FI109901B - Menetelmä uusien terapeuttisesti käyttökelpoisten bentseenisulfonyyli-imiinijohdannaisten valmistamiseksi - Google Patents
Menetelmä uusien terapeuttisesti käyttökelpoisten bentseenisulfonyyli-imiinijohdannaisten valmistamiseksi Download PDFInfo
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- FI109901B FI109901B FI962235A FI962235A FI109901B FI 109901 B FI109901 B FI 109901B FI 962235 A FI962235 A FI 962235A FI 962235 A FI962235 A FI 962235A FI 109901 B FI109901 B FI 109901B
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- compound
- dichloro
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- acid
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- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- QJDUDPQVDAASMV-UHFFFAOYSA-M sodium;ethanethiolate Chemical compound [Na+].CC[S-] QJDUDPQVDAASMV-UHFFFAOYSA-M 0.000 description 1
- 239000007892 solid unit dosage form Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- BUXTXUBQAKIQKS-UHFFFAOYSA-N sulfuryl diisocyanate Chemical compound O=C=NS(=O)(=O)N=C=O BUXTXUBQAKIQKS-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- RBQXBPIDVWJGNC-UHFFFAOYSA-N tert-butyl n-[2-[4-(benzenesulfonamido)-5,7-dichloroquinoline-2-carbonyl]phenyl]carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=CC=C1C(=O)C(NC1=CC(Cl)=CC(Cl)=C11)=CC1=NS(=O)(=O)C1=CC=CC=C1 RBQXBPIDVWJGNC-UHFFFAOYSA-N 0.000 description 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- BWHOZHOGCMHOBV-BQYQJAHWSA-N trans-benzylideneacetone Chemical compound CC(=O)\C=C\C1=CC=CC=C1 BWHOZHOGCMHOBV-BQYQJAHWSA-N 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- COHOGNZHAUOXPA-UHFFFAOYSA-N trimethyl(phenyl)stannane Chemical compound C[Sn](C)(C)C1=CC=CC=C1 COHOGNZHAUOXPA-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229940102001 zinc bromide Drugs 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15901493A | 1993-11-29 | 1993-11-29 | |
| US15901493 | 1993-11-29 | ||
| PCT/US1994/012658 WO1995014669A1 (en) | 1993-11-29 | 1994-11-03 | Novel benzenesulfonylimine derivatives as inhibitors of il-1 action |
| US9412658 | 1994-11-03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI962235L FI962235L (fi) | 1996-05-28 |
| FI962235A0 FI962235A0 (fi) | 1996-05-28 |
| FI109901B true FI109901B (fi) | 2002-10-31 |
Family
ID=22570705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI962235A FI109901B (fi) | 1993-11-29 | 1996-05-28 | Menetelmä uusien terapeuttisesti käyttökelpoisten bentseenisulfonyyli-imiinijohdannaisten valmistamiseksi |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5684017A (enExample) |
| EP (1) | EP0731791B1 (enExample) |
| JP (1) | JPH09506345A (enExample) |
| KR (1) | KR100340375B1 (enExample) |
| CN (1) | CN1044116C (enExample) |
| AT (1) | ATE177083T1 (enExample) |
| AU (1) | AU683114B2 (enExample) |
| CA (1) | CA2175458C (enExample) |
| DE (1) | DE69416859T2 (enExample) |
| DK (1) | DK0731791T3 (enExample) |
| ES (1) | ES2131297T3 (enExample) |
| FI (1) | FI109901B (enExample) |
| GR (1) | GR3029827T3 (enExample) |
| HU (1) | HU219565B (enExample) |
| IL (1) | IL111776A (enExample) |
| NO (1) | NO306211B1 (enExample) |
| NZ (1) | NZ276577A (enExample) |
| PT (1) | PT731791E (enExample) |
| TW (1) | TW279161B (enExample) |
| WO (1) | WO1995014669A1 (enExample) |
| ZA (1) | ZA949303B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| US6861053B1 (en) * | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| US6562629B1 (en) | 1999-08-11 | 2003-05-13 | Cedars-Sinai Medical Center | Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum |
| DE19705133A1 (de) * | 1997-02-11 | 1998-08-13 | Hoechst Ag | Sulfonamid-substituierte Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| EP1030665A4 (en) * | 1997-10-17 | 2002-11-27 | Aventis Pharm Prod Inc | THERAPEUTIC USE OF CHINOLINE DERIVATIVES |
| DE19858253A1 (de) * | 1998-12-17 | 2000-06-21 | Aventis Pharma Gmbh | Verwendung von Inhibitoren des KQt1-Kanals zur Herstellung eines Medikaments zur Behandlung von Krankheiten, die durch Helminthen und Ektoparasiten hervorgerufen werden |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| PT2295081T (pt) | 2001-06-26 | 2019-02-01 | Amgen Inc | Anticorpos contra opgl |
| AU2002345796A1 (en) * | 2001-06-26 | 2003-03-03 | Beth Israel Deaconess Medical Center | Compositions and methods for inhibiting platelet activation and thrombosis |
| CA2511823A1 (en) | 2002-12-30 | 2004-07-22 | Amgen Inc. | Combination therapy with co-stimulatory factors |
| KR100687522B1 (ko) * | 2005-05-28 | 2007-02-27 | 한국화학연구원 | 2,2-디메틸-3-에스테르-4-알콕시-6-알킬 아미노벤조피란 유도체를 유효성분으로 함유하는 pge2 활성에 관련된 염증질환 치료제 |
| CN104447489B (zh) * | 2014-12-29 | 2017-01-11 | 南京工业大学 | 3,4-二芳基马来酰亚胺衍生物及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3742951A (en) * | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| US3921636A (en) * | 1973-01-15 | 1975-11-25 | Alza Corp | Novel drug delivery device |
| US4031894A (en) * | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| GB8719102D0 (en) * | 1987-08-12 | 1987-09-16 | Merck Sharp & Dohme | Therapeutic agents |
| HU217425B (hu) * | 1991-02-27 | 2000-01-28 | Merrell Dow Pharmaceuticals Inc. | Eljárás NMDA antagonista hatású kinolinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| CA2177146C (en) * | 1993-11-29 | 1999-07-06 | George Ku | Heterocyclic benzenesulfonylimine derivatives as inhibitors of il-1 action |
-
1994
- 1994-11-03 KR KR1019960702804A patent/KR100340375B1/ko not_active Expired - Fee Related
- 1994-11-03 EP EP95901762A patent/EP0731791B1/en not_active Expired - Lifetime
- 1994-11-03 DE DE69416859T patent/DE69416859T2/de not_active Expired - Fee Related
- 1994-11-03 DK DK95901762T patent/DK0731791T3/da active
- 1994-11-03 US US08/649,663 patent/US5684017A/en not_active Expired - Fee Related
- 1994-11-03 ES ES95901762T patent/ES2131297T3/es not_active Expired - Lifetime
- 1994-11-03 CN CN94194304A patent/CN1044116C/zh not_active Expired - Fee Related
- 1994-11-03 AT AT95901762T patent/ATE177083T1/de not_active IP Right Cessation
- 1994-11-03 JP JP7515081A patent/JPH09506345A/ja active Pending
- 1994-11-03 NZ NZ276577A patent/NZ276577A/en unknown
- 1994-11-03 CA CA002175458A patent/CA2175458C/en not_active Expired - Fee Related
- 1994-11-03 PT PT95901762T patent/PT731791E/pt unknown
- 1994-11-03 AU AU10879/95A patent/AU683114B2/en not_active Ceased
- 1994-11-03 WO PCT/US1994/012658 patent/WO1995014669A1/en not_active Ceased
- 1994-11-03 HU HU9601435A patent/HU219565B/hu not_active IP Right Cessation
- 1994-11-23 ZA ZA949303A patent/ZA949303B/xx unknown
- 1994-11-24 TW TW083111032A patent/TW279161B/zh active
- 1994-11-27 IL IL11177694A patent/IL111776A/xx active IP Right Grant
-
1996
- 1996-05-28 NO NO962155A patent/NO306211B1/no unknown
- 1996-05-28 FI FI962235A patent/FI109901B/fi not_active IP Right Cessation
-
1999
- 1999-03-30 GR GR990400918T patent/GR3029827T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO962155D0 (no) | 1996-05-28 |
| FI962235L (fi) | 1996-05-28 |
| NO306211B1 (no) | 1999-10-04 |
| NZ276577A (en) | 1997-11-24 |
| HUT76273A (en) | 1997-07-28 |
| AU683114B2 (en) | 1997-10-30 |
| TW279161B (enExample) | 1996-06-21 |
| IL111776A0 (en) | 1995-01-24 |
| AU1087995A (en) | 1995-06-13 |
| KR100340375B1 (ko) | 2002-11-13 |
| ATE177083T1 (de) | 1999-03-15 |
| PT731791E (pt) | 2000-11-30 |
| DE69416859T2 (de) | 1999-08-05 |
| HU9601435D0 (en) | 1996-07-29 |
| KR960706476A (ko) | 1996-12-09 |
| JPH09506345A (ja) | 1997-06-24 |
| ES2131297T3 (es) | 1999-07-16 |
| WO1995014669A1 (en) | 1995-06-01 |
| CA2175458C (en) | 1999-03-02 |
| CN1044116C (zh) | 1999-07-14 |
| GR3029827T3 (en) | 1999-06-30 |
| IL111776A (en) | 1999-06-20 |
| DK0731791T3 (da) | 1999-09-27 |
| ZA949303B (en) | 1995-08-07 |
| EP0731791B1 (en) | 1999-03-03 |
| US5684017A (en) | 1997-11-04 |
| NO962155L (no) | 1996-05-28 |
| FI962235A0 (fi) | 1996-05-28 |
| EP0731791A1 (en) | 1996-09-18 |
| DE69416859D1 (de) | 1999-04-08 |
| HU219565B (hu) | 2001-05-28 |
| CA2175458A1 (en) | 1995-06-01 |
| CN1136311A (zh) | 1996-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |