CN104136441B - 促性腺激素释放激素受体拮抗剂、其制备方法和包含该促性腺激素释放激素受体拮抗剂的药物组合物 - Google Patents

促性腺激素释放激素受体拮抗剂、其制备方法和包含该促性腺激素释放激素受体拮抗剂的药物组合物 Download PDF

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CN104136441B
CN104136441B CN201380011513.6A CN201380011513A CN104136441B CN 104136441 B CN104136441 B CN 104136441B CN 201380011513 A CN201380011513 A CN 201380011513A CN 104136441 B CN104136441 B CN 104136441B
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trifluoromethyl
benzyl
amino
pyrimidine
fluoro
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CN104136441A (zh
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金善美
金载善
李珉姬
李素英
李峰镛
申瑛娥
朴依善
李晶娥
韩敏永
安才承
俞兑暻
金薰泽
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Tiumbio Co ltd
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SK Chemicals Co Ltd
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
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    • C07—ORGANIC CHEMISTRY
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
CN201380011513.6A 2012-02-28 2013-02-28 促性腺激素释放激素受体拮抗剂、其制备方法和包含该促性腺激素释放激素受体拮抗剂的药物组合物 Active CN104136441B (zh)

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CN201610104516.XA CN105732649B (zh) 2012-02-28 2013-02-28 促性腺激素释放激素受体拮抗剂、其制备方法和包含该拮抗剂的药物组合物

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KR10-2012-0020479 2012-02-28
KR20120020479 2012-02-28
PCT/KR2013/001660 WO2013129879A1 (en) 2012-02-28 2013-02-28 Gonadotropin releasing hormone receptor antagonists, method for the preparation thereof and pharmaceutical composition comprising the same

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CN201610104516.XA Active CN105732649B (zh) 2012-02-28 2013-02-28 促性腺激素释放激素受体拮抗剂、其制备方法和包含该拮抗剂的药物组合物

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EP (1) EP2820021B1 (enExample)
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KR (1) KR101495260B1 (enExample)
CN (2) CN104136441B (enExample)
AU (1) AU2013226661B2 (enExample)
BR (1) BR112014021331B1 (enExample)
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RU2674977C2 (ru) 2013-10-30 2018-12-14 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Производные пиразолопиримидона или пирролотриазона, способ их получения и их фармацевтические применения
AU2018305633B2 (en) * 2017-07-28 2022-11-24 Jiangsu Hengrui Medicine Co., Ltd. Method for preparing pyrimidone heteroaryl derivative and intermediate of pyrimidone heteroaryl derivative
KR101973074B1 (ko) 2018-11-30 2019-04-26 주식회사 티움바이오 퓨로피리미딘 화합물의 염 및 결정형, 및 이를 포함하는 약학적 조성물
CN109651265A (zh) * 2019-02-16 2019-04-19 安徽诺全药业有限公司 一种Elagolix的制备方法
CN112955181B (zh) 2019-03-26 2024-08-13 新型医药公司 一种长效脂肪酸缀合的GnRH衍生物及含其的药物组合物
KR20210155350A (ko) 2020-06-15 2021-12-22 한상왕 녹차 추출물 및 비타민 d3를 유효성분으로 포함하는 자궁근종 개선용 조성물
CN115124545B (zh) * 2022-08-31 2023-01-03 南京远淑医药科技有限公司 一种促性腺激素释放激素受体拮抗剂中间体的合成方法
KR102738115B1 (ko) 2024-03-25 2024-12-05 한상왕 자궁근종 예방, 개선 또는 치료용 약학 조성물
KR20250160081A (ko) * 2024-05-03 2025-11-11 주식회사 티움바이오 에스트로겐-의존성 질환 치료 또는 예방용 약학적 조성물

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EP2390250A2 (en) * 2009-11-20 2011-11-30 Sk Chemicals Co., Ltd. Gonadotropin releasing hormone receptor antagonists, manufacturing method thereof, and pharmaceutical composition containing same

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EP2390250A2 (en) * 2009-11-20 2011-11-30 Sk Chemicals Co., Ltd. Gonadotropin releasing hormone receptor antagonists, manufacturing method thereof, and pharmaceutical composition containing same

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AU2013226661A1 (en) 2014-10-16
CN104136441A (zh) 2014-11-05
JP2015510868A (ja) 2015-04-13
US9481684B2 (en) 2016-11-01
CN105732649A (zh) 2016-07-06
EP2820021A1 (en) 2015-01-07
BR112014021331A2 (enExample) 2017-06-20
ES2613856T3 (es) 2017-05-26
EP2820021A4 (en) 2015-10-21
US20150166558A1 (en) 2015-06-18
CN105732649B (zh) 2019-02-05
BR112014021331A8 (pt) 2017-10-10
EP2820021B1 (en) 2016-11-30
CA2865547A1 (en) 2013-09-06
JP6209171B2 (ja) 2017-10-04
BR112014021331B1 (pt) 2020-12-15
AU2013226661B2 (en) 2017-08-31
CA2865547C (en) 2020-03-10
KR101495260B1 (ko) 2015-02-26
MX357841B (es) 2018-07-26
WO2013129879A1 (en) 2013-09-06
MX2014010345A (es) 2014-11-14
KR20130102002A (ko) 2013-09-16

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