CN108813499A - A kind of bee glue soft capsule formula and preparation process - Google Patents
A kind of bee glue soft capsule formula and preparation process Download PDFInfo
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- CN108813499A CN108813499A CN201810746003.8A CN201810746003A CN108813499A CN 108813499 A CN108813499 A CN 108813499A CN 201810746003 A CN201810746003 A CN 201810746003A CN 108813499 A CN108813499 A CN 108813499A
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- propolis
- glue
- alcohol
- bee
- raw material
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- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000007901 soft capsule Substances 0.000 title claims abstract description 21
- 238000009472 formulation Methods 0.000 title description 3
- 241000241413 Propolis Species 0.000 claims abstract description 91
- 229940069949 propolis Drugs 0.000 claims abstract description 91
- 239000002994 raw material Substances 0.000 claims abstract description 39
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000000605 extraction Methods 0.000 claims abstract description 13
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- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- OQIQSTLJSLGHID-WNWIJWBNSA-N aflatoxin B1 Chemical compound C=1([C@@H]2C=CO[C@@H]2OC=1C=C(C1=2)OC)C=2OC(=O)C2=C1CCC2=O OQIQSTLJSLGHID-WNWIJWBNSA-N 0.000 description 2
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- RTIXKCRFFJGDFG-UHFFFAOYSA-N chrysin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=CC=C1 RTIXKCRFFJGDFG-UHFFFAOYSA-N 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 2
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- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 2
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- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 2
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- 239000003908 antipruritic agent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 150000002215 flavonoids Chemical class 0.000 description 1
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- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
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- 206010022000 influenza Diseases 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000010687 lubricating oil Substances 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
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- 239000000203 mixture Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
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- 239000003973 paint Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
- A23L29/04—Fatty acids or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/045—Organic compounds containing nitrogen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Jellies, Jams, And Syrups (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of bee glue soft capsule formulas, including calculate in parts by weight：10-15 parts of propolis；20-30 parts of vegetable oil；25-30 parts of gelatin；5-10 parts of glycerol；25-30 parts of water.By propolis extraction, ingredient, change glue, pelleting sizing, ball drying is washed, ball is picked and is packaged to be product；Formula of the invention is produced using natural propolis raw material, and the formula is less using the additive of commercial synthesis, and effective component general flavone is more, has preferable raising immunity effect；More effective component can effectively be retained by the preparation process simultaneously.
Description
Technical field
The invention belongs to bee glue product technical fields, and in particular to a kind of bee glue soft capsule formula and preparation process.
Background technique
Propolis be honeybee acquired from the gemma, bark or trunk of plant come resin, and be mixed into thereon frontal gland secretion,
A kind of colloidal mixture with aromatic odor that beeswax and a small amount of pollen are process.Propolis contains there are many chemical component, main
There are chromocor compound, acid compounds, alcohol compound.Propolis has antibacterial, anti-inflammatory, analgesic, antipruritic, activating microcirculation and removing stasis medicinal, promotees
Into local organization regeneration and the effects of cutin-softening, in health care, food industry, daily chemical industry, coatings industry etc.
Aspect is all widely used.In terms of health care：Different types of bee glue product is for skin disease, canker sore, periodontal
Disease, gastritis, gastric and duodenal ulcer, rhinitis chronic, pharyngitis, tympanitis, burn, diseases of oral mucosa have significant curative effect and have
There are analgesia and local anaesthesia to use, for reducing blood lipid and prevention of arterial atherosis, treatment glycosuria, tuberculosis, corn, each gynecological disease
Have a better effect.Propolis infected by influenza and crazy exanthema virus etc. have deactivation.Informal dress propolis can be remarkably reinforced body and exempt from
Epidemic disease power plays the effect of anti-treating diseases and making health-care.In the food industry, propolis is widely answered due to its natural strong bacteriostasis
For food processing industry, as a kind of ideal natural antiseptic agent.In daily chemical industry, people production soap, perfumed soap,
Shampoo, bath foam raw material in a certain proportion of propolis is added, manufactured goods have centainly scytitis and various ringworms
Therapeutic effect.The toothpaste made of propolis, mouthwash etc. have good result to treatment canker sore and halitosis, are made of propolis
Cosmetics, beauty moisturizing can be played the role of.In addition, can be used for the paint that propolis is processed various in coatings industry
Wooden noble furniture, musical instrument etc..
Bee glue product application range is wider, and derived product is more, wherein bee glue capsule be a kind of oral health care product or
The essence of propolis can be extracted and then be obtained the product with high concentration effective component, to reach preferable by drug
Health care or therapeutic effect.But existing bee glue product formula is more, but commercial synthesis additive therein is more, and existing system
Standby technique is easy to cause the agglomeration of propolis raw material when crushing, and causes its dispersion uneven, effective so as to cause manufactured product
Component content is uneven.
Summary of the invention
In order to solve the above problems existing in the present technology, natural propolis raw material is utilized it is an object of that present invention to provide a kind of
The bee glue soft capsule formula and its preparation process of preparation.
The technical scheme adopted by the invention is as follows：A kind of bee glue soft capsule formula, including calculate in parts by weight：
Further, the vegetable oil includes but is not limited to corn oil.
Further, the propolis be it is purified after bee glue powder.
A kind of preparation process being used to prepare above-mentioned bee glue capsule, specific step is as follows：
S1. propolis extracts：Propolis raw material is first stirred extraction using alcohol as extracting solution and obtains alcohol extract, is then mentioned
It is pure to obtain propolis extract；
S2. ingredient：Emulsifying in propolis extract and vegetable oil investment material-compound tank is stirred, place is de-gassed to material
Reason, inspects sample by random samples after degassing, then will wait pelleting between the batch can push-in pelleting equipped with glue A；
S3. change glue：It will be preheated in ready gelatin, glycerol and water additionization glue tank, inspect sample by random samples after then vacuumizing,
And glue liquid B is imported in insulation barrel and insulation barrel is pushed between pelleting and waits pelleting；
S4. pelleting is formed：Ready glue A and glue liquid B are subjected to pelleting technique, pelleting content is adjusted to
500mg, ball recanalization are that 760mg is produced, and it is 8 turns/min, air quantity in 2000m that sizing rotating cage revolving speed, which is arranged,3-3000m3
And it was formed by 2-3 hours and capsule and pill is made；
S5. it is dry to wash ball：To be cleaned into excessively qualitative capsule and pill using alcohol, by the capsule and pill after cleaning 24-35 DEG C,
Relative humidity is dried in the environment of being lower than 40%；
S6. ball and packaging are picked：Qualified drying capsule and pill is got from drying room, is lower than in 20-28 DEG C of room temperature, relative humidity
40% pick carries out picking ball between ball under environment, and checks one by one and record of weighing, and is then packaged to be according to product specification
Final bee glue capsule product.
Further, specific step is as follows for the propolis extraction in the step S1：
(1.1) it first carries out an acceptance inspection to raw material, qualified propolis raw material will have been examined to be put in storage；
(1.2) propolis raw material of storage is put into freezer and is freezed, the propolis raw material after freezing is put into pulverizer
In crushed, and cross 20 mesh filter screen formed propolis raw material powder；
(1.3) smashed raw material powder is put into hopper, and is passed through alcohol into hopper and carries out the alcohol extracting of room temperature adverse current；
(1.4) supernatant after alcohol extracting filtration system progress is passed through to filter out impurity twice and obtain filtrate, wherein the
Primary filtering mesh number is 60 mesh, and it is 300 mesh that second, which is filtered mesh number,；
(1.5) filtered filtrate is tested, is passed through in multi-function extractor after the assay was approved, then vacuumize and add
Dark thick shape propolis glue medicinal extract after extraction is obtained pure propolis through supercooling by recuperation of heat alcohol；
(1.6) obtained pure propolis is entered back between crushing and uses pulverizer progress low temperature finely divided, finally by propolis
Powder is fitted into polybag and covering aluminium foil bag, and it is spare to be entered freezer after the assay was approved.
Further, the detailed process of the step (1.2) is：Propolis raw material is got according to production ordering, by propolis original
Material is put into freezing 3h or more in -18 DEG C of freezer, so that propolis is reached complete stiff frangible degree, by the propolis raw material after freezing
It is transported into workshop, is put into pulverizer and crushes, using the filter screen of 20 mesh, granular size enters the next step after reaching requirement,
What is not up to required re-starts freezing, crushes and conscientiously fill in the record of production.
Further, the detailed process of the step (1.3) is：Smashed virgin rubber powder is put into hopper, magazine clamp
It is cooling to prevent propolis agglomeration that layer is passed through ice water, adjusts propolis fltting speed with screw rod, by the edible alcohol of 95% concentration from storage tank
Middle releasing is simultaneously passed through in hopper, controls alcohol influx and inflow velocity with flowmeter, making alcohol dosage is the 4 of propolis raw material
Times, carry out the alcohol extracting of room temperature adverse current；And counterflow extraction apparatus effective length 12m, extraction time 1h.
Further, the detailed process of the step (1.5) is：Filtered filtrate is passed through in multi-function extractor,
Steam valve heating is opened, recovered alcohol starts to vacuumize when extracting solution is heated to 65 DEG C in tank, opens big steam valve, closing mentions
Tank vent valve is taken, recycling can vent valve is closed, discharging valve opens vacuum pump；Vacuum pump is closed when vacuum degree reaches 0.06MPa
Air-breathing tube valve keeps vacuum degree and 65 DEG C ± 5 DEG C of temperature；Alcohol after the recovery enters in alcohol recycle equipment, and detection is qualified
After can reuse；After recovered alcohol, dark thick shape propolis medicinal extract after being extracted obtains pure propolis through supercooling.
Further, the detailed process of the step (1.6) is：Temperature control is at 18-26 DEG C between crushing, relative humidity
It is then finely divided to propolis progress low temperature with the cooling control pulverizer temperature of circulating chilled water at 5-10 DEG C in 30-45%, by bee
Rubber powder crosses 120 meshes, and is fitted into big polybag by 10kg/ bags of specifications, then covering aluminium foil bag, and loading amount range is 1000g ± 5g,
It is spare to be entered freezer after the assay was approved.
Further, in the step S3 the specific steps are：
(3.1) it is first preheated, by material according to gelatin, glycerol, water with 1：0.3：In 1 ratio additionization glue tank, and
Stirring is opened, feed inlet is closed, unlatchingization glue tank vent valve simultaneously opens big steam valve, keeps the temperature in glue pot at 80-85 DEG C
Between material is preheated, preheating time, 20-30min can enter subsequent processing after stabilizing the temperature；
(3.2) big steam valve is opened, closingization glue tank vent valve closes recycling can vent valve, and discharging valve opens vacuum pump；
Vacuum pump air-breathing tube valve is closed when changing the vacuum degree in glue tank and reaching 0.07MPa, keeps vacuum degree, it is true in making glue tank
Reciprocal of duty cycle reaches 0.07MPa；
(3.3) temperature in controlization glue tank keeps the movement of glue liquid surface to fall after rise steady, vacuumizes between 60-85 DEG C
After keeping 20-30min, the steam bubble in glue is observed, then keep vacuum 10-15min；
(3.4) it extracts sample to be detected, after detection is qualified, by insulation barrel being connected to glue tank, by the glue of qualification
It inputs in insulation barrel, insulation barrel is pushed between pelleting and connect it with host, temperature is set in 60 DEG C, is remembered on tag card
Record starts soaking time, sets soaking time as 3 hours.
Beneficial effects of the present invention are：
Formula of the invention is produced using natural propolis raw material, and the formula is less using the additive of commercial synthesis,
And effective component general flavone is more, has preferable raising immunity effect；It can effectively be protected by the preparation process simultaneously
Stay more effective component.
Specific embodiment
Further explaination is done to the present invention combined with specific embodiments below.
Embodiment 1：
The present embodiment provides a kind of formulas of bee glue capsule, wherein each bee glue capsule product includes that 1000 propolis are soft
Capsule, and the raw material that each bee glue capsule product includes is：Propolis 150g, corn oil 350g, gelatin 416.5g, glycerol 125g and
416.5 grams of water, preparation process is as follows：
1, it first carries out an acceptance inspection to raw material, root Ju GB/T24283-2009《Propolis》National standard carry out an acceptance inspection to raw material,
Qualified propolis raw material storage will have been examined.GB/T24283-2009 described here is to propolis raw material and propolis ethyl alcohol second
The standard that alcohol extracting thing is detected, including organoleptic requirements and physicochemical requirements, wherein " total yellow for principle active component
The content of ketone " is defined.
2, propolis raw material is got according to production ordering, propolis raw material is put into freezing 3h or more in -18 DEG C of freezer, makes bee
Glue reaches complete stiff frangible degree, and the propolis raw material after freezing is transported into workshop, is put into pulverizer and crushes, using 20 mesh
Filter screen, granular size, which reaches, enters the next step after requirement, and what is not up to required re-starts freezing, crushing and conscientious
Fill in the record of production.
3, smashed virgin rubber powder is put into hopper, hopper interlayer is passed through ice water cooling to prevent propolis agglomeration, with screw rod
Adjust propolis fltting speed；The edible alcohol of 95% concentration is released from storage tank, controls alcohol influx and inflow with flowmeter
Speed, alcohol dosage are equivalent to 4 times of propolis raw material amounts (kg/L)；Carry out the alcohol extracting of room temperature adverse current, counterflow extraction apparatus effective length
12m, extraction time 1h；Perform bath manufacturing records.Strict implement is inflammable, explosive dangerous material safety regulation for operations and the precautionary measures.
4, then be filtered, the integrity of filter screen should be examined and ensured before filtering, the supernatant after room temperature alcohol extracting into
Enter room temperature filtration system, filtering mesh number for the first time is 60 mesh, and it is 300 mesh that second, which is filtered mesh number, filters out impurity and obtains propolis and mentions
Take liquid.
5, it tests to filtered filtrate, enters in multi-function extractor after the assay was approved, open steam valve heating,
Recovered alcohol starts to vacuumize when extracting solution is heated to 65 DEG C in tank, opens big steam valve, closes extractor vent valve, closes
Recycling can vent valve, discharging valve open vacuum pump, and vacuum pump air-breathing tube valve is closed when vacuum degree reaches 0.06MPa, keep
Vacuum degree with 65 DEG C ± 5 DEG C of temperature.Alcohol after the recovery enters in alcohol recycle equipment, can reuse after detection is qualified.It returns
After receiving alcohol, the dark thick shape propolis medicinal extract after being extracted obtains pure propolis through supercooling.
6, by between the push-in crushing of pure propolis, temperature control is at 18 DEG C -26 DEG C between crushing, and relative humidity is in 30%-45%.With
The cooling control pulverizer temperature of circulating chilled water is finely divided to propolis progress low temperature at 5 DEG C -10 DEG C, and bee glue powder is crossed 120 meshes.
It is fitted into big polybag by 10kg/ bags of specifications, then covering aluminium foil bag, loading amount range is 1000g ± 5g, is entered after the assay was approved cold
Library is spare.It because propolis heat is easy bonding, is preferably crushed before facing ingredient, to guarantee that it is mixed into vegetable oil in blending process and has
There is good dispersibility.
7, prepare before then carrying out ingredient, weighing area should keep 20-28 DEG C of room temperature, and relative humidity is below 60%.It opens
Material-compound tank is preheated, and carries out the corresponding record of production.First by corn oil, bee glue powder investment material-compound tank, opens material-compound tank and stir
It mixes, adjusts mixing speed, material is carried out emulsifying 5 minutes every 5 minutes unlatching homogeneous emulsifying machines, repeatedly, makes object
Until material is uniformly mixed.Root Ju material-compound tank operating instruction is de-gassed material, after degassing, extracts sample and is examined
It surveys, after detection is qualified, head tank is connected on material-compound tank, material inputs in head tank, and head tank is pushed between pelleting.
8, then progress glue, by material according to gelatin：Glycerol：Water=1：0.3：In 1 ratio additionization glue tank, and open
Open stirring, close feed inlet, unlatchingizations glue tank vent valve simultaneously opens big steam valve, the temperature in holding glue pot 80-85 DEG C it
Between material is preheated, preheating time 20-30 point after stabilizing the temperature, into subsequent processing.Then it vacuumizes, opens big
Steam valve, closingization glue tank vent valve close recycling can vent valve, and discharging valve opens vacuum pump.The vacuum degree changed in glue tank reaches
Vacuum pump air-breathing tube valve is closed when to 0.07MPa, keeps vacuum degree, and the vacuum degree in making glue tank reaches 0.07MPa.Control
Change the temperature in glue tank between 60-85 DEG C, keeps the movement of glue liquid surface to fall after rise steady.After vacuumizing holding 20-30 minutes, see
The steam bubble in glue is examined, then keeps vacuum 10-15 minutes.It extracts sample to be detected, after detection is qualified, insulation barrel is connected
It connects on changing glue tank, by qualified glue input insulation barrel, insulation barrel is pushed between pelleting, and insulation barrel is connect with host, and will
Temperature is set in 60 DEG C, and record starts soaking time on tag card, sets soaking time as 3 hours.
9, pelleting is carried out, is kept for 21-6 DEG C of room temperature between pelleting, relative humidity 40%-55%.By pelleting technological procedure and
SOP requires to load onto specified mold；Operator, review should sign per capita；Adjustment is to line and oiling time.Adjusting glue temperature,
Expanding and arranging box temperature, while rubber thickness and the uniformity are monitored, the detection of per half an hour and record are primary later.By pelleting content
Be adjusted to 500mg, ball recanalization be 760mg, can formally produce.Per half an hour detection and record one-time detection in production process
Content uniformity.Ball shape is gone through at any time and whether has leakage phenomenon, and per half an hour record is primary.Keep a close eye on pellet press fortune
Market condition, is replenished in time lubricating oil.Sizing rotating cage revolving speed should be 8 turns/min, and air quantity is answered in 2000m3-3000m3, setting time
At 2-3 hours.Then it carries out washing ball, the capsule and pill by stipulated time sizing carries out washing ball, when washing ball by ball SOP regulation is washed
It is cleaned using 95% edible alcohol, makes capsule and pill clean surface oil stains-less.Washed capsule and pill through QC personnel inspect by random samples it is qualified after, fill in
Between product circulation block and give drying process.
10, when dry, drying room is first kept for 24-35 DEG C of room temperature, 40% or less relative humidity.By dry technological procedure
It requires to be operated with SOP, the temperature and humidity of regular check drying room simultaneously makes a record.The drying time of capsule and pill is controlled through QC
Personnel can receive ball weighing after inspecting qualification by random samples, fill in intermediate products production flow card, deliver intermediate station.
11, it then carries out picking ball, picks 20-28 DEG C of room temperature of holding between ball, 40% or less relative humidity is connected to production ordering.From
Drying room gets the capsule and pill of dry qualification, checks the name of an article, specification, lot number, quantity, is placed in lamp inspection desk, checks one by one, picks abnormity
Ball, big piller, bubble ball, oil leak ball etc..Qualified capsule and pill and unqualified capsule and pill are installed respectively, weighing record.
12, it packs
The product specification is 0.5g/ × 90/bottle.Inner packaging material oral stable medicinal polythene bottle with high density is answered
Meet the regulation of YBB00122002；Al-plastic sealing gasket should meet the regulation of YBB00212004.
Embodiment 2：
The present embodiment provides a kind of formulas of bee glue capsule, wherein each bee glue capsule product includes that 1000 propolis are soft
Capsule, and the raw material that each bee glue capsule product includes is：Propolis 160g, corn oil 350g, gelatin 412.2g, glycerol 125g and
410.8 grams of water.Its preparation process is same as Example 1.
Embodiment 3：
The present embodiment provides a kind of formulas of bee glue capsule, wherein each bee glue capsule product includes that 1000 propolis are soft
Capsule, and the raw material that each bee glue capsule product includes is：Propolis 155g, corn oil 353g, gelatin 415.6g, glycerol 122g and
412.4 grams of water.Its preparation process is same as Example 1.
