CN104430384A - Bactericidal composition - Google Patents
Bactericidal composition Download PDFInfo
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- CN104430384A CN104430384A CN201410729655.2A CN201410729655A CN104430384A CN 104430384 A CN104430384 A CN 104430384A CN 201410729655 A CN201410729655 A CN 201410729655A CN 104430384 A CN104430384 A CN 104430384A
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- penconazole
- acid amides
- chlorobenzene ether
- ether acid
- bactericidal composition
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Abstract
The invention belongs to the technical field of pesticides and relates to a bactericidal composition. The bactericidal composition is characterized in that active ingredients include chlorobenzene ether amide and penconazole. The composition can be prepared into emulsion in water, suspension concentrates and water dispersible granules, has obvious synergistic effects, has the effects of lengthening the lasting period and reducing the use cost, and is environment-friendly.
Description
Technical field
The invention belongs to technical field of pesticide, contain the bactericidal composition with synergistic effect of chlorobenzene ether acid amides and penconazole specifically.
Background technology
Chlorobenzene ether acid amides is Central China Normal University's pyrazol acid amide compounds newly developed, has good control efficiency, have good preventive effect simultaneously to the banded sclerotial blight of paddy rice and wheat to the disease such as epidemic disease, downy mildew, tikka of the plants such as cucumber, tomato, potato.Field trial shows do not have cross resistance with existing bactericide.Structural formula is as follows:
Penconazole (Penconazole) a kind ofly has protection, treatment and the interior absorption triazole bactericidal agent of eradicant action concurrently; it is sterol demethylation inhibitors; can by tissue resorption such as root of the crop, stem, leaves; and upwards conduct; show there is good control efficiency to fruit white rot of grape through toxicity mensuration and field control effectiveness test result.
Cucumber downy mildew is the more serious disease of cucumber, all can be injured from seedling stage to strain, mainly cause harm blade and stem.The suitable onset temperature of this disease is 16 DEG C-24 DEG C, Seedling Stage is fallen ill, there is irregular chlorisis yellowish-brown spot in cotyledon front, strain is fallen ill, many from forward position, greenhouse, there is water stain shape, light green fleck in morbidity strain before this middle and lower part blade reverse side, front does not show, rear scab expands gradually, front exposed.Be badly in need of good to the quick-acting of cucumber downy mildew, that the lasting period is long medicament in the market.
Summary of the invention
The object of this invention is to provide and a kind ofly there is synergistic effect and the bactericidal composition of safety and environmental protection, for preventing and treating cucumber downy mildew, compared with existing pesticide control, realizing improving drug effect, decreasing pollution, the object that reduces costs.Be specifically related to the bactericidal composition of chlorobenzene ether acid amides and penconazole.
Utilize above-mentioned bactericidal composition, be equipped with the known auxiliary agent of those skilled in that art, make formulation of the present invention with the known method of those skilled in that art, comprise aqueous emulsion, suspending agent and water dispersible granules.
In above-mentioned bactericidal composition, the weight ratio of chlorobenzene ether acid amides and penconazole is 1:60-60:1.
Above-mentioned bactericidal composition has following characteristics: 1, use complex preparation, have very strong synergistic effect; 2, the mode of action is unique, with existing bactericide without cross resistance; 3, the advanced environmental protection of formulation, can be good at playing drug effect, environmentally friendly; 4, drug effect is rapid, and the lasting period is long.
Embodiment
For determining chlorobenzene ether acid amides and the composite synergistic effect of penconazole two kinds of active ingredients, first applicant uses these two kinds of compositions to carry out indoor biometrics test, after the action character analyzing two kinds of active ingredients, the raw object surveyed is decided to be Cuba artificial downy mildew (Pseudoperonospora cubensis) by us, this Pseudomonas Mastigomycotina fungi, can cause the downy mildew of cucumber.
