CN108339075A - Pharmaceutical composition and preparation method for treating osteoproliferation, lumbar muscle strain - Google Patents
Pharmaceutical composition and preparation method for treating osteoproliferation, lumbar muscle strain Download PDFInfo
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- CN108339075A CN108339075A CN201810495788.6A CN201810495788A CN108339075A CN 108339075 A CN108339075 A CN 108339075A CN 201810495788 A CN201810495788 A CN 201810495788A CN 108339075 A CN108339075 A CN 108339075A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The present invention relates to field of medicaments, in particular to a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain and preparation method.Raw material includes mainly：Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae.Monarch drug in a prescription of the water fiber crops as pharmaceutical composition from root treatment osteoproliferation, reduces inflammation.The ministerial drug of Rhizoma Chuanxiong and corydalis tuber as pharmaceutical composition, as adjutant, sensible yang-energy, promoting the circulation of qi removing toxic substances assist monarch drug in a prescription and are treated with ministerial drug for blood-activating and qi-promoting, analgesic, the inflammation for reducing waist muscle, leek roots and Bulbus Allii Fistulosi.Pepper, which is used as, makes medicine, dissolving phlegm, removing toxic substances that complication be effectively relieved.Kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae dispellieg cold and dampness, treatment rheumatism, reconcile drug it is strong, promote blood circulation, assist the through lesion such as monarch drug in a prescription, ministerial drug, promote drug reach lesion time and assimilation effect；Treatment waist distending pain is ached, and recurrent exerbation is avoided.
Description
Technical field
The present invention relates to field of medicaments, in particular to a kind of for treating osteoproliferation, the medicine group of lumbar muscle strain
Close object and preparation method.
Background technology
Hyperostosis be also known as hyperplastic osteoarthritis, Osteoarthritis, degenerative joint disease, senescent arthritis,
Hypertrophiarthritis is the denaturation of the soft tissues such as cartilage, interverbebral disc, ligament due to constituting joint, degenerates, and joint margins form bone
Thorn, the variations such as synovial membrane plumpness, and there is osteoclasia, cause secondary osteoproliferation, lead to dysarthrasis, when by abnormal load
When lotus, cause arthralgia, a kind of disease of the symptoms such as limitation of activity is divided to primary and two kinds secondary.
Currently, there are many method for the treatment of osteoproliferation, doctor trained in Western medicine mainly uses based on operation, and supplemented by drug therapy, recurrence can
Energy property is higher, cannot eradicate sufferer, unsatisfactory curative effect.
Invention content
The purpose of the present invention is to provide a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain and preparation side
Method is intended to improve the bad problem of existing curative effect of medication.
The present invention provides a kind of technical solution：
It is a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, for treating osteoproliferation, lumbar muscle strain
The raw material of pharmaceutical composition includes mainly the following components counted in parts by weight：
10-20 parts of water fiber crops, 2-9 parts of Rhizoma Chuanxiong, 3-9 parts of corydalis tuber, 2-8 parts of leek roots, 1-7 parts of Bulbus Allii Fistulosi, 1-5 parts of pepper, kaempferia galanga
2-6 parts, 11-17 parts windproof, 4-12 parts of Rhizoma Et Radix Notopterygii, 2-7 parts of Radix Glycyrrhizae, 7-13 parts of pinellia.
The present invention also provides a kind of technical solutions：
It is a kind of above-mentioned for treating osteoproliferation, the preparation method of the pharmaceutical composition of lumbar muscle strain, including：
Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae, pinellia are mixed to get
Mixture is ground into the medicinal powder of 200-300 mesh by mixture；
Use alcoholic strength that alcohol is obtained by filtration after boiling 20-30 minutes at 0.2-0.3MPa for the wine of 55-65% in medicinal powder
Extract.
It is provided in an embodiment of the present invention to be used to treat having for osteoproliferation, the pharmaceutical composition of lumbar muscle strain and preparation method
Beneficial effect is：
Monarch drug in a prescription of the water fiber crops as pharmaceutical composition, primary treatment rheumatic arthritis from root treatment osteoproliferation, reduce
Inflammation.The ministerial drug of Rhizoma Chuanxiong and corydalis tuber as aforementioned pharmaceutical compositions, blood-activating and qi-promoting, analgesic, the inflammation for reducing waist muscle, delays
Solve osteoproliferation or the pain of lumbar muscle strain.The adjutant of leek roots and Bulbus Allii Fistulosi as pharmaceutical composition, sensible yang-energy, promoting the circulation of qi solution
Poison assists monarch drug in a prescription and is treated with ministerial drug.Make medicine of the pepper as aforementioned pharmaceutical compositions, complication is effectively relieved in dissolving phlegm, removing toxic substances.
Kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae dispellieg cold and dampness, treatment rheumatism, reconcile drug it is strong, promote blood circulation, assist monarch drug in a prescription, ministerial drug
Etc. through lesion, time and assimilation effect that drug reaches lesion are promoted；Treatment waist distending pain is ached, and recurrent exerbation is avoided.
Safflower, pyrola, Moschus, safflower, radix aconiti agrestis etc. can auxiliary water fiber crops treat arthralgia, auxiliary Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae
Etc. promoting blood circulation and removing blood stasis, promote blood circulation, treat osteoproliferation, improve lumbar pressure, avoid it is overworked caused by damage.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
Below to the embodiment of the present invention for treat osteoproliferation, the pharmaceutical composition of lumbar muscle strain and preparation method into
Row illustrates.
It is a kind of to be used to treat osteoproliferation, the pharmaceutical composition of lumbar muscle strain, for treating osteoproliferation or psoas labor
Damage.By treat osteoproliferation, lumbar muscle strain pharmaceutical composition raw material mainly include in parts by weight based on following components：
10-20 parts of water fiber crops, 2-9 parts of Rhizoma Chuanxiong, 3-9 parts of corydalis tuber, 2-8 parts of leek roots, 1-7 parts of Bulbus Allii Fistulosi, 1-5 parts of pepper, kaempferia galanga
2-6 parts, 11-17 parts windproof, 4-12 parts of Rhizoma Et Radix Notopterygii, 2-7 parts of Radix Glycyrrhizae.
Water fiber crops are the herb of contrayerva great Ye ramies, for treating rheumatic arthritis, rheumatoid arthritis, branch
Tracheitis etc..
Monarch drug in a prescription of the water fiber crops as aforementioned pharmaceutical compositions, primary treatment rheumatic arthritis, from root treatment osteoproliferation,
Reduce inflammation.
Rhizoma Chuanxiong is usually used in blood-activating and qi-promoting, and wind-expelling pain-stopping, Rhizoma Chuanxiong pungent-warm perfume (or spice) is dry, walks without keeping, and can go scattered, and uplink is up to mountain peak
Top；Enter blood system again, downlink is up to the sea of blood.Promoting blood circulation effect is extensive, suitable for the various illnesss of stagnation of blood stasis；Wind-expelling pain-stopping, effectiveness
It is favourable, the diseases such as head wind headache, arthralgia pain due to rheumatism can be controlled.
Corydalis tuber cures mainly promoting blood circulation；Dissipate the stasis of blood；Qi-regulating；Analgesic.The main all pains of trusted subordinate's waist and knee；Irregular menstruation；Abdominal mass；Metrorrhagia；Postpartum
Bruise；Lochiorrhagia；Traumatic injury.
The ministerial drug of Rhizoma Chuanxiong and corydalis tuber as aforementioned pharmaceutical compositions, blood-activating and qi-promoting, analgesic, the inflammation for reducing waist muscle
Disease alleviates osteoproliferation or the pain of lumbar muscle strain.
Leek roots have the effect of middle benefit gas, promoting the circulation of qi, the scattered stasis of blood, removing toxic substances.It is usually used in interior cold abdominal pain, dyspeptic abdominal distention, obstruction of qi in the chest pain is red
Under leukorrhea, bleeding from five sense organs or subcutaneous tissue is spitted blood, dermatitis rhus, sore tinea, traumatic injury.
Bulbus Allii Fistulosi has the effect of inducing sweat and dispelling exogenous evils, sensible yang-energy.It is mainly used for catching cold, yin-cold excess, refusing yang is in outer, arteries and veins
It is micro-, it faints inverse, diarrhea, external application for curing sore carbuncle serious case of furuncle.
The adjutant of leek roots and Bulbus Allii Fistulosi as aforementioned pharmaceutical compositions, sensible yang-energy, promoting the circulation of qi removing toxic substances, assists monarch drug in a prescription and is controlled with ministerial drug
It treats.
Pepper middle benefit gas, lower gas, dissolving phlegm, removing toxic substances.Cold phlegm dyspepsia, coldness and pain in the epigastrium are controlled, clear water, diarrhea, cold dysentery are vomitted in gastric disorder causing nausea.
And solve bromatotoxin.
Make medicine of the pepper as aforementioned pharmaceutical compositions, complication is effectively relieved in dissolving phlegm, removing toxic substances.
Kaempferia galanga is acrid in flavour and warm in nature.Returns spleen, stomach.Warming middle-JIAO for eliminating dampness, promoting qi circulation and relieving pain.For chest and abdomen crymodynia, cold-dampness is vomited and diarrhoea, bone sticking larynx, tooth
Bitterly, treating swelling and pain by traumatic injury etc..
It is windproof to expel pathogenic wind from the body surface, the effect of expel endogenous wind to relieve convulsion, relieving convulsion.For diseases caused by external factors exterior syndrome, rubella itch, arthralgia pain due to rheumatism is broken
It catches cold just, the insufficiency of the spleen with overabundance of dampness.
Rhizoma Et Radix Notopterygii is warm-natured, dispellieg cold and dampness, for catching cold, headache and adiapneustia, cold-dampness numbness, upper limb rheumatalgia pain.
Radix Glycyrrhizae gas is micro-, sweet and special.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc., can reconcile some drugs
It is strong.
Kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae dispellieg cold and dampness, treatment rheumatism, reconcile drug it is strong, promote blood circulation, assist monarch
The through lesion such as medicine, ministerial drug promotes time and assimilation effect that drug reaches lesion；Treatment waist distending pain is ached, and is avoided anti-
Recurrence is made.
Further, above-mentioned raw materials include mainly the following components counted in parts by weight：
12-16 parts of water fiber crops, 4-8 parts of Rhizoma Chuanxiong, 4-7 parts of corydalis tuber, 3-6 parts of leek roots, 4-6 parts of Bulbus Allii Fistulosi, 2-4 parts of pepper, kaempferia galanga
3-5 parts, 14-16 parts windproof, 8-10 parts of Rhizoma Et Radix Notopterygii, 4-6 parts of Radix Glycyrrhizae.
In the present embodiment, above-mentioned raw materials include mainly the following components counted in parts by weight：
Water fiber crops 15 parts, 6 parts of Rhizoma Chuanxiong, 6 parts of corydalis tuber, 5 parts of leek roots, 5 parts of Bulbus Allii Fistulosi, 3 parts of pepper, 5 parts of kaempferia galanga, it is 14 parts windproof,
8 parts of Rhizoma Et Radix Notopterygii, 6 parts of Radix Glycyrrhizae.
In other embodiments of the invention, above-mentioned raw materials further include the following components counted in parts by weight：
1-3 parts of safflower, 2-7 parts of the root of Chinese clematis, 7-12 parts of pyrola, 2-6 parts of Moschus, 3-7 parts of safflower, 4-14 parts of radix aconiti agrestis.
Safflower invigorate blood circulation, removing blood stasis and analgesics contribute to controlling through closing, dysmenorrhoea, lochia, chest impediment and cardialgia, stasis of blood, chest
Coerce shouting pain, traumatic injury, sore swell and ache curative curative effect.
Damp and hot chill, migraines, jaundice edema, fish-bone fishbone larynx, waist are controlled in root of Chinese clematis energy wind-damp dispelling, diuresis, promoting menstruation, analgesia
Knee legs and feet crymodynia.
Pyrola cures mainly：Main lumbago due to the kidney deficiency, arthralgia pain due to rheumatism, muscles and bones impotence, new chronic cough cough, spit blood, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, wound
Bleeding.
Moschus cures mainly pyreticosis coma, apoplexy coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, blood stasis, dysmenorrhoea, accumulation, Xin Fubao
Bitterly, arthralgia pain due to rheumatism, traumatic injury.
Safflower is promoting blood circulation and removing blood stasis, dissipates Yu Kaijie.Troubled thoughts pent-up is controlled, chest diaphragm ruffian is bored, spits blood, and typhoid fever is gone mad, and shies and is afraid of in a trance, woman
Female's Amenorrhea, postpartum blood stasis abdominal pain, tumbling and swelling.
Radix aconiti agrestis is used for wind-cold-dampness arthralgia, and arthralgia, trusted subordinate's crymodynia, cold hernia is had a pain and narcotic analgesic.
Safflower, pyrola, Moschus, safflower, radix aconiti agrestis etc. can auxiliary water fiber crops treat arthralgia, auxiliary Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae
Etc. promoting blood circulation and removing blood stasis, promote blood circulation, treat osteoproliferation, improve lumbar pressure, avoid it is overworked caused by damage.
The present invention also provides a kind of above-mentioned for treating osteoproliferation, the preparation method of the pharmaceutical composition of lumbar muscle strain,
Including：
Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are mixed to get mixture,
Mixture is ground into the medicinal powder of 200-300 mesh；
Use alcoholic strength that alcohol is obtained by filtration after boiling 20-30 minutes at 0.2-0.3MPa for the wine of 55-65% in medicinal powder
Extract.
Further, in other embodiments of the invention, further include that filtered filter residue is impregnated using vinegar, concentration is gone
It mixes, concentrates with alcohol extract except the smell of vinegar is filtered.
Further, in other embodiments of the invention, use before wine boiling medicinal powder further include by medicinal powder stir-fry for
It is golden yellow.
In other embodiments of the invention, wine is the wine made by sophorae honey, and the mass ratio of wine and medicinal powder is
3-5:1。
Further, in other embodiments of the invention, further include by safflower, the root of Chinese clematis, pyrola, Moschus, safranine
Flower, radix aconiti agrestis mixing, are added the 8-10 times of distilled water measured, after impregnating 5-6 hours, boil 3-4 hours and filtrate is obtained by filtration, by alcohol extracting
Liquid is mixed with filtrate.
Further, in other embodiments of the invention, further include by alcohol extract drying be powder, auxiliary material is then added
Tablet or capsule is made.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
Present embodiments provide it is a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, mainly by following
Step is made：
Stock：Water fiber crops 20g, Rhizoma Chuanxiong 9g, corydalis tuber 9g, leek roots 8g, Bulbus Allii Fistulosi 7g, pepper 5g, kaempferia galanga 6g, windproof 17g, Rhizoma Et Radix Notopterygii
12g, Radix Glycyrrhizae 7g,.
Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are mixed to get mixture,
Mixture is ground into the medicinal powder of 300 mesh；
Medicinal powder is used alcoholic strength, and for 65% wine, alcohol extract is obtained by filtration after 30 minutes in the boiling at 0.3MPa.
It is powder by alcohol extract drying, auxiliary material is then added, tablet is made.
Embodiment 2
Present embodiments provide it is a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, mainly by following
Step is made：
Stock：Water fiber crops 10g, Rhizoma Chuanxiong 2g, corydalis tuber 3g, leek roots 2g, Bulbus Allii Fistulosi 1g, pepper 1g, kaempferia galanga 2g, windproof 11g, Rhizoma Et Radix Notopterygii
4g, Radix Glycyrrhizae 2g.
Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are mixed to get mixture,
Mixture is ground into the medicinal powder of 200 mesh；
Medicinal powder is used alcoholic strength, and for 60% wine, alcohol extract is obtained by filtration after 30 minutes in boiling at 0.2 mpa.
It is powder by alcohol extract drying, auxiliary material is then added, capsule is made.
Embodiment 3
Present embodiments provide it is a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, mainly by following
Step is made：
Stock：Water fiber crops 16g, Rhizoma Chuanxiong 8g, corydalis tuber 7g, leek roots 6g, Bulbus Allii Fistulosi 6g, pepper 4g, kaempferia galanga 5g, windproof 16g, Rhizoma Et Radix Notopterygii
10g, Radix Glycyrrhizae 6g.
Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are mixed to get mixture,
Mixture is ground into the medicinal powder of 200 mesh；
Medicinal powder is used alcoholic strength, and for 55% wine, alcohol extract is obtained by filtration after 30 minutes in boiling at 0.2 mpa.
Filtered filter residue is impregnated using vinegar, concentration removal smell of vinegar filtering is mixed with alcohol extract, concentrated.Dry is powder
Then end is added auxiliary material and tablet is made.
Embodiment 4
Present embodiments provide it is a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, mainly by following
Step is made：
Stock：Water fiber crops 12g, Rhizoma Chuanxiong 4g, corydalis tuber 4g, leek roots 3g, Bulbus Allii Fistulosi 4g, pepper 2g, kaempferia galanga 3g, windproof 14g, Rhizoma Et Radix Notopterygii
8g, Radix Glycyrrhizae 4g.
Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are mixed to get mixture,
Mixture is ground into the medicinal powder of 200 mesh；
It is golden yellow by medicinal powder stir-frying, medicinal powder uses alcoholic strength, and for 55% wine, boiling is filtered after twenty minutes at 0.2 mpa
Obtain alcohol extract.
Filtered filter residue is impregnated using vinegar, concentration removal smell of vinegar filtering is mixed with alcohol extract, concentrated.Dry is powder
Then end is added auxiliary material and tablet is made.
Embodiment 5
Present embodiments provide it is a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, mainly by following
Step is made：
Stock：Water fiber crops 15g, Rhizoma Chuanxiong 6g, corydalis tuber 6g, leek roots 5g, Bulbus Allii Fistulosi 5g, pepper 3g, kaempferia galanga 5g, windproof 14g, Rhizoma Et Radix Notopterygii
8g, Radix Glycyrrhizae 6g.
Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are mixed to get mixture,
Mixture is ground into the medicinal powder of 300 mesh；
It is golden yellow by medicinal powder stir-frying, medicinal powder uses alcoholic strength, and for 65% wine, the boiling at 0.3MPa is filtered after twenty minutes
Obtain alcohol extract, the mass ratio of wine and medicinal powder is 3:1.
Filtered filter residue is impregnated using vinegar, concentration removal smell of vinegar filtering is mixed with alcohol extract, concentrated.Dry is powder
Then end is added auxiliary material and tablet is made.
Embodiment 6
Present embodiments provide it is a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, mainly by following
Step is made：
Stock：Water fiber crops 15g, Rhizoma Chuanxiong 6g, corydalis tuber 6g, leek roots 5g, Bulbus Allii Fistulosi 5g, pepper 3g, kaempferia galanga 5g, windproof 14g, Rhizoma Et Radix Notopterygii
8g, Radix Glycyrrhizae 6g,；Safflower 1g, root of Chinese clematis 2g, pyrola 7g, Moschus 2g, safflower 3g, radix aconiti agrestis 4g.
Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are mixed to get mixture,
Mixture is ground into the medicinal powder of 300 mesh；
It is golden yellow by medicinal powder stir-frying, medicinal powder uses alcoholic strength, and for 65% wine, the boiling at 0.3MPa is filtered after twenty minutes
Obtain alcohol extract, the mass ratio of wine and medicinal powder is 4:1.
Safflower, the root of Chinese clematis, pyrola, Moschus, safflower, radix aconiti agrestis are mixed, the distilled water of 9 times of amounts is added, is impregnated 5 hours
Afterwards, it boils 3 hours and filtrate is obtained by filtration.
Filtered filter residue is impregnated using vinegar, concentration removal smell of vinegar filtering is mixed with alcohol extract, above-mentioned filtrate, concentrated.
Dry is powder, auxiliary material is then added, tablet is made.
Embodiment 7
Present embodiments provide it is a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, mainly by following
Step is made：
Stock：Water fiber crops 15g, Rhizoma Chuanxiong 6g, corydalis tuber 6g, leek roots 5g, Bulbus Allii Fistulosi 5g, pepper 3g, kaempferia galanga 5g, windproof 14g, Rhizoma Et Radix Notopterygii
8g, Radix Glycyrrhizae 6g, safflower 3g, root of Chinese clematis 7g, pyrola 12g, Moschus 6g, safflower 7g, radix aconiti agrestis 14g.
Water fiber crops, Rhizoma Chuanxiong, corydalis tuber, leek roots, Bulbus Allii Fistulosi, pepper, kaempferia galanga, windproof, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae are mixed to get mixture,
Mixture is ground into the medicinal powder of 300 mesh；
It is golden yellow by medicinal powder stir-frying, medicinal powder uses alcoholic strength, and for 65% wine, the boiling at 0.3MPa is filtered after 30 minutes
Obtain alcohol extract, the mass ratio of wine and medicinal powder is 4:1.
Safflower, the root of Chinese clematis, pyrola, Moschus, safflower, radix aconiti agrestis are mixed, the distilled water of 8 times of amounts is added, is impregnated 5 hours
Afterwards, it boils 4 hours and filtrate is obtained by filtration.
Filtered filter residue is impregnated using vinegar, concentration removal smell of vinegar filtering is mixed with alcohol extract, above-mentioned filtrate, concentrated.
Dry is powder, auxiliary material is then added, tablet is made.
Test example
Articulatio genus hyperosteogeny 80, lumbar vertebrae hyperosteogeny 80, cervical vertebrae hyperosteogeny 80 are chosen in various big hospital.Altogether
240 patients are divided into 8 groups, respectively 7 corresponding groups of embodiment 1- embodiments and control group at random.Clinical manifestation：Big portion
There is a chronic ache at point morbidity position, part cervical vertebra hyperplasia patient, there is a radiated pain of dorsocephalad, and with cold and
The abnormal sensories such as numbness, small part cervical vertebra hyperplasia patient have vegetative nerve functional disturbance, such as nausea, dizzy, tinnitus symptom.Separately
There is some patientss painful area to have obvious muscle spasmus or muscle tonue outside.
The drug that embodiment 1- embodiments 7 are prepared is respectively adopted, 2 times a day, 6 tablets each time in treatment group.Control group,
Using the drug for the treatment of osteoproliferation purchased in market, 2 times a day, 6 tablets each time, taken before sleeping.Two groups of courses for the treatment of are 4 weeks, course for the treatment of knot
Curative effect is counted after beam.The Primary Cares such as appropriate sports are given during treatment.
Criterion of therapeutical effect：Reference《Clinical disease diagnosis is according to healing improvement standard》It drafts.Recovery from illness：Clinical symptoms disappear completely
It loses, Imageology disappears or is obviously improved；It is effective：Clinical symptoms disappear substantially or major part is obviously improved, and iconography is apparent
Improve；Effectively：Clinical symptoms part is obviously improved, the improvement or unchanged of iconography part；In vain：Clinical symptoms and iconography are equal
It is unchanged.Patient's curative treatment the results are shown in Table 1.
1 each embodiment of table is compared with the effect of control group
From the results shown in Table 1, pharmaceutical composition provided in an embodiment of the present invention has osteoproliferation preferable
Curative effect, cure rate are superior to control group；In addition, the cure rate for the pharmaceutical composition that embodiment 6 is provided with embodiment 7 is superior to reality
The pharmaceutical composition of the offer of example 5 is provided, the pharmaceutical composition that embodiment 1- embodiments 4 provide further is better than.In addition, testing
Cheng Zhong, inventor also found that lumbar vertebrae hyperosteogeny accounts for 60 or more the percent of recovery from illness number in each embodiment recovery from illness number.It says
Bright pharmaceutical composition provided in an embodiment of the present invention is good to lumbar vertebrae hyperosteogeny effect in articulatio genus hyperosteogeny and neck bone
Matter hyperplasia.In addition, during the test, subject indicates that medication rear waist is more flexible, without tingle sense.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, which is characterized in that described for treating hyperostosis
The raw material of raw, lumbar muscle strain pharmaceutical composition includes mainly the following components counted in parts by weight：
10-20 parts of water fiber crops, 2-9 parts of Rhizoma Chuanxiong, 3-9 parts of corydalis tuber, 2-8 parts of leek roots, 1-7 parts of Bulbus Allii Fistulosi, 1-5 parts of pepper, kaempferia galanga 2-6
Part, 11-17 parts windproof, 4-12 parts of Rhizoma Et Radix Notopterygii, 2-7 parts of Radix Glycyrrhizae.
2. according to claim 1 for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, which is characterized in that institute
It includes the following components counted in parts by weight to state raw material mainly：
12-16 parts of the water fiber crops, Rhizoma Chuanxiong 4-8 parts described, corydalis tuber 4-7 parts described, leek roots 3-6 parts described, the Bulbus Allii Fistulosi 4-6
Part, it is pepper 2-4 parts described, kaempferia galanga 3-5 parts described, described 14-16 parts windproof, Rhizoma Et Radix Notopterygii 8-10 parts described, Radix Glycyrrhizae 4-6 parts described.
3. according to claim 1 for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, which is characterized in that institute
It includes the following components counted in parts by weight to state raw material mainly：
15 parts of the water fiber crops, 6 parts of the Rhizoma Chuanxiong, 6 parts of the corydalis tuber, 5 parts of the leek roots, 5 parts of the Bulbus Allii Fistulosi, the pepper 3
Part, 5 parts of the kaempferia galanga, windproof 14 parts described, 8 parts of the Rhizoma Et Radix Notopterygii, 6 parts of the Radix Glycyrrhizae.
4. according to claim 1-3 any one of them for treating osteoproliferation, the pharmaceutical composition of lumbar muscle strain, feature
It is, the raw material further includes the following components counted in parts by weight：
1-3 parts of safflower, 2-7 parts of the root of Chinese clematis, 7-12 parts of pyrola, 2-6 parts of Moschus, 3-7 parts of safflower, 4-14 parts of radix aconiti agrestis.
5. a kind of according to any one of claims 1-4 for treating osteoproliferation, the system of the pharmaceutical composition of lumbar muscle strain
Preparation Method, which is characterized in that including：
By the water fiber crops, Rhizoma Chuanxiong, the corydalis tuber, the leek roots, the Bulbus Allii Fistulosi, the pepper, the kaempferia galanga, described anti-
Wind, the Rhizoma Et Radix Notopterygii, the Radix Glycyrrhizae are mixed to get mixture, and the mixture is ground into the medicinal powder of 200-300 mesh；
Use alcoholic strength that alcohol is obtained by filtration after boiling 20-30 minutes at 0.2-0.3MPa for the wine of 55-65% in the medicinal powder
Extract.
6. according to claim 5 any one of them preparation method, which is characterized in that further include filtered using vinegar immersion
Filter residue, concentration removal smell of vinegar filtering are mixed with the alcohol extract, are concentrated.
7. according to claim 5 any one of them preparation method, which is characterized in that before medicinal powder described in the wine boiling
Further include that the medicinal powder stir-fries as golden yellow.
8. according to claim 5 any one of them preparation method, which is characterized in that the wine is to make to obtain by sophorae honey
Wine, the mass ratio of the wine and the medicinal powder is 3-5:1.
9. according to claim 5 any one of them preparation method, which is characterized in that further include by safflower, the root of Chinese clematis, deer rank
Grass, Moschus, safflower, radix aconiti agrestis mixing, are added the 8-10 times of distilled water measured, after impregnating 5-6 hours, boil 3-4 hours and filter
To filtrate, the alcohol extract is mixed with the filtrate.
10. according to claim 5 any one of them preparation method, which is characterized in that further include being by alcohol extract drying
Then powder is added auxiliary material and tablet or capsule is made.
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