CN104349777B - 用于治疗脊髓性肌萎缩的化合物 - Google Patents
用于治疗脊髓性肌萎缩的化合物 Download PDFInfo
- Publication number
- CN104349777B CN104349777B CN201380019368.6A CN201380019368A CN104349777B CN 104349777 B CN104349777 B CN 104349777B CN 201380019368 A CN201380019368 A CN 201380019368A CN 104349777 B CN104349777 B CN 104349777B
- Authority
- CN
- China
- Prior art keywords
- bases
- pyrimidin
- pyridos
- pyrazine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(CN(*=C)C(*)=N)=O Chemical compound CC(CN(*=C)C(*)=N)=O 0.000 description 38
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- ZUYOOCCQYSTVKL-UHFFFAOYSA-N Cc(nc(C)c1c2)c[n]1nc2C(N=C(C=C1)N2C=C1N1CCN(C)CC1)=CC2=O Chemical compound Cc(nc(C)c1c2)c[n]1nc2C(N=C(C=C1)N2C=C1N1CCN(C)CC1)=CC2=O ZUYOOCCQYSTVKL-UHFFFAOYSA-N 0.000 description 1
- HHTQJDDDHFRUST-UHFFFAOYSA-N Cc1c[n](cc(cc2C3CC3)Br)c2n1 Chemical compound Cc1c[n](cc(cc2C3CC3)Br)c2n1 HHTQJDDDHFRUST-UHFFFAOYSA-N 0.000 description 1
- QZFUEGAUIVSNAW-UHFFFAOYSA-N Cc1c[n](cc(cc2CO)Br)c2n1 Chemical compound Cc1c[n](cc(cc2CO)Br)c2n1 QZFUEGAUIVSNAW-UHFFFAOYSA-N 0.000 description 1
- ZIDLRAIJMLAPKO-UHFFFAOYSA-N Cc1c[n](cc(cc2CO)C(N=C(C=C3)N4C=C3F)=CC4=O)c2n1 Chemical compound Cc1c[n](cc(cc2CO)C(N=C(C=C3)N4C=C3F)=CC4=O)c2n1 ZIDLRAIJMLAPKO-UHFFFAOYSA-N 0.000 description 1
- RFOCFKMQECELTI-UHFFFAOYSA-N Cc1c[n](cc(cc2CO)C(N=C(C=C3)N4C=C3N3CCNCC3)=CC4=O)c2n1 Chemical compound Cc1c[n](cc(cc2CO)C(N=C(C=C3)N4C=C3N3CCNCC3)=CC4=O)c2n1 RFOCFKMQECELTI-UHFFFAOYSA-N 0.000 description 1
- YDNHWCQEYAZBMF-UHFFFAOYSA-N Cc1c[s]c(C(N=C(C=C2)N3C=C2F)=CC3=O)n1 Chemical compound Cc1c[s]c(C(N=C(C=C2)N3C=C2F)=CC3=O)n1 YDNHWCQEYAZBMF-UHFFFAOYSA-N 0.000 description 1
- FSHWOSSUZXYOIJ-UHFFFAOYSA-N Cc1c[s]c(C(N=C(C=C2)N3C=C2N2CCNCC2)=CC3=O)n1 Chemical compound Cc1c[s]c(C(N=C(C=C2)N3C=C2N2CCNCC2)=CC3=O)n1 FSHWOSSUZXYOIJ-UHFFFAOYSA-N 0.000 description 1
- XDMLMZPEHPBYBY-UHFFFAOYSA-N Cc1nc(ccc(C(C(C(OC)=O)C(OC)=O)=O)c2)c2[o]1 Chemical compound Cc1nc(ccc(C(C(C(OC)=O)C(OC)=O)=O)c2)c2[o]1 XDMLMZPEHPBYBY-UHFFFAOYSA-N 0.000 description 1
- SDDCVDYTJPRZIY-UHFFFAOYSA-N Nc(c(O)cc(Br)c1)c1F Chemical compound Nc(c(O)cc(Br)c1)c1F SDDCVDYTJPRZIY-UHFFFAOYSA-N 0.000 description 1
- XUHBVNJJIGFVBS-UHFFFAOYSA-N Nc(c(OCc1ccccc1)cc(Br)c1)c1F Chemical compound Nc(c(OCc1ccccc1)cc(Br)c1)c1F XUHBVNJJIGFVBS-UHFFFAOYSA-N 0.000 description 1
- WGOLHUGPTDEKCF-UHFFFAOYSA-N Nc(nc1)ccc1Br Chemical compound Nc(nc1)ccc1Br WGOLHUGPTDEKCF-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810234432.7A CN108299314B (zh) | 2012-02-10 | 2013-02-08 | 用于治疗脊髓性肌萎缩的化合物 |
| CN202411603136.1A CN119528903A (zh) | 2012-02-10 | 2013-02-08 | 用于治疗脊髓性肌萎缩的化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261597523P | 2012-02-10 | 2012-02-10 | |
| US61/597,523 | 2012-02-10 | ||
