CN104958459A - Traditional Chinese medicament for adjuvant fracture treatment and preparation method for traditional Chinese medicament - Google Patents
Traditional Chinese medicament for adjuvant fracture treatment and preparation method for traditional Chinese medicament Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicament for adjuvant fracture treatment and a preparation method for the traditional Chinese medicament. The traditional Chinese medicament comprises the following raw medicinal materials: benzoin, fringed iris herb, coastal glehnia root, buglossoides, sinomenium acutum, gaultheria, antipathes japonica brook, caulophyllum robustum, cinnamomum tamala, anisochilus, rubia yunnanensis, canescent wikstroemia, olgaea lomonossowii, elsholtzia blanda, sophora viciifolia, caesalpinia minax hance, celastrus orbiculatus, begonia root, semi-pinnated brake herb, thorny elaeagnus fruit and jasminum giraldii diels. The traditional Chinese medicament has the beneficial effects that the traditional Chinese medicament is applied to the treatment of various types of bone fractures, and can be matched with the conventional treatment to effectively relieve or eliminate the pain of a bone fracture patient caused by clamping plate fixation, plaster immobilization and operation traction, quick formation of calluses is promoted, fracture healing is accelerated, the physiological healing period comes earlier obviously, the treatment effect is good, the treatment course is short, the cure rate is high, and toxic and side effects are avoided.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly a kind of Chinese medicine and preparation method thereof of adjunctive treatment of bone fracture.
Background technology
According to tcm theory: skeleton is the support of human body, has lacuna in it, hide bone marrow." Plain Questions arteries and veins wants precise and tiny opinion " claims " bone person, fu-viscera of marrow "." Plain Questions should resemble large opinion " explicitly points out: " kidney producing bone marrow, kidney essense is sufficient, then bone marrow biochemistry is active." namely human skeleton rely on the nutrition of bone marrow, bone marrow is kidney essense life.It is raw active that kidney essense enriches then medullization, and skeleton is firm, strong, once because of various pathological factor and oldly to suffer from a deficiency of the kidney, then can not fill the raw marrow of bone, skeleton loses supports, fragility is unable and form osteoporosis, is " Plain Questions vital QI of the body connecting with natural QI opinion " so-called: " kidney qi is wound, and processus styloideus radii is bad.Say in " ancient Chinese medical classics essential ideas ": " kidney storing essence, the raw marrow of essence, marrow bone growth promoting, therefore the conjunction of bone person kidney is also ", " essence foot is marrow foot then, and marrow is in bone, and then bone is strong for marrow foot ".Bone injury, femur head necrosis, osteoporosis, fracture all belong to Chinese medicine orthopaedics category.And osteoporosis be reduce with bone amount, the microstructure degeneration of bone for feature, cause the fragility of bone to increase and be easy to occur a kind of general bone energy disease of fracture.The traditional Chinese medical science is thought, suffering from a deficiency of the kidney is the basic reason that osteoporosis occurs.Even if the slight wound of sufferers of osteoporosis face also can cause fracture, the probability of fracture is higher, belongs to Chinese medicine atrophic debility of bones category.Therefore according to the tcm theory of ＂ kidney governing bones ＂, suffering from a deficiency of the kidney is that osteoporotic morbidity is crucial, therefore the suitable invigorating the kidney and strengthening the bones for the treatment of, if kidney essense is sufficient, then muscles and bones is effectively hard.Fracture is also clinical common multiple disease, and orthopedics and traumatology of Chinese medicine has the history of several thousand in China, in fractures, have accumulated rich experience."Nei Jing" is said: " impairment of QI resulting in pain, injury of configuration resulting in swelling ".Wang Bing note: " gas is invisible therefore grieved, and the tangible then wound of blood is swollen ".Fracture and injury QI and blood, hyperamization arteries and veins is from through absurd row, and stagnant blood is detained, and form blood stasis, so that QI-blood circulation is not normal, and the stasis of blood is long-pending does not fall apart, for swelling as pain." blood not reviver's stasis of blood does not go, and the stasis of blood does not go then can not connect " therefore control and work as blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, reunion of bone.
The healing of bone injury, union of fracture is a complicated pathological processes, in periosteum, osteoblastic regeneration is the basis of union of fracture, its agglutination can be divided into hematoma to be formed, fibrous callus is formed, the process of the several alternately evolution successively of reconstruction of osseous callus formation and callus, union of fracture is divided into intermembranous ossification and endochondral ossification, and fracture in latter 24 hours, the periosteum at fracture end place starts hypertrophy plumpness, the internal layer hyperplasia of periosteum, produce osteoid tissue, form area of new bone, i.e. intermembranous ossification, its process is rapid, and is connected firmly.When os endochondrale is fracture, periosteum bone cortex and contiguous soft tissue are damaged, angiorrhexis is hemorrhage, hematoma is formed at fractures, because blood cell destroys, Fibrin exudation, granulation tissue is formed, hematoma starts machine, hematoma is surrounded by the proliferation of fibrous tissue being positioned at perihematoma, and stretches into wherein, is replaced by absorption by the effect of phagocyte and foreign-body giant cell.The absorption replacement of hematoma, often needs 2 ~ 3 weeks or the longer time just can complete.After absorption of hematoma substitutes, inmature fibrous tissue between fracture site, major part changes cartilage into, and intercalation is between the external callus of two fracture sites, and chondrocyte is through hyper-proliferative, degeneration, calcification and ossify, and this often needs 1 ~ 3 month.
Fracture is that the structural continuity in epiphyseal plate or joint is separated or interrupts.That fractures is categorized as closure and opening, imperfection and completeness is divided into by the breaking degree of fracture, stability and unstability can be divided into again by manual reduction, be divided into fissure fracture, subperiosteal fracture, cortical bone or periosteum portion fractures to fracture, tear fracture, transverse fracture, oblique fracture, spiral fracture, comminuted fracture, epiphysiolysis, compression fracture, depressed fracture etc. by the form of fracture line.At present, large hospital is all generally first by after fracture site normotopia with artificial to the treatment of fracture patient, with steel wire or with steel plate, Boards wall, and then at affected part outside plaster fixing, bed is rested, and this method relies on the spontaneous recovery regeneration capacity of the human body of patient own to engage fracture site; Or taking the blood circulation promoting medicines such as some similar YUNNAN BAIYAO again, object promotes that fracture heals or stop-pass antiinflammatory early; So-called " 100 days injured in the sinews or bones " need three months after fractures or the recovery of longer time in other words, namely dally over one's work, bring misery again to patient.
At present, the method for set a broken bone fracture mainly comprises Chinese traditional treatment and western medical treatment.Western medical treatment bone injury adopts hormone therapy or takes calcium preparation; Fracture mainly contains manual reduction and extenal fixation such as plintlet binder is fixed and continuous traction etc., generally takes open reduction internal fixtion etc. to critically ill patient, painful large because performing the operation, costly, and postoperative sequela of may leaving over, and make majority be reluctant to accept.Traditional Chinese medical science traditional therapy is pain relieving by force often, symptomatic treatment in acute condition, the rules such as relieving the primary symptom in a chronic case, and that tests is clinical, though there is certain curative effect, control symptom and produce effects slowly, healing only has the wait physiology normal healing phase, is about 7 ~ 10 weeks, and patient's course of disease and painful phase extend.Therefore, the multiplex hormone of current set a broken bone and a large amount of supplementary calcium preparation, the most employing patient of fracture beats the methods such as clamping plate, plaster fixing, operation traction, there is the course for the treatment of long, cure slow, patient pain's drawback such as unbearably, for such situation, clinically can effectively alleviate sufferer misery in the urgent need to one, also can the medicine of accelerating union of bone fracture.
Summary of the invention
In order to overcome the deficiencies in the prior art, the object of this invention is to provide Chinese medicine of a kind of adjunctive treatment of bone fracture and preparation method thereof, its Chinese medicine can coordinate traditional treatment, accelerates the healing of fracture and has no side effect.
For solving the problems of the technologies described above, provide a kind of Chinese medicine of adjunctive treatment of bone fracture, wherein, described Chinese medicine comprises following raw medicinal material: Benzoinum, Herba Iridis japonicae, Radix Glehniae, Fructus Lithospermi Zollingeri, Sinomenium acutum, Gaultheria, Hai Liu, Radix Caulophylli, Chai Gui, Herba lysimachiae capillipedis, Radix Rubiae Yunnanensis, Flos Wikstroemiae Dolichanthae, hedgehog chrysanthemum, Herba Elsholtziae penduliforare, Radix Sophorae Viciifoliae, Semen Caesalpiniae Minacis, Celastrus orbiculatus Thunb., Radix Bischofiae Javanicae, Herba Pteridis Semipinnatae, Fructus Elaeagni and Radix Jasmini Giraldii.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can be preferably: Benzoinum 10 ~ 25 parts, Herba Iridis japonicae 20 ~ 45 parts, Radix Glehniae 10 ~ 25 parts, Fructus Lithospermi Zollingeri 15 ~ 30 parts, Sinomenium acutum 35 ~ 55 parts, Gaultheria 5 ~ 25 parts, 5 ~ 25 parts, the willow in sea, Radix Caulophylli 6 ~ 26 parts, 14 ~ 30 parts, bavin osmanthus, Herba lysimachiae capillipedis 20 ~ 35 parts, Radix Rubiae Yunnanensis 17 ~ 28 parts, Flos Wikstroemiae Dolichanthae 5 ~ 18 parts, hedgehog chrysanthemum 17 ~ 34 parts, Herba Elsholtziae penduliforare 24 ~ 48 parts, Radix Sophorae Viciifoliae 22 ~ 44 parts, Semen Caesalpiniae Minacis 15 ~ 30 parts, Celastrus orbiculatus Thunb. 16 ~ 28 parts, Radix Bischofiae Javanicae 10 ~ 30 parts, Herba Pteridis Semipinnatae 13 ~ 27 parts, Fructus Elaeagni 10 ~ 35 parts and Radix Jasmini Giraldii 20 ~ 45 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can also be preferably: Benzoinum 15 ~ 22 parts, Herba Iridis japonicae 25 ~ 40 parts, Radix Glehniae 14 ~ 24 parts, Fructus Lithospermi Zollingeri 17 ~ 26 parts, Sinomenium acutum 45 ~ 50 parts, Gaultheria 13 ~ 21 parts, 9 ~ 20 parts, the willow in sea, Radix Caulophylli 10 ~ 25 parts, 20 ~ 30 parts, bavin osmanthus, Herba lysimachiae capillipedis 25 ~ 30 parts, Radix Rubiae Yunnanensis 20 ~ 26 parts, Flos Wikstroemiae Dolichanthae 10 ~ 15 parts, hedgehog chrysanthemum 20 ~ 30 parts, Herba Elsholtziae penduliforare 30 ~ 45 parts, Radix Sophorae Viciifoliae 25 ~ 40 parts, Semen Caesalpiniae Minacis 20 ~ 28 parts, Celastrus orbiculatus Thunb. 20 ~ 25 parts, Radix Bischofiae Javanicae 15 ~ 25 parts, Herba Pteridis Semipinnatae 16 ~ 24 parts, Fructus Elaeagni 17 ~ 32 parts and Radix Jasmini Giraldii 25 ~ 40 parts.
In described Chinese medicine, the ratio of weight and number of various raw medicinal material can be preferably again: Benzoinum 16 parts, Herba Iridis japonicae 35 parts, Radix Glehniae 18 parts, Fructus Lithospermi Zollingeri 19 parts, Sinomenium acutum 48 parts, Gaultheria 15 parts, 11 parts, extra large willow, Radix Caulophylli 14 parts, 22 parts, bavin osmanthus, Herba lysimachiae capillipedis 28 parts, Radix Rubiae Yunnanensis 24 parts, Flos Wikstroemiae Dolichanthae 11 parts, hedgehog chrysanthemum 29 parts, Herba Elsholtziae penduliforare 33 parts, Radix Sophorae Viciifoliae 26 parts, Semen Caesalpiniae Minacis 26 parts, Celastrus orbiculatus Thunb. 24 parts, Radix Bischofiae Javanicae 16 parts, Herba Pteridis Semipinnatae 17 parts, Fructus Elaeagni 23 parts and Radix Jasmini Giraldii 38 parts.
In described Chinese medicine, the ratio of weight and number of various raw medicinal material can be preferably again: Benzoinum 21 parts, Herba Iridis japonicae 27 parts, Radix Glehniae 22 parts, Fructus Lithospermi Zollingeri 25 parts, Sinomenium acutum 45 parts, Gaultheria 20 parts, 18 parts, extra large willow, Radix Caulophylli 23 parts, 28 parts, bavin osmanthus, Herba lysimachiae capillipedis 25 parts, Radix Rubiae Yunnanensis 20 parts, Flos Wikstroemiae Dolichanthae 15 parts, hedgehog chrysanthemum 26 parts, Herba Elsholtziae penduliforare 40 parts, Radix Sophorae Viciifoliae 35 parts, Semen Caesalpiniae Minacis 20 parts, Celastrus orbiculatus Thunb. 21 parts, Radix Bischofiae Javanicae 22 parts, Herba Pteridis Semipinnatae 20 parts, Fructus Elaeagni 30 parts and Radix Jasmini Giraldii 26 parts.
When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine is liniment, its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds a part 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds a part 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Beneficial effect of the present invention: the present invention is applicable to the treatment of various bone fracture, traditional treatment can be coordinated, the pain that effective alleviation or elimination bone fracture patient cause when playing clamping plate, plaster fixing, operation traction, promote that callus is formed rapidly, accelerate the healing of fracture, the physiological healing phase obviously shifts to an earlier date, and good effect, short treating period, cure rate are high and have no side effect.
Detailed description of the invention
The invention provides a kind of Chinese medicine of adjunctive treatment of bone fracture, wherein, Chinese medicine comprises following raw medicinal material: Benzoinum, Herba Iridis japonicae, Radix Glehniae, Fructus Lithospermi Zollingeri, Sinomenium acutum, Gaultheria, Hai Liu, Radix Caulophylli, Chai Gui, Herba lysimachiae capillipedis, Radix Rubiae Yunnanensis, Flos Wikstroemiae Dolichanthae, hedgehog chrysanthemum, Herba Elsholtziae penduliforare, Radix Sophorae Viciifoliae, Semen Caesalpiniae Minacis, Celastrus orbiculatus Thunb., Radix Bischofiae Javanicae, Herba Pteridis Semipinnatae, Fructus Elaeagni and Radix Jasmini Giraldii.
Wherein, the pharmacology of various raw medicinal material is as follows:
Benzoinum: [another name] clumsy shellfish Luo Xiang.[source] medical material Ji Yuan: be the resin of Styracaceae plant Benzoinum and Styrax tonkinensis.[nature and flavor] are pungent; Bitter; Property is put down.[return through] heart; Liver; Spleen channel.[function cures mainly] has one's ideas straightened out refreshment; Eliminating phlegm is warded off dirty; Promoting flow of QI and blood; Pain relieving.Wind-phlegm Jue in master; Infantile convulsion is gone into a coma, puerperal blood faints; Trusted subordinate's pain; Migratory arthralgia arthrodynia of the extremities.[extracts] " China's book on Chinese herbal medicine "
Herba Iridis japonicae: [another name] wild duck nebula, Rohdea japonica, swallow flower, blue flower hinge are cut, purple swallow, Radix et Rhizoma Iridis Sanguineae, Rhizoma Belamcandae, cross mountain tiger, Radix scopoliae sinensis, hexagonal grass, the Rhizoma Anemarrhenae, announcement JIANCAO, sword cutter grass, Orchid, flat bamboo, golden shoulder pole, Semen Sojae Preparatum leaf, flat Folium Bambusae.[source] medical material Ji Yuan: be the herb of irides Herba Iridis japonicae.Latin plant animal mineral name: Iris japonica Thunb.[nature and flavor] bitter; Cold; Mild toxicity.[function cures mainly] reducing swelling and alleviating pain; Heat-clearing and toxic substances removing.Main hepatitis; Hepatomegaly; Pain in the hepatic region; Stomachache; Laryngopharynx swelling and pain; Have blood in stool.[extracts] " China's book on Chinese herbal medicine "
Radix Glehniae: [another name] geographical north Radix Adenophorae (Radix Glehniae); Glehniae,radix; Root Radix Glehniae; Dish sun ginseng; RADIX GLEHNIAE from Liaoning of China; Wild Herba Coriandri root.[source] medical material Ji Yuan: be the root of samphire Radix Glehniae.[nature and flavor] sweet in the mouth; Cool in nature.[return through] returns lung; Stomach warp.[function cures mainly] nourishing YIN and clearing away lung-heat; Reinforcing stomach reg fluid.Main dryness of the lung dry cough; Asthenia hemoptysis; Stomach level is not enough; Tianjin wound is done.[extracts] " China's book on Chinese herbal medicine "
Fructus Lithospermi Zollingeri: [another name] Herba Veronicae Peregrinae, Ma Fei.[source] medical material Ji Yuan: be the fruit of Radix Sophorae Viciifoliae section plant zollinger gromwell or DABAI tattooing.Gather and store: the 7-9 month gathers when fruit is ripe, dries.[nature and flavor] Gan Xin; Temperature.[return through] taste warp.[function cures mainly] warming spleen and stomach for dispelling cold; Reducing swelling and alleviating pain; Reducing swelling and alleviating pain.Main bright gastral cavity cold type of pain is done swollen; General acid regurgitation water; Treating swelling and pain by traumatic injury; Fracture.[extracts] " China's book on Chinese herbal medicine "
Sinomenium acutum: [another name] seeks Radix seu Caulis fici Martinii, Caulis Sinomenii, Yunnan Radix Stephaniae Tetrandrae, Fructus Aristolochiae Kwangsiensis, large Sinomenium acutum, rock are shown in anxious, Solanum lyratum Thunb., Cortex Ampelopsis Aconitifoliae Radicis, sheep passeris montani saturati wood, drum rattan, soybean pod rattan, Flos Echinopsis latifolii, climb Cortex Illici difengpi, hair Radix Stephaniae Tetrandrae, blue or green Radix Stephaniae Tetrandrae, wind dragon, bitter rattan, black Radix Stephaniae Tetrandrae, Caulis Seu Radix Kadsurae Oblongifoliae, chase after that bone falls apart, native rattan.[source] medical material Ji Yuan: be the rattan of menispermaceous plants Sinomenium acutum or hair Sinomenium acutum.[nature and flavor] are bitter; Pungent; Flat.[return through] liver; Spleen channel.[function cures mainly] dispelling wind and removing obstruction in the collateral; Removing damp and stopping pain.Main air pain of dampness syndrome; Severe and migratory arthralgia; The arthroncus of knee; Beriberi swells and ache.[extracts] " China's book on Chinese herbal medicine "
Gaultheria: [another name] tiger urine, tiger face, MANSHANXIANG, ox head medicine medicine.[source] medical material Ji Yuan: be root or the stem and leaf of ericad Gaultheria.[nature and flavor] are pungent; Warm in nature.[function cures mainly] expelling wind and removing dampness; Removing obstruction in the collateral to relieve pain.Main air pain of dampness syndrome; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Hai Liu: [source] medical material Ji Yuan: be colony's branch of Anthipatharians animal black japan horny coral.Latin plant animal mineral name: Antipathes japonica Brook.[nature and flavor] sweet in the mouth; Property is put down.[function cures mainly] stops blooding; Pain relieving; Arresting convulsion.Main hemorrhoid; Hemorrhage; Stomachache; Infantile convulsion.[extracts] " China's book on Chinese herbal medicine "
Radix Caulophylli: [another name] red hair paint, search that leopard cat, red capillary are pungent, flame fork, the tight celestial being of spun gold seven, exceedingly high key, Wei, hot pepper seven, Os Gallus domesticus Rhizoma Cimicifugae.[source] medical material Ji Yuan: be the root welding technology of Berberidaceae plant Radix Caulophylli.Latin plant animal mineral name: Caulophyllum robustum Maxim.[nature and flavor] are pungent; Bitter; Warm in nature.[return through] liver; Stomach warp.[function cures mainly] promoting blood circulation to remove blood stasis; Expelling wind and removing dampness; Promoting the circulation of QI to relieve pain.Main menoxenia; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; The cold pain of gastral cavity abdomen; Traumatic injury, rheumatic arthralgia.[extracts] " China's book on Chinese herbal medicine "
Chai Gui: [another name] Cortex Cinnamomi Tamalae, Cortex cinnamomi japonici (Ramulus Cinnamomi), Celastrus orbiculatus Thunb..[source] medical material Ji Yuan: be bark or the leaf in canella bavin osmanthus.[nature and flavor] are pungent; Sweet; Temperature.[return through] liver; Spleen channel.[function cures mainly] promoting the flow of QI-blood by warming the meridian; Promoting the circulation of QI to relieve pain.Main arthralgia due to cold-dampnes; Epigastric pain; Dysmenorrhea; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Herba lysimachiae capillipedis: [another name] Herba lysimachiae capillipedis, rake grass.[source] medical material Ji Yuan: be the root and rhizome of labiate Herba lysimachiae capillipedis.[nature and flavor] acrid in the mouth; Warm in nature.[function cures mainly] removing dampness keeps away turbid; Inducing diuresis to remove edema.Main summer-heat is aobvious vomits and diarrhoea; Edema; Dysuria.[extracts] " China's book on Chinese herbal medicine "
Radix Rubiae Yunnanensis: [another name] Yunnan Herba Salviae Chinensis, Radix Rubiae Yunnanensis, little red medicine.[source] medical material Ji Yuan: for the root of grass is wished in dicotyledon medicine Maguireothamnus speciosus Yunnan.[nature and flavor] are sweet; Temperature.[return through] Liver Channel.[function cures mainly] relaxing muscles and tendons to promote blood circulation; Promoting tissue regeneration by removing blood stasis; Take good care of QI and blood.Main rheumatalgia; Traumatic injury, menoxenia; Amenorrhea; Leukorrhagia; Puerperal arthralgia; Pulmonary tuberculosis hemoptysis; Dizzy insomnia; Anemia.[extracts] " China's book on Chinese herbal medicine "
Flos Wikstroemiae Dolichanthae: [another name] Laolong sets flower, tiger Flos Cannabis.[source] medical material Ji Yuan: be the alabastrum of Isolated From Thymelaeaceae Species Flos Wikstroemiae Dolichanthae.[nature and flavor] acrid in the mouth; Bitter; Cold in nature; Poisonous.[return through] stomach warp.[function cures mainly] removing fluid-retention by purgation; Disappear hard removing mass.Main phlegm retention; Cough with dyspnea; Edema; Generalized edema with distention of the chest and abdomen in larynx; Lump in the abdomen mass beside the umbilicus.[extracts] " China's book on Chinese herbal medicine "
Hedgehog chrysanthemum: [another name] Radix Cirsii Japonici.[source] medical material Ji Yuan: be the herb of feverfew hedgehog chrysanthemum.[nature and flavor] bitter in the mouth; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main sore and toxic; Scrofula; Spit blood; Epistaxis; Anovulatory dysfunctional uterine hemorrhage; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Herba Elsholtziae penduliforare: [another name] xanthate, Elsholtzia, red, little Herba Moslae of Huang, DIAOHUANG, Pedicularis grandiflora, Herba lamii barbati.[source] medical material Ji Yuan: be the herb of labiate tassel Herba Moslae.[nature and flavor] bitter in the mouth; Pungent; Cool in nature.[function cures mainly] clearing away lung-heat to relieve cough; Heat-clearing and toxic substances removing.Main flow sense; Pneumonia; Bronchitis; Cholecystitis; Urinary tract infection; Tonsillitis; Mastitis; Anthrax; Trauma infection contamination.[extracts] " China's book on Chinese herbal medicine "
Radix Sophorae Viciifoliae: [another name] spends thorn, bitter tattooing in vain.[source] medical material Ji Yuan: be the flower of leguminous plant Radix Sophorae Viciifoliae.Latin plant animal mineral name: Sophora davidii (Franch.).[nature and flavor] bitter in the mouth; Cool in nature.[return through] liver; Urinary bladder channel.[function cures mainly] clearing away summer-heat.Main summer-heat excessive thirst.[extracts] " China's book on Chinese herbal medicine "
Semen Caesalpiniae Minacis: [another name] Semen Caesalpiniae Minacis, crow medicated pillow, native Semen Caesalpiniae Minacis, blue or green Serpentis, cat core, wide Semen Caesalpiniae Minacis, Parmelia saxatilis Ach. life, salt caput fruit.[source] medical material Ji Yuan: be the seed of leguminous plant beak pod Semen Caesalpiniae.Latin plant animal mineral name: Caesalpinia minax Hance.[nature and flavor] are bitter; Cool cold; Nontoxic.[return through] heart; Spleen; Kidney channel.[function cures mainly] clearing away heat and eliminating dampness, eliminating stasis to stop pain.Main anemopyretic cold, dysentery stranguria with turbid discharge, hiccup, carbuncle, skin ulcer tinea, traumatic injury, venom.[extracts] " China's book on Chinese herbal medicine "
Celastrus orbiculatus Thunb.: [another name] Celastrus aceleatus Merr, hang wide whip, XIANGLONGCAO, Cortex Ampelopsis Aconitifoliae Radicis, great Nan Serpentis, Lobaria pulmonaria (L.) Hoffm., Rhizoma Dioscoreae Nipponicae, old tendon Bovis seu Bubali, Huang Guoteng.[source] medical material Ji Yuan: be the rattan of Celastraceae plant Celastrus orbiculatus Thunb..[nature and flavor] are bitter; Pungent; Tepor.[return through] liver; Urinary bladder channel.[function cures mainly] expelling wind and removing dampness; Inducing menstruation to relieve menalgia; Promoting blood circulation and detoxication.Main rheumatic arthritis; Numb limbs and tense tendons, paralysis; Headache; Toothache; Hernia; Dysmenorrhea; Amenorrhea; Infantile convulsion; Osteopatia sprain; Dysentery; Acute filthy disease; Herpes zoster.[extracts] " China's book on Chinese herbal medicine "
Radix Bischofiae Javanicae: [another name] YIKOUXUE, gold thread hoist, red white two balls, Radix Bischofiae Javanicae.[source] medical material Ji Yuan: be the root of Begoniaceae plant Flos Begoniae Evansianae.[function cures mainly] blood stasis dispelling; Hemostasis; Clearing away heat-damp and promoting diuresis.Main traumatic injury; Spit blood, spit blood; Epistaxis; Knife injury is hemorrhage; Metrorrhagia; Blood stasis amenorrhea; Menoxenia; Leukorrhagia; Stranguria with turbid discharge; Dysentery; Stomachache; Laryngopharynx swelling and pain.[extracts] " China's book on Chinese herbal medicine "
Herba Pteridis Semipinnatae: [another name] licorice fern, Radix Glycyrrhizae Herba Pteridis creticae, Herba Lobeliae Chinensis, half of Herba pteridii latiusculi, half Herba Pteridis Multifidae, Pe1lionia tsoongii (Merr.) Merr. medicine, phoenix tail grass, monolateral flag, half of comb.[source] medical material Ji Yuan: be herb or the rhizome of Pteridaceae plant Herba Pteridis Semipinnatae.[nature and flavor] are bitter; Pungent; Cool.[return through] liver; Large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Cooling blood for hemostasis; Removing toxic substances and promoting subsidence of swelling.Master has loose bowels; Dysentery; Jaundice; Conjunctival congestion and swelling pain; Toothache; Spit blood; Bleeding hemorrhoids; Traumatic hemorrhage; Traumatic injury; Skin pruritus; Venom.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Fructus Elaeagni: [another name] Lu Douzi, passeris montani saturati shortcake, king mother-in-law's milk, the ruined son of Pu, half are beaten containing spring, half spring, sweet rod, Fructus Elaeagni Umbellatae, sheep milk milk, false lantern, Flos Mume bubble, salty gourd head, Fructus Kaki Pu, native Fructus Corni, nourishing YIN pellet, Folium machili velutinae, wild water Fructus Vitis viniferae, hesperidium, Mai Lan, Clear and Bright son, Pan Sangguo, wild Chinese date, Caput Caprae seu ovis bubble, Bai Yedan, half Semen Strychni, little blue or green six, youth youth son, speckle short, bristly hair or beard, flag Qi.[source] medical material Ji Yuan: be the fruit of Elaeangnaceae plant Fructus Elaeagni.[nature and flavor] acid; Puckery; Flat.[return through] lung; Stomach; Large intestine channel.[function cures mainly] astringing to arrest diarrhea; Strengthening the spleen to promote digestion; Relieving cough and asthma; Hemostasis.Master has loose bowels; Dysentery; Inappetence; Dyspepsia; Cough and asthma; Metrorrhagia; Hemorrhoid hematochezia.[extracts] " China's book on Chinese herbal medicine "
Radix Jasmini Giraldii: [another name] whole bark, front skin, Jasminum floridum Bge., mountain are rescued, black buphthalmos.[source] is the fragrant root of Oleaceae plants flavin.[nature and flavor] are bitter; Puckery; Warm in nature.[return through] lung meridian.[function cures mainly] eliminating stasis to stop pain.Main traumatic injury stasis of blood pain; Fracture; Knife injury.[extracts] " China's book on Chinese herbal medicine "
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can be preferably: Benzoinum 10 ~ 25 parts, Herba Iridis japonicae 20 ~ 45 parts, Radix Glehniae 10 ~ 25 parts, Fructus Lithospermi Zollingeri 15 ~ 30 parts, Sinomenium acutum 35 ~ 55 parts, Gaultheria 5 ~ 25 parts, 5 ~ 25 parts, the willow in sea, Radix Caulophylli 6 ~ 26 parts, 14 ~ 30 parts, bavin osmanthus, Herba lysimachiae capillipedis 20 ~ 35 parts, Radix Rubiae Yunnanensis 17 ~ 28 parts, Flos Wikstroemiae Dolichanthae 5 ~ 18 parts, hedgehog chrysanthemum 17 ~ 34 parts, Herba Elsholtziae penduliforare 24 ~ 48 parts, Radix Sophorae Viciifoliae 22 ~ 44 parts, Semen Caesalpiniae Minacis 15 ~ 30 parts, Celastrus orbiculatus Thunb. 16 ~ 28 parts, Radix Bischofiae Javanicae 10 ~ 30 parts, Herba Pteridis Semipinnatae 13 ~ 27 parts, Fructus Elaeagni 10 ~ 35 parts and Radix Jasmini Giraldii 20 ~ 45 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can also be preferably: Benzoinum 15 ~ 22 parts, Herba Iridis japonicae 25 ~ 40 parts, Radix Glehniae 14 ~ 24 parts, Fructus Lithospermi Zollingeri 17 ~ 26 parts, Sinomenium acutum 45 ~ 50 parts, Gaultheria 13 ~ 21 parts, 9 ~ 20 parts, the willow in sea, Radix Caulophylli 10 ~ 25 parts, 20 ~ 30 parts, bavin osmanthus, Herba lysimachiae capillipedis 25 ~ 30 parts, Radix Rubiae Yunnanensis 20 ~ 26 parts, Flos Wikstroemiae Dolichanthae 10 ~ 15 parts, hedgehog chrysanthemum 20 ~ 30 parts, Herba Elsholtziae penduliforare 30 ~ 45 parts, Radix Sophorae Viciifoliae 25 ~ 40 parts, Semen Caesalpiniae Minacis 20 ~ 28 parts, Celastrus orbiculatus Thunb. 20 ~ 25 parts, Radix Bischofiae Javanicae 15 ~ 25 parts, Herba Pteridis Semipinnatae 16 ~ 24 parts, Fructus Elaeagni 17 ~ 32 parts and Radix Jasmini Giraldii 25 ~ 40 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can be preferably again: Benzoinum 16 parts, Herba Iridis japonicae 35 parts, Radix Glehniae 18 parts, Fructus Lithospermi Zollingeri 19 parts, Sinomenium acutum 48 parts, Gaultheria 15 parts, 11 parts, extra large willow, Radix Caulophylli 14 parts, 22 parts, bavin osmanthus, Herba lysimachiae capillipedis 28 parts, Radix Rubiae Yunnanensis 24 parts, Flos Wikstroemiae Dolichanthae 11 parts, hedgehog chrysanthemum 29 parts, Herba Elsholtziae penduliforare 33 parts, Radix Sophorae Viciifoliae 26 parts, Semen Caesalpiniae Minacis 26 parts, Celastrus orbiculatus Thunb. 24 parts, Radix Bischofiae Javanicae 16 parts, Herba Pteridis Semipinnatae 17 parts, Fructus Elaeagni 23 parts and Radix Jasmini Giraldii 38 parts.
Wherein, in described Chinese medicine, the ratio of weight and number of various raw medicinal material can be preferably again: Benzoinum 21 parts, Herba Iridis japonicae 27 parts, Radix Glehniae 22 parts, Fructus Lithospermi Zollingeri 25 parts, Sinomenium acutum 45 parts, Gaultheria 20 parts, 18 parts, extra large willow, Radix Caulophylli 23 parts, 28 parts, bavin osmanthus, Herba lysimachiae capillipedis 25 parts, Radix Rubiae Yunnanensis 20 parts, Flos Wikstroemiae Dolichanthae 15 parts, hedgehog chrysanthemum 26 parts, Herba Elsholtziae penduliforare 40 parts, Radix Sophorae Viciifoliae 35 parts, Semen Caesalpiniae Minacis 20 parts, Celastrus orbiculatus Thunb. 21 parts, Radix Bischofiae Javanicae 22 parts, Herba Pteridis Semipinnatae 20 parts, Fructus Elaeagni 30 parts and Radix Jasmini Giraldii 26 parts.
When the dosage form of described Chinese medicine is granule, its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine is liniment, its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds a part 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds a part 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1: granule
Get Benzoinum 210g, Herba Iridis japonicae 270g, Radix Glehniae 220g, Fructus Lithospermi Zollingeri 250g, Sinomenium acutum 450g, Gaultheria 200g, extra large willow 180g, Radix Caulophylli 230g, bavin osmanthus 280g, Herba lysimachiae capillipedis 250g, Radix Rubiae Yunnanensis 200g, Flos Wikstroemiae Dolichanthae 150g, hedgehog chrysanthemum 260g, Herba Elsholtziae penduliforare 400g, Radix Sophorae Viciifoliae 350g, Semen Caesalpiniae Minacis 200g, Celastrus orbiculatus Thunb. 210g, Radix Bischofiae Javanicae 220g, Herba Pteridis Semipinnatae 200g, Fructus Elaeagni 300g and Radix Jasmini Giraldii 260g.
Its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 6 times, mixture is the ethanol of 90%, be heated to boiling reflux 4.5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.08, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.15 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.
Embodiment 2: liniment
Get Benzoinum 160g, Herba Iridis japonicae 350g, Radix Glehniae 180g, Fructus Lithospermi Zollingeri 190g, Sinomenium acutum 480g, Gaultheria 150g, extra large willow 110g, Radix Caulophylli 140g, bavin osmanthus 220g, Herba lysimachiae capillipedis 280g, Radix Rubiae Yunnanensis 240g, Flos Wikstroemiae Dolichanthae 110g, hedgehog chrysanthemum 290g, Herba Elsholtziae penduliforare 330g, Radix Sophorae Viciifoliae 260g, Semen Caesalpiniae Minacis 260g, Celastrus orbiculatus Thunb. 240g, Radix Bischofiae Javanicae 160g, Herba Pteridis Semipinnatae 170g, Fructus Elaeagni 230g and Radix Jasmini Giraldii 380g.
Its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds part 9 times amount soak by water 3 hours, filters and obtains decocting liquid; Second time adds part 8 times amount soak by water 2.5 hours, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by granule prepared by embodiments of the invention 1, (concentration is 7.26g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage granule LD50>36.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 72.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 5.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.087g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine of the present invention is 834 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: granule prepared by Chinese medicine embodiment 1 of the present invention presses 9.45,19.83 and 37.46g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: get the court's clinic case 138 example, wherein man 71 example, female 67 example; 22 ~ 68 years old age, the course of disease 1 ~ 9 day; Traffic accident injury 43 example, crush injury 52 example, get injured by a fall 28 example, other reason cause injury 15 example; Closed fracture 66 example, open fracture 72 example; Transverse breakage fracture 28 example, diagonal break fracture 54 example, spiral fracture fracture 34 example, comminuted fracture 22 example.Be divided into three groups at random, be respectively treatment group 46 people, wherein man 24 example, female 22 example; 23 ~ 68 years old age, the course of disease 1 ~ 9 day; Traffic accident injury 14 example, crush injury 18 example, get injured by a fall 9 example, other reason cause injury 5 example; Closed fracture 21 example, open fracture 25 example; Transverse breakage 9 cases of fracture, diagonal break Fractures in 18 Patients, spiral fracture fracture 12 example, comminuted fracture 7 example.Matched group 46 people, wherein man 23 example, female 23 example; 22 ~ 68 years old age, the course of disease 1 ~ 9 day; Traffic accident injury 14 example, crush injury 17 example, get injured by a fall 10 example, other reason cause injury 5 example; Closed fracture 23 example, open fracture 23 example; Transverse breakage fracture 10 example, diagonal break Fractures in 18 Patients, spiral fracture fractures in 11 cases, comminuted fracture 7 example.Blank group 46 people, wherein man 24 example, female 22 example; 23 ~ 67 years old age, the course of disease 1 ~ 9 day; Traffic accident injury 15 example, crush injury 17 example, get injured by a fall 9 example, other reason cause injury 5 example; Closed fracture 22 example, open fracture 24 example; Transverse breakage 9 cases of fracture, diagonal break Fractures in 18 Patients, spiral fracture fractures in 11 cases, comminuted fracture 8 example.
Therapeutic Method:
Blank group: after adopting operation and traditional method reduction, adopts different fixing meanss to fix according to fracture concrete condition.
Matched group: on blank group treatment basis, take " three-flower " bone-knitting powder, each 5g, every day 2 times, 1 week is a course for the treatment of, is used in conjunction 8 courses for the treatment of;
Treatment group: on treatment of control group basis, takes the granule of the embodiment of the present invention 1, each 10 grams, and every day 3 times, 1 week is a course for the treatment of, is used in conjunction 8 courses for the treatment of;
Taking the photograph X-ray film at treatments period, understand growth of spur situation, judging the clinical healing time in conjunction with having a medical check-up with or without callus.
Curative effect judging standard: clinical cure: local standard be local activity without exception, without tenderness and longitudinal percussion pain; Iconography standard is that X-ray film shows moderate to a large amount of growth of spur, and fracture line is fuzzy, has seriality callus to pass through fracture line; Profile is that lower limb are not held up and turned, the continuous walking 3min on level land, and is no less than 30 steps; Continuous Observation 2 weeks fractures are indeformable.Take a turn for the better: local tenderness and longitudinally to kowtow alleviation of pain light; X-ray is shown with moderate or a small amount of growth of spur, and the fuzzyyer and fracture end of fracture line is without hardening phenomenon.Invalid: clinical symptoms is without alleviating, and x-ray shows that fracture line is without improvement or to the disunion phase.
Therapeutic outcome: in table 1 and table 2.
After table 1 three components does not treat 8 courses for the treatment of, treatment situation statistics is as follows:
| Group | n | Clinical cure | Take a turn for the better | Invalid | Effectively total |
| Treatment group | 46 | 41 | 4 | 1 | 45(97.83％) |
| Matched group | 46 | 28 | 12 | 6 | 40(86.96％) |
| Blank group | 46 | 19 | 14 | 13 | 33(71.74％) |
Known by table 1, relative to blank group and matched group, treatment group can significantly improve total effective rate and clinical cure ratio.
Table 2 three groups of clinical cure patient healing times and clinical cure ration statistics as follows:
| Group | n | 2 courses for the treatment of | 4 courses for the treatment of | 6 courses for the treatment of | 8 courses for the treatment of |
| Treatment group | 41 | 2(4.3％) | 15(32.6％) | 34(73.9％) | 41(89.1％) |
| Matched group | 28 | 0(0％) | 9(19.6％) | 20(43.5％) | 28(60.9％) |
| Blank group | 19 | 0 | 5(10.9％) | 13(28.3％) | 19(41.3％) |
Known by table 2, relative to blank group and matched group, treatment group can significantly improve clinical cure ratio and shorten healing time; In addition, according to clinical observation, the pain caused when bone fracture patient plays clamping plate, plaster fixing, operation traction can effectively be alleviated or eliminate to treatment group Chinese medicine at short notice.
Concrete case 1: Liu, man, 55 years old, because accidentally falling from scaffold, right lower limb traumatic injury, at once shank severe pain, action of can not standing, suffer from lower limb far-end angulation deformity, tenderness was sharp-pointed, and can touch to obtain bony crepitus, X-ray examination is shown in right tibiofibula lower fracture, and far-end shifts forward.Diagnosis: right tibiofibula lower fracture.Therapeutic Method: 1, manual reduction, correct deformity; 2, clip plate holder is tied up fixing.3, the granule of the oral embodiment of the present invention 1, each 10g, every day 3 times, within about 10 days, patient pain obviously alleviates, and after 15 days, patient can hold up relatives' walking with descending; After 3 weeks, x-ray mating plate shows fracture end good apposition, and fracture line is fuzzy, clinical cure, removes clamping plate, terminates treatment.
Concrete case 2: the Qin, man, 27 years old, because wound of playing basketball causes right humeral shaft fracture.Therapeutic Method: 1, reduction: under assistant maintains traction, in doctor props up fracture with two hands thumbs proximal lateral pushes to, all the other four finger rings are embraced outside distal medial pulls to, make inside two fracture sites concordant, and micro-outside angulation, then two thumbs inwardly push away again, correct angulation, two fracture sites are calmed down return former.Then forearm is placed in neutral position, before suffering limb is suspended to breast with super shoulder Boards wall, scarf bandage; 2, the granule of the embodiment of the present invention 1 for oral administration, each 10 grams, every day 3 times 7 days is a course for the treatment of; Allow patient start after 5 days to temper elbow joint flexion-extension motion voluntarily simultaneously.After surrounding, remove extenal fixation, check X sheet shows: fracture site has seriality bone cangue to be passed through, and fracture reduction is good to line, and patient's right upper extremity function is recovered (shoulder, elbow, wrist joint function recover completely) completely.
Claims (9)
1. the Chinese medicine of an adjunctive treatment of bone fracture, it is characterized in that, described Chinese medicine comprises following raw medicinal material: Benzoinum, Herba Iridis japonicae, Radix Glehniae, Fructus Lithospermi Zollingeri, Sinomenium acutum, Gaultheria, Hai Liu, Radix Caulophylli, Chai Gui, Herba lysimachiae capillipedis, Radix Rubiae Yunnanensis, Flos Wikstroemiae Dolichanthae, hedgehog chrysanthemum, Herba Elsholtziae penduliforare, Radix Sophorae Viciifoliae, Semen Caesalpiniae Minacis, Celastrus orbiculatus Thunb., Radix Bischofiae Javanicae, Herba Pteridis Semipinnatae, Fructus Elaeagni and Radix Jasmini Giraldii.
2. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of various raw medicinal material is: Benzoinum 10 ~ 25 parts, Herba Iridis japonicae 20 ~ 45 parts, Radix Glehniae 10 ~ 25 parts, Fructus Lithospermi Zollingeri 15 ~ 30 parts, Sinomenium acutum 35 ~ 55 parts, Gaultheria 5 ~ 25 parts, 5 ~ 25 parts, the willow in sea, Radix Caulophylli 6 ~ 26 parts, 14 ~ 30 parts, bavin osmanthus, Herba lysimachiae capillipedis 20 ~ 35 parts, Radix Rubiae Yunnanensis 17 ~ 28 parts, Flos Wikstroemiae Dolichanthae 5 ~ 18 parts, hedgehog chrysanthemum 17 ~ 34 parts, Herba Elsholtziae penduliforare 24 ~ 48 parts, Radix Sophorae Viciifoliae 22 ~ 44 parts, Semen Caesalpiniae Minacis 15 ~ 30 parts, Celastrus orbiculatus Thunb. 16 ~ 28 parts, Radix Bischofiae Javanicae 10 ~ 30 parts, Herba Pteridis Semipinnatae 13 ~ 27 parts, Fructus Elaeagni 10 ~ 35 parts and Radix Jasmini Giraldii 20 ~ 45 parts.
3. Chinese medicine according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of various raw medicinal material is: Benzoinum 15 ~ 22 parts, Herba Iridis japonicae 25 ~ 40 parts, Radix Glehniae 14 ~ 24 parts, Fructus Lithospermi Zollingeri 17 ~ 26 parts, Sinomenium acutum 45 ~ 50 parts, Gaultheria 13 ~ 21 parts, 9 ~ 20 parts, the willow in sea, Radix Caulophylli 10 ~ 25 parts, 20 ~ 30 parts, bavin osmanthus, Herba lysimachiae capillipedis 25 ~ 30 parts, Radix Rubiae Yunnanensis 20 ~ 26 parts, Flos Wikstroemiae Dolichanthae 10 ~ 15 parts, hedgehog chrysanthemum 20 ~ 30 parts, Herba Elsholtziae penduliforare 30 ~ 45 parts, Radix Sophorae Viciifoliae 25 ~ 40 parts, Semen Caesalpiniae Minacis 20 ~ 28 parts, Celastrus orbiculatus Thunb. 20 ~ 25 parts, Radix Bischofiae Javanicae 15 ~ 25 parts, Herba Pteridis Semipinnatae 16 ~ 24 parts, Fructus Elaeagni 17 ~ 32 parts and Radix Jasmini Giraldii 25 ~ 40 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Benzoinum 21 parts, Herba Iridis japonicae 27 parts, Radix Glehniae 22 parts, Fructus Lithospermi Zollingeri 25 parts, Sinomenium acutum 45 parts, Gaultheria 20 parts, 18 parts, extra large willow, Radix Caulophylli 23 parts, 28 parts, bavin osmanthus, Herba lysimachiae capillipedis 25 parts, Radix Rubiae Yunnanensis 20 parts, Flos Wikstroemiae Dolichanthae 15 parts, hedgehog chrysanthemum 26 parts, Herba Elsholtziae penduliforare 40 parts, Radix Sophorae Viciifoliae 35 parts, Semen Caesalpiniae Minacis 20 parts, Celastrus orbiculatus Thunb. 21 parts, Radix Bischofiae Javanicae 22 parts, Herba Pteridis Semipinnatae 20 parts, Fructus Elaeagni 30 parts and Radix Jasmini Giraldii 26 parts.
5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Benzoinum 16 parts, Herba Iridis japonicae 35 parts, Radix Glehniae 18 parts, Fructus Lithospermi Zollingeri 19 parts, Sinomenium acutum 48 parts, Gaultheria 15 parts, 11 parts, extra large willow, Radix Caulophylli 14 parts, 22 parts, bavin osmanthus, Herba lysimachiae capillipedis 28 parts, Radix Rubiae Yunnanensis 24 parts, Flos Wikstroemiae Dolichanthae 11 parts, hedgehog chrysanthemum 29 parts, Herba Elsholtziae penduliforare 33 parts, Radix Sophorae Viciifoliae 26 parts, Semen Caesalpiniae Minacis 26 parts, Celastrus orbiculatus Thunb. 24 parts, Radix Bischofiae Javanicae 16 parts, Herba Pteridis Semipinnatae 17 parts, Fructus Elaeagni 23 parts and Radix Jasmini Giraldii 38 parts.
6. according to the Chinese medicine described in claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
7., according to the Chinese medicine for the treatment of fracture described in claim 1 to 5, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds a part 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds a part 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
8. a preparation method for Chinese medicine as described in as arbitrary in claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine is granule, and its preparation method comprises the following steps:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, take backflow as solvent, take filtering residue as solute, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder,
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.
9. a preparation method for Chinese medicine as described in as arbitrary in claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine is liniment, and its preparation method comprises the following steps:
Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 200 mesh sieves, the enable fine powder amount by 200 mesh sieves at least reaches 60%, collects and obtains fine powder a by the fine powder of 200 mesh sieves;
Step 2: the coarse powder not by 200 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds a part 8-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Second time adds a part 6-10 times amount soak by water 1-3 hour, filters and obtains decocting liquid; Merge twice decocting liquid, filter to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;
Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510408902.3A CN104958459A (en) | 2015-07-13 | 2015-07-13 | Traditional Chinese medicament for adjuvant fracture treatment and preparation method for traditional Chinese medicament |
Applications Claiming Priority (1)
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105770346A (en) * | 2016-04-29 | 2016-07-20 | 伏传升 | Traditional Chinese medicine preparation for treating talus fracture and preparing method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742795A (en) * | 2005-09-19 | 2006-03-08 | 蓝子花 | Luoshiteng medicated liquor |
| CN103230535A (en) * | 2013-05-03 | 2013-08-07 | 蔡光正 | Medicinal liquor with function of activating collaterals to ease pain |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1742795A (en) * | 2005-09-19 | 2006-03-08 | 蓝子花 | Luoshiteng medicated liquor |
| CN103230535A (en) * | 2013-05-03 | 2013-08-07 | 蔡光正 | Medicinal liquor with function of activating collaterals to ease pain |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770346A (en) * | 2016-04-29 | 2016-07-20 | 伏传升 | Traditional Chinese medicine preparation for treating talus fracture and preparing method thereof |
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