CN1041536C - 纳他霉素的连续生产 - Google Patents

纳他霉素的连续生产 Download PDF

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Publication number
CN1041536C
CN1041536C CN92110468A CN92110468A CN1041536C CN 1041536 C CN1041536 C CN 1041536C CN 92110468 A CN92110468 A CN 92110468A CN 92110468 A CN92110468 A CN 92110468A CN 1041536 C CN1041536 C CN 1041536C
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CN
China
Prior art keywords
tennecetin
substratum
inoculum
fermention medium
fermentation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN92110468A
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English (en)
Chinese (zh)
Other versions
CN1070688A (zh
Inventor
P·T·奥尔森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DCV Inc
Original Assignee
Bio-Technical Resources Inc (us) 1035 South Seventh Street Manitowoe Wiscon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio-Technical Resources Inc (us) 1035 South Seventh Street Manitowoe Wiscon filed Critical Bio-Technical Resources Inc (us) 1035 South Seventh Street Manitowoe Wiscon
Publication of CN1070688A publication Critical patent/CN1070688A/zh
Application granted granted Critical
Publication of CN1041536C publication Critical patent/CN1041536C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/626—Natamycin; Pimaricin; Tennecetin

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN92110468A 1991-08-05 1992-08-05 纳他霉素的连续生产 Expired - Fee Related CN1041536C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74053691A 1991-08-05 1991-08-05
US740,536 1991-08-05

Publications (2)

Publication Number Publication Date
CN1070688A CN1070688A (zh) 1993-04-07
CN1041536C true CN1041536C (zh) 1999-01-06

Family

ID=24976936

Family Applications (1)

Application Number Title Priority Date Filing Date
CN92110468A Expired - Fee Related CN1041536C (zh) 1991-08-05 1992-08-05 纳他霉素的连续生产

Country Status (13)

Country Link
EP (1) EP0598009B1 (enExample)
JP (1) JP2801966B2 (enExample)
CN (1) CN1041536C (enExample)
AU (1) AU2408092A (enExample)
CA (1) CA2115036C (enExample)
DE (1) DE69214654T2 (enExample)
ES (1) ES2093272T3 (enExample)
IL (1) IL102728A (enExample)
MX (1) MX9204520A (enExample)
NZ (1) NZ243827A (enExample)
TW (1) TW213489B (enExample)
WO (1) WO1993003171A1 (enExample)
ZA (1) ZA925869B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705609A (en) * 1988-06-28 1998-01-06 La Jolla Cancer Research Foundation Decorin fragments inhibiting cell regulatory factors
US5591438A (en) * 1990-12-07 1997-01-07 Bio-Technical Resources L.P. Natamycin recovery
CN100393738C (zh) * 2005-07-05 2008-06-11 广州市微生物研究所 纳他霉素的提取纯化方法
CN100590194C (zh) * 2007-09-29 2010-02-17 北京市农林科学院 一株产纳他霉素的利迪链霉菌及其应用
CN102108373A (zh) * 2009-12-25 2011-06-29 南通远大生物科技发展有限公司 纳他霉素的生产工艺及其在水产品保鲜中的应用
WO2014191449A1 (en) 2013-05-31 2014-12-04 Dsm Ip Assets B.V. Microbial agriculture
US20160128336A1 (en) 2013-05-31 2016-05-12 Dsm Ip Assets B.V. Microbial agriculture
CN103875657B (zh) * 2014-04-03 2016-01-20 广州市微生物研究所 一种含纳他霉素的抗紫外农用水分散粒剂及其制备方法
CN113481266A (zh) * 2021-07-28 2021-10-08 山东省医药生物技术研究中心（山东省病毒研究所） 一种利用纳他霉素发酵副产物提高纳他霉素发酵产量的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB846933A (en) * 1956-07-23 1960-09-07 American Cyanamid Co New antifungal substance, pimaricin, and method of producing same
US3015612A (en) * 1957-02-21 1962-01-02 Nat Res Dev Continuous fermentation apparatus for the production of a chemical product
US4167450A (en) * 1977-07-13 1979-09-11 University Of New Hampshire Method and apparatus for the production of secondary metabolites by the maintenance-state cultivation of microorganisms
DE3381997D1 (de) * 1982-08-23 1990-12-20 Unisearch Ltd Herstellung sekundaerer metaboliten aus mikroorganismen.

Also Published As

Publication number Publication date
JPH06508763A (ja) 1994-10-06
EP0598009A1 (en) 1994-05-25
MX9204520A (es) 1993-02-01
CN1070688A (zh) 1993-04-07
WO1993003171A1 (en) 1993-02-18
IL102728A0 (en) 1993-01-31
CA2115036A1 (en) 1993-02-18
ZA925869B (en) 1994-02-07
CA2115036C (en) 2002-11-12
JP2801966B2 (ja) 1998-09-21
DE69214654D1 (de) 1996-11-21
TW213489B (enExample) 1993-09-21
ES2093272T3 (es) 1996-12-16
NZ243827A (en) 1995-03-28
DE69214654T2 (de) 1997-04-30
AU2408092A (en) 1993-03-02
EP0598009B1 (en) 1996-10-16
IL102728A (en) 1996-05-14

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Free format text: CORRECT: PATENTEE; FROM: BIO-TECHNICAL RESOURCES INC., (US) 1035, SOUTH SEVENTH STREET, MANITOWOE, WISCON TO: DCV INC

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Address before: Wisconsin, USA

Patentee before: BIO-TECHNICAL RESOURCES L.P.

C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee