CN102988534A - External medicine for treating burns and scalds and preparation method thereof - Google Patents
External medicine for treating burns and scalds and preparation method thereof Download PDFInfo
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Abstract
Description
the
技术领域 technical field
本发明涉及一种中药制剂,具体地说,涉及一种治疗烧烫伤外用药及其制备方法。 The invention relates to a traditional Chinese medicine preparation, in particular to an external medicine for treating burns and scalds and a preparation method thereof.
the
背景技术 Background technique
烧烫伤是临床上的一种常见病,目前临床上一般采用两种方法来治疗烧烫伤:一是轻度烧烫者只是抗感染,作一般的烧烫伤的药物处理;二是大面积重度烧烫伤者需要在采用抗感染,防止呼吸衰竭处理的基础上,做植皮手术。治疗烧烫伤的中药种类很多,和西药相比,具有副作用小、治疗成本低的优点。但普遍存在治疗效果差、治疗时间长,有时会留下疤痕等问题。 Burns and scalds are clinically a common disease, and generally adopt two methods to treat burns and scalds clinically at present: the one, mild burns are only anti-infected, and are treated with general burns and scalds; Scald patients need to do skin grafting on the basis of anti-infection and prevention of respiratory failure. There are many kinds of traditional Chinese medicines for treating burns and scalds. Compared with western medicines, they have the advantages of few side effects and low treatment cost. However, there are generally problems such as poor treatment effect, long treatment time, and sometimes leaving scars.
烧烫伤是生活中常见的意外伤害,沸水、滚粥、热油、热蒸气等烧烫是常会发生的事。根据烧烫伤的严重程度及烧烫伤的部位、面积大小和烧烫伤的深浅度来判断,一般分为一度、二度和三度烧伤:一度烧烫伤:只伤及表皮层,受伤的皮肤发红、肿胀,觉得火辣辣地痛,但无水泡出现;二度烧烫伤:伤及真皮层,局部红肿、发热,疼痛难忍,有明显水泡;三度烧烫伤:全层皮肤包括皮肤下面的脂肪、骨和肌肉都受到仿害,皮肤焦黑、坏死。目前治疗烧烫伤的药物也有许多,如市售的烧伤止痛膏、湿润烧伤膏、磺胺嘧啶银等外用药膏。上述药物对局部小创伤疗效显著,但对于大面积或重度烧烫伤病人还需要入院治疗,高昂的医疗成本会给患者和其家庭带来经济上的负担。 Burns and scalds are common accidental injuries in life. Burns from boiling water, porridge, hot oil, hot steam, etc. are common occurrences. Judging by the severity of the burn and the location, size and depth of the burn, it is generally divided into first-degree, second-degree and third-degree burns: first-degree burn: only the epidermis is injured, and the injured skin is red , swelling, burning pain, but no blisters; second-degree burns: injury to the dermis, local redness, swelling, fever, unbearable pain, and obvious blisters; third-degree burns: full-thickness skin including fat under the skin, Both bones and muscles were damaged, and the skin was charred and necrotic. There are also many medicines for the treatment of burns and scalds at present, such as commercially available burn analgesic ointment, moist burn ointment, silver sulfadiazine and other external ointments. The above-mentioned drugs have a significant effect on small local trauma, but patients with large or severe burns still need to be admitted to the hospital for treatment, and the high medical costs will bring economic burdens to the patients and their families.
the
发明内容 Contents of the invention
本发明的目的是解决以上缺陷,提供一种用于治疗烧烫伤的外用药,其材料简单易得,材料价格低廉,使用方便,能够快速治疗烧烫伤,减少红肿疼痛,本发明的另一个目的是提供该外用烧烫伤药的制备方法。 The purpose of the present invention is to solve the above defects, provide a kind of external medicine for treating burns and scalds, its material is simple and easy to get, the material is cheap, easy to use, can quickly treat burns and scalds, reduce redness and pain, another purpose of the present invention The invention provides a preparation method of the externally used burn and scald medicine.
本发明的目的是通过以下方式实现的: The purpose of the present invention is achieved in the following ways:
一种治疗烧烫伤外用药,它是由原料药苦参、山大刀、家贼草和茶籽油或者氯霉素水按照下述重量份配比而成:苦参30~50份、山大刀10~30份、家贼草30~50份和茶籽油或者氯霉素水2~10份。 An external medicine for treating burns and scalds, which is prepared by mixing raw materials Sophora flavescens, Rhododendron, house thief grass and tea seed oil or chloramphenicol water according to the following parts by weight: 30-50 parts of Sophora flavescens, 10 parts of Rhododendron ~30 parts, 30~50 parts of house thief grass and 2~10 parts of tea seed oil or chloramphenicol water.
作为优选方案,所述各组分重量份配比为苦参35~45份、山大刀15~25份、家贼草35~45份和茶籽油或者氯霉素水5~10份。 As a preferred solution, the weight ratio of each component is 35-45 parts of sophora flavescens, 15-25 parts of mountain dagger, 35-45 parts of house thief grass and 5-10 parts of tea seed oil or chloramphenicol water.
作为优选方案,所述各组分重量份配比为苦参40份、山大刀20份、家贼草40份和茶籽油或者氯霉素水10份。 As a preferred solution, the weight ratio of each component is 40 parts of sophora flavescens, 20 parts of mountain dagger, 40 parts of house thief grass and 10 parts of tea seed oil or chloramphenicol water.
以上选用的苦参性味性寒,味苦,功能主治清热燥湿,抗炎,抗过敏,对多种皮肤真菌也有抑制作用;用于热痢,便血,黄疸尿闭,赤白带下,阴肿阴痒,湿疹,湿疮,皮肤瘙痒,疥癣麻风;外治滴虫性阴道炎,是治疗皮肤外伤的常用中药。 The above selected Sophora flavescens is cold in nature and taste, bitter in taste, and its functions are mainly for clearing away heat and dampness, anti-inflammation, anti-allergic, and also has inhibitory effect on various skin fungi; Swollen vulva itching, eczema, eczema, skin itching, mange and leprosy; external treatment of trichomonal vaginitis, is a commonly used traditional Chinese medicine for skin trauma.
以上选用的山大刀别名刀伤木和刀背香,具有清热解毒,祛风去湿,活血止痛功效;用于治感冒发热,扁桃体炎,咽喉肿痛,白喉;风湿骨痛,腰肌劳损,胸中滞痛;跌打损伤,骨折;蛇咬伤;疮疡肿毒。同时外用效果显著,可煎水熏洗,研末调敷或捣敷。 The Shandao selected above is also known as Dao Shangmu and Dao Bei Xiang, which have the effects of clearing away heat and detoxification, expelling wind and dampness, promoting blood circulation and relieving pain; it is used to treat colds and fever, tonsillitis, sore throat, diphtheria; Stagnant pain; bruises, fractures; snake bites; sores and swollen toxins. At the same time, the effect of external application is remarkable. It can be decocted for fumigation and washing, powdered for application or pounded for application.
以上选用的家贼草别名鞋草和鞋哒草,是粤西一带的传统土叫法,具有止伤口痛,清热,消炎,能促进渗出物吸收,促嫩肉生,消肿解毒功效,用于治烫伤、灼伤、烧伤,复原快,愈后无瘢痕。 The house thief grass selected above is also known as Xiequcao and Xiedacao. It is a traditional local name in western Guangdong. It has the effects of relieving wound pain, clearing away heat, reducing inflammation, promoting the absorption of exudate, promoting tender meat, reducing swelling and detoxification. It is used to treat scalds, burns, and burns, with quick recovery and no scars after healing.
以上选用的茶籽油就是用茶树的种子榨成的油,茶籽油的功效:具有解毒消炎,镇痛等作用,能润滑和软化血管壁,降低胆固醇血脂,平常肝火虚旺、咽喉疼痛、咳嗽,在睡前喝1-2汤匙茶籽油,次日即可见效。茶花籽是老年野生茶花树的果实的种籽,果实的成熟期亦正是茶花盛开时期,原来茶花果实的成长期需要一整年时间,在这段时间,它吸收了天地间的日月精华,茶树种子从开花至成熟长达4年,聚集了茶树的精华其营养成份极高。 The tea seed oil selected above is the oil squeezed from the seeds of the tea tree. The effects of tea seed oil: detoxification, anti-inflammatory, analgesic, etc., can lubricate and soften the blood vessel wall, reduce cholesterol and blood lipids, and usually relieve liver fire, sore throat, For coughing, drink 1-2 tablespoons of tea seed oil before going to bed, and it will be effective the next day. Camellia seeds are the seeds of the fruit of the old wild camellia tree. The ripening period of the fruit is also the period when the camellia is in full bloom. It turns out that the growth period of the camellia fruit takes a whole year. During this period, it absorbs the essence of the sun and the moon between heaven and earth , Tea tree seeds take up to 4 years from flowering to maturity, and gather the essence of tea tree, which has extremely high nutritional content.
以上选用的氯霉素水为一种常用的西药药水,曾广泛用于治疗各种敏感菌感染,可用于有特效作用敏感菌所致的严重感染,氯霉素在脑脊液中浓度较高,也常用于治疗其他药物疗效较差的脑膜炎患者,必要时可用静脉滴注给药,但外用此药较少。 The chloramphenicol water selected above is a commonly used western medicine liquid, which has been widely used to treat various sensitive bacterial infections, and can be used for severe infections caused by sensitive bacteria with special effects. Chloramphenicol has a higher concentration in the cerebrospinal fluid and can It is often used to treat meningitis patients with poor curative effect of other drugs, and it can be given by intravenous infusion if necessary, but this drug is rarely used for external use.
将以上所述的药物组合使得各药物功效产生协同作用,该药经其长期临床试验,从而可以产生显著的功效和显著的进步,配方简单,作用互补,材料价格低廉易得,治疗效果确切,其清热解毒,止痛消肿效率显著,加快细胞组织修复,可增强人体免疫力,同时还促进新陈代谢,化腐生肌,使创面愈合快,愈后不留疤痕,有效治疗各种烫伤、灼伤和烧伤。 Combining the above-mentioned drugs makes the effects of each drug produce a synergistic effect. The drug has undergone long-term clinical trials, which can produce significant efficacy and significant progress. The formula is simple, the functions are complementary, the materials are cheap and easy to obtain, and the therapeutic effect is definite. It clears heat and detoxifies, relieves pain and reduces swelling, speeds up the repair of cells and tissues, can enhance human immunity, and at the same time promotes metabolism, decomposes putrefaction and promotes muscle growth, so that wounds can heal quickly without leaving scars, and can effectively treat various scalds, burns and burns .
本发明的另一个目的是通过以下方式实现的: Another object of the present invention is achieved in the following manner:
治疗烧烫伤外用药的制备方法,配制方法如下: The preparation method of external medicine for treating burns and scalds, the preparation method is as follows:
A. 原料药的炮制 A. Processing of APIs
1)苦参:将苦参晒干,剁块,研磨成粉末; 1) Sophora flavescens: Dried Sophora flavescens, chopped into pieces, and ground into powder;
2)山大刀:将山大刀晒干,燃烧至炭状,再研磨成炭粉,燃烧至炭状时不宜直接烧成粉末; 2) Shandao: Dry the Shandao in the sun, burn it until it is charcoal, and then grind it into charcoal powder. When it is burned to charcoal, it is not suitable to be directly fired into powder;
3)家贼草:将家贼草晒干,燃烧至炭状,再研磨成炭粉,燃烧至炭状时不宜直接烧成粉末; 3) House thief grass: dry the house thief grass, burn it to a charcoal shape, and then grind it into charcoal powder. When it is burned to a charcoal shape, it is not suitable to be directly burned into powder;
4)茶籽油:茶籽油是用茶树的种子榨成的油,榨出来的液体油用瓶装使用。 4) Tea seed oil: Tea seed oil is oil squeezed from the seeds of the tea tree, and the liquid oil squeezed out is bottled for use. the
B. 配制 B. Preparation
按给定的配比将苦参、山大刀和家贼草的各原料药粉合并后搅拌均匀,再滴入给定配比的茶籽油或者氯霉素水,再充分搅拌均匀至药粉全部湿润。 According to the given ratio, combine the raw material medicine powders of Sophora flavescens, mountain dagger and house thief grass, and then stir evenly, then drop in the tea seed oil or chloramphenicol water with the given ratio, and then fully stir until the medicine powder is completely wet.
因粉末状易于吸收,且粉末可直接研磨,加工方便快捷,可自行制药,滴入液体药材茶籽油或者氯霉素水,方便搅拌,使药粉全部湿润后使用更方便,使用时可直接涂覆于创面,湿润后的药粉可贴覆在创面层,易于吸收,形成一层保护层。 Because the powder is easy to absorb, and the powder can be directly ground, the processing is convenient and fast, and it can be used for self-preparation. It is easy to stir when adding the liquid medicinal material tea seed oil or chloramphenicol water, and it is more convenient to use after the medicine powder is completely wet. Covering the wound surface, the wet powder can be attached to the wound surface layer, which is easy to absorb and forms a protective layer.
使用方法,将本烧伤外用药涂覆于烧烫伤创面部位,创面较重者涂药次数应控制频繁,涂药时间应为三小时涂一次,较轻者一天涂两次即可。涂药后感觉清凉,短时间内起止痛作用,两个小时内能消除肿胀,四个小时内明显好转。注意,本发明药物仅限于外用,不可内服。 How to use: apply this medicine for external use on burns and scalds. For severe wounds, the frequency of application should be controlled. The application time should be once every three hours, and twice a day for milder wounds. After applying the medicine, it feels cool and cool, and it acts as an analgesic in a short period of time. The swelling can be eliminated within two hours, and it will obviously take a turn for the better within four hours. Note that the medicine of the present invention is limited to external use and cannot be taken orally.
the
具体实施方式 Detailed ways
下面结合具体实施方式对本发明作进一步详细描述。 The present invention will be further described in detail below in conjunction with specific embodiments.
本发明治疗烧烫伤外用药,它的合组分重量配比为:苦参30~50份、山大刀10~30份、家贼草30~50份和茶籽油或者氯霉素水2~10份。 The external medicine for treating burns and scalds of the present invention has the weight ratio of the combined components: 30-50 parts of Sophora flavescens, 10-30 parts of Shandao, 30-50 parts of Jasmine japonica and 2-10 parts of tea seed oil or chloramphenicol water. share.
本发明治疗烧烫伤外用药,它的各组分优选重量配比为:苦参35~45份、山大刀15~25份、家贼草35~45份和茶籽油或者氯霉素水5~10份。 The external medicine for treating burns and scalds of the present invention, the preferred weight ratio of its components is: 35 to 45 parts of Sophora flavescens, 15 to 25 parts of Shandao, 35 to 45 parts of Jasmine, and 5 to 5 parts of tea seed oil or chloramphenicol water. 10 servings.
本发明治疗烧烫伤外用药,它的各组分最佳重量配比为:苦参40份、山大刀20份、家贼草40份和茶籽油或者氯霉素水10份。 The external medicine for treating burns and scalds of the present invention has the optimal weight ratio of its components: 40 parts of Sophora flavescens, 20 parts of Shandao, 40 parts of Jasmine and 10 parts of tea seed oil or chloramphenicol water.
实施例一: Embodiment one:
苦参30份、山大刀30份、家贼草40份,另外加入的茶籽油8份。 30 parts of sophora flavescens, 30 parts of mountain dagger, 40 parts of house thief grass, and 8 parts of tea seed oil added in addition.
实施例二: Embodiment two:
苦参40份、山大刀30份、家贼草30份,另外加入的茶籽油8份。 40 parts of sophora flavescens, 30 parts of mountain dagger, 30 parts of house thief grass, and 8 parts of tea seed oil added in addition.
实施例三: Embodiment three:
苦参40份、山大刀20份、家贼草40份,另外加入的茶籽油或者氯霉素水10份。 40 parts of sophora flavescens, 20 parts of mountain dagger, 40 parts of house thief grass, and 10 parts of tea seed oil or chloramphenicol water added.
实施例四: Embodiment four:
苦参50份、山大刀20份、家贼草30份,另外加入的氯霉素水10份。 50 parts of sophora flavescens, 20 parts of mountain dagger, 30 parts of house thief grass, and 10 parts of chloramphenicol water added in addition.
实施例五: Embodiment five:
苦参30份、山大刀20份、家贼草50份,另外加入的氯霉素水10份。 30 parts of sophora flavescens, 20 parts of mountain dagger, 50 parts of house thief grass, and 10 parts of chloramphenicol water added in addition.
上述各实施例在配备本发明烧烫伤外用药时均按以下方法进行: Above-mentioned each embodiment all carries out by following method when being equipped with external medicine for burn and scald of the present invention:
A. 原料药的炮制 A. Processing of APIs
1)苦参:将苦参晒干,剁块,研磨成粉末; 1) Sophora flavescens: Dried Sophora flavescens, chopped into pieces, and ground into powder;
2)山大刀:将山大刀晒干,燃烧至炭状,再研磨成炭粉,燃烧至炭状时不宜直接烧成粉末; 2) Shandao: Dry the Shandao in the sun, burn it until it is charcoal, and then grind it into charcoal powder. When it is burned to charcoal, it is not suitable to be directly fired into powder;
3)家贼草:将家贼草晒干,燃烧至炭状,再研磨成炭粉,燃烧至炭状时不宜直接烧成粉末; 3) House thief grass: dry the house thief grass, burn it to a charcoal shape, and then grind it into charcoal powder. When it is burned to a charcoal shape, it is not suitable to be directly burned into powder;
4)茶籽油:茶籽油是用茶树的种子榨成的油,榨出来的液体油用瓶装使用。 4) Tea seed oil: Tea seed oil is oil squeezed from the seeds of the tea tree, and the liquid oil squeezed out is bottled for use. the
B. 配制 B. Preparation
按给定的配比将苦参、山大刀和家贼草的各原料药粉合并后搅拌均匀,再滴入给定配比的茶籽油或者氯霉素水,再充分搅拌均匀至药粉全部湿润。 According to the given ratio, combine the raw material medicine powders of Sophora flavescens, mountain dagger and house thief grass, and stir evenly, then drop in tea seed oil or chloramphenicol water with a given ratio, and then fully stir until the medicine powders are all wet.
因粉末状易于吸收,且粉末可直接研磨,加工方便快捷,可自行制药,滴入液体药材茶籽油或者氯霉素水,方便搅拌,使药粉全部湿润后使用更方便,使用时可直接涂覆于创面,湿润后的药粉可贴覆在创面层,易于吸收,形成一层保护层。 Because the powder is easy to absorb, and the powder can be directly ground, the processing is convenient and fast, and it can be used for self-preparation. It is easy to stir when adding the liquid medicinal material tea seed oil or chloramphenicol water, and it is more convenient to use after the medicine powder is completely wet. Covering the wound surface, the wet powder can be attached to the wound surface layer, which is easy to absorb and forms a protective layer.
使用方法,将本烧伤外用药涂覆于烧烫伤创面部位,注意,本发明药物仅限于外用,不可内服。 The method of use is to apply the medicine for external use on burns and scald wounds. Note that the medicine of the present invention is limited to external use and cannot be taken orally.
临床资料: clinical information:
从患者中选取100例,发病原因均为火焰、热沸水、热油、热金属等烫伤、烧伤,其中,男性患者60例,女性患者40例,年龄为10~40岁,疗程控制为6小时~15天,烧烫伤程度为一度50例,二度30例,三度20例。 100 cases were selected from the patients, all of which were caused by fire, hot boiling water, hot oil, hot metal and other scalds and burns. Among them, there were 60 male patients and 40 female patients, aged from 10 to 40 years old, and the course of treatment was controlled for 6 hours ~ 15 days, the degree of burns was first degree in 50 cases, second degree in 30 cases, and third degree in 20 cases.
本临床患者分别采用以上五个实施例配比用药,在一度烧烫伤患者是抽取30例作为试验最佳配比方案,其中在患者患病程度相同的情况下,所使用药量相同,用药时间相同,所产生的治疗效果最佳,最终得出,实用例三为最佳方案。 In this clinical patient, the above five examples of proportioning medications were used respectively, and 30 patients with first-degree burns were selected as the best proportioning scheme for the test. In the case of patients with the same degree of illness, the amount of medicine used was the same, and the time of medication was the same. Equally, the therapeutic effect produced is the best, finally draws, practical example 3 is the best scheme.
对于一度和二度烧烫伤,用本发明药品直接涂覆在烧烫伤处,开始1小时内留意患者触觉,患者半小时内明显减轻疼痛,一小时内完全没有疼痛感;一天用药两次,一天内烧烫伤处已经形成保护膜,连续用药四次后,两天内烧烫伤处已经形大面积愈合,连接用药五天内完全愈合,并不留下任何疤痕。 For first-degree and second-degree burns, apply the medicine of the present invention directly on the burn and scald, pay attention to the patient's sense of touch within one hour, and the patient will obviously relieve pain within half an hour, and have no pain at all within one hour; take medicine twice a day, one day A protective film has been formed on the internal burns and scalds. After four consecutive medications, the burns and scalds have healed in a large area within two days, and completely healed within five days of consecutive medications without leaving any scars.
对于三度烧烫伤,用本发明药品直接涂覆在烧烫伤处,涂覆的药层稍厚,完全覆盖患处,两个小时后药品完全吸收,继续涂覆本发明药品,间隔两小时内重复换药涂上新药,连续用药五天后,烧烫伤患处显著好转,转为轻二度伤后可一天用药两次,连续用药五天内大面积愈合,10天内完全愈合,并不留任何疤痕。 For third-degree burns, use the medicine of the present invention to directly coat the burn and scald. The coated medicine layer is slightly thicker and covers the affected area completely. After two hours, the medicine is completely absorbed. Continue to coat the medicine of the present invention and repeat within two hours. Change the dressing and apply new medicine. After five days of continuous use, the burns and scalds have improved significantly. After turning into a mild second-degree injury, you can use the medicine twice a day. The large area will heal within five days of continuous use, and it will heal completely within 10 days without leaving any scars.
本发明烧烫伤药经其长期临床试验,从而可以产生显著的功效和显著的进步,配方简单,作用互补,材料价格低廉易得,治疗效果确切,其清热解毒,止痛消肿效率显著,加快细胞组织修复,可增强人体免疫力,同时还促进新陈代谢,化腐生肌,使创面愈合快,愈后不留疤痕,有效治疗各种烫伤、灼伤和烧伤。 The burn and scald medicine of the present invention can produce significant efficacy and significant progress through its long-term clinical tests, the formula is simple, the effect is complementary, the material is cheap and easy to get, the therapeutic effect is definite, its heat-clearing and toxic substances removing, pain-relieving and detumescence efficiency are remarkable, accelerate cell Tissue repair can enhance human immunity, and at the same time promote metabolism, decompose putrefaction and regenerate muscle, make wounds heal quickly, leave no scars after healing, and effectively treat various scalds, burns and burns.
以上内容是结合具体的优选实施例对本发明所作的进一步详细说明,不能认定本发明的具体实施只局限于这些说明。 The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be assumed that the specific implementation of the present invention is limited to these descriptions.
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