CN104306852B - A kind of preparation method of the medicinal liquor for treating rheumatic arthritis - Google Patents

A kind of preparation method of the medicinal liquor for treating rheumatic arthritis Download PDF

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CN104306852B
CN104306852B CN201410549736.4A CN201410549736A CN104306852B CN 104306852 B CN104306852 B CN 104306852B CN 201410549736 A CN201410549736 A CN 201410549736A CN 104306852 B CN104306852 B CN 104306852B
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周遂记
温自力
周亚光
李中亚
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HENAN SIZHITANG PHARMACEUTICAL Co Ltd
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Abstract

A kind of preparation method of the medicinal liquor for treating rheumatic arthritis, first crushes wild aconite root and galangal, steams, and after the black millet after cooling and after immersion is well mixed, adds mixture quality distiller's yeast and water, is placed in ceramic vessel and ferments;Water is added in fermentate, liquid A is filtered to obtain after ultrasonication;Radix Angelicae Sinensis and cloves are crushed, bafillus natto is subsequently adding and sterilized water is well mixed, be placed in ceramic vessel and ferment;In tunning, white wine is added, 50 60 DEG C of insulations are heated to after immersion, cooling is filtered to take filtrate, obtains medical liquid B;Liquid A and medical liquid B mix, and obtain liquid C;The brown granulated sugar to coke yellow will be fried in iron pan, be added in liquid C, stirring is filtered to being completely dissolved, and gained liquid is the medicinal liquor of the treatment protrasion of the lumbar intervertebral disci.Medicinal liquor of the present invention is clearing heat and detoxicating, and swelling and pain relieving activates blood circulation and disperses blood clots, it is possible to resolve the inflammation of periarticular;And regulating immunological function;Especially there is preferable therapeutic effect to treatment rheumatic arthritis.

Description

A kind of preparation method of the medicinal liquor for treating rheumatic arthritis
Technical field
The present invention relates to a kind of medicinal liquor, specifically a kind of preparation method of the medicinal liquor for treating rheumatic arthritis.
Background technology
Rheumatic arthritis belongs to allergic disease, is one of main performance of rheumatic fever, more with febris acuta and pass Section pain onset, typical performance is slight or moderate heating, and migratory polyarthritis, affected joints are generally knee, ankle, shoulder, elbow, wrist Common to be transferred to another joint by a joint etc. large joint, lesion is locally presented red, swollen, scorching hot, severe pain, some patients Also there are several joints to fall ill simultaneously, atypical patient only have arthralgia and without the performance of other inflammation, acute inflammation typically in Disappear within 2-4 weeks, do not stay sequelae, but often recurrent exerbation.If active rheumatism influences heart, myocarditis can occur, or even leave Valve disorder.Rheumatic arthritis onset is more anxious, and affected joints start to invade and joint of lower extremity person accounts for based on large joint 85%, knee and ankle-joint are most commonly seen, are secondly shoulder, elbow and wrist, and the Minor articulus of hand and foot are rare, arthropathy in multiple and Migrans, local joint inflammation substantially, is presented with red, swollen, heat, pain, tenderness and limitation of activity.
Rheumatic arthritis belongs to allergic disease, is one of main performance of rheumatic fever, more with febris acuta and pass Section pain onset, typical performance is slight or moderate heating, and migratory polyarthritis, affected joints are generally knee, ankle, shoulder, elbow, wrist Common to be transferred to another joint by a joint etc. large joint, lesion is locally presented red, swells, scorching hot, severe pain, some patients Also there are several joints to fall ill simultaneously, atypical patient only have arthralgia and without the performance of other inflammation, acute inflammation typically in Disappear within 2-4 weeks, do not stay sequelae, but often recurrent exerbation, if active rheumatism influence heart, can occur myocarditis, or even leave Valve disorder.
The content of the invention
The present invention seeks to the deficiency for solution above-mentioned technical problem, there is provided a kind of medicinal liquor for treating rheumatic arthritis Preparation method, prepared medicinal liquor, can wind-dispelling, dehumidifying, eliminating cold to stop pain, for the treatment of rheumatic arthritis.
A kind of preparation method of the medicinal liquor for treating rheumatic arthritis, comprises the following steps:
Step one, take wild aconite root 20-25 parts, Radix Angelicae Sinensis 8-10 parts, cloves 8-10 parts, galangal 8- respectively according to parts by weight It is 10 parts, black millet 50-80 parts, watter milkwort root leaf or bark 6-9 parts and brown granulated sugar 30-33 parts, standby;
Step 2, by taken wild aconite root and galangal, be ground into the Chinese medicinal granule that particle diameter is 2.5-5.0mm, it is standby;By institute Chinese medicinal granule be placed in 95-100 DEG C at steam 50-70 minute, take out and be cooled to 40-45 DEG C, it is standby;Add in taken black millet Enter the water of 5-10 times of its quality, soak 5-8 hours, pull out and drain, it is standby;
Step 3, will steam after be cooled to 40-45 DEG C of wild aconite root and galangal Chinese medicinal granule and immersion after black millet Mixture is obtained after well mixed, the distiller's yeast of its quality 2-3% and the water of 15-20 times of quality is added in the resulting mixture, again Well mixed being placed in ceramic vessel is fermented 2-3 days, takes out fermentate;In gained fermentate, 15-20 times of its quality is added Water, is heated to 60-70 DEG C and soaks 5-6 hours, filters to obtain liquid A, standby;
Step 4, the Chinese medicinal granule that taken Radix Angelicae Sinensis and cloves are ground into a diameter of 3.0-8.0mm;In gained Chinese medicinal granule In, add taken watter milkwort root leaf or bark to be well mixed, obtain mixture, be subsequently adding mixture quality 2-3% bafillus natto and The sterilized water of quality 2-4%, is well mixed again, is placed in ceramic vessel and ferments 2-3 days, takes out tunning;In gained fermentation In product, the white wine of 3-6 times of tunning quality is added, immersion is heated to 50-60 DEG C and is incubated 2-3 hours after 3-4 hours, then Room temperature is cooled to, filtrate is filtered to take, medical liquid B is obtained, it is standby;
Step 5, gained liquid A and medical liquid B are mixed, obtain liquid C;Taken brown granulated sugar is placed in iron pan and is fried to Jiao Yellow, is added in liquid C, and stirring stands 24-26 hours to being completely dissolved, filtering, and gained liquid is to prepare treatment rheumatism The arthritic medicinal liquor of property.
The get it filled parts by weight of each bulk drug of wine of step one are preferably:25 parts of wild aconite root, 8.3 parts of Radix Angelicae Sinensis, cloves 8.3 Part, 8.3 parts of galangal, 70 parts of black millet, 8 parts of watter milkwort root leaf or bark and 30 parts of brown granulated sugar.
Beneficial effect is:
1st, medicinal liquor of the present invention is formed by the Chinese medicine compatibility such as wild aconite root, Radix Angelicae Sinensis, galangal, cloves.Wherein radix aconiti agrestis taste is pungent, Hardship, property heat, very toxic, thoughts of returning home liver the spleen channel has the effect of antalgic, dispelling wind and eliminating dampness, has good to wind-cold-dampness arthralgia, numb limb Effect, is monarch drug in a prescription;Radix Angelicae Sinensis acrid-sweet flavor, warm in nature, the work(with enrich blood easypro liver, promoting blood circulation and stopping pain, for treating rheumatic Bi syndrome, residence has " to be controlled Wind first controls blood, and blood wind is from going out " reason, be ministerial drug;Galangal taste is pungent, property heat, returns spleen stomach, can warming spleen and stomach for dispelling cold analgesic, be assistant Medicine;Cloves taste is pungent, warm in nature, returns spleen lung channel has middle benefit gas to drop inverse, effect tonified the kidney and support yang.It is subject to white wine, warming channel and activating blood circulation, powdered medicine ' Tongluosan ' It is cold.Wine assisting drug, wine helps medicine gesture, and four medicine compatibilities, monarch is mutually coordinated, and anti-inflammatory, analgesia, promoting blood circulation Eradicates blood stasis and smoothing collaterals, wind-dispelling dissipate Cold, dampness removing dredging collateral, it is intended that drive away the wind-cold damp pathogen for invading;Clearing heat and detoxicating, swelling and pain relieving activates blood circulation and disperses blood clots, it is intended that solve joint week The inflammation enclosed;Row mends and mutually helps, attacks benefit combination, it is intended that strengthens the body resistance to consolidate the constitution, adjusts immunologic function;Especially to treatment rheumatic arthritis tool There is preferable therapeutic effect;The medicinal liquor treatment rheumatic arthritis of rheumatic arthritis is treated simultaneously with convenient, safe, honest and clean Valency, eutherapeutic feature.
2nd, the present invention is fermented wild aconite root and galangal Chinese medicinal granule using distiller's yeast in ceramic vessel, can be by wild aconite root and height The effective ingredient beneficial to treatment rheumatic arthritis in galingal is separated out, and the subsequently Radix Angelicae Sinensis of bacillus natto to ferment and cloves Liquid mixing after reach more preferable therapeutic effect;Bafillus natto is in the middle of various beneficial bacterias, best to environment resistance, can With one of the strain for the small intestine that goes directly, it is oral after can change human enteric bacteria and grow thickly state, function normalization is helped digest, so that row Just it is smooth, maintain body physiological balance;And acid can be produced, regulating intestinal canal flora, enhancing animal cell immunity is put and answered;Using receiving Beans fermentation of bacillus Radix Angelicae Sinensis and cloves, in addition to it medicine can to greatest extent be played into its effect, can also adjust human body Immunity, improves the utilization rate of medicine.
Specific embodiment
A kind of preparation method of the medicinal liquor for treating rheumatic arthritis, comprises the following steps:
Step one, take wild aconite root 20-25 parts, Radix Angelicae Sinensis 8-10 parts, cloves 8-10 parts, galangal 8- respectively according to parts by weight It is 10 parts, black millet 50-80 parts, watter milkwort root leaf or bark 6-9 parts and brown granulated sugar 30-33 parts, standby;
Step 2, by taken wild aconite root and galangal, be ground into the Chinese medicinal granule that particle diameter is 2.5-5.0mm, it is standby;By institute Chinese medicinal granule be placed in 95-100 DEG C at steam 50-70 minute, take out and be cooled to 40-45 DEG C, it is standby;Add in taken black millet Enter the water of 5-10 times of its quality, soak 5-8 hours, pull out and drain, it is standby;
Step 3, will steam after be cooled to 40-45 DEG C of wild aconite root and galangal Chinese medicinal granule and immersion after black millet Mixture is obtained after well mixed, the distiller's yeast of its quality 2-3% and the water of 15-20 times of quality is added in the resulting mixture, again Well mixed being placed in ceramic vessel is fermented 2-3 days, takes out fermentate;In gained fermentate, 15-20 times of its quality is added Water, is heated to 60-70 DEG C and soaks 5-6 hours, is filtrated to get liquid, obtains liquid A, standby;
