CN104222424A - Health cortex lycii tea with blood lipid and blood sugar reducing effects and preparation method of health cortex lycii tea - Google Patents

Abstract

The invention provides a health cortex lycii tea with blood lipid and blood sugar reducing effects. The health cortex lycii tea comprises the following raw materials in parts by weight: 10-50 parts of cortex lycii, 10-20 parts of parasitic loranthus, 10-20 parts of cortex acanthopanacis, 10-20 parts of white mulberry root barks, 10-20 parts of dogwoods, 10-20 parts of tuckahoe, 10-20 parts of salvia miltiorrhiza, 10-20 parts of ligusticum chuanxiong, 10-20 parts of fructus viticis, 10-20 parts of radix polygoni multiflori preparata, 10-20 parts of rhizoma curculiginis, 10-20 parts of mulberries, 10-20 parts of glossy privet fruits, 10-20 parts of white paeony roots, 10-20 parts of polygonum cuspidatum and 10-20 parts of sculellaria barbata. The cortex lycii can be used for treating polydipsia as well as day and night thirst and is capable of inducing urination. Modern pharmacological researches prove that the cortex lycii contains guanidine derivatives and has a blood sugar reducing effect. The health cortex lycii tea also has blood lipid and blood pressure reducing effects, the blood pressure reducing effect is related to central nerves, and the health cortex lycii tea can be used for blocking sympathetic nerve endings and directly relaxing blood vessels. The health cortex lycii tea is fragrant, bitter a little as well as sweet and mellow; and due to the addition of traditional Chinese medicines which have the effects of promoting blood circulation to remove blood stasis, are light in taste and cannot destroy the sweet taste of the cortex lycii, the taste is not influenced, the health cortex lycii tea is easily accepted by people, and the blood lipid and blood sugar reducing effects can be better improved.

Description

Root bark of Chinese wolf-berry health protection tea of a kind of blood lipid-reducing blood sugar-decreasing and preparation method thereof

Technical field

The present invention relates to the health products containing deriving from plant composition, particularly a kind of root bark of Chinese wolf-berry health protection tea and preparation method thereof of blood lipid-reducing blood sugar-decreasing.

Background technology

Motherland's medical science does not have the name of disease of hyperlipidemia, but about the discussion of the aspect such as symptom, the cause of disease, the interpretation of the cause, onset and process of an illness, treatment of hyperlipidemia described in have in many Gu doctor nationalitys, the people of the obesity of Hyperlipemia that what " cream people ", " fertile people " in Huangdi's Internal Classics referred to is exactly.Along with the raising of people's living standard, the illness rate of China coronary heart disease crowd is also improving constantly, and sicken age is tending towards rejuvenation, and coronary heart disease has become the killer of serious threat people life.The main cause of coronary heart disease is coronary atherosclerosis, and atherosclerotic is also the one of the main reasons of other position arterial disease.Causing arteriosclerotic hazards has a lot, such as hyperlipidemia (especially hypercholesterolemia), diabetes, and hypertension is fat or overweight, smoking etc., and wherein hypercholesterolemia is the most important hazards of atherosclerotic.One of most important progress of modern medicine is exactly specify that to lower blood cholesterol (TC) especially LDL.C, can significantly reduce coronary heart disease case fatality rate.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, add that long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, the agricultural chemicals remained in the absorption of a large amount of three height (high heat, high protein, higher fatty acid), more than three (anticorrisive agent is many, flavoring agent is many, hormone many) food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, obesity and diabetes have just become the rich man's disease of city gang.

When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Diabetes are a kind of syndrome due to insulin secretion, insulin action or both carbohydrate, protein and fat metabolic disturbances simultaneously caused by existing defects.Essential characteristic is that blood sugar increases, long-term damage is dysfunction and the exhaustion of various organ, comprise the vascular conditions of constantly progress, namely PVR, blind, ephrosis, renal failure, DPN companion foot ulcers, amputation and autonomic nervous function change, and also have the danger of ever-increasing cardiovascular, the cerebrovascular and peripheral angiopathy.

The root bark of Chinese wolf-berry is the root skin of matrimony vine, and medicine is studied as dry product, sweet in flavor and cold in property, enters lung, liver, kidney channel." General Records of Holy Universal Relief " is recorded, and the root bark of Chinese wolf-berry is drunk, and controls and quenches one's thirst, day and night frequent taking of water, little facility.Chinese wolfberry soup in Japan " doctor heart side ", controls and quenches one's thirst one's lips are dry and one's mouth parched, join gypsum, wheat boils soup and is taken in small doses at short intervals with this product.Modern pharmacological research: the root bark of Chinese wolf-berry contains the derivative of guanidine, has hypoglycemic activity." traditional Chinese medicine information " is reported: the root bark of Chinese wolf-berry has reducing effect to mouse glucose and adrenal gland disposition hyperglycaemia, has certain alleviate effect to the infringement of diabetic rat model beta Cell of islet morphosis.In addition, this product also has lipopenicillinase, hypotensive effect, and its hypotensive effect is relevant with nervous centralis, may for blocking SNE and direct vasodilator.

The root bark of Chinese wolf-berry is the dry root skin of matrimony vine of solanaceae plant or lycium barbarum.Nature and flavor: sweet, cold.Return lung, liver, kidney channel.The cool blood of function, reducing the asthenic fever, purte the white.Be applicable to deficiency of Yin hectic fever, night sweat, hectic fever due to yin; Cough with lung heat; Blood-heat bleeding go out blood trouble.Shennong's Herbal is recorded: " in main five, perverse trend, hankers quenching one's thirst, general arthralgia." therefore, ancient books is also recorded and confirmed that the root bark of Chinese wolf-berry can control diabete (diabetes).

The main component of the root bark of Chinese wolf-berry is: containing cinnamic acid and volume aldehydes matter, and betaine is still separated to B mono-sitosterol, linoleic acid and Kukoamine etc.These effective compositions can reduce " three is high " (high fat of blood, hypertension, hyperglycaemia) just.Hypoglycemic process mainly has facilitation to B cell excreting insulin.Modern pharmacology also confirms, the oral blood sugar that makes of its decoction reduces, and presents reduction blood fat.Can also reduce blood pressure, decreasing heart rate, heavy dose can cause atrioventricular block.Modern Chinese medicine is clinical also applies root bark of Chinese wolf-berry treatment diabetes widely, and decocting, for tea drink frequently, has certain hypoglycemic and lipid-lowering effect; As the root bark of Chinese wolf-berry made the decocting liquid of 4% concentration, white sugar of suitably adding some points, also has good curative effect to hypotensive.Though root bark of Chinese wolf-berry tea hypoglycemic hypertension and hyperlipemia is good, for catching cold, deficiency-cold in spleen and stomach, loose stool, chronic gastritis, the disease such as cardiac insufficiency patient to be cautious use of.

