CN109985095A - A method of preparing Shuanghuanglian oral liquid for livestock clarification preparation - Google Patents
A method of preparing Shuanghuanglian oral liquid for livestock clarification preparation Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a kind of methods for preparing Shuanghuanglian oral liquid for livestock clarification preparation, preparation method are as follows: honeysuckle, radix scutellariae, Fructus Forsythiae are extracted, are concentrated, and buffer salt alkalescent system is constructed in concentrate and increases the solubility and stability of active principle, then is centrifuged off invalid impurity；Add water with liquid；Through acid solution adjust prepare solution ph and etc. be prepared；Shuanghuanglian oral liquid preparation character clarification prepared by the present invention and stability height, are compared with the traditional method, shorten the production cycle, reduce costs.
Description
Technical field
The present invention relates to a kind of methods for preparing Shuanghuanglian oral liquid for livestock clarification preparation, particularly relate to a kind of for for animals
Clarification Shuanghuanglian oral liquid preparation and its extraction and purification method.
Background technique
In recent years, flourishing along with cultivation industry, the cultivation of centralization intensity also bring the day of livestock and poultry
Beneficial diversification complicates, and use of a large amount of chemicals in Production of Livestock and Poultry, the abuse of drug makes pathogenic microorganism tolerance
Increase, not only increases the difficulty for the treatment of disease, also seriously threaten the health of the mankind.
Shuanghuanglian oral liquid is that veterinary clinic uses a kind of wider pure Chinese medicine compound preparation, by radix scutellariae, honeysuckle, Fructus Forsythiae
3 taste Chinese medicinal compositions have relieving the exterior syndrome with drugs pungent in flavor and cool in property, clearing heat and detoxicating effect, can be used for the disease treatment of dog, cat, chicken cold, fever.It is modern
Medical research, Shuanghuanglian oral liquid can resist multiple pathogenic microorganisms as pure Chinese medicinal preparation, and the sterilization with wide spectrum is made
With, thus livestock and poultry are intensive, are able to be widely applied and promote in cultivation industry of scale.
The production technology of Shuanghuanglian oral liquid for livestock execute 2015 version " Republic of China Veterinary Pharmacopoeia " record technique,
Complex operation, higher cost.Currently, commercially available enterprise uses the Shuanghuanglian oral liquid product of medicinal material extract production, generality
Shape does not meet clear quality requirement；And hyperfiltration treatment is used, the clarity of solution can be promoted, but macromolecule Chinese medicine is caused to have
It imitates the loss of ingredient and clarification system stability is poor, it is difficult to maintain the long period；Meanwhile hyperfiltration treatment to process equipment require compared with
Height and easily limitation production capacity, increase production cost.
Summary of the invention
Aiming at the problems existing in the prior art, the present invention provides a kind of simple, effective extracting and purifying method, energy
Enough effective simplified production procedures, solve the production problem of Shuanghuanglian oral liquid clarification system stability difference, and largely
Shuanghuanglian oral liquid for livestock character clear stable is improved, and product active constituent content is largely wanted better than standards of pharmacopoeia
It asks.
A kind of above-mentioned purpose that the invention is realized by the following technical scheme: Shuanghuanglian oral liquid for livestock clarification preparation of preparing
Method, comprising the following steps:
(1) radix scutellariae, honeysuckle, Fructus Forsythiae extracting in water, filtering, gained extracting solution are concentrated to get concentrate；
(2) buffer salt is added in concentrate and adjusts pH value, stand, centrifugation, centrifugate is Shuanghuanglian oral liquid intermediate；
(3) Shuanghuanglian oral liquid intermediate adjusts pH value with acid solution；Add water constant volume；Centrifugation, it is filling, sterilizing to get
Shuanghuanglian oral liquid clarification preparation.
In the step (1) prescription of Shuanghuanglian oral liquid preparation be configured to (shared weight percent hundred compare) radix scutellariae 25%,
Honeysuckle 25%, Fructus Forsythiae 50%；Specification is that every 1ml is equivalent to crude drug in whole 1.5g；Raw material can be medicine materical crude slice, a sub- goods, coarse powder, thin
Powder, impalpable powder or Ultramicro-powder.
In the step (2), concentrate is 7-9 with the pH value range that buffer salt is adjusted；Buffer salt is selected from phosphate, acetic acid
One or more of salt, citrate, bicarbonate are used in mixed way.
In the step (2), concentrate takes centrifuging process to clean after standing, and centrifugal speed control range is
6000‐12000rpm。
In the step (3), Shuanghuanglian oral liquid is 5-7 with the pH value range that acid solution is adjusted.
In the step (3), when centrifugation, revolving speed 6000-12000rpm.
Using content of baicalin >=12.0mg, chlorogenic acid in the every 1ml of Shuanghuanglian oral liquid preparation of the method for the present invention preparation
Content >=1.0mg, Determination of forsythin >=1.5mg.
Using the Shuanghuanglian oral liquid preparation of the method for the present invention preparation according to version " Chinese Pharmacopoeia " clarity inspection in 2015
Method inspection, meets clarification request；Accelerated study on the stability (1. 60 ± 2 DEG C of temperature, the decentralization of 75% ± 5% condition of relative humidity
It sets 10 days；2. placed 6 months under the conditions of 40 ± 2 DEG C of temperature, relative humidity 75% ± 5%), sample keeps clarification character, radix scutellariae
Glycosides, chlorogenic acid and Determination of forsythin are without significant changes.
The beneficial effects of the present invention are:
1, the present invention uses high speed centrifugation technique in intermediate production process, effective to remove Chinese medicine during the extraction process
The invalid components such as the subtle soil, plant amylum, pectin, crude protein, the tannin that introduce preferably are realized and are separated by solid-liquid separation；In increase
While the clarity of mesosome, purifies, is enriched effective component.
2, the present invention effectively ensures scutelloside, chlorogenic acid, company using buffer salt alkalescent system is constructed in concentrate
Stick up the dissolubility and ingredient stability of the ingredients such as glycosides.
3, when solution is prepared, using alkaline solution and acid solution carry out sequence soda acid allotment, double Huangs are further improved
The even clarification character and stability of oral liquid formulations.
4, the Shuanghuanglian oral liquid clarification preparation of the method for the present invention used one-step extraction, with version " the Chinese people in 2015
Republic's veterinary drug allusion quotation " in the Shuanghuanglian oral liquid technique recorded compare:
1. reducing technology difficulty and the demand to special process equipment, the adaptability of production technology is promoted；Such as veterinary drug allusion quotation work
Skill requires separately extraction, multiple alcohol precipitation, acid heavy, both increases technology difficulty and device requirement.
2. having saved the technique production duration of product, technique production capacity is substantially improved；If veterinary drug allusion quotation technique requires separately to extract,
It compares the present invention and needs one extraction production line of more occupancy, compare alcohol precipitation multiple in veterinary drug allusion quotation technique, sour heavy, resting process,
Production cycle in invention at least saves 24 hours.
3. saving manufacturing cost, product cost is stabilized；Veterinary drug allusion quotation technique is compared, the method for the present invention can give birth to by saving
Produce the duration, reduce production equipment demand, promote production capacity etc. directly saves production cost, to stabilize product cost.
4. the quality standard that the active constituent contents such as scutelloside, chlorogenic acid, forsythin are higher than veterinary drug allusion quotation in product limits.
Specific embodiment
With reference to preferred implementation method of the invention below detailed description and including embodiment this public affairs can be more easily to understand
Open content.Part term can be referred in the following description, and these terms are defined as following meanings.
Specific gravity in the present invention refers to the density ratio relative to water.