| PCT/US2013/025292 WO2013119916A2 (en) | 2012-02-10 | 2013-02-08 | Compounds for treating spinal muscular atrophy |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810234432.7A Division CN108299314B (zh) | 2012-02-10 | 2013-02-08 | 用于治疗脊髓性肌萎缩的化合物 |
| CN202411603136.1A Division CN119528903A (zh) | 2012-02-10 | 2013-02-08 | 用于治疗脊髓性肌萎缩的化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104349777A CN104349777A (zh) | 2015-02-11 |
| CN104349777B true CN104349777B (zh) | 2018-05-01 |
Family
ID=48948163
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380019368.6A Active CN104349777B (zh) | 2012-02-10 | 2013-02-08 | 用于治疗脊髓性肌萎缩的化合物 |
| CN201810234432.7A Active CN108299314B (zh) | 2012-02-10 | 2013-02-08 | 用于治疗脊髓性肌萎缩的化合物 |
| CN202411603136.1A Pending CN119528903A (zh) | 2012-02-10 | 2013-02-08 | 用于治疗脊髓性肌萎缩的化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810234432.7A Active CN108299314B (zh) | 2012-02-10 | 2013-02-08 | 用于治疗脊髓性肌萎缩的化合物 |
| CN202411603136.1A Pending CN119528903A (zh) | 2012-02-10 | 2013-02-08 | 用于治疗脊髓性肌萎缩的化合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US9586955B2 (https=) |
| EP (2) | EP2812004B1 (https=) |
| JP (2) | JP6092897B2 (https=) |
| KR (2) | KR102341596B1 (https=) |
| CN (3) | CN104349777B (https=) |
| AR (1) | AR092794A1 (https=) |
| AU (2) | AU2013216870B2 (https=) |
| BR (1) | BR112014019750B1 (https=) |
| CA (1) | CA2863874C (https=) |
| CL (1) | CL2014002100A1 (https=) |
| CO (1) | CO7061082A2 (https=) |
| CR (1) | CR20140376A (https=) |
| DK (1) | DK2812004T3 (https=) |
| EA (2) | EA037123B1 (https=) |
| EC (1) | ECSP14017269A (https=) |
| ES (1) | ES2697174T3 (https=) |
| HU (1) | HUE039779T2 (https=) |
| IL (2) | IL233959A (https=) |
| MA (1) | MA35920B1 (https=) |
| MX (2) | MX354074B (https=) |
| NZ (1) | NZ628186A (https=) |
| PE (1) | PE20142364A1 (https=) |
| PH (2) | PH12018501711B1 (https=) |
| PL (1) | PL2812004T3 (https=) |
| SG (2) | SG11201404713PA (https=) |
| TR (1) | TR201813877T4 (https=) |
| TW (2) | TWI629274B (https=) |
| UA (1) | UA116981C2 (https=) |
| WO (1) | WO2013119916A2 (https=) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10327940B2 (en) | 2008-11-09 | 2019-06-25 | 3D Systems, Inc. | Spiral brace |
| MX352861B (es) | 2011-12-30 | 2017-12-13 | Ptc Therapeutics Inc | Compuestos para tratar la atrofia muscular espinal. |
| MX357834B (es) | 2012-01-26 | 2018-07-26 | Ptc Therapeutics Inc | Compuestos de tipo isocumarina sustituidos para tratar la atrofia muscular espinal. |
| EP2812004B1 (en) * | 2012-02-10 | 2018-06-27 | PTC Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| CA2865957C (en) | 2012-03-01 | 2020-02-11 | F. Hoffmann-La Roche Ag | Compounds for treating spinal muscular atrophy |
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