CN104136030B - 磺酰基氨基吡咯烷酮衍生物，及其制备及治疗应用 - Google Patents

磺酰基氨基吡咯烷酮衍生物，及其制备及治疗应用 Download PDF

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Publication number
CN104136030B
CN104136030B CN201280070270.9A CN201280070270A CN104136030B CN 104136030 B CN104136030 B CN 104136030B CN 201280070270 A CN201280070270 A CN 201280070270A CN 104136030 B CN104136030 B CN 104136030B
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China
Prior art keywords
base
amino
isoquinolin
oxo
pyrrolidin
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Expired - Fee Related
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CN201280070270.9A
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English (en)
Chinese (zh)
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CN104136030A (zh
Inventor
N·阿莱特
J-M·阿尔滕伯格
J-P·赫劳尔特
R·基尔希
G·拉萨尔
S·马拉特
M-C·菲利波-奥茨
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Sanofi Aventis France
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Sanofi Aventis France
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201280070270.9A 2011-12-21 2012-12-19 磺酰基氨基吡咯烷酮衍生物，及其制备及治疗应用 Expired - Fee Related CN104136030B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11306733.4 2011-12-21
EP11306733.4A EP2606893A1 (en) 2011-12-21 2011-12-21 Sulphonylaminopyrrolidinone derivatives, their preparation and their therapeutic application
PCT/EP2012/076224 WO2013092756A1 (en) 2011-12-21 2012-12-19 Sulphonylaminopyrrolidinone derivatives, their preparation and their therapeutic application

Publications (2)

Publication Number Publication Date
CN104136030A CN104136030A (zh) 2014-11-05
CN104136030B true CN104136030B (zh) 2017-03-01

Family

ID=47428640

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280070270.9A Expired - Fee Related CN104136030B (zh) 2011-12-21 2012-12-19 磺酰基氨基吡咯烷酮衍生物，及其制备及治疗应用

Country Status (18)

Country Link
US (1) US9150544B2 (https=)
EP (2) EP2606893A1 (https=)
JP (1) JP6104936B2 (https=)
KR (1) KR20140106703A (https=)
CN (1) CN104136030B (https=)
AR (1) AR089397A1 (https=)
AU (1) AU2012357123B2 (https=)
BR (1) BR112014014869A2 (https=)
CA (1) CA2859575A1 (https=)
ES (1) ES2559854T3 (https=)
IL (1) IL233238A (https=)
IN (1) IN2014CN04861A (https=)
MX (1) MX347620B (https=)
RU (1) RU2014129787A (https=)
SG (1) SG11201403336QA (https=)
TW (1) TWI568727B (https=)
UY (1) UY34543A (https=)
WO (1) WO2013092756A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1307759B1 (it) 1998-03-31 2001-11-19 Schurr Stahlecker & Grill Dispositivo per condensare un composito di fibre stirato.
DE19838762B4 (de) 1998-08-26 2009-04-16 Maschinenfabrik Rieter Ag Spinnmaschine mit einer Vielzahl von Spinnstellen
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
CN104557928B (zh) * 2015-02-14 2016-08-24 佛山市赛维斯医药科技有限公司 一种含二环酰胺结构凝血因子Xa抑制剂、其制备方法及其用途
CN112969698A (zh) * 2018-11-08 2021-06-15 葛兰素史密斯克莱知识产权发展有限公司 化学化合物
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide
CN113264819B (zh) * 2021-05-25 2024-11-05 都创(上海)医药开发有限公司 一种基于连续流反应技术快速合成3-溴-2-氟苯甲醛的方法
TW202404583A (zh) 2022-06-08 2024-02-01 加拿大商再諾製藥公司 吡啶胺衍生物及其作為鉀通道調節劑之用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1244798A (zh) * 1996-12-13 2000-02-16 罗纳·布朗克罗尔药制品有限公司 磺酸或磺酰氨基n－(杂芳烷基)－氮杂环酰胺化合物
WO2001039759A2 (en) * 1999-12-02 2001-06-07 Aventis Pharma Deutschland Gmbh Sulfonic acid or sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121947A1 (de) * 1991-07-03 1993-01-07 Basf Ag 2-(3-(4-amidino-phenyl))-propionsaeurederivate, ihre herstellung und verwendung
US6602864B1 (en) 1996-12-13 2003-08-05 Aventis Pharma Deutschland Gmbh Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds
IL123986A (en) * 1997-04-24 2011-10-31 Organon Nv Medicinal compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1244798A (zh) * 1996-12-13 2000-02-16 罗纳·布朗克罗尔药制品有限公司 磺酸或磺酰氨基n－(杂芳烷基)－氮杂环酰胺化合物
WO2001039759A2 (en) * 1999-12-02 2001-06-07 Aventis Pharma Deutschland Gmbh Sulfonic acid or sulfonylamino n-(heteroaralkyl)-azaheterocyclylamide compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A new era for anticoagulants;Massimo Franchini等;《European Journal of Internal Medicine》;20090630;第20卷;第562-568页 *

Also Published As

Publication number Publication date
AR089397A1 (es) 2014-08-20
TW201331195A (zh) 2013-08-01
EP2793887A1 (en) 2014-10-29
MX2014007671A (es) 2014-11-25
AU2012357123B2 (en) 2016-12-15
JP2015502382A (ja) 2015-01-22
MX347620B (es) 2017-05-04
WO2013092756A1 (en) 2013-06-27
KR20140106703A (ko) 2014-09-03
AU2012357123A1 (en) 2014-07-10
IL233238A0 (en) 2014-08-31
IN2014CN04861A (https=) 2015-09-18
US9150544B2 (en) 2015-10-06
EP2606893A1 (en) 2013-06-26
TWI568727B (zh) 2017-02-01
JP6104936B2 (ja) 2017-03-29
IL233238A (en) 2016-10-31
EP2793887B1 (en) 2015-10-21
SG11201403336QA (en) 2014-07-30
BR112014014869A2 (pt) 2017-06-13
RU2014129787A (ru) 2016-02-10
UY34543A (es) 2013-06-28
ES2559854T3 (es) 2016-02-16
CA2859575A1 (en) 2013-06-27
CN104136030A (zh) 2014-11-05
US20140329801A1 (en) 2014-11-06

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Granted publication date: 20170301

Termination date: 20181219