Compendium of Material Medica: the taste benefit not only son of matrimony vine, and root does not also terminate in and brings down a fever.But the smell of root, seedling, son is slightly different, and cure mainly also may not without not.Gai Qimiao is sky essence, bitter sweet and cool, and the hot person of part of the body cavity above the diaphragm housing the heart and lungs cardiopulmonary visitor should it; Root is ground bone, sweet light and cold, and the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels liver hot person that suffers from a deficiency of the kidney should it, and this is the medicine that divides of three burnt gas all, and so-called heat is excessive in interior, rush down with sweet cold also.Then sweet flat and moisten as son, property is grown and mends, and can not bring down a fever, only can kidney tonifying moistening lung, and production of sperm benefit gas, this is the medicine of flat benefit, and so-called insufficiency of essence person, tonifying with drugs of thick flavor also.Point and with it, then each master to some extent, holds concurrently and with it, then kills two birds with one stone.Common people but know that golden cypress, wind-weed bitter cold are to control the inferior burnt yin fire, and fire falls in the tonifying yin of meaning by the root of large-flowered skullcap, coptis bitter cold to control the fire of the part of the body cavity above the diaphragm housing the heart and lungs, clothes are caused injury vigour for a long time, and do not know matrimony vine, bone, Gan Hanping mends, and vital essence is filled and pathogenic fire is wonderful from what move back, cherishs! Give tasting and bring down a fever with sweet wormwood assistant ground bone, have distinguished service repeatly, the non-analogy person of people." book on Chinese herbal medicine converges and says ": the grand cloud of Wang Shao, is intimately eyes afflicted with calaract in bone, decocts Kidney-Yin, and with the bone skin in ground, sweet cold clear and rich, mud is not stagnant, non-glutinous rehmannia, root of herbaceous peony cocurrent flow." book on Chinese herbal medicine just ": the root bark of Chinese wolf-berry, also, southern person's bitter taste is light, and micro-have Gan Xin, and northern person is large, and bitterness is bad for boxthorn root, and only southern person of being used as medicine is good.Its property is pungent cold, is apt to into blood system, all not because of chill heat the most suitable marrow the moon point person.This thing is cool and not high, and can manage consumptive disease, gas is light and pungent, therefore also clearing lung-heat." medicineization justice ": the root bark of Chinese wolf-berry, dispels without fixed empty evil, interior apart from sweat hectic fever due to yin outward, upper reason head wind, in go chest to coerce gas, lower sharp intestine and small intestine, logically to prove effective.Enter Xiebai San, clear golden regulating the qi flowing in the channels, treating lung heat has She to cough; Same blood-nourishing drugs, reinforcing yin essence expelling pathogenic factors from muscles and skin, adjusts the not enough skin of sore acne burnt.With its property Great Cold, wine decocts two liang, controls the jaundice with damp-heat pathogen magical effect the most.Moutan bark can be dehematized middle heat, the heat during the root bark of Chinese wolf-berry can degas, and should not use." book on Chinese herbal medicine is newly organized ": the root bark of Chinese wolf-berry, non-golden cypress, the wind-weed comparable, though the root bark of Chinese wolf-berry enters kidney and not cool kidney, stop the cool bone ear into kidney, cool kidney must injure one's stomach to letting out kidney, and cool bone instead can kidney-nourishing and raw marrow, golden cypress, the wind-weed let out kidney and injure one's stomach, therefore disconnected can not multiplexly lose also to get, the raw marrow of bone skin kidney-nourishing, disconnected indispensable use and figure merit.Dynamic for moving back deficiency of Yin fire, the disease of hectic fever due to yin labor heat, with the medicine of tonifying yin, adds the root bark of Chinese wolf-berry or five money or one or two, the marrow begun in the cool bone of energy, and heat in boning also.

Modern selects some health foods or functional food to be to improve the health.The function of health products mainly improves blood circulation of human body, enriching yin and nourishing kidney, improves body immunity.The various health products sold on the market now, dragons and fishes jumbled together for medicine, and the amusement of great majority just false propaganda, what have does not only have health-care components, also causes the huge injury of the person.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.How the efficacy exertion of the root bark of Chinese wolf-berry not being injured human body again to maximum, and obviously improve mouthfeel, people can be accepted, is our problem in the urgent need to address.Containing a large amount of active material health products safely and effectively inside the root bark of Chinese wolf-berry, greatly can improve body immunity, be the key that people expect to deal with problems always.

Summary of the invention

Technical problem to be solved by this invention is, the various health products sold on the market now, dragons and fishes jumbled together for medicine, and the amusement of great majority just false propaganda, what have does not only have health-care components, also causes the huge injury of the person.Chinese medicine odor is poor, and a lot of people is reluctant long-term taking; Even if take, be medicine three points of poison, allow during people's long-term taking and also produce resisting psychology.The root bark of Chinese wolf-berry is sweet in flavor and cold in property, enters lung, liver, kidney channel." General Records of Holy Universal Relief " is recorded, and the root bark of Chinese wolf-berry is drunk, and controls and quenches one's thirst, day and night frequent taking of water, little facility.Modern pharmacological research: the root bark of Chinese wolf-berry contains the derivative of guanidine, has hypoglycemic activity.This product also has lipopenicillinase, hypotensive effect, and its hypotensive effect is relevant with nervous centralis, may for blocking SNE and direct vasodilator.Delicate fragrance of the present invention overflows, micro-bitter glycol; Add some promoting blood circulation and removing blood stasis, mouthfeel is light, does not destroy the Chinese medicine in root bark of Chinese wolf-berry taste sugariness road, does not affect mouthfeel, makes people be easy to accept, can reach effect of hypoglycemic preferably.

For solving above-mentioned technical barrier, the invention provides a kind of root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing, described in it, root bark of Chinese wolf-berry health protection tea comprises the raw material of following parts by weight: the root bark of Chinese wolf-berry 10 ~ 50 parts, parasitic loranthus 10 ~ 20 parts, cortex acanthopanacis 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, fructus viticis 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, thizoma curculiginis 10 ~ 20 parts, mulberries 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, Sculellaria barbata 10 ~ 20 parts.

The root bark of Chinese wolf-berry health protection tea of described blood lipid-reducing blood sugar-decreasing, in root bark of Chinese wolf-berry health protection tea described in it, the parts by weight of various raw material can be: the root bark of Chinese wolf-berry 10 ~ 30 parts, parasitic loranthus 10 ~ 15 parts, cortex acanthopanacis 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, Ligusticum wallichii 10 ~ 15 parts, fructus viticis 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, thizoma curculiginis 10 ~ 20 parts, mulberries 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, Sculellaria barbata 10 ~ 20 parts.

The root bark of Chinese wolf-berry health protection tea of described blood lipid-reducing blood sugar-decreasing, in root bark of Chinese wolf-berry health protection tea described in it, the parts by weight of various raw material also can be: the root bark of Chinese wolf-berry 10 ~ 40 parts, parasitic loranthus 10 ~ 20 parts, cortex acanthopanacis 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, fructus viticis 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, thizoma curculiginis 10 ~ 15 parts, mulberries 10 ~ 15 parts, the fruit of glossy privet 10 ~ 15 parts, the root of herbaceous peony 10 ~ 15 parts, giant knotweed 10 ~ 15 parts, Sculellaria barbata 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing, it is characterized in that, the preparation process of described root bark of Chinese wolf-berry health protection tea comprises following aspect:

A. the preparation of the root bark of Chinese wolf-berry;

B. heating in all the other raw material soaking ethanol described is extracted into medicinal extract;

C. again the medicinal extract that all the other raw materials extract is condensed into granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the root bark of Chinese wolf-berry prepared, sterilizing is prepared into health care medicinal tea;

In described step a, matrimony vine usage tree root is excavated in early spring, late fall, clean earth, fresh is cut into the segment of 5-10 centimeter length, then vertical profile is to xylem, put in food steamer hot slightly, when skin is easily peeled off, take out and peel skin zone, dry, large with block, meat is thick, be good without core and impurity person, put into iron pan slow fire and to stir-fry 10-15 minute.

In described step b, all the other raw materials can be got and clean impurity elimination, add in the ethanol accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, stand for standby use.

In described step c, the medicinal extract that above-mentioned steps obtains can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the concentrate of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.5g crude drug amount; Paste after concentrated adds honey mediation and makes granule; Or convection drying makes pulvis.

In described steps d, the granule of the root bark of Chinese wolf-berry made and other raw materials of refinement, pulvis or paste can be mixed, pack after ultraviolet ray sterilization bactericidal.

For solving the problems of the technologies described above, the present invention reoffers the preparation method of a kind of root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing, and its preparation process can also be:

A. the preparation of the root bark of Chinese wolf-berry, as component 1;

B. all the other bulk drugs described are extracted as component 2;

C. component 1 and component 2 are mixed, add appropriate propolis or dextrin mediation granulation after concentrated, bottle after ultraviolet ray sterilization bactericidal.

In described step a, early spring, late fall excavate matrimony vine usage tree root, clean earth, fresh is cut into the segment of 5-10 centimeter length, then vertical profile is to xylem, put in food steamer hot slightly, when skin is easily peeled off, take out and peel skin zone, dry, large with block, meat is thick, be good without core and impurity person, put into iron pan slow fire and to stir-fry 10-15 minute; The root bark of Chinese wolf-berry fried to be steeped in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, stand for standby use, become component 1; In described step b, all the other raw medicinal materials are mixed, all the other raw materials are put into the ethanol accounting for its quality 10 times amount and soak more than 24 hours, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; The dregs of a decoction of the medicinal material crossed by above-mentioned alcohol extract again add the water heating and refluxing extraction 2 times accounting for its quality 10 times amount, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; Above-mentioned two kinds of extracts are merged, as component 2; In described step c, blending ingredients 1 and component 2, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, and by gained concentrate adjustment proportion to 1.46, decompression, the paste after concentrated adds propolis or dextrin mediation granulation, bottles after ultraviolet ray sterilization bactericidal.

The technique effect that the present invention is useful is, the root bark of Chinese wolf-berry is sweet in flavor and cold in property, enters lung, liver, kidney channel." General Records of Holy Universal Relief " is recorded, and the root bark of Chinese wolf-berry is drunk, and controls and quenches one's thirst, day and night frequent taking of water, little facility.Modern pharmacological research: the root bark of Chinese wolf-berry contains the derivative of guanidine, has hypoglycemic activity.This product also has lipopenicillinase, hypotensive effect, and its hypotensive effect is relevant with nervous centralis, may for blocking SNE and direct vasodilator.The micro-bitter glycol of the present invention; Add some promoting blood circulation and removing blood stasis, mouthfeel is light, does not destroy the Chinese medicine in root bark of Chinese wolf-berry taste sugariness road, does not affect mouthfeel, makes people be easy to accept, can reach effect of hypoglycemic preferably.Do not have the unpleasant taste of traditional Chinese medicine being difficult to swallow, make people be easy to accept, can significantly improve immunity, Chinese medicine hypoglycemic, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.

Detailed description of the invention

In the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.

Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, people more than half is made to be in sub-health state, show as: dizzy, nervous, weak, poor appetite, failure of memory, insomnia, indifferent to etc. to thing, in addition, long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, a large amount of three height (high heat, high protein, higher fatty acid), more than three, (anticorrisive agent is many, flavoring agent is many, hormone is many) agricultural chemicals residual in the absorption of food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, go down to make three high disease (hypertension for a long time like this, hyperglycaemia, high fat of blood), cardiovascular and cerebrovascular disease, cancers etc. so-called " modern civilization diseases " rise rapidly, and constantly rejuvenation, the serious health and lives jeopardizing the mankind.A variety of causes makes immune system normally can not play protective effect, and in the case, very easily cause the infection such as bacterium, virus, fungi, therefore hypoimmunity the most directly shows is exactly liable to illness.

Experiment proves

1, the root bark of Chinese wolf-berry is to the effect of cardiovascular system: all have obvious hypotensive effect with the preserved material of the root bark of Chinese wolf-berry, tincture and decoction to anesthetized dog, cat, intravenous rabbit injection, and with decreased heart rate and accelerated breathing, also have obvious hypotensive effect to not anesthetized rat gavage. root bark of Chinese wolf-berry injection can make its blood pressure drop to zero and dead to anesthetized dog intravenous injection 0.375g/kg, low dose of duplicate injection has no tachylaxis. and root bark of Chinese wolf-berry methanolic extract also has obvious antihypertensive activity to rat intravenous injection 0.5g (crude drug)/kg. between root bark of Chinese wolf-berry pressure reducing period, the visible decreased heart rate of electrocardiogram, P-R interval prolongation, T ripple lowers, toxic dose can make guinea pig heart produce the partial and even completeness retardance of Atrioventricular Conduction. and the hypotensive effect of the root bark of Chinese wolf-berry is apart from outside maincenter participation, also may be relevant with its blocking-up SNE and direct vasodilatory effect. in addition, matrimony vine element A and matrimony vine element B has the effect of anti-cortex hormone of aadrenaline and feritin, also be one of its hypotensive effect mechanism.

2, hypoglycemic and effect for reducing blood fat: gavage root bark of Chinese wolf-berry decoction to rabbit, the blood sugar short time is first made to raise, then reduce lastingly, not yet to recover after 4 ~ 8 hours. the hyperglycaemia caused for Injection of Adrenaline there is no obvious antagonism, but hyperglycaemia can be shortened hold time. rabbit hypodermic injection root bark of Chinese wolf-berry medicinal extract, also blood sugar can be made to reduce. root bark of Chinese wolf-berry water decoction has the infringement of the morphosis of alloxan diabetes mouse islets B cell and certain alleviates effect. root bark of Chinese wolf-berry medicinal extract gavage, Experimental Rabbit serum total cholesterol content can be made to decline, but it is little on content of triglyceride impact, hepatic fat content is also had no significant effect. betaine then has lipotropy.

3, resisting pathogenic microbes effect: root bark of Chinese wolf-berry decoction has stronger inhibitory action to typhoid bacillus, paratyphoid bacillus A and bacterium flexneri, but to staphylococcus aureus without effect; Have A type capital, influenza Asia section 68-1 Strain and suppress its cytopathic effect; Be poor efficiency antibacterial medicines to tubercle bacillus.

4, refrigeration function: root bark of Chinese wolf-berry water extract, ethanol extract and ether residue water extract gavage or inject has remarkable antipyretic effect to artificial fever rabbit.After its ether extract and alcohol extract, the water extract of residue there is no effect. and its refrigeration function is more weak than aminopyrine, about equal with other alexipyretics.

5, other effects: root bark of Chinese wolf-berry water decoction produces interleukin 2 to normal mouse boosting cell inhibitory action; Produce reduction to caused by cyclophosphamide mouse boosting cell interleukin 2 to be significantly increased humidification; Interleukin 2 caused by imuran is produced and extraordinaryly has inhibitory action.Root bark of Chinese wolf-berry injection (100%) has remarkable excitation to unpregnancy rat and mouse isolated uterine.

The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.

The acid of Fructus Corni taste, adstringency, tepor.Return liver, kidney channel.Tonify the liver and kidney, puckery essence takes off admittedly.For dizzy tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, under uterine bleeding band, profuse sweating is collapsed, and interior heat is quenched one's thirst, for astringent drug, it contains cornin, not sieve glucoside, the 7-O-methyl not multiple effective ingredient such as iridoid glycosides and saponin, ursolic acid, tartaric acid, gallic acid, malic acid, Fructus Corni tannin 1,2,3 such as sieve glucoside, Cornuside, sweroside, loganin.There are obvious diuresis, lipopenicillinase, antibacterial effect leukocytic with elevating blood, have obvious curative effects to the disease such as dizzy tinnitus, the soreness of waist caused by treatment liver-kidney deficiency and the disease such as seminal emission, frequent micturition caused by the deficiency of the kidney yin.Again because it has the menorrhalgia that astringing to arrest bleeding effect is usually used in caused by human female void, the inferior disease of uterine bleeding band, good therapeutic action is all had to the common disease of andrology, gynaecology, in a large number for the production of help medicine, therefore be listed in one of traditional Chinese medicines 40 kinds of large kinds, there is market widely at traditional Chinese medicine circle.

The Chinese medicine fleece-flower root have Radix Polygoni Multiflori and RADIX POLYGONI MULTIFLORI PREPARATA point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for RADIX POLYGONI MULTIFLORI PREPARATA with black soya bean liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, the carbuncle that disappears, relax bowel, and is usually used in treatment scrofula sore carbuncle, rubella itch, the dry constipation of intestines; The filling liver kidney of RADIX POLYGONI MULTIFLORI PREPARATA function, benefiting essence-blood, black beard and hair, strengthening the bones and muscles, under sallow for the deficiency of blood, dizzy tinnitus, poliosis, soreness and weakness of waist and knees, extremity numbness, uterine bleeding band, chronic malaria body is empty etc.RADIX POLYGONI MULTIFLORI PREPARATA of the present invention is the good merchantable brand of invigrating kidney.

Parasitic loranthus is bitter; Sweet; Property is put down.There is wines used as antirheumatic, liver and kidney benefiting, strengthening the bones and muscles, antiabortive effect.Enter the heart, kidney two warp.Function cures mainly: filling liver kidney; Strengthening the bones and muscles; Wines used as antirheumatic; Antiabortive.Main soreness of waist and knee joint; Muscles and bones impotence is weak; Limbs are hemiplegia; Arthralgia due to wind-dampness; Head is wrong dizzy; Fetal irritability, metrostaxis.For arthralgia due to wind-dampness, soreness and weakness of waist and knees, muscles and bones is unable, uterine bleeding through many, blood leaking in gestation, fetal irritability; Hypertension.

Cortex acanthopanacis is the root skin of the drying of Araliaceae machaka acanthopanax gracilistylus.Have another name called white thorn, order bone, chase after that wind makes, CORTEX ACANTHOPANACIS etc.Main product in Hubei, Hunan, Henan, Anhui, the ground such as Sichuan.Chinese medicine cortex acanthopanacis has wines used as antirheumatic, filling liver kidney, the effects such as strengthening the bones and muscles.Record in Compendium of Material Medica: " tonifying middle-Jiao and Qi, control rheumatism impotence numbness, strengthen the bone." modern study, this product also has the effect such as antitumor, antifatigue, reduction WBV, atherosclerosis formation.Cortex acanthopanacis is easy to use, decoct soup, enter ball, fall apart or leaching slender acanthopanax bark spirit, but fire excess from yin deficiency person is cautious use of.

Thizoma curculiginis have tonify the kidney and support yang, benefiting essence-blood, strengthening the bones and muscles and promoting circulation of blood detumescence effect, be mainly used in the illnesss such as the insufficiency of the kidney yang, impotence and seminal emission, consumptive disease internal injury and arthralgia and myalgia.Kidney-replenishing, strengthening the bones and muscles, loose cold-dampness.Control impotence cold sperm, aconuresis, uterine bleeding, trusted subordinate's crymodynia, cold arthralgia of loins and legs, ulcer, scrofula, the deficiency of yang is cold rushes down.Impotence essence is cold, the diseases such as waist knee is air-cooled, muscles and bones impotence numbness.Have thizoma curculiginis ball in ancient prescription, can strengthen the bone, benefit spirit, improving eyesight, black beard and hair." Haiyao Bencao, Oversea Materia Medica ": main air, mend warm waist pin, clear five viscera settling, strengthening the bones and muscles, helps digestion.Declare and mend again, main husband's seven kinds of impairments, improve visual and auditory acuity, beneficial biceps, filling out marrow, Yiyang." Japan hanako materia medica ": control all general mood, mends general debility, the lower gas of appetizing.

The root of herbaceous peony is cool in nature, and bitter acid, is slightly cold, has soft liver of enriching blood, flat liver pain relieving.Astringe yin receives the effects such as sweat, is applicable to fever due to yin deficiency, irregular menstruation, chest abdomen pain over the hypochondriac region, four limbs contraction suddenly, rushes down dysentery stomachache, spontaneous sweating, uterine bleeding, the inferior disease of band.Paeoniflorin has antibacterial, antipyretic, anti-inflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, hemangiectasis, antagonism acute myocardial ischemia, Antiaggregating activity on platelet, calmness, analgesia, spasmolysis, antiulcer, adjustment blood sugar.Root of herbaceous peony decoction can suppress shigella dysenteriae, streptococcus pneumonia, Escherichia coli, typhoid bacillus, hemolytic streptococcus, Pseudomonas aeruginosa etc.The deficiency of blood deficiency of Yin, chest abdomen pain over the hypochondriac region, pain in the hepatic region, cholecystitis, gallstone pain, to rush down the condition subject such as dysentery stomachache, women's menalgia, spontaneous perspiration easy sweat night sweat, systremma, spasm of limbs pain, uneasy leg syndrome suitable edible.

Giant knotweed is clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, loose stasis of blood analgesic therapy, relieving cough and reducing sputum.For joint pain, jaundice with damp-heat pathogen, through closing, postpartum blood stasis does not Xia ， wei lump in the abdomen, coughing with a lot of sputum, scald, traumatic injury, carbuncle sore tumefacting virus.Giant knotweed contains knotweed glucoside, organic acid, glycoside, polysaccharide etc.Having clearing heat and detoxicating, cooling and heatstroke-eliminating, stomach invigorating food effect clearly, is a kind of polygonaceae plant.

Sculellaria barbata taste is pungent; Bitter; Cold in nature.Return lung channel; Liver Channel; Kidney channel.Function: heat-clearing, removing toxic substances, the loose stasis of blood, hemostasis, inducing diuresis to reduce edema, analgesic therapy.Control haematemesis, bleeding from five sense organs or subcutaneous tissue, blood drenches, and dysentery characterized by blood in the stool, jaundice, has sore throat, lung carbuncle, furunculosis, scrofula, sore, cancerous swelling, falls wound of forging a knife, snake bite." Quanzhou book on Chinese herbal medicine ": heat-clearing, removing toxic substances, method wind, loose blood, promoting the circulation of qi, Li Shui, dredging collateral, the broken stasis of blood, pain relieving.Main blood for oral administration drenches, and spits blood, bleeding from five sense organs or subcutaneous tissue; External application smelting venomous snake bite, ulcer, furunculosis, nameless sores or boils.Guangzhou army " conventional Chinese herbal medicine handbook ": clearing heat and detoxicating.For cancerly see the effect improving symptom; Appendicitis, hepatitis.

Ligusticum wallichii enters liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, hypochondriac pain abdomen ache, arthritis muscle contraction, through closing, difficult labour, postpartum stasis blocking block pain, ulcer sores.For irregular menstruation, through closing dysmenorrhoea, lump in the abdomen is suffered from abdominal pain, the shouting pain of the chest side of body, tumbling and swelling, headache, arthralgia due to wind-dampness." detailed outline " carries: " eliminating dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (adrenaline, potassium chloride cause).Can also coronary vasodilator be expanded, increase CF.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation coronary artery causes.

Fructus viticis fructus viticis Classification system: FRUCTUS VITICIS.For anemopyretic cold, headache head wind.The pungent wind that can fall apart of this product, be slightly cold heat-clearing, frivolous up, the heresy of main loose women's head-ornaments, and have the effect of wind-expelling pain-stopping, with controlling affection of exogenous wind-heat, headache and dizzy, is often equal to use with chrysanthemum, peppermint, and headache head wind normal being equal to tribulus terrestris, Ligusticum wallichii, yncaria stem with hooks is used.For red eye, swell pain, the many tear of blurred vision.This product energy dispelling wind and heat from the body, the clear sharp head, therefore available controlling in wind-heat is attacked, red eye, swell pain, the many tear of blurred vision, often joins chrysanthemum, cicada slough, the equivalent use of felwort; This product property of medicine rises to be sent out, and the clear sharp head, is equal to use with the Radix Astragali, Radix Codonopsis, the root of herbaceous peony, also availablely controls lucid yang failing to raise, and order gives birth to ocular, and the diseases such as Hiccough and deaf, as Yiqicongming Decoction.

The fruit of glossy privet, sweet-bitter flavor, cool in nature, return liver kidney channel, there is the merit that nourishing liver and kidney, beneficial the moon nourishes blood.Modern medicine study proves, the fruit of glossy privet includes ursolic acid, sweet mellow wine, glucose, fatty wet goods, has cardiac stimulant, diuresis and hepatoprotective effect, the leucocyte decline quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, Escherichia coli.The acid of the oleanolic acid fruit of glossy privet, Ligustrum lucidum Ait, ursolic acid, stearic acid, oleic acid, sweet mellow wine, betulin, phosphatide and carbohydrate is contained as Fructus Ligustri Lucidi polysaccharide, arabinose, glucose etc. in the fruit of glossy privet, also containing 15 seed amino acids, 11 kinds of trace elements and volatilization wet goods.Research thinks that the fruit of glossy privet has hypoglycemic and reducing blood lipid and has study of anti-atherogenic effect, and antibacterial, antivirus action in addition, fruit of glossy privet decoction all has inhibitory action to staphylococcus aureus, shigella flexneri, typhoid bacillus, Pseudomonas aeruginosa and Escherichia coli.Medium degree inhibitory action is had to Type B adenovirus.Increasing leukocyte: the fruit of glossy privet and component preparation thereof all have certain influence to haemocyte, it declines to leucocyte caused by chemotherapy rising effect.Compound containing the fruit of glossy privet also has effect in increasing leukocyte.Anti thrombotic action: oleanolic acid can accelerate the mobility of platelet cell, reduce the collision between blood platelet, make it not easily adhesion and gathering, more not easily deposit at endangium, slow down or prevent thrombosis, the deposition of lipid inner membrance can be reduced again, for the thrombotic diseases preventing and treating the elderly provides part Experiment foundation.Anti-ageing raising immunity: fruit of glossy privet decoction can make mouse immune organ thymus gland, spleen weight increase; Significantly improve mice serum hemolytic antibody active, impact mouse spleen lymphocyte being produced to proleulzin has dual regulation.The fruit of glossy privet has significant immunological enhancement, scavenging free radicals thus anti-ageing.Application fruit of glossy privet control: angiocardiopathy, coronary heart disease, hyperlipidemia, diabetes, thrombopenia, leukopenia, chronic nephritis, chronic bronchitis, intractable aypnia, Chronic Benzene Poisoning, tumour, malnutrition, immunologic hypofunction disease, seborrhea

Mulberries nourishing yin and nourishing blood medicine; Promote the production of body fluid medicine; Aperitive.To enrich blood enriching yin, promote the production of body fluid and moisturize.For dizzy tinnitus, palpitation and insomnia, poliosis, Tianjin wound is thirsty, and interior heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney-nourishing, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control liver-kidney Yin deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Both can food, can be used as medicine again, the traditional Chinese medical science thinks the sweet acid of mulberries taste, and cold nature, enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of intelligence development of nourishing heart.There is enriching yin of enriching blood, promote the production of body fluid to quench thirst, the effects such as ease constipation is dry, cure mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus palpitaition, irritated insomnia, soreness and weakness of waist and knees, poliosis, dry of quenching one's thirst, the diseases such as dry and hard excrement.

The root bark of white mulberry: the alcohol extract 5 ~ 6mg/kg of the root bark of white mulberry, to the decline that anesthetized rabbit, dog duodenal administration can make animal blood pressure obvious and lasting.And oral to the animal 20g/kg of experimental renal hypertension, also can produce obvious hypotensive effect.Cut off both sides vagus nerve or cut off spinal cord in 5th ~ 6 cervical vertebras, its hypotensive effect is constant.The extract of root bark of white mulberry ether, hot water or warm methyl alcohol, during to rabbit hemostasis 1g (crude drug)/kg, can make blood pressure decline 2 ~ 3.3kPa.A kind of material [fusing point (decomposition) is 144 DEG C] is raised from the root bark of white mulberry, to rabbits after intravenous note 10mg/kg, blood pressure significantly declines immediately, cuts off neck vagus nerve or cervical vertebra, this effect still exists, therefore infers that in extract may be acetylcholine sample material.Mulberry bark extract can suppress isolated frog heart, excited rabbits infestines, and the effect of reducing blood pressure can be resisted by atropine.Point out this kind of step-down to suppress, may inhibit vasomotor center and occur, step-down seemingly has increase to renal blood flow simultaneously.Isolated sanggenon quiet note rabbit from the root bark of white mulberry, can significantly step-down, and cyclomorusin, mulberry skin furans C etc. have hypotensive effect.

Specific embodiment 1:

Early spring, late fall excavate matrimony vine root, clean earth, fresh is cut into the segment of 5-10 centimeter length, vertical profile is to xylem again, puts in food steamer hot slightly, when skin is easily peeled off, taking-up peels skin zone, dry, large with block, meat is thick, be good without core and impurity person, put into iron pan slow fire and to stir-fry 10-15 minute.

Again by all the other raw material parasitic loranthus, cortex acanthopanacis, the root bark of white mulberry, Fructus Corni, Poria cocos, the red sage root, Ligusticum wallichii, fructus viticis, RADIX POLYGONI MULTIFLORI PREPARATA, thizoma curculiginis, mulberries, the fruit of glossy privet, the root of herbaceous peony, giant knotweed, Sculellaria barbata, extracts, makes paste, granule or pulvis.

The paste of the root bark of Chinese wolf-berry prepared and extract, granule or pulvis are mixed, ultraviolet radiation for sterilizing and disinfecting packs.

Specific embodiment 2:

Early spring, late fall excavate matrimony vine root, clean earth, fresh is cut into the segment of 5-10 centimeter length, then vertical profile is to xylem, puts in food steamer hot slightly, when skin is easily peeled off, taking-up peels skin zone, dries, large with block, meat is thick, be good without core and impurity person, put into iron pan slow fire to stir-fry 10-15 minute, about 5000g.

Get other raw materials parasitic loranthus 1500g again, cortex acanthopanacis 1500g, root bark of white mulberry 1500g, Fructus Corni 1500g, Poria cocos 1500g, red sage root 1500g, Ligusticum wallichii 1500g, fructus viticis 1500g, RADIX POLYGONI MULTIFLORI PREPARATA 1500g, thizoma curculiginis 1500g, mulberries 1500g, fruit of glossy privet 1500g, root of herbaceous peony 1500g, giant knotweed 1500g, Sculellaria barbata 1500g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.50, set to 0 ~ 5 DEG C of deepfreezes 24 hours, refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.5g crude drug amount, then adds honey and is in harmonious proportion, make granule, the root bark of Chinese wolf-berry be mixed with, ultraviolet disinfection, pack and get final product.

Specific embodiment 3:

Early spring, late fall excavate matrimony vine root, clean earth, fresh is cut into the segment of 5-10 centimeter length, then vertical profile is to xylem, puts in food steamer hot slightly, when skin is easily peeled off, taking-up peels skin zone, dries, large with block, meat is thick, be good without core and impurity person, put into iron pan slow fire to stir-fry 10-15 minute, about 4000g.Get other raw materials parasitic loranthus 1200g again, cortex acanthopanacis 1200g, root bark of white mulberry 1300g, Fructus Corni 1100g, Poria cocos 1100g, red sage root 1200g, Ligusticum wallichii 1200g, fructus viticis 1100g, RADIX POLYGONI MULTIFLORI PREPARATA 1200g, thizoma curculiginis 1100g, mulberries 1200g, fruit of glossy privet 1100g, root of herbaceous peony 1300g, giant knotweed 1200g, Sculellaria barbata 1100g, get bulk drug clean dry, in 70 DEG C of baking ovens, dry 1-3h, take out and be placed in cooling in drying box, pulverized 80-100 mesh sieve with pulverizer.To be soaked the particle that sieves in water 12 hours, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds water again, and half an hour is boiled in third time heating, filters; Three filtrates are combined, powder is placed in 70-90% ethanol and soaks 1-2 hour, is heated to 60 DEG C-70 DEG C in water-bath, lixiviate 2h, every 10min stirs once, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges leaching liquor, is condensed into pasty state.Then add honey to be in harmonious proportion, make granule, the root bark of Chinese wolf-berry be mixed with, ultraviolet disinfection, pack and get final product.

Specific embodiment 4:

Early spring, late fall excavate matrimony vine root, clean earth, fresh is cut into the segment of 5-10 centimeter length, then vertical profile is to xylem, puts in food steamer hot slightly, when skin is easily peeled off, taking-up peels skin zone, dries, large with block, meat is thick, be good without core and impurity person, put into iron pan slow fire to stir-fry 10-15 minute, about 3500g.The root bark of Chinese wolf-berry fried to be steeped in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, becomes component 1, all the other raw medicinal materials are mixed, parasitic loranthus 1200g, cortex acanthopanacis 1200g, root bark of white mulberry 1300g, Fructus Corni 1100g, Poria cocos 1100g, red sage root 1200g, Ligusticum wallichii 1200g, fructus viticis 1100g, RADIX POLYGONI MULTIFLORI PREPARATA 1200g, thizoma curculiginis 1100g, mulberries 1200g, fruit of glossy privet 1100g, root of herbaceous peony 1300g, giant knotweed 1200g, Sculellaria barbata 1100g, shredded 100 ~ 120 mesh sieves, after sieving, fine powder is for subsequent use, coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, 3 ~ 7 days are flooded together with more than 70 degree ethanol, then heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill, filter, filtrate is got after separation, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, and merge leaching liquor, being condensed into pasty state becomes component 2, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.60, and the paste after concentrated adds propolis or dextrin and is in harmonious proportion and granulates, and bottles after ultraviolet ray sterilization bactericidal.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.

Pharmacological experiment:

Observe the present invention to the impact of animal used as test blood pressure and blood lipoid.Method: adopt the diabetic mouse model caused by alloxan, with streptozotocin mycin (STZ) and the method giving high caloric diet copies type ii diabetes rat model, treat respectively with the present invention, Glipizide, then claim its body weight, measure serum triglyceride, cholesterol, serum insulin content and carry out dextrose tolerance test.Result: the present invention obviously reduces the blood sugar of diabetic mice, alleviates the body weight of diabetes B rat, stops fat generation.Also can reduce Peripheral Blood insulin level simultaneously, improve the ubiquitous notable feature of this diabetes B of insulin resistance.Conclusion: the present invention has obvious hypoglycemic lipid-lowering effect.

1 materials and methods

1.1 animals used as test: Wister rat, male, body weight 200 ~ 250g; Every only about the 18 ~ 20g of Kunming mouse (male and female dual-purpose), above animal is Shandong agricultural college animal center and provides.

1.2 high-calorie feed: mixed with sucrose, refining lard by basal feed, its total amount of heat is 20.08KJ/g (protein 15%, carbohydrate 51%, fat 25%).

1.3 medicines and reagent: root bark of Chinese wolf-berry 35g, parasitic loranthus 12g, cortex acanthopanacis 13g, root bark of white mulberry 11g, Fructus Corni 12g, Poria cocos 12g, red sage root 11g, Ligusticum wallichii 12g, fructus viticis 11g, RADIX POLYGONI MULTIFLORI PREPARATA 12g, thizoma curculiginis 11g, mulberries 12g, fruit of glossy privet 12g, root of herbaceous peony 12g, giant knotweed 11g, Sculellaria barbata 12g, (purchased from Shandong College of Traditional Chinese Medicine's Baokang hospital clinic), make after water decoction-alcohol sedimentation 100% liquid for subsequent use.STZ is Sigma Products, lot number: S0130; Alloxan is Sigma Products, faces the used time is made into 1% solution with citric acid one sodium citrate buffer solution of 0.1mmol/L, pH4.2; Glipizide tablet is Hainan Jin Xiao pharmaceutical Co. Ltd product, lot number: 001213; Blood sugar kit, Cholesterol Kit, Triglyceride Reagent box and serum insulin radioimmunological kit are all purchased from Beijing Zhongsheng Biological Engineering High Technology Company.

1.4 laboratory apparatus: semi-automatic biochemical analyzer: EPPENDORF-F6124 type, Germany; Radioimmunoassay instrument: naval's Medical Devices head factory, China.

The preparation of 1.5 experimental models: the preparation of diabetic hyperlipemia rat model: rat tail vein fast injection STZ30mg/kg, feeds with basal feed, freely drinks water, and tail vein blood after 2 weeks, carries out dextrose tolerance test; Select impaired glucose tolerance rat to feed with Prof. Du Yucang high-calorie feed, continue nursing 2 months.

The preparation of diabetic mouse model: get Kunming mouse, fasting 10h, then tail vein injection alloxan 100mg/kg, gets blood from mouse orbit after 72h, surveys blood glucose value; Blood glucose value is modeling success more than 11.0mmol/L person, for later experiment.

1_6 observation index and method: body weight: weigh with the electronic scale that Sartorius (Germany) produces.Blood sugar: GOD-PAP method.Serum triglyceride: GPO-PAP method.Serum cholesterol: CHO13-PAP method.Above 3 indexs, all by the operation of medicine box description, are produced EPPENDORF-F6124 type semi-automatic biochemical analyzer with Germany and are measured.Serum insulin is with putting the method for exempting from, and by specification operates.

1.7 data processings: experimental data represents with-X ± S, data statistics validity adopts t inspection.

2 experimental results

2.1 the present invention are on the impact of normal mouse blood sugar: get mouse 30, random point 3 groups: normal group, of the present invention group (5g/kg) and Glipizide group (1.3mg/kg).The morning every day gastric infusion, continuous 14d, fasting 6h after last administration, in mouse orbit get blood survey blood sugar.Result shows, the present invention does not have hypoglycemic activity (P > 0.05) to normal mouse.In table 1.

Table 1 the present invention is on the impact of normal mouse blood sugar.(x±s)

Group	N	Blood sugar mmol/L
			Normal group	10	6.21±1.34
Of the present invention group	10	5.34±1.16*
			Glipizide group	10	5.59±0.86**

Note: compare with normal group, * P > 0.05, * * P < 0.01

2.2 the present invention are on the impact of alloxan diabetes mouse: get normal mouse 10, survey its blood glucose value, feed with conventional feed.Separately get into mould mouse 50, be divided into 5 groups at random, be i.e. model group, of the present invention group (high, medium and low dosage group) and Glipizide group, successive administration 14d.Above 6 groups of mouse orbits are got blood, are surveyed its blood glucose value by 1h after last administration.

Result shows, give with alloxan after, model group compared with normal control group mice blood sugar level significantly raises, and still maintains higher level to experiment 14d its blood sugar.Of the present invention group of blood sugar level is starkly lower than model group, shows that the present invention can make alloxan diabetes mouse blood sugar reduce (P < 0.05), but still higher than Normal group (P < 0.05).In table 2.

Table 2 the present invention is on the impact (x ± s) of alloxan diabetes mouse blood sugar

Note: compare with normal group, * P < 0.05, * * * P < 0.01; Compare with model group, △ P < 0.05, △ △ △ P < 0.001

2.3 the present invention are to the effect of diabetic hyperlipemia rat

2.3.1 the present invention is on the impact of diabetic hyperlipemia rat body weight: grouping, administration is the same, day administration 1 time, continuous gavage 30 days.Experimental session drinking water for animals and feed without restriction.

Result shows, model group body weight is apparently higher than normal group (P < 0.01), of the present invention group and Glipizide group body weight are starkly lower than model group (P < 0.01, P < 0.05), of the present invention group and Glipizide group compare indifference (P > 0.05, P > 0.05) with normal group.Illustrate that the present invention has the effect of certain reduction rat model body weight.In table 3.

Table 3 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat body weight

Group	N	Dose	Body weight (g)
				Normal group	10	——	246.00±15.84
Model group	10	——	316.5±18.34**
				Of the present invention group (low)	10	5g/kg	285.65±15.31△
Of the present invention group (in)	10	10g/kg	280.26±18.34△△
				Of the present invention group (height)	10	15g/kg	270.45±17.43△△
Glipizide group	10	1.3mg/kg	272.67±19.65△

Note: compare with normal group, * * P < 0.01; △ P < 0.05, △ △ P < 0.01 is compared with model group

2.3.2 the present invention is on the impact of diabetic hyperlipemia rat glucose tolerance: grouping is the same with administration.Rat Fast 8h, intraperitoneal injection 1.11mol/L glucose solution 2g/kg, docking is got blood and is surveyed (0), 30,60 and 120min blood glucose value at once.Check through t, model group IGT (compares with 120min at once, P < 0.05), Analysis of variance, this group 30,60 and 120min blood sugar are apparently higher than normal group (P < 0.001, P < 0.01 and P < 0.05).Of the present invention group 30 and 60min are significantly higher than normal group (P < 0.001, P < 0.01), but be also starkly lower than model group (P < 0.01, P < 0.05), and normal glucose tolerance (at once comparing with 120min, P > 0.05).In table 4.

Table 4 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat glucose tolerance

Note: compare with normal group, * P < 0.05, * * P < 0.01, * * * P < 0.001; Compare with model group, △ P < 0.05, △ △ P < 0.01; At once compare with this group, ▲ P < 0.05.

2.3.3 the present invention is on the impact of diabetic hyperlipemia rat blood serum triglycerides, cholesterol: grouping, administration is the same.Result shows, the obvious rising of model group serum triglyceride, cholesterol and normal group (P < 0.001, P < 0.001); Two places soup is respectively organized all higher than normal group (P < 0.01, P < 0.001), but is starkly lower than model group (P < 0.001, P < 0.001); Glipizide is all apparently higher than control group (P < 0.001, P < 0.001), but no significant difference (P > 0.05, P > 0.05) is compared with model group.Illustrate that the present invention has certain reduction serum triglyceride, the effect of cholesterol, row pyrazine does not but have this to act on.In table 5.

Table 5 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat blood serum triglycerides, cholesterol

Note: compare with normal group, * P < 0.01, * * P < 0.001; Compare with model group, △ P < 0.001

2.3.4 the present invention is on the impact of diabetic hyperlipemia rat blood serum insulin: grouping, administration is the same.Result shows, model group serum insulin is apparently higher than normal group (P < 0.01); The present invention respectively organizes and is starkly lower than model group (P < 0.05 with Glipizide group, P < 0.05), but also higher than normal group (P < 0.05, P < 0.05).Illustrate that the present invention has the effect of certain reduction serum insulin, this effect is similar to Glipizide.In table 6.

Table 6 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat blood serum insulin

Group	N	Dose	Insulin μ IU/ml
				Normal group	10	——	22.84±2.42

Model group	10	——	28.11±2.41**
				Of the present invention group (low)	10	5g/kg	25.58±1.33*△
Of the present invention group (low)	10	10g/kg	24.24±1.64*△
				Of the present invention group (low)	10	15g/kg	23.12±1.32*△
Glipizide group	10	1.3mg/kg	24.06±1.48*△

Note: compare with normal group, * P < 0.01, * * P < 0.001; Compare with model group, △ P < 0.005

Experiment shows that the present invention obviously can reduce blood glucose in diabetic mice, but the blood sugar level of intact animal is not affected, its hypoglycemic mechanism has nothing to do with directly stimulating the effect of B cell excreting insulin, the damage of B cell may be alleviated with it, recover the impaired 26S Proteasome Structure and Function of pancreas islet and pass through relevant to glycometabolic adjustment.Also can reduce Peripheral Blood insulin level simultaneously, improve the ubiquitous feature of this diabetes B of insulin resistance.In addition, the present invention can alleviate the body weight of diabetes B rat, presses down the generation that resistance is fat, makes body weight can control, in normal scope, to reduce the hyperlipidemia that diabetes occur together.

The main component of the root bark of Chinese wolf-berry is: containing cinnamic acid and volume aldehydes matter, and betaine is still separated to B mono-sitosterol, linoleic acid and Kukoamine etc.These effective compositions can reduce " three is high " (high fat of blood, hypertension, hyperglycaemia) just.Hypoglycemic process mainly has facilitation to B cell excreting insulin.Modern pharmacology also confirms, the oral blood sugar that makes of its decoction reduces, and presents reduction blood fat.Can also reduce blood pressure, decreasing heart rate, heavy dose can cause atrioventricular block.Modern Chinese medicine is clinical also applies root bark of Chinese wolf-berry treatment diabetes widely, and decocting, for tea drink frequently, has certain hypoglycemic and lipid-lowering effect; As the root bark of Chinese wolf-berry made the decocting liquid of 4% concentration, white sugar of suitably adding some points, also has good curative effect to hypotensive.Modern Chinese herbal medicine pharmacology has confirmed that parasitic loranthus of the present invention, Poria cocos, the root bark of white mulberry have certain hypoglycemic or effect for reducing fat, although the composition of pharmacodynamics of the present invention it be not immediately clear, hypoglycemic lipid-lowering effect of the present invention can not be ignored, and has good material base.We are certain to the improvement result of the pathogenetic essence-deficiency of Yin of glycosuria, and compare with traditional Chinese medical theory from the cloudy thanks to scorching interpretation of the cause, onset and process of an illness of diabete to nourishing Yin and clearing heat diagnosis and treatment based on an overall analysis of the illness and the patient's condition and conform to, its mechanism of action needs to be furtherd investigate from now on.

In recent years, along with improving constantly of people's living standard, the disease incidence such as diabetes, coronary heart disease increases day by day.Chinese herbal medicine effect is stablized, few side effects, and research has the Chinese herbal medicine of hypoglycemic lipid-lowering effect, can provide more method for clinical treatment diabetes, hyperlipidemia.

Claims (10)

1. the root bark of Chinese wolf-berry health protection tea of a blood lipid-reducing blood sugar-decreasing, it is characterized in that, described root bark of Chinese wolf-berry health protection tea comprises the raw material of following parts by weight: the root bark of Chinese wolf-berry 10 ~ 50 parts, parasitic loranthus 10 ~ 20 parts, cortex acanthopanacis 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, fructus viticis 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, thizoma curculiginis 10 ~ 20 parts, mulberries 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, Sculellaria barbata 10 ~ 20 parts.

2. the root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing according to claim 1, it is characterized in that, in described root bark of Chinese wolf-berry health protection tea, the parts by weight of various raw material are: the root bark of Chinese wolf-berry 10 ~ 30 parts, parasitic loranthus 10 ~ 15 parts, cortex acanthopanacis 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the red sage root 10 ~ 15 parts, Ligusticum wallichii 10 ~ 15 parts, fructus viticis 10 ~ 20 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 20 parts, thizoma curculiginis 10 ~ 20 parts, mulberries 10 ~ 20 parts, the fruit of glossy privet 10 ~ 20 parts, the root of herbaceous peony 10 ~ 20 parts, giant knotweed 10 ~ 20 parts, Sculellaria barbata 10 ~ 20 parts.

3. the root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing according to claim 1, it is characterized in that, in described root bark of Chinese wolf-berry health protection tea, the parts by weight of various raw material are: the root bark of Chinese wolf-berry 10 ~ 40 parts, parasitic loranthus 10 ~ 20 parts, cortex acanthopanacis 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the red sage root 10 ~ 20 parts, Ligusticum wallichii 10 ~ 20 parts, fructus viticis 10 ~ 15 parts, RADIX POLYGONI MULTIFLORI PREPARATA 10 ~ 15 parts, thizoma curculiginis 10 ~ 15 parts, mulberries 10 ~ 15 parts, the fruit of glossy privet 10 ~ 15 parts, the root of herbaceous peony 10 ~ 15 parts, giant knotweed 10 ~ 15 parts, Sculellaria barbata 10 ~ 15 parts.

4. the preparation method of the root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described root bark of Chinese wolf-berry health protection tea comprises following aspect:

A. the preparation of the root bark of Chinese wolf-berry;

B. heating in all the other raw material soaking ethanol described is extracted into medicinal extract;

C. again the medicinal extract that all the other raw materials extract is condensed into granule, pulvis or paste;

D. concentrated granule, pulvis or paste are mixed with the root bark of Chinese wolf-berry prepared, sterilizing is prepared into health care medicinal tea.

5. the preparation method of the root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing according to claim 4, is characterized in that, in described step a, early spring, late fall excavate matrimony vine usage tree root, clean earth, fresh is cut into the segment of 5-10 centimeter length, then vertical profile is to xylem, put in food steamer hot slightly, when skin is easily peeled off, take out and peel skin zone, dry, large with block, meat is thick, be good without core and impurity person, put into iron pan slow fire and to stir-fry 10-15 minute.

6. the preparation method of the root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing according to claim 4, is characterized in that, in described step b, get all the other raw materials and clean impurity elimination, add in the ethanol accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, stand for standby use.

7. the preparation method of the root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing according to claim 4, it is characterized in that, in described step c, medicinal extract above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 80 DEG C, relative density is the medicinal extract of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, medicinal extract is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.5g crude drug amount; Paste after concentrated adds honey mediation and makes granule; Or convection drying makes pulvis.

8. the preparation method of the root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing according to claim 4, is characterized in that, in described steps d, the granule of the root bark of Chinese wolf-berry made and other raw materials of refinement, pulvis or paste is mixed, packs after ultraviolet ray sterilization bactericidal.

9. the preparation method of the root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing according to any one of claims 1 to 3, it is characterized in that, its preparation process can also be:

A. the preparation of the root bark of Chinese wolf-berry, as component 1;

B. all the other bulk drugs described are extracted as component 2;

C. component 1 and component 2 are mixed, add appropriate propolis or dextrin mediation granulation after concentrated, bottle after ultraviolet ray sterilization bactericidal.

10. the preparation method of the root bark of Chinese wolf-berry health protection tea of blood lipid-reducing blood sugar-decreasing according to claim 9, is characterized in that, in described step a, early spring, late fall excavate matrimony vine usage tree root, clean earth, fresh is cut into the segment of 5-10 centimeter length, then vertical profile is to xylem, put in food steamer hot slightly, when skin is easily peeled off, take out and peel skin zone, dry, large with block, meat is thick, be good without core and impurity person, put into iron pan slow fire and to stir-fry 10-15 minute; The root bark of Chinese wolf-berry fried to be steeped in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, stand for standby use, become component 1; In described step b, all the other raw medicinal materials are mixed, all the other raw materials are put into the ethanol accounting for its quality 10 times amount and soak more than 24 hours, heating and refluxing extraction 2 times, each 1 ~ 2 hour, No. 2 extracts are merged and leaves standstill; The dregs of a decoction of the medicinal material crossed by above-mentioned alcohol extract again add the water heating and refluxing extraction 2 times accounting for its quality 10 times amount, each 1 ~ 2 hour, are merged by No. 2 extracts and leave standstill; Above-mentioned two kinds of extracts are merged, as component 2; In described step c, blending ingredients 1 and component 2, reducing pressure after reclaiming ethanol, it is concentrated to put into inspissator, and by gained concentrate adjustment proportion to 1.46, decompression, the paste after concentrated adds propolis or dextrin mediation granulation, bottles after ultraviolet ray sterilization bactericidal.