CN104203953B - (s)‑4‑氨基‑n‑(1‑(4‑氯苯基)‑3‑羟丙基)‑1‑(7h‑吡咯并[2,3‑d]嘧啶‑4‑基)哌啶‑4‑甲酰胺的晶型 - Google Patents

(s)‑4‑氨基‑n‑(1‑(4‑氯苯基)‑3‑羟丙基)‑1‑(7h‑吡咯并[2,3‑d]嘧啶‑4‑基)哌啶‑4‑甲酰胺的晶型 Download PDF

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CN104203953B
CN104203953B CN201380020297.1A CN201380020297A CN104203953B CN 104203953 B CN104203953 B CN 104203953B CN 201380020297 A CN201380020297 A CN 201380020297A CN 104203953 B CN104203953 B CN 104203953B
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compound
ray powder
powder diffraction
crystal formation
diffraction pattern
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CN104203953A (zh
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G.P.汤金森
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AstraZeneca AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201380020297.1A 2012-04-17 2013-04-16 (s)‑4‑氨基‑n‑(1‑(4‑氯苯基)‑3‑羟丙基)‑1‑(7h‑吡咯并[2,3‑d]嘧啶‑4‑基)哌啶‑4‑甲酰胺的晶型 Active CN104203953B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261625312P 2012-04-17 2012-04-17
US61/625312 2012-04-17
PCT/GB2013/050973 WO2013156772A1 (en) 2012-04-17 2013-04-16 Crystalline forms of (s) -4-amino-n- (1- (4 - chlorophenyl) - 3 - hydroxypropyl) -1- (7h - pyrrolo [2, 3-d] pyrimidi n-4-yl) piperidine-4-carboxamide

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CN104203953A CN104203953A (zh) 2014-12-10
CN104203953B true CN104203953B (zh) 2016-11-16

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US (2) US9487525B2 (cg-RX-API-DMAC7.html)
EP (1) EP2847194B1 (cg-RX-API-DMAC7.html)
JP (2) JP2015514741A (cg-RX-API-DMAC7.html)
KR (1) KR20150002767A (cg-RX-API-DMAC7.html)
CN (1) CN104203953B (cg-RX-API-DMAC7.html)
AU (1) AU2013204533B2 (cg-RX-API-DMAC7.html)
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ES (1) ES2650797T3 (cg-RX-API-DMAC7.html)
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KR102518994B1 (ko) * 2014-05-28 2023-04-05 아스트라제네카 아베 Azd5363의 제조 방법 및 그에 사용되는 신규 중간체
WO2017078752A1 (en) * 2015-11-06 2017-05-11 The Penn State Research Foundation Compositions and methods relating to cancer
WO2022147519A1 (en) 2021-01-04 2022-07-07 Teva Pharmaceuticals International Gmbh Solid state forms of capivasertib and process for preparation thereof
CN119789849A (zh) * 2022-08-31 2025-04-08 阿斯利康(瑞典)有限公司 药物制剂
CR20250538A (es) 2023-05-26 2026-04-21 Astrazeneca Ab Composiciones farmacéuticas
WO2025238662A1 (en) * 2024-05-15 2025-11-20 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of 4-amino-n-[(1s)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide and its salts
CN122234059A (zh) * 2024-12-12 2026-06-19 安礼特（上海）医药科技有限公司 卡匹色替盐型及其制备方法

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MX2014012642A (es) 2014-11-25
CA2869936A1 (en) 2013-10-24
CN104203953A (zh) 2014-12-10
ES2650797T3 (es) 2018-01-22
TW201345913A (zh) 2013-11-16
BR112014025586A2 (cg-RX-API-DMAC7.html) 2017-06-20
SG11201405963YA (en) 2014-11-27
RU2652377C2 (ru) 2018-04-26
AU2013204533B2 (en) 2017-02-02
EP2847194A1 (en) 2015-03-18
EP2847194B1 (en) 2017-10-04
HK1206337A1 (en) 2016-01-08
BR112014025586B1 (pt) 2022-02-22
KR20150002767A (ko) 2015-01-07
RU2014143529A (ru) 2016-06-10
JP2018039807A (ja) 2018-03-15
US20170027943A1 (en) 2017-02-02
US20150087661A1 (en) 2015-03-26
MY175052A (en) 2020-06-03
TWI605046B (zh) 2017-11-11
US10039766B2 (en) 2018-08-07
CA2869936C (en) 2020-07-28
WO2013156772A1 (en) 2013-10-24
AU2013204533A1 (en) 2013-10-31
JP2015514741A (ja) 2015-05-21
IL234966A0 (en) 2014-12-31
US9487525B2 (en) 2016-11-08

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