蜂研究所 | Formulation and production process of bee glue capsule |
| CN1360897A (en) * | 2000-12-28 | 2002-07-31 | 上海大承生物制品有限公司 | Bee glue purifying technological process |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1460487A (en) | 2003-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109833377B (en) | Camellia oleifera Abel extract and preparation method and application thereof | |
| CN102526754A (en) | Application of gum extracted from Abelmoschus manihot as matrix of Chinese medicinal gel | |
| CN103125802B (en) | Nutrition taking propolis cream, medlar cream, honey and desert ginseng powder as raw materials and preparation method of nutrition | |
| KR20100067575A (en) | Preparation of Resonant Rings Containing Seaweed Algae | |
| CN105920439A (en) | Effective part composition containing corn stigma extract and preparation method and application of effective part composition | |
| CN105616462B (en) | Moringa oleifera extract for promoting intestinal growth and preparation method and application thereof | |
| CN1330296C (en) | Propolis soft capsule and its preparation method | |
| CN101991606B (en) | Preparation method of solid water-soluble lead-removed propolis | |
| CN101380100B (en) | Preparation method of velvet deerhorn liquor | |
| CN102676349B (en) | Giant salamander bone healthcare wine and preparation method thereof | |
| CN101381667B (en) | Preparation method of pilose antler blood alcohol | |
| CN1230191C (en) | Health care combination of propolis for reducing blood sugar and fat as well as method for mfg. its capsule | |
| CN104255954B (en) | A kind of Abelmoschus manihot （L.） Medic compound basic seed oil and its preparation method and application | |
| CN1954878A (en) | Preparation method of ginger allicin immunity soft capsult | |
| RU2303993C1 (en) | Treatment and prophylaxis means applicable for treating young agricultural animals and method for preventing and treating calves for gastrointestinal tract diseases | |
| CN1330256C (en) | Propolis honey sweets and preparation process | |
| CN103127234A (en) | Propolis soft capsule and production process thereof | |
| KR101093006B1 (en) | Method for producing functional health food containing bezoar bovis used microbes and the functional health food produced by the same | |
| CN100453073C (en) | Compound radical lobelia dripping pill and its preparing method | |
| RO128709B1 (en) | Nutritive supplement with hypoglycemic and antioxidant activity and process for preparing the same | |
| CN105853532A (en) | Chinese herbal medicinal bait for preventing and treating Aeromonas hydrophila induced diseases of Chinese softshell turtles, and preparation method thereof | |
| CN106173172A (en) | A kind of reducing blood pressure and blood fat health-care chewing gum and preparation method thereof | |
| CN1480202A (en) | Propolis drop pills and its preparing method | |
| CN105962231A (en) | Pumpkin and capsella bursa-pastoris jelly capable of moistening lung and preparation method thereof | |
| CN101606989B (en) | Novel preparation method of trollius chinensis granular preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070808 |