Step 4, the Chinese medicinal granule that taken Radix Angelicae Sinensis and cloves are ground into a diameter of 3.0-8.0mm;In gained Chinese medicinal granule In, add taken watter milkwort root leaf or bark to be well mixed, obtain mixture, be subsequently adding mixture quality 2-3% bafillus natto and The sterilized water of quality 2-4%, is well mixed again, is placed in ceramic vessel and ferments 2-3 days, takes out tunning;In gained fermentation In product, the white wine of 3-6 times of tunning quality is added, immersion is heated to 50-60 DEG C and is incubated 2-3 hours after 3-4 hours, then Room temperature is cooled to, filtrate is filtered to take, medical liquid B is obtained, it is standby;
Step 5, gained liquid A and medical liquid B are mixed, obtain liquid C;Taken brown granulated sugar is placed in iron pan and is fried to Jiao Yellow, is added in liquid C, and stirring stands 24-26 hours to being completely dissolved, filtering, and gained liquid is to prepare treatment rheumatism The arthritic medicinal liquor of property.
The get it filled parts by weight of each bulk drug of wine of step one are preferably:25 parts of wild aconite root, 8.3 parts of Radix Angelicae Sinensis, cloves 8.3 Part, 8.3 parts of galangal, 70 parts of black millet, 8 parts of watter milkwort root leaf or bark and 30 parts of brown granulated sugar.
Embodiment 1
A kind of preparation method of the medicinal liquor for treating rheumatic arthritis, comprises the following steps:
Step one, taken respectively according to parts by weight 25 parts of wild aconite root, 8.3 parts of Radix Angelicae Sinensis, 8.3 parts of cloves, 8.3 parts of galangal, 30 parts of 70 parts of black millet, 8 parts of watter milkwort root leaf or bark and brown granulated sugar, it is standby;
Step 2, by taken wild aconite root and galangal, be ground into the Chinese medicinal granule that particle diameter is 2.5mm, it is standby;By in gained Medicine particle is steamed 50 minutes at being placed in 95 DEG C, and taking-up is cooled to 40 DEG C, standby;5 times of its quality is added in taken black millet Water, soaks 5 hours, pulls out and drains, standby;
Step 3, will steam after be cooled to 40 DEG C of wild aconite root and galangal Chinese medicinal granule and immersion after black millet mixing Mixture is obtained after uniform, the distiller's yeast of its quality 2% and the water of 15 times of quality are added in the resulting mixture, be well mixed again It is placed in ceramic vessel and ferments 2 days, takes out fermentate;In gained fermentate, the water of 15 times of its quality is added, be heated to 60 DEG C Immersion 5 hours, filters to obtain liquid A, standby;
Step 4, the Chinese medicinal granule that taken Radix Angelicae Sinensis and cloves are ground into a diameter of 3.0mm;In gained Chinese medicinal granule, Add taken watter milkwort root leaf or bark to be well mixed, obtain mixture, be subsequently adding the bafillus natto and quality of mixture quality 2% 2% sterilized water, is well mixed again, is placed in ceramic vessel and ferments 2 days, takes out tunning;In gained tunning, The white wine of 3 times of tunning quality is added, immersion is heated to 50 DEG C and is incubated 2 hours after 3 hours, be subsequently cooled to room temperature, filters Filtrate is taken, medical liquid B is obtained, it is standby;
Step 5, gained liquid A and medical liquid B are mixed, obtain liquid C;Taken brown granulated sugar is placed in iron pan and is fried to Jiao Yellow, is added in liquid C, and stirring stands 24 hours to being completely dissolved, filtering, and gained liquid is to prepare treatment rheumatic Arthritic medicinal liquor.
Embodiment 2
A kind of preparation method of the medicinal liquor for treating rheumatic arthritis, comprises the following steps:
Step one, take 20 parts of wild aconite root, 8 parts of Radix Angelicae Sinensis, 8 parts of cloves, 8 parts of galangal, black millet respectively according to parts by weight 30 parts of 50 parts, 6 parts of watter milkwort root leaf or bark and brown granulated sugar, it is standby;
Step 2, by taken wild aconite root and galangal, be ground into the Chinese medicinal granule that particle diameter is 3.0mm, it is standby;By in gained Medicine particle is steamed 60 minutes at being placed in 98 DEG C, and taking-up is cooled to 44 DEG C, standby;8 times of its quality is added in taken black millet Water, soaks 7 hours, pulls out and drains, standby;
Step 3, will steam after be cooled to 42 DEG C of wild aconite root and galangal Chinese medicinal granule and immersion after black millet mixing Mixture is obtained after uniform, the distiller's yeast of its quality 2.5% and the water of 18 times of quality are added in the resulting mixture, mix equal again Even being placed in ceramic vessel is fermented 2 days, takes out fermentate;In gained fermentate, the water of 18 times of its quality is added, be heated to 65 DEG C immersion 5.5 hours, filters to obtain liquid A, standby;
Step 4, the Chinese medicinal granule that taken Radix Angelicae Sinensis and cloves are ground into a diameter of 6.0mm;In gained Chinese medicinal granule, Add taken watter milkwort root leaf or bark to be well mixed, obtain mixture, be subsequently adding the bafillus natto and matter of mixture quality 2.5% The sterilized water of amount 3%, is well mixed again, is placed in ceramic vessel and ferments 3 days, takes out tunning;In gained tunning In, the white wine of 4 times of tunning quality is added, immersion is heated to 55 DEG C and is incubated 2.5 hours after 3.5 hours, be subsequently cooled to room Temperature, filters to take filtrate, obtains medical liquid B, standby;
Step 5, gained liquid A and medical liquid B are mixed, obtain liquid C;Taken brown granulated sugar is placed in iron pan and is fried to Jiao Yellow, is added in liquid C, and stirring stands 25 hours to being completely dissolved, filtering, and gained liquid is to prepare treatment rheumatic Arthritic medicinal liquor.
Embodiment 3
A kind of preparation method of the medicinal liquor for treating rheumatic arthritis, comprises the following steps:
Step one, take 22 parts of wild aconite root, 10 parts of Radix Angelicae Sinensis, 10 parts of cloves, 10 parts of galangal, black small respectively according to parts by weight 32 parts of 80 parts of rice, 9 parts of watter milkwort root leaf or bark and brown granulated sugar, it is standby;
Step 2, by taken wild aconite root and galangal, be ground into the Chinese medicinal granule that particle diameter is 5.0mm, it is standby;By in gained Medicine particle is steamed 70 minutes at being placed in 100 DEG C, and taking-up is cooled to 45 DEG C, standby;10 times of its quality is added in taken black millet Water, soak 8 hours, pull out and drain, it is standby;
Step 3, will steam after be cooled to 45 DEG C of wild aconite root and galangal Chinese medicinal granule and immersion after black millet mixing Mixture is obtained after uniform, the distiller's yeast of its quality 3% and the water of 20 times of quality are added in the resulting mixture, be well mixed again It is placed in ceramic vessel and ferments 3 days, takes out fermentate;In gained fermentate, the water of 20 times of its quality is added, be heated to 70 DEG C Immersion 6 hours, filters to obtain liquid A, standby;
Step 4, the Chinese medicinal granule that taken Radix Angelicae Sinensis and cloves are ground into a diameter of 8.0mm;In gained Chinese medicinal granule, Add taken watter milkwort root leaf or bark to be well mixed, obtain mixture, be subsequently adding the bafillus natto and quality of mixture quality 3% 4% sterilized water, is well mixed again, is placed in ceramic vessel and ferments 3 days, takes out tunning;In gained tunning, The white wine of 6 times of tunning quality is added, immersion is heated to 60 DEG C and is incubated 3 hours after 4 hours, be subsequently cooled to room temperature, filters Filtrate is taken, medical liquid B is obtained, it is standby;
Step 5, gained liquid A and medical liquid B are mixed, obtain liquid C;Taken brown granulated sugar is placed in iron pan and is fried to Jiao Yellow, is added in liquid C, and stirring stands 26 hours to being completely dissolved, filtering, and gained liquid is to prepare treatment rheumatic Arthritic medicinal liquor.
Clinical test
1st, experimental subjects:Through patient 200 of the regular examination in hospital with rheumatic arthritis, there is Bones and joints office in patient The symptom of portion's redness, pain, heating and limitation of movement.
2nd, treatment method:Oral medication treats the medicinal liquor of rheumatic arthritis, and morning and evening administered at empty stomach is used once, 5 milliliters every time, Calculated when medication, sugar and sweet food, and the thing that overheat is subcooled should not be eaten within 2 hours.Auxiliary treatment rheumatic Arthritic medicinal liquor applies outward arthritis sore spot in right amount;It is within 7 days 1 course for the treatment of.
3rd, evaluation criterion is treated:
Cure:Illness disappears, muscle is light, and Bones and joints freedom of movement, adverse reaction disappears;
It is effective:Pain relief, inflammation mitigates, adverse reaction reduction;
Effectively:Meet healing or effective standard.
It is invalid:The state of an illness is unchanged on inspection, without improvement sign.
4th, therapeutic effect:
Rheumatoid arthritis patients to 200 ages 16-62 Sui treat, wherein curing rheumatic arthritis 150 Example, effective 43, efficient as a result to prove the medicinal liquor of present invention treatment rheumatic arthritis up to 96.5%, formula is reasonable, prepares Method rationally, there is preferable therapeutic action to rheumatic arthritis.
Bafillus natto of the present invention, is common bafillus natto strain, can be commercially available by market.

Claims (1)

1. a kind of preparation method of the medicinal liquor for treating rheumatic arthritis, it is characterised in that:Comprise the following steps:
Step one, take 22 parts of wild aconite root, 10 parts of Radix Angelicae Sinensis, 10 parts of cloves, 10 parts of galangal, black millet 80 respectively according to parts by weight 32 parts of part, 9 parts of watter milkwort root leaf or bark and brown granulated sugar, it is standby;
Step 2, by taken wild aconite root and galangal, be ground into the Chinese medicinal granule that particle diameter is 2.5-5.0mm, it is standby;By in gained Medicine particle is steamed 50-70 minutes at being placed in 95-100 DEG C, and taking-up is cooled to 40-45 DEG C, standby;It is added in taken black millet The water of 5-10 times of quality, soaks 5-8 hours, pulls out and drains, standby;
Step 3, will steam after be cooled to 40-45 DEG C of wild aconite root and galangal Chinese medicinal granule and immersion after black millet mixing Mixture is obtained after uniform, the distiller's yeast and 15-20 times of water of its quality 2-3% are added in the resulting mixture, be well mixed again It is placed in ceramic vessel and ferments 2-3 days, takes out fermentate;In gained fermentate, the water of 15-20 times of its quality is added, heated Soaked 5-6 hours to 60-70 DEG C, filter to obtain liquid A, it is standby;
Step 4, the Chinese medicinal granule that taken Radix Angelicae Sinensis and cloves are ground into a diameter of 3.0-8.0mm;In gained Chinese medicinal granule, Add taken watter milkwort root leaf or bark to be well mixed, obtain mixture, be subsequently adding the bafillus natto and 2- of mixture quality 2-3% 4% sterilized water, is well mixed again, is placed in ceramic vessel and ferments 2-3 days, takes out tunning;In gained tunning In, the white wine of 3-6 times of tunning quality is added, immersion is heated to 50-60 DEG C and is incubated 2-3 hours, then cools down after 3-4 hours To room temperature, filtrate is filtered to take, obtain medical liquid B, it is standby;
Step 5, gained liquid A and medical liquid B are mixed, obtain liquid C;Taken brown granulated sugar is placed in iron pan and is fried to coke yellow, It is added in liquid C, stirring stands 24-26 hours to being completely dissolved, filtering, gained liquid is to prepare treatment rheumatic to close Save scorching medicinal liquor.
CN201410549736.4A 2014-10-17 2014-10-17 A kind of preparation method of the medicinal liquor for treating rheumatic arthritis Active CN104306852B (en)

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CN1368341A (en) * 2001-02-05 2002-09-11 杨孟君 Nano medicine 'Pitong' and its preparing process
CN101095710A (en) * 2007-07-11 2008-01-02 浙江大学 Method for improving the main efficacy composition of panax notoginseng through zymolysis
CN103484288A (en) * 2013-08-19 2014-01-01 刘军科 Method for improving effect of medicinal liquor and probiotic composition

Patent Citations (3)

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CN1368341A (en) * 2001-02-05 2002-09-11 杨孟君 Nano medicine 'Pitong' and its preparing process
CN101095710A (en) * 2007-07-11 2008-01-02 浙江大学 Method for improving the main efficacy composition of panax notoginseng through zymolysis
CN103484288A (en) * 2013-08-19 2014-01-01 刘军科 Method for improving effect of medicinal liquor and probiotic composition

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