CN1189162C - Formulation and production process of bee glue capsule - Google Patents
Formulation and production process of bee glue capsule Download PDFInfo
- Publication number
- CN1189162C CN1189162C CNB001074229A CN00107422A CN1189162C CN 1189162 C CN1189162 C CN 1189162C CN B001074229 A CNB001074229 A CN B001074229A CN 00107422 A CN00107422 A CN 00107422A CN 1189162 C CN1189162 C CN 1189162C
- Authority
- CN
- China
- Prior art keywords
- bee glue
- lead
- present
- propolis
- bee
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Jellies, Jams, And Syrups (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to a formula of bee glue soft capsules and a processing technology thereof, which belongs to the field of medicinal chemical industry. The present invention needs to solve the following problems: (1), a technology for removing lead in bee glue is used; (2), a scientific formula and a processing technology are used, which enables the bee glue to dissolve in a medium and to be separately and uniformly packaged. The present invention has the main technical characteristics that (1), a simple chemical method of adding water acetic acid used as a lead removing agent and a cold filtration (with an imported nylon net of 400 meshes at 0 to 4 DEG C) method are combined for descending the content of heavy metal lead contained in bee glue raw materials below 10PPm (conformingto the international food standard), and impurities approximately occupying 35 to 50% of bee glue and beeswax are separated; (2), the scientific formula is selected, which enables the bee glue to be sufficiently dissolved in the medium and separately and uniformly packaged so as to guarantee quality. The phenomenon of non-uniform content of bee glue soft capsule products in the market at present is overcome.
Description
Technical Field
The invention belongs to the field of: pharmaceutical and chemical engineering.
Background
At present, the soft capsule technology is adopted in medicine and health care products. However, the difficulty of encapsulating propolis is high. Because propolis is difficult to dissolve and is unevenly subpackaged, a scientific formula and a processing technology are adopted to ensure that propolis is fully dissolved in a solvent, the subpackaging is uniform, and the quality is ensured.
Disclosure of Invention
The purpose of the invention is as follows:
(1) removing heavy metal lead in propolis to make its content less than or equal to 10ppm, and removing excessive beeswax and impurities;
(2) the scientific formula is selected to dissolve the propolis in the medium, so that the product quality is improved by uniform split charging, and the defects of poor palatability, large waste and inconvenience in carrying of the existing propolis liquid product are overcome.
The invention adopts the following technical scheme:
(1) formulation of
33 percent of 100 percent of pure propolis powder and 67 percent of medicinal grease.
(2) Pure propolis lead-removing purification technology
The propolis extraction process is shown in the attached figure.
Mixing the filtrate (1) and the filtrate (2), adding 0.2 per mill of glacial acetic acid lead removing agent, stirring, standing at 0-4 deg.C for 24 hr, sucking supernatant, filtering with 400 mesh nylon net, and concentrating at low temperature to recover ethanol. The solid substance is 100% pure lead-removed propolis.
The technology can be realized by the ordinary technicians in the pharmaceutical chemical field.
The invention has the advantages that:
(1) propolis produced at present in China is affected by iron gauze on a beehive gauze cover, automobile exhaust and pesticides, and the content of heavy metal lead is seriously exceeded. The invention adopts a simple 400-mesh imported nylon net to remove lead in a particle state, and glacial acetic acid is added by a chemical method to change lead in an ionic state into lead acetate precipitate to be removed.
The chemical equation is as follows:
(2) propolis products on the market today are mainly propolis liquids. The propolis is extremely bad in palatability, is easy to hang on the wall of a container, wastes more than 20 percent and is not easy to carry. The capsule shell of the propolis hard capsule contains food pigment and the like. The propolis soft capsule has poor marketability, overcomes the defects of poor palatability, easiness in hanging cups, high consumption and difficulty in carrying, does not contain any pigment, and has a shelf life of three years.
(3) Overcomes the error that the prior commonly adopted steam wax removal method seriously damages the medicinal components and reaches the standard of the international food sanitation law.
Claims (1)
1. The purification and lead removal processing technology of the propolis is characterized by comprising the following steps: adding 0.2 ‰ glacial acetic acid lead removing agent into propolis ethanol extractive solution, stirring, standing at 0-4 deg.C for 24 hr, and filtering supernatant with 400 mesh nylon net to remove metal lead and beeswax to make lead content less than 10 ppm.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB001074229A CN1189162C (en) | 2000-05-12 | 2000-05-12 | Formulation and production process of bee glue capsule |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB001074229A CN1189162C (en) | 2000-05-12 | 2000-05-12 | Formulation and production process of bee glue capsule |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1323586A CN1323586A (en) | 2001-11-28 |
CN1189162C true CN1189162C (en) | 2005-02-16 |
Family
ID=4578693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB001074229A Expired - Fee Related CN1189162C (en) | 2000-05-12 | 2000-05-12 | Formulation and production process of bee glue capsule |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1189162C (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1330296C (en) * | 2003-06-08 | 2007-08-08 | 刘进祖 | Propolis soft capsule and its preparation method |
CN100369603C (en) * | 2005-08-30 | 2008-02-20 | 浙江蜂之语蜂业集团有限公司 | Product recipe for bee glue soft capsule inclusion |
CN102940182A (en) * | 2012-10-29 | 2013-02-27 | 射阳县庆缘康蜂产品厂 | Low energy propolis hard capsule preparation method |
CN108813499A (en) * | 2018-07-09 | 2018-11-16 | 武汉康思农生物科技有限公司 | A kind of bee glue soft capsule formula and preparation process |
-
2000
- 2000-05-12 CN CNB001074229A patent/CN1189162C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1323586A (en) | 2001-11-28 |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |