CN1323586A - Formulation and production process of bee glue capsule - Google Patents
Formulation and production process of bee glue capsule Download PDFInfo
- Publication number
- CN1323586A CN1323586A CN00107422A CN00107422A CN1323586A CN 1323586 A CN1323586 A CN 1323586A CN 00107422 A CN00107422 A CN 00107422A CN 00107422 A CN00107422 A CN 00107422A CN 1323586 A CN1323586 A CN 1323586A
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- China
- Prior art keywords
- propolis
- lead
- mesh
- formulation
- prescription
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
The invention relates to the prescription and processing technique for making soft capsule of bee glue. Main technical features are as followings: (1) combining chemical method that simply adding delead agent glacial acetic acid, and cold filtering method (0-4 deg.C 400 mesh imported nylon meshwork) to reduce heavy metal lead contained propolis raw material to below 10ppm (conform with international standard), also to separate out the impurity and beeswax which are about 35-50% in propolis, (2) scientific prescription is selected to make propolis to be dissolved in medium and subpackeged evenly, quality guaranteed. The invented product is different to the products on market that the content of propolis in soft capsules is uneven.
Description
1. The method belongs to the field of: pharmaceutical and chemical engineering.
2. At present, the soft capsule technology is adopted in medicine and health care products, but the difficulty of filling the propolis into the capsule is high, because the propolis is difficult to dissolve and is not uniformly packaged, a scientific formula and a processing technology are required to be adopted, so that the propolis is fully dissolved in a solvent, the packaging is uniform, and the quality is ensured.
3. The purpose of the invention is as follows:
(1) removing heavy metal lead in propolis to make its content less than or equal to 10ppm, and removing excessive beeswax and impurities.
(2) The scientific formula is selected to dissolve the propolis in the medium, so that the propolis can be uniformly packaged and the product quality can be improved. Overcomes the defects of poor palatability, large waste and inconvenient carrying of the existing propolis liquid products.
4. The invention comprises the following steps:
(1) formulation of
33 percent of 100 percent of pure propolis powder and 67 percent of medicinal grease.
2. Pure propolis lead-removing purification technology
Extracting propolis (raw material) with ethanol twice (the propolis extraction process flow chart is shown in the attached figure of the specification) to obtain filtrate (1) and filtrate (2).
(2) Filtering the filtrate (1): mixing the filtrates (2), adding 0.2 ‰ glacial acetic acid lead removing agent, stirring, standing at 0-4 deg.C for 24 hr, sucking supernatant, filtering with 400 mesh nylon net, concentrating at low temperature, and recovering ethanol to obtain 100% pure lead-removed propolis.
5. The technology can be realized by the ordinary technicians in the pharmaceutical chemical field.
6. The invention has the advantages that:
(1) the propolis produced in China at present is affected by iron gauze on a beehive gauze cover, automobile exhaust and pesticides, the content of heavy metal lead seriously exceeds the standard, the invention adopts a simple 400-mesh imported nylon net to remove lead in a particle state, and glacial acetic acid is added by a chemical method to change lead in an ionic state into lead acetate precipitate to be removed.
The chemical equation is as follows:
(2) the propolis products on the market are mainly propolis liquid, the palatability is extremely poor, the propolis is easy to hang on the container wall, the consumption is over 20 percent, and the propolis isnot easy to carry. The propolis hard capsule has the capsule skin with food pigment and the like, has poor commodity property, overcomes the defects of poor palatability, easy cup hanging, large consumption and difficult carrying, does not contain any pigment, and has the quality guarantee period of three years.
Best mode for carrying out the invention: 1. technology transfer: 2. and (5) technical stranding.
Claims (2)
1. Formulation of
33% of propolis and 67% of medicinal grease.
2. Processing technology
(1) The propolis lead removal technology comprises the following steps: adding 0.2 per mill glacial acetic acid lead removing agent into the ethanol extract, standing for 2 hours, and filtering the supernatant with 400-mesh imported nylon net to remove metallic lead, so that the lead content is less than or equal to 10ppm, and the standard of the international food sanitation law is met.
(2) Low-temperature wax removal technology: after being placed at 0-4 ℃ for 24 hours, the solution is filtered by a 400-mesh nylon net to remove fine wax in the solution, thereby overcoming the error that the prior method generally adopts a steam wax removal method to seriously damage the medicinal components.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001074229A CN1189162C (en) | 2000-05-12 | 2000-05-12 | Formulation and production process of bee glue capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB001074229A CN1189162C (en) | 2000-05-12 | 2000-05-12 | Formulation and production process of bee glue capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1323586A true CN1323586A (en) | 2001-11-28 |
| CN1189162C CN1189162C (en) | 2005-02-16 |
Family
ID=4578693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB001074229A Expired - Fee Related CN1189162C (en) | 2000-05-12 | 2000-05-12 | Formulation and production process of bee glue capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1189162C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330296C (en) * | 2003-06-08 | 2007-08-08 | 刘进祖 | Propolis soft capsule and its preparation method |
| CN100369603C (en) * | 2005-08-30 | 2008-02-20 | 浙江蜂之语蜂业集团有限公司 | Product recipe for bee glue soft capsule inclusion |
| CN102940182A (en) * | 2012-10-29 | 2013-02-27 | 射阳县庆缘康蜂产品厂 | Low energy propolis hard capsule preparation method |
| CN108813499A (en) * | 2018-07-09 | 2018-11-16 | 武汉康思农生物科技有限公司 | A kind of bee glue soft capsule formula and preparation process |
-
2000
- 2000-05-12 CN CNB001074229A patent/CN1189162C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1330296C (en) * | 2003-06-08 | 2007-08-08 | 刘进祖 | Propolis soft capsule and its preparation method |
| CN100369603C (en) * | 2005-08-30 | 2008-02-20 | 浙江蜂之语蜂业集团有限公司 | Product recipe for bee glue soft capsule inclusion |
| CN102940182A (en) * | 2012-10-29 | 2013-02-27 | 射阳县庆缘康蜂产品厂 | Low energy propolis hard capsule preparation method |
| CN108813499A (en) * | 2018-07-09 | 2018-11-16 | 武汉康思农生物科技有限公司 | A kind of bee glue soft capsule formula and preparation process |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1189162C (en) | 2005-02-16 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |