CN104144942A - 来自游动放线菌属菌种se50/110的新的放射菌整合和接合元件作为用于相关放线菌基因转化的质粒 - Google Patents

来自游动放线菌属菌种se50/110的新的放射菌整合和接合元件作为用于相关放线菌基因转化的质粒 Download PDF

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Publication number
CN104144942A
CN104144942A CN201280060526.8A CN201280060526A CN104144942A CN 104144942 A CN104144942 A CN 104144942A CN 201280060526 A CN201280060526 A CN 201280060526A CN 104144942 A CN104144942 A CN 104144942A
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protein
aice
amino acids
sequence
actinoplanes
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Chinese (zh)
Inventor
A·克莱因
K·泽尔贝尔
H·韦尔曼
W·罗森
A·皮勒
P·施魏恩特克
J·卡利诺夫斯基
U·韦迈尔
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Bayer Pharma AG
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Bayer Pharma AG
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Publication of CN104144942A publication Critical patent/CN104144942A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280060526.8A 2011-12-08 2012-12-04 来自游动放线菌属菌种se50/110的新的放射菌整合和接合元件作为用于相关放线菌基因转化的质粒 Pending CN104144942A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11192618.4 2011-12-08
EP11192618 2011-12-08
PCT/EP2012/074366 WO2013083566A1 (en) 2011-12-08 2012-12-04 New actinomycete integrative and conjugative element from actinoplanes sp. se50/110 as plasmid for genetic transformation of related actinobacteria

Publications (1)

Publication Number Publication Date
CN104144942A true CN104144942A (zh) 2014-11-12

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CN201280060526.8A Pending CN104144942A (zh) 2011-12-08 2012-12-04 来自游动放线菌属菌种se50/110的新的放射菌整合和接合元件作为用于相关放线菌基因转化的质粒

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Country Link
US (2) US9217154B2 (enExample)
EP (1) EP2788373B1 (enExample)
JP (1) JP2015501641A (enExample)
KR (1) KR20140109922A (enExample)
CN (1) CN104144942A (enExample)
AR (1) AR089117A1 (enExample)
CA (1) CA2858259A1 (enExample)
ES (1) ES2718331T3 (enExample)
HK (1) HK1203970A1 (enExample)
IL (1) IL232587A (enExample)
IN (1) IN2014CN04155A (enExample)
WO (1) WO2013083566A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112592878A (zh) * 2020-12-25 2021-04-02 上海交通大学 增强正调控蛋白基因表达以提高阿卡波糖发酵水平的方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2718331T3 (es) 2011-12-08 2019-07-01 Bayer Ip Gmbh Nuevo elemento integrador y conjugador de actinomiceto de Actinoplanes sp. SE50/110 como plásmido para la transformación genética de actinobacterias relacionadas
CN112522174B (zh) * 2020-12-25 2022-08-09 上海交通大学 一种敲除负调控蛋白基因以提高阿卡波糖发酵水平的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1172161A (zh) * 1996-03-22 1998-02-04 拜尔公司 阿卡维基转移酶及其制备与应用
WO2012016960A1 (en) * 2010-08-04 2012-02-09 Bayer Pharma Aktiengesellschaft Genomics of actinoplanes utahensis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2064092C2 (de) 1970-12-28 1983-06-01 Bayer Ag, 5090 Leverkusen Inhibitoren für Glykosidhydrolasen aus Actinomyceten
DE2209834C3 (de) 1972-03-01 1978-04-20 Bayer Ag, 5090 Leverkusen Herstellung von Saccharase-Inhibitoren
US4062950A (en) 1973-09-22 1977-12-13 Bayer Aktiengesellschaft Amino sugar derivatives
DE2347782C3 (de) 1973-09-22 1979-10-11 Bayer Ag, 5090 Leverkusen Aminozuckerderivate, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
EP2173880A2 (en) * 2007-07-27 2010-04-14 Wyeth a Corporation of the State of Delaware Vectors and methods for cloning gene clusters or portions thereof
ES2718331T3 (es) 2011-12-08 2019-07-01 Bayer Ip Gmbh Nuevo elemento integrador y conjugador de actinomiceto de Actinoplanes sp. SE50/110 como plásmido para la transformación genética de actinobacterias relacionadas

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1172161A (zh) * 1996-03-22 1998-02-04 拜尔公司 阿卡维基转移酶及其制备与应用
WO2012016960A1 (en) * 2010-08-04 2012-02-09 Bayer Pharma Aktiengesellschaft Genomics of actinoplanes utahensis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HOSTED: "Characterization of the Micromonospora rosaria pMR2 plasmid and development of a high G+C codon optimized integrase for site-specific integration", 《PLASMID》 *
TE POELE: "Actinomycete integrative and conjugative elements", 《ANTONIE VAN LEEUWENHOEK》 *
TE POELE: "Actinomycete integrative and conjugative pMEA-like elements of Amycolatopsis and Saccharopolyspora decoded", 《PLASMID》 *
顾觉奋: "阿卡波糖生物合成和发酵工艺研究进展", <国外医药(抗生素分册)> *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112592878A (zh) * 2020-12-25 2021-04-02 上海交通大学 增强正调控蛋白基因表达以提高阿卡波糖发酵水平的方法

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Publication number Publication date
WO2013083566A1 (en) 2013-06-13
HK1203970A1 (en) 2015-11-06
EP2788373A1 (en) 2014-10-15
IN2014CN04155A (enExample) 2015-07-17
JP2015501641A (ja) 2015-01-19
US9217154B2 (en) 2015-12-22
US9562249B2 (en) 2017-02-07
EP2788373B1 (en) 2019-01-23
AR089117A1 (es) 2014-07-30
IL232587A0 (en) 2014-06-30
US20140349346A1 (en) 2014-11-27
ES2718331T3 (es) 2019-07-01
CA2858259A1 (en) 2013-06-13
IL232587A (en) 2017-08-31
US20160130622A1 (en) 2016-05-12
KR20140109922A (ko) 2014-09-16

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