CN1044116C - 用作il－1作用抑制剂的苯磺酰亚胺衍生物及其用途 - Google Patents

用作il－1作用抑制剂的苯磺酰亚胺衍生物及其用途 Download PDF

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Publication number
CN1044116C
CN1044116C CN94194304A CN94194304A CN1044116C CN 1044116 C CN1044116 C CN 1044116C CN 94194304 A CN94194304 A CN 94194304A CN 94194304 A CN94194304 A CN 94194304A CN 1044116 C CN1044116 C CN 1044116C
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China
Prior art keywords
compound
chloro
acid
reaction
milliliters
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Expired - Fee Related
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CN94194304A
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English (en)
Chinese (zh)
Other versions
CN1136311A (zh
Inventor
R·L·哈里森
G·库
S·B·梅克兰茨
C·R·多尔顿
D·M·斯坦莫里克
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Aventis Pharmaceuticals Inc
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Merrell Dow Pharmaceuticals Inc
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Publication of CN1136311A publication Critical patent/CN1136311A/zh
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
CN94194304A 1993-11-29 1994-11-03 用作il－1作用抑制剂的苯磺酰亚胺衍生物及其用途 Expired - Fee Related CN1044116C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15901493A 1993-11-29 1993-11-29
US159014 1993-11-29

Publications (2)

Publication Number Publication Date
CN1136311A CN1136311A (zh) 1996-11-20
CN1044116C true CN1044116C (zh) 1999-07-14

Family

ID=22570705

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94194304A Expired - Fee Related CN1044116C (zh) 1993-11-29 1994-11-03 用作il－1作用抑制剂的苯磺酰亚胺衍生物及其用途

Country Status (21)

Country Link
US (1) US5684017A (enExample)
EP (1) EP0731791B1 (enExample)
JP (1) JPH09506345A (enExample)
KR (1) KR100340375B1 (enExample)
CN (1) CN1044116C (enExample)
AT (1) ATE177083T1 (enExample)
AU (1) AU683114B2 (enExample)
CA (1) CA2175458C (enExample)
DE (1) DE69416859T2 (enExample)
DK (1) DK0731791T3 (enExample)
ES (1) ES2131297T3 (enExample)
FI (1) FI109901B (enExample)
GR (1) GR3029827T3 (enExample)
HU (1) HU219565B (enExample)
IL (1) IL111776A (enExample)
NO (1) NO306211B1 (enExample)
NZ (1) NZ276577A (enExample)
PT (1) PT731791E (enExample)
TW (1) TW279161B (enExample)
WO (1) WO1995014669A1 (enExample)
ZA (1) ZA949303B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6562629B1 (en) 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
DE19705133A1 (de) * 1997-02-11 1998-08-13 Hoechst Ag Sulfonamid-substituierte Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
AU9696198A (en) * 1997-10-17 1999-05-10 Aventis Pharmaceuticals Products Inc. Therapeutic uses of quinoline derivatives
DE19858253A1 (de) * 1998-12-17 2000-06-21 Aventis Pharma Gmbh Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
WO2003001968A2 (en) * 2001-06-26 2003-01-09 Beth Israel Deaconess Medical Center Compositions and methods for inhibiting platelet activation and thrombosis
TR201809678T4 (tr) 2001-06-26 2018-07-23 Amgen Fremont Inc Opgl ye karşi antikorlar.
WO2004060911A2 (en) 2002-12-30 2004-07-22 Amgen Inc. Combination therapy with co-stimulatory factors
KR100687522B1 (ko) * 2005-05-28 2007-02-27 한국화학연구원 2,2-디메틸-3-에스테르-4-알콕시-6-알킬 아미노벤조피란 유도체를 유효성분으로 함유하는 pge2 활성에 관련된 염증질환 치료제
CN104447489B (zh) * 2014-12-29 2017-01-11 南京工业大学 3,4-二芳基马来酰亚胺衍生物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992015565A1 (en) * 1991-02-27 1992-09-17 Merrell Dow Pharmaceuticals Inc. Nmda antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3742951A (en) * 1971-08-09 1973-07-03 Alza Corp Bandage for controlled release of vasodilators
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
US3921636A (en) * 1973-01-15 1975-11-25 Alza Corp Novel drug delivery device
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
GB8719102D0 (en) * 1987-08-12 1987-09-16 Merck Sharp & Dohme Therapeutic agents
ES2129794T3 (es) * 1993-11-29 1999-06-16 Merrell Pharma Inc Derivados de bencenosulfonilimina heterociclicos como inhibidores de la accion de il-1.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992015565A1 (en) * 1991-02-27 1992-09-17 Merrell Dow Pharmaceuticals Inc. Nmda antagonists

Also Published As

Publication number Publication date
CA2175458A1 (en) 1995-06-01
CA2175458C (en) 1999-03-02
KR100340375B1 (ko) 2002-11-13
HUT76273A (en) 1997-07-28
JPH09506345A (ja) 1997-06-24
FI962235L (fi) 1996-05-28
DE69416859D1 (de) 1999-04-08
AU1087995A (en) 1995-06-13
HU219565B (hu) 2001-05-28
US5684017A (en) 1997-11-04
DK0731791T3 (da) 1999-09-27
NO306211B1 (no) 1999-10-04
NZ276577A (en) 1997-11-24
NO962155D0 (no) 1996-05-28
IL111776A (en) 1999-06-20
AU683114B2 (en) 1997-10-30
DE69416859T2 (de) 1999-08-05
CN1136311A (zh) 1996-11-20
WO1995014669A1 (en) 1995-06-01
EP0731791A1 (en) 1996-09-18
TW279161B (enExample) 1996-06-21
HU9601435D0 (en) 1996-07-29
FI109901B (fi) 2002-10-31
IL111776A0 (en) 1995-01-24
KR960706476A (ko) 1996-12-09
NO962155L (no) 1996-05-28
GR3029827T3 (en) 1999-06-30
ZA949303B (en) 1995-08-07
FI962235A0 (fi) 1996-05-28
PT731791E (pt) 2000-11-30
EP0731791B1 (en) 1999-03-03
ATE177083T1 (de) 1999-03-15
ES2131297T3 (es) 1999-07-16

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