The test method of indoor biometrics: reference standard NY/T1156.7-2006, adopts growth rate method to measure medicament to the inhibitory action of cucumber downy mildew pathogen mycelial growth.On the basis of preliminary experiment, from each medicament, design 5 concentration within the scope of 10%-90% are reached to germ mycelial growth inhibition rate, it is for subsequent use by the 95% former medicine of chlorobenzene ether acid amides and the former medicine of 90% penconazole with acetone to be first that solvent is made into the liquid of series concentration, then liquid is joined in 1% ratio in the PDA medium melting also cool to room temperature, after fully shaking up, pour in the culture dish (Φ 90mm) of sterilizing and make band medicine flat board, often process and repeat, to add the process of sterile water for blank for four times; With card punch (Φ 5mm) the picking bacterium of downy mildew of cucumber bacterium cake of sterilizing, mycelia faces down aseptic inoculation in the central authorities of band medicine flat board, be inverted in the interior cultivation of constant incubator of 27 DEG C, adopt right-angled intersection method to measure colony diameter after cultivating 6d, calculate the EC of each medicament to pathogen
50, and calculate toxicity index according to the following equation, compare virulence and the bacteriostasis of different agents.Former medicine used is tested in above-mentioned raw test and reagent is all bought from other producers.
The co-toxicity coefficient method representation that the co-toxicity of mixture preparation adopts Sun Yun abundant:
The theoretical toxicity index TTI=∑ of mixture preparation (percentage of this pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture).
Be synergistic effect when CTC is greater than 120, being antagonism when being less than 80, is addition time between 80-120.
Table 1 chlorobenzene ether acid amides, penconazole and different ratio thereof are to the measurement result of cucumber downy mildew co-toxicity coefficient
Analyze above-mentioned data can find out, when chlorobenzene ether acid amides and penconazole are composite in varing proportions, the co-toxicity coefficient (CTC) of formula is all greater than 120, the prevention and control capability of cucumber downy mildew is had to the synergistic effect of different proportion.Visible, the composite favourable agents becoming control of chlorobenzene ether acid amides and penconazole.
Tested by indoor biometrics, determine chlorobenzene ether acid amides and penconazole two kinds of active ingredients composite after, good synergistic effect can be had.Below by way of instantiation in order to further describe the present invention, but the present invention is absolutely not only only limitted to these embodiments following.In formula, percentage is all weight percentage, and the former medicine used and auxiliary agent are other producers and buy.
Formulation examples is as follows:
Example one, 30.5% chlorobenzene ether acid amides penconazole suspending agent
Example two, 61% chlorobenzene ether acid amides penconazole water dispersible granules
Example three, 20.8% chlorobenzene ether acid amides penconazole aqueous emulsion
Example four, 15.6% chlorobenzene ether acid amides penconazole water dispersible granules
Example five, 11% chlorobenzene ether acid amides penconazole water dispersible granules
Example six, 33% chlorobenzene ether acid amides penconazole water dispersible granules
Example seven, 18% chlorobenzene ether acid amides penconazole water dispersible granules
Example eight, 30% chlorobenzene ether acid amides penconazole suspending agent
Example nine, 20% chlorobenzene ether acid amides penconazole water dispersible granules
Above example is selected to carry out preventing and treating the field trial of cucumber downy mildew, the effect of control cucumber downy mildew of determining to fill a prescription, simultaneously with the Contrast on effect of chlorobenzene ether acid amides and penconazole single dose, the control efficiency of the checking embodiment of the present invention.Concrete test method is with reference to GB/T17980.26-2000.Test site is North Huaihe River Area of Anhui Province, and the time is on May 5th, 2014, and test each process four repetition, community randomized arrangement, each plot area is 32m
2, adopt back-pack electric compression sprayer, dispenser was sunny calm for the same day, and the planting habit of planting habit all with local of all communities is identical, records the synoptic data on the dispenser same day and a week thereafter, specific as follows:
Table 2 duration of test meteorological data
Investigation method is: every community gets 4 investigation at random, and look into two strains at often, whole blade is investigated in every strain.
The grade scale of disease index:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for 6% ~ 10% of whole leaf area;
5 grades: lesion area accounts for 11% ~ 25% of whole leaf area;
7 grades: lesion area accounts for 26% ~ 50% of whole leaf area;
9 grades: lesion area accounts for more than 51% of whole leaf area.
Table 320% chlorobenzene ether acid amides penconazole water dispersible granules and different agents are to the preventive effect of cucumber downy mildew
As can be seen from above-mentioned data, chlorobenzene ether acid amides and penconazole complex preparation after medicine 7 days preventive effects all more than 70%, and 24% chlorobenzene ether amide suspending agents, 7 days preventive effects after medicine are 40.30%, the preventive effect of 10% penconazole missible oil is 38.58%, compare chlorine two kinds of single doses, complex preparation has good synergistic effect.After medicine 21 days, all complex preparations all exceeded 72% to the preventive effect of cucumber downy mildew, and the lasting period of composite rear preparation extends, more lasting to the control efficiency of cucumber downy mildew.
Claims (2)
1. a bactericidal composition, is characterized in that: active component is made up of chlorobenzene ether acid amides and penconazole, and the weight ratio of described chlorobenzene ether acid amides and penconazole is 1:60 ~ 60:1.
2. composition according to claim 1, is characterized in that: make aqueous emulsion, suspending agent, water dispersible granules by active component and auxiliary material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410729655.2A CN104430384B (en) | 2014-12-03 | 2014-12-03 | A kind of bactericidal composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410729655.2A CN104430384B (en) | 2014-12-03 | 2014-12-03 | A kind of bactericidal composition |
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| Publication Number | Publication Date |
|---|---|
| CN104430384A true CN104430384A (en) | 2015-03-25 |
| CN104430384B CN104430384B (en) | 2016-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410729655.2A Active CN104430384B (en) | 2014-12-03 | 2014-12-03 | A kind of bactericidal composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112772663A (en) * | 2019-11-04 | 2021-05-11 | 东莞市东阳光菌阳氢专利农药有限公司 | Composition containing flufenoxanil and penconazole, preparation and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226244A (en) * | 1996-07-24 | 1999-08-18 | 拜尔公司 | Carbanilides used as pesticides |
| CN102246791A (en) * | 2011-07-09 | 2011-11-23 | 海利尔药业集团股份有限公司 | Compounded pesticide sterilizing composition |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
-
2014
- 2014-12-03 CN CN201410729655.2A patent/CN104430384B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226244A (en) * | 1996-07-24 | 1999-08-18 | 拜尔公司 | Carbanilides used as pesticides |
| CN103391925A (en) * | 2010-11-15 | 2013-11-13 | 拜耳知识产权有限责任公司 | 5-halogenopyrazolecarboxamides |
| CN102246791A (en) * | 2011-07-09 | 2011-11-23 | 海利尔药业集团股份有限公司 | Compounded pesticide sterilizing composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112772663A (en) * | 2019-11-04 | 2021-05-11 | 东莞市东阳光菌阳氢专利农药有限公司 | Composition containing flufenoxanil and penconazole, preparation and application thereof |
| CN112772663B (en) * | 2019-11-04 | 2024-01-16 | 东莞市东阳光菌阳氢专利农药有限公司 | Composition containing fluoride phenylate amide and penconazole, preparation and application thereof |
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| CN104430384B (en) | 2016-03-30 |
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Address after: 102488, Beijing, Fangshan District Star Street, No. 1 hospital green sail, No. 16, building 8 Applicant after: Beijing Yanhua Yongle Biotechnology Co., Ltd. Address before: 102488 No. 8, Liangxiang, Beijing, Fangshan District Applicant before: Beijing Yanhua Yongle Biotechnology Co., Ltd. |
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Effective date of registration: 20180103 Address after: 063600 Leting County Economic Development Zone, Tangshan City, Hebei Patentee after: Yanhua Yongle (Leting) Biological Technology Co. Ltd. Address before: 102488, Beijing, Fangshan District Star Street, No. 1 hospital green sail, No. 16, building 8 Patentee before: Beijing Yanhua Yongle Biotechnology Co., Ltd. |
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