CN104411320A - Composition comprising natural extracts as active ingredients for improving condition of hair and scalp, and method for preparing same - Google Patents
Composition comprising natural extracts as active ingredients for improving condition of hair and scalp, and method for preparing same Download PDFInfo
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Abstract
The present invention relates to a composition comprising natural extracts as active ingredients for improving the condition of the hair and scalp, to a method for preparing same, and to a method for improving the condition of the hair and scalp by applying natural extracts thereto. The composition for improving the condition of the hair and scalp according to the present invention comprises natural extracts as active ingredients, and therefore the composition of the present invention is free of side effects or toxicity, and can be applied in an economically advantageous and easy manner as the composition does not require a surgical procedure.
Description
[technical field]
The present invention relates to and comprise natural extract as the hair of effective ingredient and scalp condition improvement composition and method of making the same, and relate to natural extract administration of the present invention to improve the method for the state of hair and scalp.
[background technology]
Male baldness as the modal type of baldness is that testosterone (testosterone) one of in androgen is converted into the dihydrotestosterone (DHT as active androgens by 5-alpha-reductase (testosterone 5 α-reductase), dihydrotestosterone), and the dihydrotestosterone of so activation combines with androgen receptor, postpone the protein synthesis of hair follicle cell, thus shorten the trophophase of hair follicle, and make hair follicle atrophy, cause alopecia thus.Further, in androgenetic alopecia process, also excessively can generate sebum, the depilation phenomenon [Dennis A.Holt, et.al, J Med.Chem., 33,943, (1990)] with inflammation occurs in final scalp.
Common alopeciaing therapeutic method is hair grafting method.That is, the method for the stopper (plug) of long crinite skin is transplanted from the scalp sites of hair growth to alopecia position.And when this method, lose time, relatively with painful, and costly required.Other non-drug therapies comprise ultraviolet radiation and exercise therapy.
An alopeciaing therapeutic method has pharmacotherapy again, Merck (Merck) company commercially sells using the oral administration hair growth promoter preparing finasteride as the effect suppressing 5-alpha-reductase, suppresses the medicine of the generation of dihydrotestosterone (DHT).But there is the problem that steroid drugs causes side effect in this.
And, it was reported, as the equol (equol) of the main metabolites of the daidzein (daidzein) one of in phytoestrogen (phytoestrogen) directly not combine with dihydrotestosterone (DHT) to the mode that testosterone has an impact, block the process as androgenic dihydrotestosterone (DHT) thus.
Therefore, need to develop not only economy but also there is no the therapeutic agent deriving from natural goods of the worry of various side effect and even toxicity.
[summary of the invention]
[inventing the technical task that will solve]
To this, the present inventor is in order to solve problem as above, confirm effect that Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan extract suppress 5-alpha-reductase by experiment, promote the fact of the growth of hair, and specify that hair and scalp condition improvement composition and method of making the same and hair and scalp condition improvement method from said extracted thing.
[solving the technical scheme of problem]
The object of the invention is to, providing package containing natural extract as the hair of effective ingredient and scalp condition improvement composition and method of making the same.
And, another object of the present invention is to, there is provided hair and scalp condition improvement method, this hair and scalp condition improvement method comprise more than one the extract be selected from the group that is made up of Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan to the step of individual administration suffering from alopecia.
[invention effect]
According to the present invention, providing package is containing suppressing the remarkably productive natural extract of 5-alpha-reductase (testosterone5 α-reductase) as the hair of effective ingredient and scalp condition improvement compositions, its preparation method and method natural extract administration being improved hair and scalp state.Above-mentioned hair and scalp condition improvement compositions comprise natural extract as effective ingredient, are thus free from side effects and even the worry of toxicity, and do not need operation, thus economical and can easily be suitable for.
[accompanying drawing explanation]
Fig. 1 is the d obtained according to experimental example 1 of the present invention
3-testosterone (d
3-testosterone) extraction chromatography of ions figure (Extracted-ion chromatograms) ((a) part of Fig. 1: reference standard (Reference standard), (b) part of Fig. 1: microsome fraction (Microsomal fraction)).
Fig. 2 is the extraction chromatography of ions figure (Extracted-ion chromatograms) ((a) part of Fig. 2: reference standard (Reference standard), (b) part of Fig. 2: microsome fraction (Microsomal fraction)) of the testosterone (testosterone) according to experimental example 1 acquisition of the present invention.
Fig. 3 is the d obtained according to experimental example 1 of the present invention
3-dihydrotestosterone (d
3-DHT, d
3-dihydrotestosterone) extraction chromatography of ions figure (Extracted-ionchromatograms) ((a) part of Fig. 3: reference standard (Reference standard), (b) part of Fig. 3: microsome fraction (Microsomal fraction)).
Fig. 4 is the dihydrotestosterone (DHT obtained according to experimental example 1 of the present invention, dihydrotestosterone) extraction chromatography of ions figure (Extracted-ionchromatograms) ((a) part of Fig. 4: reference standard (Reference standard), (b) part of Fig. 4: microsome fraction (Microsomal fraction)).
Fig. 5 represents the extent of growth of the hair of the process along with the time obtained according to experimental example 4 of the present invention.
[embodiment]
In order to reach object as above, the preferred example of the present invention provides hair and scalp condition improvement compositions, and this hair and scalp condition improvement compositions comprise more than one extract in the group being selected from and being made up of Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan as effective ingredient.
Further, the present invention again one preferably an example providing package containing the hair grooming compositions of above-mentioned composition.
And, the present invention another preferably an example ameliorative way of hair and scalp state is provided, the ameliorative way of this hair and scalp state comprises more than one the extract be selected from the group that is made up of Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan to the step of individual administration suffering from alopecia.
And, the present invention also one preferably an example preparation method of above-mentioned hair and scalp condition improvement compositions is provided, the preparation method of this hair and scalp condition improvement compositions comprises: utilize water, ethanol or their mixed solvent to extract more than one step in the group being selected from and being made up of Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan;
The extract obtained by said extracted step is carried out the step of filtration under diminished pressure; And
The filtrate obtained by above-mentioned filtration step is carried out the step of concentrating under reduced pressure.
Below, the present invention is described in more detail.
Testosterone (testosterone) one of in androgen is converted into the dihydrotestosterone (DHT as active androgens by 5-alpha-reductase (testosterone 5 α-reductase), dihydrotestosterone), the dihydrotestosterone of activation like this combines with androgen receptor, and postpone the protein synthesis of hair follicle cell, thus shorten the trophophase of hair follicle, and make hair follicle atrophy, cause alopecia.Further, in androgenetic alopecia process, also excessively generate sebum, finally, the alopecia [Dennis A.15Holt, et.al, J Med.Chem., 33,943, (1990)] with inflammation occurs in scalp.
Therefore, by suppressing above-mentioned 5-alpha-reductase, can be anti-loss and promote hair growth promoting, and, can prevent or reduce sebum secretion and the dandruff, also can prevent or improve scalp inflammation (Olsen EA, Hordinsky M, Whiting D, et al " The importance of dual5alpha-reductase inhibition in 20 the treatment of MPB:results of arandomized placebo-controlled study of dutasteride versusfinasteride " .J Am Acad Dermatol.55 (6), 2006, Leyden, James, Dunlap, Frank, Miller, Bruce, Winters, Peter, Lebwohl, Mark, Hecker, David, Kraus, Stephen, Baldwin, Hilary et al. " Finasteride in the treatmentof men with frontal male pattern hair loss " .Journal of the 25American Academy of Dermatology 40 (6 Pt 1): 930 – 7., 1999).
The present inventor in order to hair and scalp condition improvement develop relatively can replace frequently occurring without the need to being not only free from side effects but also not having toxicity and to improving hair and scalp state has the preparation deriving from natural goods of the neomorph of outstanding effect and studies of existing medicament of side effect, result, the extract and the fraction thereof that confirm specific medical material suppress the Be very effective of 5-alpha-reductase (testosterone 5a-reductase) to be given prominence to, thus complete the present invention.
In this manual, " extract " refers to the various organs from each medical material, the material obtained as extracted from leaf, flower, stem, fruit, seed and root etc. or herb.
And, in this manual, " improvement " refers to that using is the prevention or the treatment that comprise symptom, and comprise the minimizing of the scope occurring symptom, delay that symptom is carried out or alleviation, symptom alleviate or stabilisation, partially or completely recover, other different favourable outcomes etc., refer in particular to the improvement of hair and scalp state.
More specifically, the improvement of above-mentioned hair and scalp state preferably can prevent or treats (promotion hair growth promoting) alopecia, and, the minimizing of sebum secretion, preventing of the dandruff or preventing of scalp inflammation can be preferably.
The present invention preferably the hair of an example and scalp condition improvement compositions comprise be selected from 16 kinds of medical materials more than one extract as effective ingredient.
As above-mentioned medical material, there are Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan, above-mentioned medical material is described in more detail.
First, Rhizoma Phragmitis (Phragmites communis) is as the rhizome of phragmites communis, effective to febrile disease, it is the medical material of the vomiting that causes of cough, pulmonary tuberculosis, pulmonary abscess, gastric heat that treatment lung-heat causes etc., Radix Paeoniae (Paeoniae Radix) hyperfunction gastrointestinal motor ability, come facilitating digestion and absorption, have inhibition to analgesia, spasmolytic, sedation and gastric acid secretion, Radix Paeoniae Alba, Radix Paeoniae Rubra, the recklessly various kind such as Radix Paeoniae, Paeonia obovata Maxim. can be used.
Poria cum Radix Pini is for entertaining the white portion of Radix Pini massonianae natively in the centre of the Poria (Poria cocos) of Polyporaceae, use as mind calming and the medical material for the treatment of of insomnia patients, amnesia etc., leaf and the root of Folium Pyrrosiae (Pyrrosia lingua (Thunberg) Farwell or congener) have antitussive, eliminate the phlegm, antiasthmatic effect, thus are used as medical material.Further, diuresis antipyretic response is presented to the symptom such as gonorrhea, urethritis, cystitis, nephritis as urogenital disease, for calculus of urethra, also coordinates with other drug and utilize.Effective to chronic bronchitis, also antiinflammatory and diuresis are presented to acute and chronic nephritis, pyelonephritis.
Effect that the root of Radix Adenophorae Trachelioidis (Adenophora remotiflora (Siebold & Zucc.) Miq.) has heat clearing away, detoxifies, reduces phlegm, be be used in removing toxic substances, furuncle is treated, eliminate the phlegm etc. medical material, Sai Naye (Folium Sennae, Senna alexandrina) plays discharge function, antibacterial, antibiosis and curariform action mask.
Lignum pterocarpi indici is Lignum pterocarpi indici (Pterocarpus santalinus Linne (pulse family, Leguminosae) trunk, have cold-blooded, hemostasis, removing toxic substances, detumescence, pain relieving effect, thus be used for wound hemorrhage or sore and toxic in mode that is oral or external, Fructus Tsaoko (Amomum tsao-ko Crevstet Lemaire) is for reducing cold air, the warm heart, stops vomiting, and removes abdominal part distension.Meanwhile, there is the effect of eliminating the phlegm, in addition, be applied to stomachache, vomiting, diarrhoea etc. that distension disease that phlegm retention causes, gastric cancer cause.
Rhizoma Alismatis (Alisma canaliculatum) is used as medical material in the mode of drying tuber, suck the dampness of health, reduce blood glucose and blood pressure, not only effective to diabetes thus, also remove the refuse in blood pressure and cholesterol, thus have and make blood flow effect smoothly, for symptoms such as nephritis, cystitis, urethritis, glycosuria, hypertension, fatty livers.
Rhizoma Osmundae (Dryopteris crassirhizoma NAKAI) is as the plant belonging to pteridophyta bracken section, the rhizome of Rhizoma Osmundae is as its composition, there will be a known pannol (filmaron), phloroglucinol (phloroglucinol) etc., as pharmacological effect, there will be a known cestode therapeutic agent, common cold treatment agent etc.
Core of Caulis et Folium Lini is as the seed of maturation of Caulis et Folium Lini (Linum usitatissimumLinne) belonging to flax family (Linaceae) (Linaceae), for the treatment of diabetes and intestinal tract disease, and infusion is used as to bronchial Catarrhal disease, Flos puerariae lobatae (Pueraria thunberginia) mainly uses the flower of not blooming completely, the headache caused for crapulence, heating, very thirsty, inappetence, abdominal distension and vomiting disease.
Rhizoma Curcumae Longae (Curcuma longa) belongs to the rhizome of the perennial book on Chinese herbal medicine of Zingiberaceae and obtains as drying, have elimination blood stasis, ventilate smooth and easy, solved the problem that menstrual phase is not in the period yet, and the medical material of effect of pain relieving.
And, Semen Trichosanthis refers to the seed of Fructus Trichosanthis cucurbitaceous (Trichosanthes kirilowiiMaximowicz) or yellow Fructus Trichosanthis (Trichosanthes kirilowii Max.var.japonicaKitamura), has the effects such as phlegm-heat cough, constipation, furuncle, galactopoiesis promotion.Especially, when being difficult to spit because febrile bronchial is scorching, protection lung, soft lung, ventilation is eliminated the phlegm, and effective to polarity bronchitis, pleuritis, pneumonia etc.
Known Fructus Cannabis is as the seed of Fructus Cannabis (Cannabis sativa), and its fat is abundant, and glossy, thus have and dry is moistened, contribute to mildly dredging intestinal, and make blood circulation effect smoothly, be also used as analgesics to having difficult labour, swelling and ache etc.
Lignum Sappan (Caesalpinia sappan L.) is as the plant belonging to pulse family (Leguminosae), be called as lignum sappan, the Soviet side, Ramulus et Folium Bischofiae Javanicae, purple etc., Lignum Sappan is not spontaneous in Korea S, but is distributed in Fujian province, Guangdong Province, Guangxi province, Guizhou Province, Yunnan Province, Hainan Province, Taiwan etc.The stem set Lignum Sappan and the heartwood of thick branch are called Lignum Sappan, and known have for the effect of heart and blood vessel, central inhibitory action, antibacterial action, hypoglycemic activity.
The hair of the present invention one example and scalp condition improvement compositions comprise more than one extract in above-mentioned 16 kinds of medical materials that 5-alpha-reductase (testosterone 5a-reductase) inhibit activities gives prominence to as effective ingredient, significantly can improve hair and scalp state thus.Preferably, the extract of Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Fructus Cannabis and Lignum Sappan can be comprised.
On the other hand, preferably, the extract of the Rhizoma Phragmitis in said extracted thing, Radix Paeoniae, Poria cum Radix Pini, Flos puerariae lobatae and Lignum Sappan can comprise with powder morphology, preferably, the extract of Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini and Rhizoma Curcumae Longae can comprise with extracting solution form, the extract of Semen Trichosanthis can comprise with oily form, and the extract of Fructus Cannabis can comprise with rare liquid form.
Above-mentioned hair and scalp condition improvement compositions according to usual the used method of each different field, can comprise suitable carrier, excipient and diluent etc., thus are suitable for as pharmaceutical compositions, functional food composite or hair composition further.
When being provided as pharmaceutical compositions, above-mentioned composition can carry out administration according to usual way in oral or parenteral mode, such as, when carrying out administration with oral way, can use with dosage forms such as powder, granule, tablet, suspending agent, latex, syrup.
Preferred dosage can for being applicable to administration object and/or the treatment of disease or the content of prevention, this can regulate according to various factors such as the secretion rate of the contamination of other compositions contained in the kind of the kind of the age of administration object, sex, general health state and body weight, disease and serious symptom degree, dosage form, compositions, compositions, route of administration and periods, suitably can be selected by general technical staff of the technical field of the invention.As above-mentioned administration object, it can be the mammals comprising the mankind.
When above-mentioned composition is provided as hair composition form, with whole hair composition weight for benchmark, preferably, above-mentioned hair and the scalp condition improvement compositions of 0.0001 ~ 99.9 percentage by weight can be comprised, more preferably, above-mentioned hair and the scalp condition improvement compositions of 0.1 ~ 50 percentage by weight can be comprised, preferably, can be selected from by refreshing flooding, hair moisturizer, suppurative mastitis, hair jelly, hair mousse, hair fixing cream, hair soap, shampoo, hair conditioner, hair care Mo be Ji the dosage form in the group that forms of hairdressing gel provides.
As a preferred example more of the present invention, there is provided hair and scalp condition improvement method, above-mentioned hair and scalp condition improvement method comprise more than one extract in the above-mentioned 16 kinds of medical materials given prominence to by 5-alpha-reductase (testosterone5a-reductase) inhibit activities to the step of individual administration suffering from alopecia.
The step of above-mentioned " administration " can realize in oral or parenteral mode, when with parenteral mode administration, can select external preparation for skin, subcutaneous injection injection mode, percutaneous dosing and topical etc., but be not limited thereto.Preferably, as external preparation for skin, the method being coated on skin can be utilized.
When topical, semi-solid (semisolid) preparation such as ointment, frost or gel can be utilized to carry out administration, when percutaneous dosing, except matrix patch or reservoir type patch (reservoir patch), also can utilize semi-solid products (water alcogel etc.), but be not limited thereto.
According to the present invention's other examples preferred, provide the preparation method of above-mentioned hair and scalp condition improvement compositions.
Preferably, above-mentioned preparation method comprises: utilize water, ethanol or their mixed solvent to extract more than one step in the group being selected from and being made up of Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan; The extract obtained by said extracted step is carried out the step of filtration under diminished pressure; And the filtrate obtained by above-mentioned filtration step is carried out the step of concentrating under reduced pressure.
In order to more improve extraction effect, preferably, above-mentioned each medical material can be passed through the operation of pulverizing before the extraction step, especially, in above-mentioned medical material, has the forms such as fruits and seeds, such as, can utilize after the instruments such as shears cut off, carry out pulverizing to use.Breaking method is not particularly limited, and such as, the various instruments such as agitator can be used to realize.
Preferably, said extracted step is by extracting separately each medical material or mix all medical materials to realize with the method that mixture state extracts, and when each medical material of extraction uses separately, Extraction solvent may be the same or different.
Further, preferably, said extracted step realizes by the method leached after each medical material or their mixture being mixed with Extraction solvent.
Preferably, above-mentioned leaching can realize in the temperature range of 30 to 40 DEG C, more preferably, can realize at the temperature of 33 to 38 DEG C, preferably, can leach 1 to 3 day, more preferably, can leach 45 to 50 hours.
Extraction solvent is not particularly limited, but preferably, water, ethanol or their mixed solvent can be used to extract, more preferably, can use ethanol, most preferably, can use the ethanol of 60 to 80% (v/v).
Further, preferably, the said extracted solvent of 400ml to 800ml can be used by every medical material 100g.
Above-mentioned filtration under diminished pressure step is not particularly limited, and realizes by method well known in the art.
Preferably, the filtrate obtained by above-mentioned filtration step can further across the step of concentrating under reduced pressure.Above-mentioned concentrating under reduced pressure step is not particularly limited, and realizes by method well known in the art, after the above step, also optionally comprises cryodesiccated step etc.
Below, by embodiment, the present invention is described in detail.Just, following examples are only for illustrating the present invention, and the present invention is not limited to following examples.
[embodiment]
[embodiment 1: the preparation of extract]
Prepare Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan and pulverize respectively.Pulverize after cutting off fruits and seeds with shears.
After above-mentioned medical material 100g and 70% (v/v) ethanol (EtOH) 600ml that interpolation is pulverized in 1000ml bottle (Duran) mixes, in thermostatic water bath, 48 hours are leached with 35 DEG C of temperature.
Utilize after the extractum of acquisition carries out filtration under diminished pressure by filter paper (water graceful (Watman) No. 21 filters), decompression concentrator is utilized to carry out the filtrate of concentration and recovery, thus obtain the extracts from crude drugs (according to crude drug, with extracting solution, powder morphology, rare liquids recovery) of lower list 1.After extract prepared by 50ml pipe dispensing, Parafilm (Parafilm) is utilized to seal, and cold preservation keeping.
[table 1]
| Crude drug name | Acquisition amount (g) | Yield (%) | Reclaim form |
| Rhizoma Phragmitis | 0.22 | 0.22 | Powder |
| Radix Paeoniae | 2.43 | 2.43 | Powder |
| Poria cum Radix Pini | 0.26 | 0.26 | Powder |
| Folium Pyrrosiae | 0.93 | 0.93 | Extracting solution |
| Radix Adenophorae Trachelioidis | 0.16 | 0.16 | Extracting solution |
| Sai Naye | 1.24 | 1.24 | Extracting solution |
| Lignum pterocarpi indici | 1.21 | 1.21 | Extracting solution |
| Fructus Tsaoko | 1.32 | 1.32 | Extracting solution |
| Rhizoma Alismatis | 0.93 | 0.93 | Extracting solution |
| Rhizoma Osmundae | 1 | 1 | Extracting solution |
| Core of Caulis et Folium Lini | 0.52 | 0.52 | Extracting solution |
| Flos puerariae lobatae | 3.65 | 3.65 | Powder |
| Rhizoma Curcumae Longae | 15 | 15 | Extracting solution |
| Semen Trichosanthis | 1.86 | 1.86 | Oil |
| Lignum Sappan | 2.78 | 2.78 | Powder |
| Fructus Cannabis | 8.83 | 8.83 | Rare liquid |
[experimental example 1: utilize the testosterone (testosterone) of GC-MS and the quantitative analysis of dihydrotestosterone]
The chromatogram (chromatogram) of the quantitative analysis of the testosterone (testosterone) in the hepatomicrosome part (liver microsomal fraction) extracted after being used for reacting and dihydrotestosterone (DHT) is shown in Fig. 1 to Fig. 4.
[experimental example 2:5-alpha-reductase suppresses efficacy assessments to measure]
In order to the 5-alpha-reductase evaluating the extract obtained by above-described embodiment l suppresses effect, first, medicine in contrast, utilizes finasteride (finasteride) (Mertk) to establish microsome fraction (Microsomal fraction) extraction conditions.
Particularly, utilize homogenizer (Homogenizer), tissue homogenizes test kit (tissuehomogenize kit), tissue grinder instrument (TissueLyzer) carrys out the above-mentioned finasteride of fractional distillation respectively to obtain fraction, and compare experiment as object, thus obtain the result of lower list 2.
[table 2]
As shown in Table 2 above, in the condition of three for extracting microsome fraction, confirm effect of 5-alpha-reductase, but when using-system beveller, effect of 5-alpha-reductase presents relatively low value, it can thus be appreciated that the activity inhibited of 5-alpha-reductase.
Repeatedly 2 times the fraction based on homogenizer is tested, and confirmed repeatability 5-alpha-reductase being suppressed to efficacy assessments, following list 3.
[table 3]
[experimental example 3: evaluate effect that natural extract suppresses 5-alpha-reductase]
Effect of 5-alpha-reductase is suppressed in order to evaluate the natural extract obtained by above-described embodiment 1, respectively each natural extract and testosterone (testosterone) are dissolved in dimethyl sulfoxide (DMSO, dimethyl sulfoxide) and methanol (MeOH) and use.
First, in order to understand the impact on two kinds of organic solvents, the testosterone solution diluting 100 μ g/mL with the concentration of 10 μ g/mL in dimethyl sulfoxide and methanol respectively compares experiment, and the result obtained thus is shown in lower list 4.
[table 4]
As shown in Table 4 above, in the two kinds of solvents diluting testosterone, all can confirming effect of 5-alpha-reductase, from the viewpoint of presenting end value similar like this, can confirm not based on the impact of organic solvent.
Utilize the efficiency analysis method of the 5-alpha-reductase set up, use 16 kinds of natural extracts obtaining according to above-described embodiment 1 and extract with the method identical with above-described embodiment 1 as a control group and the Arillus Longan extract, Semen Phaseoli extract and the Semen Ziziphi Spinosae extract that obtain, thus repeatedly 2 times suppression effect of 5-alpha-reductase is tested, and the result obtained thus is shown in lower list 5.
[table 5]
As shown in Table 5 above, effect of 5-alpha-reductase is not presented completely according to medical material 16 kinds of extracts of the embodiment of the present invention 1 acquisition, thus can confirm that the effect suppressing 5-alpha-reductase is given prominence to, on the contrary, in Arillus Longan extract as a control group, Semen Phaseoli extract and Semen Ziziphi Spinosae extract, can confirm with used concentration independently, do not suppress effect of 5-alpha-reductase.Especially, all namely Radix Sophorae Flavescentis is the same with existing known positive controls (positive control) for known the present invention 16 kinds of natural extracts, suppresses effect of 5-alpha-reductase to be given prominence to.
[experimental example 4: the mensuration utilizing the mouse hair growth-promoting effect of the present composition]
In order to understand the effect of Anti-hair loss of the present invention and hair growth composition for promoting, utilize C57BL/6N mice to confirm the hair growth promotion effects of this compositions.Above-mentioned Anti-hair loss and hair growth composition for promoting employ Fructus Cannabis extract and Lignum Sappan extract.After the hair of mice of 7 weeks is removed completely after C57BL/6N mice being entered the life of second catagen (catagen), be coated with the present composition and the control substance of plant drug of each 150 μ l once a day for every 10 mices, continuously coating 5 weeks.The hair growth with the naked eye compared along with the process of time promotes degree, and is derived conclusion (Fig. 5).As negative control group, employ 80% ethanol not having hair growth promotion effects, as positive controls, employ 3% minoxidil.Lower list 6 is by the table of perusal comparative analysis along with the extent of growth of the hair of the process of time.
[table 6]
In above-mentioned table 6, "-" refers to that hair does not almost grow, and "+" refers to that hair grows along with the process of time, and the quantity of "+" is more, and hair growth amount is more.Known in Fructus Cannabis extract and Lignum Sappan extract hair growth, this means compositions of the present invention promote hair growth.
[experimental example 5: the mensuration of hair growth promoting area]
Photo being measured for the hair growth promoting obtained by above-mentioned experimental example 4, in order to measure the ratio of unhairing area and hair growth promoting area, employing the i-Solution Lite as image analysis program.First, measure plucked whole area, and after measuring the area of hair growth promoting, determine hair growth promoting ratio with the percentage ratio (%) relative to whole area.The growth ratio of unhairing area along with the process of time and hair has been shown in lower list 7.
[table 7]
By the order of positive controls (3% minoxidil), HD-23 (Fructus Cannabis extract), present high hair growth promoting rate, when HD-124 (Lignum Sappan extract), after 5 weeks, the increase of significant hair growth promoting rate can be confirmed.
Claims (9)
1. a hair and scalp condition improvement compositions, it is characterized in that, comprise more than one extract in the group being selected from and being made up of Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan as effective ingredient.
2. hair according to claim 1 and scalp condition improvement compositions, it is characterized in that, above-mentioned hair and scalp condition improvement compositions comprise Rhizoma Phragmitis extract, Radix Paeoniae Alba extract, Poria extract, Folium Pyrrosiae extract, Fructus Cannabis extract and Lignum Sappan extract.
3. hair according to claim 1 and scalp condition improvement compositions, is characterized in that, above-mentioned hair and scalp condition improvement compositions are used for prevention or hair growth.
4. hair according to claim 1 and scalp condition improvement compositions, is characterized in that, above-mentioned hair and scalp condition improvement compositions, for reducing sebum secretion, prevent the dandruff, or prevent scalp inflammation.
5. a hair grooming compositions, is characterized in that, comprises the hair according to any one of Claims 1-4 and scalp condition improvement compositions.
6. hair grooming compositions according to claim 5, it is characterized in that, above-mentioned hair grooming compositions to be selected from by refreshing flooding, hair moisturizer, suppurative mastitis, hair jelly, hair mousse, hair fixing cream, hair soap, shampoo, hair conditioner, hair care Mo be Ji the dosage form in the group that forms of hairdressing gel provides.
7. a preparation method for the hair according to any one of Claims 1-4 and scalp condition improvement compositions, is characterized in that, comprising:
Water, ethanol or their mixed solvent is utilized to extract more than one step in the group being selected from and being made up of Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Radix Adenophorae Trachelioidis, Sai Naye, Lignum pterocarpi indici, Fructus Tsaoko, Rhizoma Alismatis, Rhizoma Osmundae, core of Caulis et Folium Lini, Flos puerariae lobatae, Rhizoma Curcumae Longae, Semen Trichosanthis, Fructus Cannabis and Lignum Sappan;
The extract obtained by said extracted step is carried out the step of filtration under diminished pressure; And
The filtrate obtained by above-mentioned filtration step is carried out the step of concentrating under reduced pressure.
8. the preparation method of hair according to claim 7 and scalp condition improvement compositions, it is characterized in that, in said extracted step, with the form of indivedual or mixture Rhizoma Phragmitis, Radix Paeoniae, Poria cum Radix Pini, Folium Pyrrosiae, Fructus Cannabis and Lignum Sappan mixed with ethanol respectively and extract.
9. the preparation method of hair according to claim 8 and scalp condition improvement compositions, is characterized in that, at 30 to 40 DEG C of temperature, carries out the said extracted of 1 to 3 day.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0080458 | 2012-07-24 | ||
| KR20120080458 | 2012-07-24 | ||
| PCT/KR2013/006585 WO2014017804A1 (en) | 2012-07-24 | 2013-07-23 | Composition comprising natural extracts as active ingredients for improving condition of hair and scalp, and method for preparing same |
| KR10-2013-0086685 | 2013-07-23 | ||
| KR1020130086685A KR20140015199A (en) | 2012-07-24 | 2013-07-23 | Composition for improving condition of hair and scalp comprising natural extracts |
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| CN104411320A true CN104411320A (en) | 2015-03-11 |
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| CN201380029691.1A Pending CN104411320A (en) | 2012-07-24 | 2013-07-23 | Composition comprising natural extracts as active ingredients for improving condition of hair and scalp, and method for preparing same |
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| JP (1) | JP2015520228A (en) |
| KR (1) | KR20140015199A (en) |
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| GB2447672B (en) | 2007-03-21 | 2011-12-14 | Ford Global Tech Llc | Vehicle manoeuvring aids |
| KR101818500B1 (en) * | 2016-02-18 | 2018-01-15 | 한국 한의학 연구원 | Composition for preventing, improviong or treating disease caused by side effect of anticancer agent comprising Phragmites communis Trin extract as effective component |
| KR101917733B1 (en) * | 2017-12-19 | 2018-11-13 | 게놈앤메디신(주) | A composition for preventing, treating or improving a prostate disease, which comprisesd of extracts of Acanthopanax sessiliflorus, Phragmitis Rhizoma, and Pinus densiflora as an active ingredients |
| KR102068068B1 (en) | 2019-04-12 | 2020-01-20 | 주식회사 씨엠컴퍼니 | Composition containing natural extracts for scalp and hair, and method for manufacturing the same |
| KR102316407B1 (en) * | 2019-11-22 | 2021-10-21 | 광주여자대학교 산학협력단 | cosmetic composition using Nandina domestica Thunb |
| KR102316415B1 (en) * | 2019-11-22 | 2021-10-21 | 광주여자대학교 산학협력단 | manufacturing method of cosmetic composition using Nandina domestica Thunb |
| KR102405458B1 (en) | 2019-12-16 | 2022-06-07 | 주식회사 퍼슨 | Cosmetic composition for preventing hair loss and promoting hair growth containing alfalfa extract, hair cosmetic including the same, and method of manufacturing the same. |
| KR102492903B1 (en) * | 2020-10-19 | 2023-01-30 | 주식회사 가인화장품 | Anti-bacterial composition and cosmetic composition for improving of dandruff or acne comprising the same |
| KR102591508B1 (en) * | 2021-02-23 | 2023-10-19 | 주식회사 가인화장품 | Anti-bacterial composition and cosmetic composition for improving of dandruff or acne comprising the same |
| KR102562486B1 (en) * | 2021-07-14 | 2023-08-01 | 동의대학교 산학협력단 | A composition that does not irritate the skin and has excellent skin moisture containing the extract of Pyrrosia hastata (Thunb. ex Houtt.) Ching as an active ingredient |
| CN114588093A (en) * | 2021-12-27 | 2022-06-07 | 华南农业大学 | Application of amomum tsao-ko in preparing shampoo |
| KR102558832B1 (en) * | 2022-09-28 | 2023-07-25 | (주)메디치코리아코스메틱 | Composition for hair decoloration agent |
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| JPH11246336A (en) * | 1998-02-27 | 1999-09-14 | Ichimaru Pharcos Co Ltd | Activated oxygen scavenger and skin beautifying cosmetic composition |
| CN101199769B (en) * | 2007-12-18 | 2010-06-09 | 申华 | External medicament for treating baldness and preparing method thereof |
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| 国家中医药管理局《中华本草》编委会: "《中华本草·维吾尔药卷》", 31 December 2005, 世纪出版集团、上海科学技术出版社 * |
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