Embodiment 4：
The present embodiment provides a kind of formulas of bee glue capsule, wherein each bee glue capsule product includes that 1000 propolis are soft
Capsule, and the raw material that each bee glue capsule product includes is：Propolis 151g, corn oil 349g, gelatin 418g, glycerol 125g and water
414 grams.Its preparation process is same as Example 1.
Embodiment 5：
The present embodiment provides a kind of formulas of bee glue capsule, wherein each bee glue capsule product includes that 1000 propolis are soft
Capsule, and the raw material that each bee glue capsule product includes is：Propolis 150g, corn oil 350g, gelatin 421.3g, glycerol 120g and
416.7 grams of water.Its preparation process is same as Example 1.
Five kinds of formulas of above-described embodiment 1-5 are detected, detection method includes organoleptic requirements and physical and chemical index, wherein feeling
Official requires to include color, flavour smell, character and impurity, specific test such as following table：
This five kinds formulas are above-mentioned testing result, meet the organoleptic requirements of its product.
Then the physical and chemical index include ash content, disintegration time limited, acid value, peroxide value, lead, arsenic, mercury, aflatoxin B1,
Total plate count, coliform, mould, yeast, pathogenic bacteria (salmonella, Shigella, staphylococcus aureus, hemolytic chain
Coccus) and its general flavone content, wherein test sample processing method is as follows：
10, sample are taken, content is squeezed out and is heated in hot bath when necessary by content as in centrifuge tube,
3000r/min is centrifuged 20min, so that propolis is separated with oil in suspension.Oil reservoir is discarded, propolis 0.8g is taken, adds methanol 20ml, is surpassed
Sonicated 20min, filtration, takes filtrate as test solution.Chrysin reference substance, galangal reference substance separately are taken, adds methanol
Mixed solution of every 1ml containing 1mg is made, as reference substance solution.According to《Pharmacopoeia of People's Republic of China》(version in 2010) is thin
Layer chromatography (annex VIB) (9.4:0.3:0.3) it is unfolded for solvent, takes out, dry, sprays with alchlor reagent, be placed in purple
It is inspected under outer smooth lamp (365nm).In sample chromatogram, on the control corresponding people position of chromatography, the fluorescent spot of same color is shown
Point.And wherein Determination of Total Flavonoids method is：Rutin standard solution is prepared, 5mg rutin is weighed, methanol is added to dissolve and be settled to
50ml is to get 100 μ g/ml；Then draw 0,1.0,2.0,3.0,4.0,5.0ml in 25ml colorimetric cylinder, add methanol to scale
Then it shakes up, the colorimetric at 360nm wavelength, asks regression equation, the general flavone content in experiment with computing.
Wherein test structure is as follows：
| Project | Index | Detection method |
| Ash content (%) | ≤3.0 | GB 5009.4-2010 |
| Disintegration time limited (min) | ≤60 | 《Pharmacopoeia of People's Republic of China》 |
| Acid value (mgKOH/g) | ≤15.0 | GB/T 5009.37-2003 |
| Peroxide value (nmol/kg) | ≤7.5 | GB/T 5009.37-2003 |
| Lead (mg/kg) | ≤1.5 | GB 5009.12-2010 |
| Arsenic (mg/kg) | ≤1.0 | GB 5009.11-2003 |
| Mercury (mg/kg) | ≤0.3 | GB 5009.17-2003 |
| Aflatoxin B1 (μ g/kg) | ≤5.0 | GB 4789.15-2010 |
| Pathogenic bacteria | It must not detect | Corresponding detection national standard |
| Total plate count (cfu/g) | ≤1000 | GB 4789.2-2010 |
| Escherichia coli (MPN/100g) | ≤40 | GB/T 4789.3-2003 |
| Mould (cfu/g) | ≤25 | GB 4789.15-2010 |
| Yeast (cfu/g) | ≤25 | GB 4789.15-2010 |
| General flavone (g/100g) | ≥5.1 | General flavone test method |
Final five groups of embodiments meet testing requirements, are qualified products, while its general flavone content is higher, by above-mentioned
Preparation process can remain into more effective component, and can prevent that bonding situation occurs when its stirring by low-temperature treatment, from
And stir evenly product.After product test manufacture and progress zoopery, experimental subjects keeps it immune by taking the product
Power significantly improves.
The present invention is not limited to above-mentioned optional embodiment, anyone can show that other are each under the inspiration of the present invention
The product of kind form.Above-mentioned specific embodiment should not be understood the limitation of pairs of protection scope of the present invention, protection of the invention
Range should be subject to be defined in claims, and specification can be used for interpreting the claims.
Claims (10)
1. a kind of bee glue soft capsule formula, it is characterised in that：Including calculating in parts by weight：
2. a kind of bee glue soft capsule formula according to claim 1, it is characterised in that：The vegetable oil includes but is not limited to
Corn oil.
3. a kind of bee glue soft capsule formula according to claim 2, it is characterised in that：The propolis be it is purified after bee
Rubber powder.
4. a kind of a kind of preparation process for the bee glue soft capsule formula for being used to prepare claim 3, it is characterised in that：Specific steps
It is as follows：
S1. propolis extracts：Propolis raw material is first stirred extraction using alcohol as extracting solution and obtains alcohol extract, is then purified
To propolis extract；
S2. ingredient：Emulsifying in propolis extract and vegetable oil investment material-compound tank is stirred, material is de-gassed,
It inspects sample after degassing by random samples, then will wait pelleting between the batch can push-in pelleting equipped with glue A；
S3. change glue：It will be preheated in ready gelatin, glycerol and water additionization glue tank, inspect sample after then vacuumizing by random samples, and will
Glue liquid B, which imports in insulation barrel and insulation barrel is pushed between pelleting, waits pelleting；
S4. pelleting is formed：Ready glue A and glue liquid B are subjected to pelleting technique, pelleting content is adjusted to 500mg, ball
Recanalization is that 760mg is produced, and it is 8 turns/min, air quantity in 2000m that sizing rotating cage revolving speed, which is arranged,3-3000m3And pass through 2-3
Hour, which is formed, is made capsule and pill；
S5. it is dry to wash ball：To be cleaned into excessively qualitative capsule and pill using alcohol, by the capsule and pill after cleaning 24-35 DEG C, it is opposite
Humidity is dried in the environment of being lower than 40%；
S6. ball and packaging are picked：Qualified drying capsule and pill is got from drying room, in 20-28 DEG C of room temperature, relative humidity lower than 40%
It picks and carries out picking ball under environment between ball, and check one by one and record of weighing, then carry out being packaged to be final bee according to product specification
Glue capsule product.
5. a kind of preparation process of bee glue soft capsule formula according to claim 4, it is characterised in that：Bee in the step S1
Specific step is as follows for glue extraction：
(1.1) it first carries out an acceptance inspection to raw material, qualified propolis raw material will have been examined to be put in storage；
(1.2) propolis raw material of storage is put into freezer and is freezed, by the propolis raw material after freezing be put into pulverizer into
Row crushes, and the filter screen for crossing 20 mesh forms propolis raw material powder；
(1.3) smashed raw material powder is put into hopper, and is passed through alcohol into hopper and carries out the alcohol extracting of room temperature adverse current；
(1.4) supernatant after alcohol extracting is passed through filtration system progress to filter out impurity twice and obtain filtrate, wherein first time
Filtering mesh number is 60 mesh, and it is 300 mesh that second, which is filtered mesh number,；
(1.5) filtered filtrate is tested, is passed through in multi-function extractor after the assay was approved, then vacuumize and heat back
It receives alcohol and the dark thick shape propolis glue medicinal extract after extraction is obtained into pure propolis through supercooling；
(1.6) obtained pure propolis is entered back between crushing and uses pulverizer progress low temperature finely divided, finally fill bee glue powder
Enter in polybag and covering aluminium foil bag, it is spare to be entered freezer after the assay was approved.
6. a kind of preparation process of bee glue soft capsule formula according to claim 5, it is characterised in that：The step (1.2)
Detailed process is：Propolis raw material is got according to production ordering, propolis raw material is put into freezing 3h or more in -18 DEG C of freezer, is made
Propolis reaches complete stiff frangible degree, and the propolis raw material after freezing is transported into workshop, is put into pulverizer and crushes, using 20
Purpose filter screen, granular size enter the next step after reaching requirement, and what is not up to required re-starts freezing, crushes and recognize
Really fill in the record of production.
7. a kind of preparation process of bee glue soft capsule formula according to claim 5, it is characterised in that：The step (1.3)
Detailed process is：Smashed virgin rubber powder is put into hopper, hopper interlayer is passed through ice water cooling to prevent propolis agglomeration, with screw rod
Propolis fltting speed is adjusted, by the edible alcohol of 95% concentration from releasing and being passed through in hopper in storage tank, controls wine with flowmeter
Smart influx and inflow velocity, making alcohol dosage is 4 times of propolis raw material, carries out the alcohol extracting of room temperature adverse current；And counterflow extraction apparatus
Effective length 12m, extraction time 1h.
8. a kind of preparation process of bee glue soft capsule formula according to claim 5, it is characterised in that：The step (1.5)
Detailed process is：Filtered filtrate is passed through in multi-function extractor, steam valve heating, recovered alcohol, when mentioning in tank are opened
When liquid being taken to be heated to 65 DEG C, start to vacuumize, open big steam valve, close extractor vent valve, closes recycling can vent valve, discharge water
Valve opens vacuum pump；Vacuum pump air-breathing tube valve is closed when vacuum degree reaches 0.06MPa, keeps vacuum degree and 65 DEG C of temperature
±5℃；Alcohol after the recovery enters in alcohol recycle equipment, can reuse after detection is qualified；After recovered alcohol, extracted
Dark thick shape propolis medicinal extract afterwards, obtains pure propolis through supercooling.
9. a kind of preparation process of bee glue soft capsule formula according to claim 5, it is characterised in that：The step (1.6)
Detailed process is：At 18-26 DEG C, relative humidity is crushed in 30-45% with the cooling control of circulating chilled water for temperature control between crushing
Machine temperature is then finely divided to propolis progress low temperature at 5-10 DEG C, bee glue powder is crossed 120 meshes, and be packed by 10kg/ bags of specifications
In big polybag, then covering aluminium foil bag, loading amount range are 1000g ± 5g, and it is spare to be entered freezer after the assay was approved.
10. a kind of preparation process of bee glue soft capsule formula according to claim 4, it is characterised in that：In the step S3
The specific steps are：
(3.1) it is first preheated, by material according to gelatin, glycerol, water with 1：0.3：In 1 ratio additionization glue tank, and open
Feed inlet is closed in stirring, and unlatchingization glue tank vent valve simultaneously opens big steam valve, keeps the temperature in glue pot between 80-85 DEG C
Material is preheated, preheating time, 20-30min can enter subsequent processing after stabilizing the temperature；
(3.2) big steam valve is opened, closingization glue tank vent valve closes recycling can vent valve, and discharging valve opens vacuum pump；Changing
Vacuum degree in glue tank closes vacuum pump air-breathing tube valve when reaching 0.07MPa, keeps vacuum degree, the vacuum degree in making glue tank
Reach 0.07MPa；
(3.3) temperature in controlization glue tank keeps the movement of glue liquid surface to fall after rise steady, vacuumizes holding between 60-85 DEG C
After 20-30min, the steam bubble in glue is observed, then keep vacuum 10-15min；
(3.4) it extracts sample to be detected, after detection is qualified, by insulation barrel being connected to glue tank, qualified glue is inputted
In insulation barrel, insulation barrel is pushed between pelleting and connect it with host, temperature is set in 60 DEG C, records and opens on tag card
Beginning soaking time set soaking time as 3 hours.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116268339A (en) * | 2022-10-21 | 2023-06-23 | 上海协美蜂产品有限公司 | Bee and wheat capsule and preparation method thereof |
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Application publication date: 20181116 |
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| RJ01 | Rejection of invention patent application after publication |