CN104168897B - 用于治疗纤维肌痛和慢性疲劳综合征的(1r,4r)-6’-氟-(N-甲基-或N,N-二甲基-)-4-苯基-4’,9’-二氢-3’H-螺-[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺 - Google Patents

用于治疗纤维肌痛和慢性疲劳综合征的(1r,4r)-6’-氟-(N-甲基-或N,N-二甲基-)-4-苯基-4’,9’-二氢-3’H-螺-[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺 Download PDF

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Publication number
CN104168897B
CN104168897B CN201380007809.0A CN201380007809A CN104168897B CN 104168897 B CN104168897 B CN 104168897B CN 201380007809 A CN201380007809 A CN 201380007809A CN 104168897 B CN104168897 B CN 104168897B
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China
Prior art keywords
fibromyalgia
purposes
indole
fluoro
dihydro
Prior art date
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Expired - Fee Related
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CN201380007809.0A
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English (en)
Chinese (zh)
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CN104168897A (zh
Inventor
S.弗罗施
K.林茨
P.布洛姆斯-芬克
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Gruenenthal GmbH
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Gruenenthal GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CN201380007809.0A 2012-02-03 2013-02-01 用于治疗纤维肌痛和慢性疲劳综合征的(1r,4r)-6’-氟-(N-甲基-或N,N-二甲基-)-4-苯基-4’,9’-二氢-3’H-螺-[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺 Expired - Fee Related CN104168897B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12000743 2012-02-03
EP12000743.0 2012-02-03
PCT/EP2013/051979 WO2013113857A1 (en) 2012-02-03 2013-02-01 (1r,4r)-6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for treating fibromyalgia and chronic fatigue syndrome

Publications (2)

Publication Number Publication Date
CN104168897A CN104168897A (zh) 2014-11-26
CN104168897B true CN104168897B (zh) 2016-09-28

Family

ID=47628188

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380007809.0A Expired - Fee Related CN104168897B (zh) 2012-02-03 2013-02-01 用于治疗纤维肌痛和慢性疲劳综合征的(1r,4r)-6’-氟-(N-甲基-或N,N-二甲基-)-4-苯基-4’,9’-二氢-3’H-螺-[环己烷-1,1’-吡喃并[3,4,b]吲哚]-4-胺

Country Status (23)

Country Link
US (1) US20130202701A1 (https=)
EP (1) EP2809320B1 (https=)
JP (1) JP6126134B2 (https=)
KR (1) KR102061482B1 (https=)
CN (1) CN104168897B (https=)
AU (1) AU2013214223B2 (https=)
BR (1) BR112014019136A8 (https=)
CA (1) CA2863572C (https=)
CY (1) CY1118799T1 (https=)
DK (1) DK2809320T3 (https=)
EA (1) EA025500B1 (https=)
ES (1) ES2629211T3 (https=)
HR (1) HRP20170581T1 (https=)
IL (1) IL233871B (https=)
LT (1) LT2809320T (https=)
MX (1) MX353740B (https=)
NZ (1) NZ629800A (https=)
PL (1) PL2809320T3 (https=)
PT (1) PT2809320T (https=)
RS (1) RS56097B1 (https=)
SI (1) SI2809320T1 (https=)
WO (1) WO2013113857A1 (https=)
ZA (1) ZA201406447B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6673924B2 (ja) 2015-01-23 2020-03-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 肝機能障害および／または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005092895A2 (en) * 2004-03-29 2005-10-06 Pfizer Japan Inc. Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists
CN1735619A (zh) * 2002-11-11 2006-02-15 格吕伦塔尔有限公司 螺环环己烷衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900420A (en) * 1997-06-19 1999-05-04 Cole; William L. Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
AU2007254751A1 (en) * 2006-05-31 2007-12-13 Sepracor Inc. Treatment of pain disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine and its formamide
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1735619A (zh) * 2002-11-11 2006-02-15 格吕伦塔尔有限公司 螺环环己烷衍生物
WO2005092895A2 (en) * 2004-03-29 2005-10-06 Pfizer Japan Inc. Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
慢性疲劳综合征的临床特征与研究进展;王斌等;《中国临床康复》;20041215;第8卷(第35期);第8078-8081页 *
纤维肌痛综合征的研究进展;崔阳等;《中华风湿病学杂志》;20060228;第10卷(第2期);第114-116页 *

Also Published As

Publication number Publication date
AU2013214223B2 (en) 2017-03-23
SI2809320T1 (sl) 2017-07-31
IL233871B (en) 2018-06-28
EP2809320A1 (en) 2014-12-10
KR20140130695A (ko) 2014-11-11
JP2015505553A (ja) 2015-02-23
US20130202701A1 (en) 2013-08-08
MX2014008865A (es) 2014-08-27
JP6126134B2 (ja) 2017-05-10
BR112014019136A8 (pt) 2017-07-11
EA025500B1 (ru) 2016-12-30
LT2809320T (lt) 2017-05-25
WO2013113857A1 (en) 2013-08-08
EA201400857A1 (ru) 2015-01-30
CN104168897A (zh) 2014-11-26
PL2809320T3 (pl) 2017-09-29
RS56097B1 (sr) 2017-10-31
IL233871A0 (en) 2014-09-30
KR102061482B1 (ko) 2020-01-03
CA2863572C (en) 2019-08-27
HK1199218A1 (en) 2015-06-26
BR112014019136A2 (https=) 2017-06-20
CA2863572A1 (en) 2013-08-08
ZA201406447B (en) 2016-02-24
DK2809320T3 (en) 2017-05-15
MX353740B (es) 2018-01-26
CY1118799T1 (el) 2018-01-10
PT2809320T (pt) 2017-06-30
AU2013214223A1 (en) 2014-09-18
HRP20170581T1 (hr) 2017-06-16
ES2629211T3 (es) 2017-08-07
NZ629800A (en) 2016-06-24
EP2809320B1 (en) 2017-03-22

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