Explanation is further explained to the present invention below with reference to embodiment, should not be understood as the limit to the scope of the present invention
System, some nonessential modifications and adaptations that professional and technical personnel in the field makes according to the content of aforementioned present invention still belong to
In protection of the invention.
Embodiment 1
A method of preparing Shuanghuanglian oral liquid for livestock clarification preparation, comprising the following steps:
(1) radix scutellariae slice 375g, honeysuckle 375g, Fructus Forsythiae 750g add water boiling to extract 3 times (small with 8 times of water 2 for the first time
When, second and third is time respectively with 6 times of water 1 hour), combined extract filters, and the extracting solution after filter is concentrated under reduced pressure into specific gravity 1.02 (70
DEG C), obtain concentrate；
(2) sodium citrate is added in concentrate, adjusts pH value to 7.0, stands 12 hours, 6000rpm centrifugation removal of impurities is centrifuged
Liquid is Shuanghuanglian oral liquid intermediate；
(3) Shuanghuanglian oral liquid intermediate 2mol/L hydrochloric acid solution adjusts pH value to 5.0；Water is added to be settled to 1000ml,
6000rpm centrifugation removal of impurities, it is filling, it sterilizes to get Shuanghuanglian oral liquid clarification preparation.
Embodiment 2
A method of preparing Shuanghuanglian oral liquid for livestock clarification preparation, comprising the following steps:
(1) radix scutellariae 375g, honeysuckle 375g, Fructus Forsythiae 750g are ground into coarse powder, and water boiling is added to extract 3 times (for the first time with 8 times
Water 2 hours, second and third was time respectively with 6 times of water 1 hour), combined extract filters, and the extracting solution after filter is concentrated under reduced pressure into specific gravity
1.05 (80 DEG C), obtain concentrate；
(2) sodium bicarbonate and sodium citrate are added in concentrate, adjusts pH value to 9.0, stands 12 hours, 12000rpm from
Heart removal of impurities, centrifugate is Shuanghuanglian oral liquid intermediate；
(3) Shuanghuanglian oral liquid intermediate 2mol/L hydrochloric acid solution adjusts pH value to 7.0；Add water constant volume 1000ml,
12000rpm centrifugation removal of impurities, it is filling, it sterilizes to get Shuanghuanglian oral liquid clarification preparation.
Embodiment 3
A method of preparing Shuanghuanglian oral liquid for livestock clarification preparation, comprising the following steps:
(1) radix scutellariae 375g, honeysuckle 375g, Fructus Forsythiae 750g are ground into Ultramicro-powder, add water boiling to extract 3 times and (use for the first time
10 times water 2 hours, second with 8 times water 1 hour, for the third time with 6 times of water 1 hour), combined extract, filtering, the extracting solution after filter
Specific gravity 1.05 (70 DEG C) are concentrated under reduced pressure into, concentrate is obtained；
(2) sodium bicarbonate, sodium acetate and sodium citrate mixture are added in concentrate, adjusts pH value to 8.0, it is small to stand 6
When, 8000rpm centrifugation removal of impurities, centrifugate is Shuanghuanglian oral liquid intermediate；
(3) Shuanghuanglian oral liquid intermediate 2mol/L hydrochloric acid solution adjusts pH value to 6.0；Add water constant volume 1000ml,
12000rpm centrifugation removal of impurities, it is filling, it sterilizes to get Shuanghuanglian oral liquid clarification preparation.
Embodiment 4
A method of preparing Shuanghuanglian oral liquid for livestock clarification preparation, comprising the following steps:
(1) radix scutellariae 375g, honeysuckle 375g, Fructus Forsythiae 750g are sub- goods, and water boiling is added to extract 3 times (for the first time with 10
Times water 2 hours, second with 8 times water 1 hour, for the third time with 6 times of water 1 hour), combined extract, filtering, the extracting solution after filter subtracts
Pressure is concentrated into specific gravity 1.01 (80 DEG C), obtains concentrate；
(2) addition sodium bicarbonate, sodium acetate, sodium phosphate and sodium citrate mixture adjusting pH value are quiet to 7.5 in concentrate
It sets 6 hours, 10000rpm centrifugation removal of impurities, centrifugate is Shuanghuanglian oral liquid intermediate；
(3) Shuanghuanglian oral liquid intermediate 2mol/L hydrochloric acid solution adjusts pH value to 6.5；Add water constant volume 1000ml,
8000rpm centrifugation removal of impurities, it is filling, it sterilizes to get Shuanghuanglian oral liquid clarification preparation.
