CN104043146A - Medical sponge for anesthesia department and preparation method thereof - Google Patents
Medical sponge for anesthesia department and preparation method thereof Download PDFInfo
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- CN104043146A CN104043146A CN201410288043.4A CN201410288043A CN104043146A CN 104043146 A CN104043146 A CN 104043146A CN 201410288043 A CN201410288043 A CN 201410288043A CN 104043146 A CN104043146 A CN 104043146A
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Abstract
The invention relates to medical sponge for the anesthesia department and a preparation method thereof. The sponge is mainly prepared from the following raw materials in parts by weight: 10-13 parts of cicada slough, 20-26 parts of corydalis tuber, 9-13 parts of pericarpium papaveris, 18-25 parts of myrrh, 5-9 parts of tubeflower duchmans pipe root, 11-14 parts of cuttlebone, 18-22 parts of camphor, 6-13 parts of dragon blood, 20-27 parts of common cyanotis root, 7-11 parts of radix clematidis and 16-25 parts of frankincense. According to the medical sponge, traditional Chinese medicinal materials with an anaesthetic pain relieving effect are added into the sponge, so that the sponge can quickly act when being used for operative anesthesia, especially local anesthesia, and can maximally achieve the effect of relieving pains of patients; the traditional Chinese medicinal formula in the sponge is scientific, and the sponge is prepared from a plurality of pure natural traditional Chinese medicinal materials in an appropriate method, so that the medical sponge is low in price and convenient to use, and does not have toxic or side effect.
Description
Technical field
The present invention relates to a kind of Anesthesia Department medicated sponge and preparation method, belonged to Chinese medicine field, be mainly used in surgery anesthesia and analgesia.
Background technology
Anesthesia refers to make patient when undergoing surgery or have wound operation, not feel pain and uncomfortable state.It is generally acknowledged, anesthesia is that a kind of nervus centralis of being produced by medicine or additive method and (or) the reversibility function of peripheral nervous system suppress, and the feature of this inhibition is mainly to feel the particularly forfeiture of the pain sensation.Clinically, anesthesia mainly comprises general anesthesia and local anesthesia.General anesthesia refers to anesthetics is entered in body by suction, vein, intramuscular injection or rectal perfusion, and central nervous system is suppressed, and causes patient to realize and disappears and the process of the painless feel in the whole body.This anesthesia method is " sleeping state " as the saying goes, and feature is that patient realizes disappearance, and whole-body muscle is lax, experiences less than pain.The most frequently used general anesthesia mode is intubation and general anaesthesia, and feature is to adopt intravenous anesthetic or inhalation anesthetic to produce general anesthesia effect, needs circulation of qi promoting cannula in art, and mechanical assistance is breathed.Local anesthesia is to utilize local anesthetic as procaine, lignocaine etc., is injected at corresponding site spinal nerves, plexus nervorum or nerve trunk and the thinner peripheral termination of nerve are blocked, and a certain position of health is temporarily lost sensibility.The feature of local anesthesia is exactly " part " that anesthesia is confined to health, and patient's consciousness is regained consciousness.Conventional method comprises intravertebral anesthesia (retardance), nerve block, field block, local infiltration anesthesia and topical anesthesia etc.
In the pertinent literature of existing anesthesia Chinese medicine, Granted publication CN 102133323 B(application number 201110049132.X) Chinese patent literature discloses a kind of herbal anesthetic, raw material by following parts by weight is made: Venenum Bufonis 13-15 part, Radix Aconiti 8-13 part, Radix Aconiti Kusnezoffii 7-13 part, Pericarpium Zanthoxyli 20-25 part, Herba Asari 16-20 part, Radix Zanthoxyli 15-18 part, Borneolum Syntheticum 7-10 part, Folium Et Cacumen Murrayae 20-30 part, Herba Houttuyniae 4-6 part, Galla Chinensis 2-4 part, Folium Artemisiae Argyi 6-8 part, Rhizoma Paridis 4-6 part, Herba Taraxaci 4-6 part, Fructus Bruceae 4-6 part, Radix Notoginseng 100-130 part and 75% ethanol 600-700 part.Application publication number CN 103705791 A(application numbers 201410017120.2) Chinese patent literature discloses a kind of medicine for clinical anesthesia and preparation method, belongs to the field of Chinese medicines; The raw material of effective ingredient of the present invention consists of Venenum Bufonis, Caulis Spatholobi, Hex godajam (colebr) Wall, Moschus, Camphora, Herba Lycopodii, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Borneolum Syntheticum, Flos Daturae, the Radix Angelicae Dahuricae, Fructus Piperis Longi, Rhizoma Imperatae, Fructus Piperis, Rhizoma Arisaematis, Coriaria sinica and Radix Cirsii Japonici.
At present, comprise that the prior art of above-mentioned patent documentation is remaining deficiency aspect solution anesthesia and pain relief, such as uncertain therapeutic efficacy is cut, with high costs, use inconvenience etc.A kind of Anesthesia Department medicated sponge is badly in need of in clinical practice.
Summary of the invention
For the deficiencies in the prior art, the object of the present invention is to provide a kind of effective lenitive Anesthesia Department medicated sponge and preparation method.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of Anesthesia Department medicated sponge, taking off the primary raw material of stating weight proportion is prepared from: Periostracum Cicadae 10-13 part, Rhizoma Corydalis 20-26 part, Pericarpium Papaveris 9-13 part, Myrrha 18-25 part, Radix aristolochiae tubiflorae 5-9 part, Endoconcha Sepiae 11-14 part, Camphora 18-22 part, Sanguis Draxonis 6-13 part, Radix Cyanotis vagae 20-27 part, Radix Clematidis 7-11 part, Olibanum 16-25 part.
Above-mentioned a kind of Anesthesia Department medicated sponge, preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: Periostracum Cicadae 11-12 part, Rhizoma Corydalis 22-24 part, Pericarpium Papaveris 10-12 part, Myrrha 20-23 part, Radix aristolochiae tubiflorae 6-8 part, Endoconcha Sepiae 12-13 part, Camphora 19-21 part, Sanguis Draxonis 9-10 part, Radix Cyanotis vagae 22-25 part, Radix Clematidis 8-10 part, Olibanum 19-22 part.
The above a kind of Anesthesia Department medicated sponge, better preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: 12 parts of Periostracum Cicadaes, 23 parts of Rhizoma Corydalis, 11 parts of Pericarpium Papaveriss, 22 parts of Myrrhas, 7 parts of Radix aristolochiae tubifloraes, 13 parts of Endoconcha Sepiaes, 20 parts of Camphoras, 10 parts of Sanguis Draxonis, 24 parts of Radix Cyanotis vagae, 9 parts of Radix Clematidis, 21 parts of Olibanums.
According to arbitrary described medicated sponge above, its preparation methods steps is as follows:
(1) get clean Periostracum Cicadae and Pericarpium Papaveris, slowly adding consumption is the refined honey that 0.3-0.5 doubly measures, and adds a cover moistening 20-60 minute (preferably 40 minutes), treats that sweet liquid inhales thoroughly, puts in heat pot and constantly fries to buff, take that to loosen tack-free be degree, taking-up airing;
(2) get clean Endoconcha Sepiae and be placed in and forge in tank, upper cover one pannikin, commissure, with yellow mud sealing, is put several rice on pannikin, with slow fire grilling, wait a meter zoom Huang, after ceasing fire, takes out, and must forge Endoconcha Sepiae, cools standby;
(3) by weight ratio, be the preferred 3:1 of 2-4:1() yellow wine and vinegar be mixed to get adjuvant, get clean Myrrha, Olibanum and Sanguis Draxonis, adding weight is the adjuvant that 0.2-0.4 doubly measures, slightly moistening, after liquid is sucked, is placed in marmite, with slow fire, heat, fry the aobvious glossy gloss to surface, taking-up is dried in the air cool, standby;
(4) Rhizoma Corydalis, Radix Cyanotis vagae, Radix aristolochiae tubiflorae, Radix Clematidis and step (1)-(3) gains are pulverized, cross 60-100 mesh sieve, add 1-3 times of water gaging to decoct 2-4 hour (preferably 3 hours), centrifugalize, Camphora is smashed to pieces with supernatant and is mixed, add dehydrated alcohol to make to reach 50% containing alcohol amount, standing 50-130 minute, filters;
(5) chitosan being mixed with to mass concentration with 1% glacial acetic acid solution is 3% chitosan solution, mixes with the ratio of 1:1 with step (4) gained filtrate;
(6) by step (5) gained solution, fish gelatin solution, by the volume ratio of 5:2:3, mix vacuumize degassing with glycerol;
(7) step (6) gained mixed liquor is placed in to silica gel mould (6cm * 3cm * 1.5cm), in-60 ℃ of freezing 16-21 hour, puts in freezer dryer-80 ℃ of lyophilisation 40 hours, Ji get Anesthesia Department medicated sponge.
According to preparation method recited above, preferably scheme is, 0.4 times of amount of consumption of step (1) refined honey.
According to preparation method recited above, preferred scheme is that the consumption of step (3) adjuvant is 0.3 times of amount.
According to preparation method recited above, preferred scheme is that step (4) is crossed 70-90 mesh sieve (preferably 80 mesh sieves).
According to preparation method recited above, preferred scheme is that step (4) amount of water is 2 times.
According to preparation method recited above, preferred scheme is that step (4) time of repose is 80-100 minute (preferably 90 minutes).
According to preparation method recited above, preferred scheme is that step (7) cooling time is 17-20 hour (preferably 19 hours).
Anesthesia Department's medicated sponge, the pharmacological effect of contained raw material is respectively:
Periostracum Cicadae: sweet, salty, cool.Return lung, Liver Channel.Effect: dispelling wind-heat, rash sore-throat relieving, expellings wind and relieving convulsion.Cure mainly anemopyretic cold, laryngopharynx swelling and pain, cough hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion cataracta, infantile convulsion is twitched, tetanus.
Rhizoma Corydalis: be the tuber of papaveraceae plant corydalis.Invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.
Pericarpium Papaveris: sour, puckery, be slightly cold.Return lung, kidney, large intestine channel.The astringing intestine to stop diarrhea of astringing the lung, reinforces the kidney, pain relieving.Cure mainly chronic cough due to asthenia of viscera, pant, have loose bowels, dysentery, proctoptosis, seminal emission, leucorrhea, trusted subordinate and bones and muscles pain.
Myrrha: be the gum resin of olive subject plant myrrh or Alan fort myrrh.Loose blood blood stasis removing, subduing swelling and relieving pain.Control and fall damage, incised wound, muscles and bones, all Tong ， of trusted subordinate mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.
Radix aristolochiae tubiflorae: be root or the herb of Aristolochiaceae birthwort Fructus Aristolochiae.Pungent, hardship, flat, gas fragrance, slightly poisonous.Heat-clearing and toxic substances removing, promoting the circulation of QI to relieve pain.Treatment of ulcer furuncle and phyma, venom, gastralgia, enteritis and dysentery, diarrhoea, Fengshi Guanjie pain, dysmenorrhea, traumatic injury.
Endoconcha Sepiae: be the inner shell of the multiple sepiellae seu sepiaes such as Sepiidae sepiella maindroni de Rochebrune, Sepia animal golden cuttlefish.Salty, puckery, temperature.Return liver, kidney channel.Astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.Cure mainly haematemesis, hematemesis, metrorrhagia, has blood in stool, epistaxis, wound hemorrhage, emission due to deficiency of the kidney spermatorrhea, leucorrhea with red and white discharge, has a stomachache noisy, belch pantothenic acid, eczema ulcer.
Camphora: pungent, heat, mild toxicity.GUIXIN, spleen channel.Sensible ward off dirty, killing parasites for relieving itching, reducing swelling and alleviating pain.Cure mainly calentura coma, Sino-Russian dampinging off, acute filthy disease is vomited and diarrhoea and is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, scabies stubborn dermatitis, tinea alba, chilblain, ecthyma, burn due to hot liquid or fire, traumatic pain, toothache, wind-fire acute conjunctivitis.
Sanguis Draxonis: be the resin in Palmae Daemonorops plant Sanguis Draxonis fruit and rattan.Sweet, salty, flat, mild toxicity.Dissipating blood stasis analgesic therapy, hemostasis, promoting tissue regeneration and ulcer healing.Cure mainly traumatic injury, ecchymoma due to internal injury, dysmenorrhea, postpartum stagnation stomachache, continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time and hemorrhoid.
Radix Cyanotis vagae: be the whole herb with root of grass family Eragrostis plant dust-brand Herba Eragrostidis pilosae.Micro-sweet, flat, mild toxicity.Return liver, stomach, kidney channel.Wind-expelling pain-stopping, counteracting toxic substances detumescence, killing parasites for relieving itching.Cure mainly rheumatic arthralgia, wind carious pain, ulcer sores, scrofula, mouthpiece swells and ache, anal fistula, rubella pruritus, skin stubborn dermatitis.
Radix Clematidis: be the root and rhizome of Ranunculaceae Actions of Clematis Species Radix Clematidis, Clematis hexapetala, northeast clematis.Pungent, salty, micro-hardship, temperature, mild toxicity.Return bladder, Liver Channel.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.Cure mainly rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, beriberi swells and ache, malaria, the bone larynx of choking with sobs.And control phlegm retention and gather.
Olibanum: the oleo-gum-resin of oozing out for skin zones such as Burseraceae Boswellia plant Boswellia carterii, Bao Da Boswellia carterii, wild Boswellia carteriis.Pungent, bitter, temperature.GUIXIN, liver, spleen channel.Invigorate blood circulation, circulation of qi promoting, pain relieving.Cure mainly trusted subordinate's pain, amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, traumatic injury stasis of blood pain, swollen ulcer drug, the sore being festered and unhealed.
Beneficial effect of the present invention is:
The Chinese medicine with analgesia effectiveness is added in sponge, in surgery anesthesia, particularly during local anesthesia, can play quick acting, to the greatest extent the effect of the maximum pain that may reduce patient; Contained Chinese prescription science in sponge, is obtained through the appropriate process of preparing Chinese medicine by multiple natural Chinese medicines material, so the present invention is cheap, easy to use, and without any side effects.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1anesthesia Department's medicated sponge, takes off the primary raw material of stating weight proportion and is prepared from (getting 16g for every part): 10 parts of Periostracum Cicadaes, 20 parts of Rhizoma Corydalis, 9 parts of Pericarpium Papaveriss, 18 parts of Myrrhas, 5 parts of Radix aristolochiae tubifloraes, 11 parts of Endoconcha Sepiaes, 18 parts of Camphoras, 6 parts of Sanguis Draxonis, 20 parts of Radix Cyanotis vagae, 7 parts of Radix Clematidis, 16 parts of Olibanums.
The preparation method of above-mentioned a kind of Anesthesia Department medicated sponge, step is as follows:
(1) get clean Periostracum Cicadae and Pericarpium Papaveris, slowly adding consumption is the refined honey of 0.3 times of amount, adds a cover moistening 20 minutes, treats that sweet liquid inhales thoroughly, puts in heat pot and constantly fries to buff, take that to loosen tack-free be degree, taking-up airing;
(2) get clean Endoconcha Sepiae and be placed in and forge in tank, upper cover one pannikin, commissure, with yellow mud sealing, is put several rice on pannikin, with slow fire grilling, wait a meter zoom Huang, after ceasing fire, takes out, and must forge Endoconcha Sepiae, cools standby;
(3) yellow wine and the vinegar that by weight ratio, are 2:1 are mixed to get adjuvant, get clean Myrrha, Olibanum and Sanguis Draxonis, and adding weight is the adjuvant of 0.2 times of amount, slightly moistening, after liquid is sucked, be placed in marmite, with slow fire, heat, fry the aobvious glossy gloss to surface, taking-up is dried in the air cool, standby;
(4) Rhizoma Corydalis, Radix Cyanotis vagae, Radix aristolochiae tubiflorae, Radix Clematidis and step (1)-(3) gains are pulverized, crossed 60 mesh sieves, add 1 times of water gaging to decoct 2 hours, centrifugalize, Camphora is smashed to pieces with supernatant and is mixed, and adds dehydrated alcohol to make to reach 50% containing alcohol amount, standing 50 minutes, filter;
(5) chitosan being mixed with to mass concentration with 1% glacial acetic acid solution is 3% chitosan solution, mixes with the ratio of 1:1 with step (4) gained filtrate;
(6) by step (5) gained solution, fish gelatin solution, by the volume ratio of 5:2:3, mix vacuumize degassing with glycerol;
(7) step (6) gained mixed liquor is placed in to silica gel mould (6cm * 3cm * 1.5cm), in-60 ℃ freezing 16 hours, put in freezer dryer-80 ℃ of lyophilisation 40 hours, Ji get Anesthesia Department medicated sponge.
typical case onekorea Spro XX, female, 28 years old.Because eyelid cutis laxa is sagging, sometimes block the visual field in April, 2013, goes to hospital to accept eyelid operation, and before operation, with embodiment 1 gained medicated sponge, stick in eyelid place patient is carried out to local anesthesia, after 10 minutes, anesthesia onset.
embodiment 2anesthesia Department's medicated sponge, takes off the primary raw material of stating weight proportion and is prepared from (getting 8g for every part): 13 parts of Periostracum Cicadaes, 26 parts of Rhizoma Corydalis, 13 parts of Pericarpium Papaveriss, 25 parts of Myrrhas, 9 parts of Radix aristolochiae tubifloraes, 14 parts of Endoconcha Sepiaes, 22 parts of Camphoras, 13 parts of Sanguis Draxonis, 27 parts of Radix Cyanotis vagae, 11 parts of Radix Clematidis, 25 parts of Olibanums.
The preparation method of above-mentioned a kind of Anesthesia Department medicated sponge, step is as follows:
(1) get clean Periostracum Cicadae and Pericarpium Papaveris, slowly adding consumption is the refined honey of 0.5 times of amount, adds a cover moistening 60 minutes, treats that sweet liquid inhales thoroughly, puts in heat pot and constantly fries to buff, take that to loosen tack-free be degree, taking-up airing;
(2) get clean Endoconcha Sepiae and be placed in and forge in tank, upper cover one pannikin, commissure, with yellow mud sealing, is put several rice on pannikin, with slow fire grilling, wait a meter zoom Huang, after ceasing fire, takes out, and must forge Endoconcha Sepiae, cools standby;
(3) yellow wine and the vinegar that by weight ratio, are 4:1 are mixed to get adjuvant, get clean Myrrha, Olibanum and Sanguis Draxonis, and adding weight is the adjuvant of 0.4 times of amount, slightly moistening, after liquid is sucked, be placed in marmite, with slow fire, heat, fry the aobvious glossy gloss to surface, taking-up is dried in the air cool, standby;
(4) Rhizoma Corydalis, Radix Cyanotis vagae, Radix aristolochiae tubiflorae, Radix Clematidis and step (1)-(3) gains are pulverized, crossed 100 mesh sieves, add 3 times of water gagings to decoct 4 hours, centrifugalize, Camphora is smashed to pieces with supernatant and is mixed, and adds dehydrated alcohol to make to reach 50% containing alcohol amount, standing 130 minutes, filter;
(5) chitosan being mixed with to mass concentration with 1% glacial acetic acid solution is 3% chitosan solution, mixes with the ratio of 1:1 with step (4) gained filtrate;
(6) by step (5) gained solution, fish gelatin solution, by the volume ratio of 5:2:3, mix vacuumize degassing with glycerol;
(7) step (6) gained mixed liquor is placed in to silica gel mould (6cm * 3cm * 1.5cm), in-60 ℃ freezing 21 hours, put in freezer dryer-80 ℃ of lyophilisation 40 hours, Ji get Anesthesia Department medicated sponge.
embodiment 3anesthesia Department's medicated sponge, takes off the primary raw material of stating weight proportion and is prepared from (getting 9g for every part): 11 parts of Periostracum Cicadaes, 22 parts of Rhizoma Corydalis, 10 parts of Pericarpium Papaveriss, 20 parts of Myrrhas, 6 parts of Radix aristolochiae tubifloraes, 12 parts of Endoconcha Sepiaes, 19 parts of Camphoras, 9 parts of Sanguis Draxonis, 22 parts of Radix Cyanotis vagae, 8 parts of Radix Clematidis, 19 parts of Olibanums.
The preparation method of above-mentioned a kind of Anesthesia Department medicated sponge, step is as follows:
(1) get clean Periostracum Cicadae and Pericarpium Papaveris, slowly adding consumption is the refined honey of 0.3 times of amount, adds a cover moistening 20 minutes, treats that sweet liquid inhales thoroughly, puts in heat pot and constantly fries to buff, take that to loosen tack-free be degree, taking-up airing;
(2) get clean Endoconcha Sepiae and be placed in and forge in tank, upper cover one pannikin, commissure, with yellow mud sealing, is put several rice on pannikin, with slow fire grilling, wait a meter zoom Huang, after ceasing fire, takes out, and must forge Endoconcha Sepiae, cools standby;
(3) yellow wine and the vinegar that by weight ratio, are 2:1 are mixed to get adjuvant, get clean Myrrha, Olibanum and Sanguis Draxonis, and adding weight is the adjuvant of 0.2 times of amount, slightly moistening, after liquid is sucked, be placed in marmite, with slow fire, heat, fry the aobvious glossy gloss to surface, taking-up is dried in the air cool, standby;
(4) Rhizoma Corydalis, Radix Cyanotis vagae, Radix aristolochiae tubiflorae, Radix Clematidis and step (1)-(3) gains are pulverized, crossed 70 mesh sieves, add 1 times of water gaging to decoct 2 hours, centrifugalize, Camphora is smashed to pieces with supernatant and is mixed, and adds dehydrated alcohol to make to reach 50% containing alcohol amount, standing 80 minutes, filter;
(5) chitosan being mixed with to mass concentration with 1% glacial acetic acid solution is 3% chitosan solution, mixes with the ratio of 1:1 with step (4) gained filtrate;
(6) by step (5) gained solution, fish gelatin solution, by the volume ratio of 5:2:3, mix vacuumize degassing with glycerol;
(7) step (6) gained mixed liquor is placed in to silica gel mould (6cm * 3cm * 1.5cm), in-60 ℃ freezing 17 hours, put in freezer dryer-80 ℃ of lyophilisation 40 hours, Ji get Anesthesia Department medicated sponge.
embodiment 4anesthesia Department's medicated sponge, takes off the primary raw material of stating weight proportion and is prepared from (getting 5g for every part): 12 parts of Periostracum Cicadaes, 24 parts of Rhizoma Corydalis, 12 parts of Pericarpium Papaveriss, 23 parts of Myrrhas, 8 parts of Radix aristolochiae tubifloraes, 13 parts of Endoconcha Sepiaes, 21 parts of Camphoras, 10 parts of Sanguis Draxonis, 25 parts of Radix Cyanotis vagae, 10 parts of Radix Clematidis, 22 parts of Olibanums.
The preparation method of above-mentioned a kind of Anesthesia Department medicated sponge, step is as follows:
(1) get clean Periostracum Cicadae and Pericarpium Papaveris, slowly adding consumption is the refined honey of 0.5 times of amount, adds a cover moistening 60 minutes, treats that sweet liquid inhales thoroughly, puts in heat pot and constantly fries to buff, take that to loosen tack-free be degree, taking-up airing;
(2) get clean Endoconcha Sepiae and be placed in and forge in tank, upper cover one pannikin, commissure, with yellow mud sealing, is put several rice on pannikin, with slow fire grilling, wait a meter zoom Huang, after ceasing fire, takes out, and must forge Endoconcha Sepiae, cools standby;
(3) yellow wine and the vinegar that by weight ratio, are 4:1 are mixed to get adjuvant, get clean Myrrha, Olibanum and Sanguis Draxonis, and adding weight is the adjuvant of 0.4 times of amount, slightly moistening, after liquid is sucked, be placed in marmite, with slow fire, heat, fry the aobvious glossy gloss to surface, taking-up is dried in the air cool, standby;
(4) Rhizoma Corydalis, Radix Cyanotis vagae, Radix aristolochiae tubiflorae, Radix Clematidis and step (1)-(3) gains are pulverized, crossed 90 mesh sieves, add 3 times of water gagings to decoct 4 hours, centrifugalize, Camphora is smashed to pieces with supernatant and is mixed, and adds dehydrated alcohol to make to reach 50% containing alcohol amount, standing 100 minutes, filter;
(5) chitosan being mixed with to mass concentration with 1% glacial acetic acid solution is 3% chitosan solution, mixes with the ratio of 1:1 with step (4) gained filtrate;
(6) by step (5) gained solution, fish gelatin solution, by the volume ratio of 5:2:3, mix vacuumize degassing with glycerol;
(7) step (6) gained mixed liquor is placed in to silica gel mould (6cm * 3cm * 1.5cm), in-60 ℃ freezing 20 hours, put in freezer dryer-80 ℃ of lyophilisation 40 hours, Ji get Anesthesia Department medicated sponge.
typical case twofeng, man, 54 years old.There are the medical histories such as chronic cough, often vomiting, constipation, dysuria, abdominal operation, wound, previously have hernia incarceration history.The abnormal bulge of abdominal part, has ascites, hepatosplenomegaly, has while standing lump outstanding, through examination in hospital, is diagnosed as abdominal external hernia, and doctor advised carries out tension-free hernioplasty.Before operation, with embodiment 4 gained medicated sponge, stick in operative incision position patient is carried out to local anesthesia, after 15 minutes, anesthesia onset.
embodiment 5anesthesia Department's medicated sponge, takes off the primary raw material of stating weight proportion and is prepared from (getting 12g for every part): 12 parts of Periostracum Cicadaes, 23 parts of Rhizoma Corydalis, 11 parts of Pericarpium Papaveriss, 22 parts of Myrrhas, 7 parts of Radix aristolochiae tubifloraes, 13 parts of Endoconcha Sepiaes, 20 parts of Camphoras, 10 parts of Sanguis Draxonis, 24 parts of Radix Cyanotis vagae, 9 parts of Radix Clematidis, 21 parts of Olibanums.
The preparation method of above-mentioned a kind of Anesthesia Department medicated sponge, step is as follows:
(1) get clean Periostracum Cicadae and Pericarpium Papaveris, slowly adding consumption is the refined honey of 0.4 times of amount, adds a cover moistening 40 minutes, treats that sweet liquid inhales thoroughly, puts in heat pot and constantly fries to buff, take that to loosen tack-free be degree, taking-up airing;
(2) get clean Endoconcha Sepiae and be placed in and forge in tank, upper cover one pannikin, commissure, with yellow mud sealing, is put several rice on pannikin, with slow fire grilling, wait a meter zoom Huang, after ceasing fire, takes out, and must forge Endoconcha Sepiae, cools standby;
(3) just weight ratio is 3:1 yellow wine and vinegar are mixed to get adjuvant, get clean Myrrha, Olibanum and Sanguis Draxonis, and adding weight is the adjuvant of 0.3 times of amount, slightly moistening, after liquid is sucked, be placed in marmite, with slow fire, heat, fry the aobvious glossy gloss to surface, taking-up is dried in the air cool, standby;
(4) Rhizoma Corydalis, Radix Cyanotis vagae, Radix aristolochiae tubiflorae, Radix Clematidis and step (1)-(3) gains are pulverized, crossed 80 mesh sieves, add 2 times of water gagings to decoct 3 hours, centrifugalize, Camphora is smashed to pieces with supernatant and is mixed, and adds dehydrated alcohol to make to reach 50% containing alcohol amount, standing 90 minutes, filter;
(5) chitosan being mixed with to mass concentration with 1% glacial acetic acid solution is 3% chitosan solution, mixes with the ratio of 1:1 with step (4) gained filtrate;
(6) by step (5) gained solution, fish gelatin solution, by the volume ratio of 5:2:3, mix vacuumize degassing with glycerol;
(7) step (6) gained mixed liquor is placed in to silica gel mould (6cm * 3cm * 1.5cm), in-60 ℃ freezing 19 hours, put in freezer dryer-80 ℃ of lyophilisation 40 hours, Ji get Anesthesia Department medicated sponge.
experimental examplein order to verify that medicated sponge of the present invention has definite curative effect to the alleviation of anesthesia and pain in operation, patient's 178 examples of performing the operation during year March in March, 2012 to 2013 have been randomly drawed, male 96 examples wherein, female's 82 examples, age 16-77 year, body weight 55-83kg, patient is divided into experimental group and matched group at random, two groups are compared on age, sex, sick kind, Surgical Operation, and difference not statistically significant, has comparability.
Experimental group carries out local anesthesia with gained of the present invention Anesthesia Department medicated sponge to patient before operation and in operation, and matched group carries out conventional preoperative preparation, the patient who undergos surgery is carried out to subcutaneous injection is conventional anaesthetizes medication (as procaine etc.).
By one, do not know that the doctor of the situation of dividing into groups observes and record patient's pain visual imitation assessment (VAS) of postoperative 8h, calculates and draw the meansigma methods of scoring.The case load that occurs untoward reaction after record anesthesia.
The observed result of experimental group and matched group is as shown in table 1:
Table 1
Observed result is analyzed: patient's pain visual imitation assessment (VAS) of the postoperative 8h of experimental group is significantly less than matched group, the patient of illustrative experiment group is starkly lower than matched group in postoperative pain, so the embodiment of the present invention 5 gained medicated sponge anaesthetic effects are remarkable, and from untoward reaction generation statistical data, can find out, medicated sponge of the present invention is without any side effects.
Claims (10)
1.Yi Zhong Anesthesia Department medicated sponge, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Periostracum Cicadae 10-13 part, Rhizoma Corydalis 20-26 part, Pericarpium Papaveris 9-13 part, Myrrha 18-25 part, Radix aristolochiae tubiflorae 5-9 part, Endoconcha Sepiae 11-14 part, Camphora 18-22 part, Sanguis Draxonis 6-13 part, Radix Cyanotis vagae 20-27 part, Radix Clematidis 7-11 part, Olibanum 16-25 part.
2. a kind of Anesthesia Department medicated sponge according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: Periostracum Cicadae 11-12 part, Rhizoma Corydalis 22-24 part, Pericarpium Papaveris 10-12 part, Myrrha 20-23 part, Radix aristolochiae tubiflorae 6-8 part, Endoconcha Sepiae 12-13 part, Camphora 19-21 part, Sanguis Draxonis 9-10 part, Radix Cyanotis vagae 22-25 part, Radix Clematidis 8-10 part, Olibanum 19-22 part.
3. a kind of Anesthesia Department medicated sponge according to claim 1, is characterized in that, takes off the primary raw material of stating weight proportion and is prepared from: 12 parts of Periostracum Cicadaes, 23 parts of Rhizoma Corydalis, 11 parts of Pericarpium Papaveriss, 22 parts of Myrrhas, 7 parts of Radix aristolochiae tubifloraes, 13 parts of Endoconcha Sepiaes, 20 parts of Camphoras, 10 parts of Sanguis Draxonis, 24 parts of Radix Cyanotis vagae, 9 parts of Radix Clematidis, 21 parts of Olibanums.
4. according to the preparation method of the arbitrary described a kind of Anesthesia Department of claim 1-3 medicated sponge, it is characterized in that, step is as follows:
(1) get clean Periostracum Cicadae and Pericarpium Papaveris, slowly adding consumption is the refined honey that 0.3-0.5 doubly measures, and adds a cover moistening 20-60 minute (preferably 40 minutes), treats that sweet liquid inhales thoroughly, puts in heat pot and constantly fries to buff, take that to loosen tack-free be degree, taking-up airing;
(2) get clean Endoconcha Sepiae and be placed in and forge in tank, upper cover one pannikin, commissure, with yellow mud sealing, is put several rice on pannikin, with slow fire grilling, wait a meter zoom Huang, after ceasing fire, takes out, and must forge Endoconcha Sepiae, cools standby;
(3) by weight ratio, be the preferred 3:1 of 2-4:1() yellow wine and vinegar be mixed to get adjuvant, get clean Myrrha, Olibanum and Sanguis Draxonis, adding weight is the adjuvant that the 0.2-0.4 of Myrrha and Olibanum weight doubly measures, slightly moistening, after liquid is sucked, is placed in marmite, with slow fire, heat, fry the aobvious glossy gloss to surface, taking-up is dried in the air cool, standby;
(4) Rhizoma Corydalis, Radix Cyanotis vagae, Radix aristolochiae tubiflorae, Radix Clematidis and step (1)-(3) gains are pulverized, cross 60-100 mesh sieve, add 1-3 times of water gaging to decoct 2-4 hour (preferably 3 hours), centrifugalize, Camphora is smashed to pieces with supernatant and is mixed, add dehydrated alcohol to make to reach 50% containing alcohol amount, standing 50-130 minute, filters;
(5) chitosan being mixed with to mass concentration with 1% glacial acetic acid solution is 3% chitosan solution, mixes with the ratio of 1:1 with step (4) gained filtrate;
(6) by step (5) gained solution, fish gelatin solution, by the volume ratio of 5:2:3, mix vacuumize degassing with glycerol;
(7) step (6) gained mixed liquor is placed in to silica gel mould (6cm * 3cm * 1.5cm), in-60 ℃ of freezing 16-21 hour, puts in freezer dryer-80 ℃ of lyophilisation 40 hours, Ji get Anesthesia Department medicated sponge.
5. preparation method according to claim 4, is characterized in that, 0.4 times of amount of consumption of step (1) refined honey.
6. preparation method according to claim 4, is characterized in that, the consumption of step (3) adjuvant is 0.3 times of amount.
7. preparation method according to claim 4, is characterized in that, step (4) is crossed 70-90 mesh sieve (preferably 80 mesh sieves).
8. preparation method according to claim 4, is characterized in that, step (4) amount of water is 2 times.
9. preparation method according to claim 4, is characterized in that, step (4) time of repose is 80-100 minute (preferably 90 minutes).
10. preparation method according to claim 4, is characterized in that, step (7) cooling time is 17-20 hour (preferably 19 hours).
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| CN104435843A (en) * | 2014-12-10 | 2015-03-25 | 青岛市市立医院 | Local anesthetic for surgical incisions |
| CN105879125A (en) * | 2016-02-22 | 2016-08-24 | 青岛市市立医院 | Common sterilizing and disinfecting sponge for anesthesia department and preparation method of sponge |
| CN106725641A (en) * | 2017-04-18 | 2017-05-31 | 浙江海洋大学 | Simple cuttlefish dissection device |
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| CN102670757A (en) * | 2012-05-30 | 2012-09-19 | 聂树霞 | Narcotic |
| CN103071002A (en) * | 2012-12-24 | 2013-05-01 | 唐雅蓉 | Traditional Chinese medicine with anesthetic effect |
| CN103372173A (en) * | 2012-04-24 | 2013-10-30 | 李家波 | Quick-effective analgesic anaesthetic paste |
| CN103705791A (en) * | 2014-01-14 | 2014-04-09 | 朱洪远 | Medicament for clinical anesthesia and preparation method thereof |
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| CN1057918C (en) * | 1995-11-06 | 2000-11-01 | 孟宪增 | New matrix magnetic therapeutic anesthesia analgesic paste |
| CN1116078C (en) * | 2000-07-20 | 2003-07-30 | 海南新阳光药业有限公司 | Disposable adhesive dressing and its production process |
| JP2003081833A (en) * | 2001-09-13 | 2003-03-19 | Taisho Pharmaceut Co Ltd | Composition for mucosa application |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101695581A (en) * | 2009-10-26 | 2010-04-21 | 西北大学 | Method for preparing human-like collagen haemostatic sponge in scale |
| CN101979029A (en) * | 2010-10-06 | 2011-02-23 | 阚景祥 | Chinese medicinal narcotic |
| CN103372173A (en) * | 2012-04-24 | 2013-10-30 | 李家波 | Quick-effective analgesic anaesthetic paste |
| CN102670757A (en) * | 2012-05-30 | 2012-09-19 | 聂树霞 | Narcotic |
| CN103071002A (en) * | 2012-12-24 | 2013-05-01 | 唐雅蓉 | Traditional Chinese medicine with anesthetic effect |
| CN103705791A (en) * | 2014-01-14 | 2014-04-09 | 朱洪远 | Medicament for clinical anesthesia and preparation method thereof |
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| CN104435843A (en) * | 2014-12-10 | 2015-03-25 | 青岛市市立医院 | Local anesthetic for surgical incisions |
| CN105879125A (en) * | 2016-02-22 | 2016-08-24 | 青岛市市立医院 | Common sterilizing and disinfecting sponge for anesthesia department and preparation method of sponge |
| CN106725641A (en) * | 2017-04-18 | 2017-05-31 | 浙江海洋大学 | Simple cuttlefish dissection device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104784747A (en) | 2015-07-22 |
| CN104784748A (en) | 2015-07-22 |
| CN104784554A (en) | 2015-07-22 |
| CN104784553A (en) | 2015-07-22 |
| CN104043146B (en) | 2015-09-02 |
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