CN1305868C - Extraction of dihydromyricetin from microwave and composition thereof - Google Patents
Extraction of dihydromyricetin from microwave and composition thereof Download PDFInfo
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- CN1305868C CN1305868C CNB2004100277824A CN200410027782A CN1305868C CN 1305868 C CN1305868 C CN 1305868C CN B2004100277824 A CNB2004100277824 A CN B2004100277824A CN 200410027782 A CN200410027782 A CN 200410027782A CN 1305868 C CN1305868 C CN 1305868C
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Abstract
The present invention provides a method for extracting dihydromyricetin and a composition thereof from stems and leaves of vitaceae plants in a microwave method. The present invention comprises the following specific steps: a fixed quantity of vitaceae plant raw materials and an extraction solvent are added into a microwave extracting tank according to the weight ratio of 5 to 10; the dihydromyricetin is extracted under the microwave with the rated power of 600W to 2000KW for 1 to 15 minutes, and the extraction temperature is from 50 to 100DEG C; the vitaceae plant raw materials and the extraction solvent are filtered to cool filter liquor, and the dihydromyricetin and composition crystals are precipitated at the bottom and the periphery of a filter liquor container. The filter liquor is filtered and dried to obtain the dihydromyricetin and the composition crystals.
Description
Technical field
The present invention relates to the extracting method of a kind of dibydro myricetrin and composition thereof.
Background technology
Dibydro myricetrin (ampelopsin/grossedentata) is a kind of compound known, document Walter Karrarr, and Birkhauser Verlag und Stuttgart (1958), P.652, NO:1640 has announced that its structural formula is:
Publication number CN 1288747A, CN 1288892A etc. disclose this compound and have had treatment hepatitis, liver protecting, antisepsis and anti-inflammation, analgesia, reducing blood-fat, eliminated the phlegm and the effect of enhancing immunity systemic immunity power and by method extraction separation dibydro myricetrin and method for compositions thereof such as solvent extraction, supersound extraction, chromatographic separation.But, not openly by microwave extraction dibydro myricetrin and method for compositions thereof.In fact, microwave method extraction dibydro myricetrin and composition thereof have more advantages.
Summary of the invention
Purpose of the present invention just provides the extracting method that adopts microwave method to extract dibydro myricetrin and composition thereof from vitaceae.
Method of the present invention is achieved in that with all kinds of SOLVENTS (water and/or organic solvent) makes to extract medium, make to extract raw material with the cauline leaf of vitaceae, make extracting method with microwave method, dibydro myricetrin and the composition thereof that contains in the vitaceae extracted.Concrete steps of the present invention are: in microwave extraction tank, add a certain amount of vitaceae raw material, add the extraction solvent by weight the ratio that is 5-10, be to extract 1-15 minute under the microwave of 600W-2000KW at rated output, extracting temperature is 50-100 ℃, filters cooling filtrate, dibydro myricetrin and composition crystallization promptly are deposited in the bottom of filtrate container and all around, and filtration drying promptly gets dibydro myricetrin and composition crystallization.
Above-mentioned all kinds of SOLVENTS refers to the various compounds that are in solution state or/and its miscellany, preferably water and/or Different concentrations of alcohol, the concentration of the preferred 65%-80% of Different concentrations of alcohol.
Above-mentioned vitaceae refers to single cropping thing and/or the mixed plant in the Vitaceae, preferred ampelopsis, the preferred Ampelopsis grossedentata of ampelopsis, ampelopsis cantoniensis, Cayratia japonica (Thunb.) Gagnep., the beautiful grape of a leaf, Northeastern Caulis seu folium ampelopsis brevipedunculatae and Vitis Amurensis plant.Because there is the phenomenon of a large amount of " different name of the same race, xenogenesis of the same name " in China in the appellation of plant resources, therefore, in ampelopsis, preferably be commonly called as the plant of " vine tea ", " the mould tea of Mao Yan ", " white tea ", " white tea cake " and " Linearstripe Rabdosia Herb tea " in China various places.
Above-mentioned microwave method is meant utilizes micro-wave energy to extract dibydro myricetrin and method for compositions thereof from vitaceae.The used rated output of microwave can select 600W-2000KW, and preferred rated output is 100-500KW.
Preferred 5-10 of said extracted time minute.
The said extracted temperature is preferably 80-100 ℃,
The dibydro myricetrin of the present invention's preparation and the advantage of method for compositions thereof are:
1. raw material does not shred, and the various common raw material on the market get final product.
2. viscous substances such as carbohydrate, natural gum do not extract in the microwave extraction liquid, and viscosity is little, filter easily.
3. the extraction yield height of dibydro myricetrin in the raw material.Than solvent method, the extraction yield of dibydro myricetrin can improve 10% in the raw material.
4. when extracting, solid-liquid ratio is little, and extracting solution does not concentrate, and cooling is placed can form crystallization in container.
5. dibydro myricetrin and content of total flavone height in the gained crystallizing and drying thing.In the exsiccant crystallization, the content of dibydro myricetrin is greater than 55%, and general flavone content is greater than 75%.
6. the explained hereafter time is short.Extract from raw material and to begin container, to form crystallization and precipitate, got final product in 2-3 hour to dibydro myricetrin and composition thereof.
Embodiment
Below by embodiment the present invention is done further concrete description, but embodiments of the present invention are not limited thereto.
Embodiment 1
Get common vine tea (Ampelopsis grossedentata) 100.0g that buys on the market, add 500g water, place in the household microwave oven, extracted 2 minutes, filtered through gauze, cooling filtrate 10 minutes, dibydro myricetrin and composition thereof promptly are deposited in container bottom.Dry sediment is weighed as 16.5g.
Embodiment 2
Get the ampelopsis cantoniensis 1.0Kg that buys on the market, add 5.0Kg water, placing power is the microwave extraction tank of 100KW, and 80 ℃ were extracted 10 minutes, filtered, and normal temperature was placed 12 hours, and dibydro myricetrin and composition thereof promptly are deposited in container bottom.Dry sediment is weighed as 150g.
Claims (7)
1, a kind of microwave method is extracted dibydro myricetrin and method for compositions thereof, it is characterized in that: in microwave extraction tank, add a certain amount of vitaceae raw material, be that 1: 5～10 ratio adds entry and/or Different concentrations of alcohol by weight, be to extract 1～15 minute under the microwave of 600W～2000KW at rated output, extracting temperature is 50～100 ℃, filter, cooling filtrate, dibydro myricetrin and composition crystallization promptly are deposited in the bottom of filtrate container and all around, and filtration drying promptly gets dibydro myricetrin and composition crystallization.
2, microwave method according to claim 1 is extracted dibydro myricetrin and method for compositions thereof, and it is characterized in that: described alcohol concn is 65%～80%.
3, microwave method according to claim 1 is extracted dibydro myricetrin and method for compositions thereof, and it is characterized in that: described vitaceae refers to single cropping thing and/or the mixed plant in the Vitaceae.
4, microwave method according to claim 3 is extracted dibydro myricetrin and method for compositions thereof, it is characterized in that: described vitaceae is Ampelopsis grossedentata, ampelopsis cantoniensis, Cayratia japonica (Thunb.) Gagnep., the beautiful grape of a leaf, Northeastern Caulis seu folium ampelopsis brevipedunculatae and Vitis Amurensis plant.
5, microwave method according to claim 1 is extracted dibydro myricetrin and method for compositions thereof, and it is characterized in that: the used rated output of described microwave is 100～500KW.
6, microwave method according to claim 1 is extracted dibydro myricetrin and method for compositions thereof, and it is characterized in that: described extraction time is 5～10 minutes.
7, microwave method according to claim 1 is extracted dibydro myricetrin and method for compositions thereof, and it is characterized in that: described extraction temperature is 80～100 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100277824A CN1305868C (en) | 2004-06-25 | 2004-06-25 | Extraction of dihydromyricetin from microwave and composition thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100277824A CN1305868C (en) | 2004-06-25 | 2004-06-25 | Extraction of dihydromyricetin from microwave and composition thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1712402A CN1712402A (en) | 2005-12-28 |
| CN1305868C true CN1305868C (en) | 2007-03-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100277824A Expired - Fee Related CN1305868C (en) | 2004-06-25 | 2004-06-25 | Extraction of dihydromyricetin from microwave and composition thereof |
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| CN (1) | CN1305868C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100404525C (en) * | 2005-01-27 | 2008-07-23 | 广州大学 | Process of extracting dihydromyricitrin from vine tea |
| CN100998424B (en) * | 2006-12-26 | 2010-12-15 | 熊新安 | Method for cooking fish with distillers' grains |
| FR2926190B1 (en) * | 2008-01-14 | 2013-07-05 | Thiomed | PROCESS FOR PREPARING PLANT EXTRACTS FOR OBTAINING A NEW GALENIC FORM |
| CN101805321B (en) * | 2010-04-16 | 2012-08-22 | 安徽省瑞森生物科技有限责任公司 | Method for extracting dihydromyricetin from vine tea |
| CN102796069B (en) * | 2012-07-04 | 2015-01-21 | 贵州省生物研究所 | Method for extracting dihydromyricetin and Ampelopsis grossedentata polysaccharide from Ampelopsis grossedentata |
| CN104876903A (en) * | 2014-02-27 | 2015-09-02 | 天津药物研究院有限公司 | Crystallization form of dihydromyricetin, preparation method thereof and pharmaceutical composition containing the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296840A (en) * | 1999-11-22 | 2001-05-30 | 湖南省衡东县天然藤茶开发有限公司 | Teng tea as beverage |
| CN1304934A (en) * | 2000-07-05 | 2001-07-25 | 中山医科大学科技开发部 | Antineoplastic medicine and its preparing process |
-
2004
- 2004-06-25 CN CNB2004100277824A patent/CN1305868C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296840A (en) * | 1999-11-22 | 2001-05-30 | 湖南省衡东县天然藤茶开发有限公司 | Teng tea as beverage |
| CN1304934A (en) * | 2000-07-05 | 2001-07-25 | 中山医科大学科技开发部 | Antineoplastic medicine and its preparing process |
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| Publication number | Publication date |
|---|---|
| CN1712402A (en) | 2005-12-28 |
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