5 comparative example of embodiment
The preparation method of two Shuanghuanglian oral liquids recorded of " Republic of China Veterinary Pharmacopoeia " version in 2015, including with
Lower step:
(1) baikal skullcap root decoction pieces 375g is added water to cook 3 times, for the first time 10 times water 2 hours, each 8 times of water 1 hour of second and third time,
Merging filtrate, filtration, filtrate are concentrated into specific gravity 1.03 (80 DEG C), and 2mol/L hydrochloric acid solution is added at 80 DEG C and adjusts pH in right amount
Value keeps the temperature 1 hour to 1.5；12 hours are stood, filtration, precipitating plus 7 times of amount water, the sodium hydroxide for being 40% with weight fraction are molten
Liquid adjusts pH value to 7.0, then plus equal volume amounts ethyl alcohol, be stirred to dissolve, filter, filtrate adjusts pH with 2mol/L hydrochloric acid solution
Value keeps the temperature 30 minutes to 2.0,60 DEG C, stands 12 hours, and filtration, precipitating plus ethyl alcohol are washed till pH value to 7.0, and it is spare to wave most ethyl alcohol,
Up to Baical Skullcap root P.E.
(2) honeysuckle 375g, Fructus Forsythiae 750g decoct 2 (10 times of water 1.5 hours, 8 times of water 1.5 after adding water temperature to soak 30 minutes
Hour)；Combined extract is concentrated into specific gravity 1.25 (80 DEG C), obtains concentrate I；Second is added in stirring when concentrate I is cooled to 40 DEG C
Alcohol makes alcohol content up to 75% (volume fraction), stands 12 hours；Supernatant is filtered off, residue adds volume fraction to be 75% ethyl alcohol
In right amount, it stirs evenly, stands 12 hours, filtration merges ethanol solution, is concentrated into specific gravity 1.03 (80 DEG C), and obtaining concentrate II is gold
Honeysuckle flower, forsythia suspense extraction；
(3) honeysuckle, Baical Skullcap root P.E is added in forsythia suspense extraction, add appropriate amount of water, the hydrogen-oxygen for being 40% with weight fraction
Change sodium solution and adjust pH value to 7.0, stirs evenly, 6 DEG C refrigerate 72 hours, filtration, adjust filtrate pH value to 7.0, water is added to be made
1000ml is stirred evenly, stand 12 hours, filtration, it is filling, sterilizing to get.
The method of inspection
The clarification character and Content Test of product
Clarity uses four annex of Pharmacopoeia of the People's Republic of China version in 2015,0902 the first method of clarity inspection technique
Detection；
Scutelloside, chlorogenic acid, Determination of forsythin detection are double using " Republic of China Veterinary Pharmacopoeia " version in 2015 two
Method under coptis oral solution item；
Study on the stability method are as follows: Example and comparative example are in the following conditions system progress accelerated test respectively: 1.
It is placed 10 days under the conditions of 60 ± 2 DEG C of temperature, relative humidity 75% ± 5%；2. 40 ± 2 DEG C of temperature, relative humidity 75% ± 5%
It is placed 6 months under part.Embodiment kind sample property keeps clarifying as the result is shown, and the content of scutelloside, chlorogenic acid, forsythin
Without significant changes；Sample has a small amount of Precipitation in comparative example 1, solution is not clarified, and scutelloside, chlorogenic acid, forsythin
Content be greatly reduced.
Remarks: standard foundation is to want under two Shuanghuanglian oral liquid items of " Republic of China Veterinary Pharmacopoeia " version in 2015
It asks.
Claims (7)
1. a kind of method for preparing Shuanghuanglian oral liquid for livestock clarification preparation, which comprises the following steps:
(1) radix scutellariae, honeysuckle, Fructus Forsythiae extracting in water, filtering, gained extracting solution are concentrated to get concentrate；
(2) buffer salt is added in concentrate and adjusts pH value, stand, centrifugation, centrifugate is Shuanghuanglian oral liquid intermediate；
(3) Shuanghuanglian oral liquid intermediate adjusts pH value with acid solution；Add water constant volume；Centrifugation, it is filling, it sterilizes to get double Huangs
Even oral solution clarification preparation.
2. a kind of method for preparing Shuanghuanglian oral liquid for livestock clarification preparation according to claim 1, it is characterised in that: step
Suddenly the prescription of Shuanghuanglian oral liquid preparation is configured to (shared weight percent hundred compares) radix scutellariae 25%, honeysuckle 25%, Fructus Forsythiae in (1)
50%；Specification is that every 1ml is equivalent to crude drug in whole 1.5g；Raw material can be medicine materical crude slice, a sub- goods, coarse powder, fine powder, impalpable powder or ultra micro
Powder.
3. a kind of method for preparing Shuanghuanglian oral liquid for livestock clarification preparation according to claim 1, it is characterised in that: step
Suddenly in (2), concentrate is 7-9 with the pH value range that buffer salt is adjusted；Buffer salt is selected from phosphate, acetate, citrate, carbon
One or more of sour hydrogen salt is used in mixed way.
4. a kind of method for preparing Shuanghuanglian oral liquid for livestock clarification preparation according to claim 1, it is characterised in that: step
Suddenly in (2), concentrate takes centrifuging process to clean after standing, and centrifugal speed control range is 6000-12000rpm.
5. a kind of method for preparing Shuanghuanglian oral liquid for livestock clarification preparation according to claim 1, it is characterised in that: step
Suddenly in (3), Shuanghuanglian oral liquid is 5-7 with the pH value range that acid solution is adjusted.
6. a kind of method for preparing Shuanghuanglian oral liquid for livestock clarification preparation according to claim 1, it is characterised in that: step
Suddenly in (3), when centrifugation, revolving speed 6000-12000rpm.
7. a kind of method for preparing Shuanghuanglian oral liquid for livestock clarification preparation according to claim 1, it is characterised in that: institute
Content of baicalin >=12.0mg, chlorogenic acid content >=1.0mg, forsythin in the every 1ml of Shuanghuanglian oral liquid preparation of preparation is stated to contain
Amount >=1.5mg.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115645364A (en) * | 2022-11-09 | 2023-01-31 | 江苏南京农大动物药业有限公司 | Shuanghuanglian oral liquid for pets |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895317A (en) * | 2012-11-09 | 2013-01-30 | 河南牧翔动物药业有限公司 | Preparation method of Shuanghuanglian oral liquid for veterinary use |
| CN102940856A (en) * | 2012-12-12 | 2013-02-27 | 杭州老桐君制药有限公司 | Method for preparing anti-viral oral liquid and product thereof |
-
2017
- 2017-12-29 CN CN201711485971.XA patent/CN109985095A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895317A (en) * | 2012-11-09 | 2013-01-30 | 河南牧翔动物药业有限公司 | Preparation method of Shuanghuanglian oral liquid for veterinary use |
| CN102940856A (en) * | 2012-12-12 | 2013-02-27 | 杭州老桐君制药有限公司 | Method for preparing anti-viral oral liquid and product thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115645364A (en) * | 2022-11-09 | 2023-01-31 | 江苏南京农大动物药业有限公司 | Shuanghuanglian oral liquid for pets |
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Application publication date: 20190709 |