CN104114544A - 用作卵泡刺激素受体激动剂的氘化噻唑烷酮类似物 - Google Patents
用作卵泡刺激素受体激动剂的氘化噻唑烷酮类似物 Download PDFInfo
- Publication number
- CN104114544A CN104114544A CN201380008413.8A CN201380008413A CN104114544A CN 104114544 A CN104114544 A CN 104114544A CN 201380008413 A CN201380008413 A CN 201380008413A CN 104114544 A CN104114544 A CN 104114544A
- Authority
- CN
- China
- Prior art keywords
- deuterium
- compound
- acid
- phenyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCOc(cc(C(C(*)(*C(C[C@@](*(C*1C2=CC(*3=C*3)=CC**2OC(*C(O)=C([C@]2C=C(*O)[C@](C(O)=C(C(O)=C)O)O)O)=C(C)C2O)OC)C1=O)=O)O)(O)O)cc1)c1OC(O)(O)O Chemical compound CCOc(cc(C(C(*)(*C(C[C@@](*(C*1C2=CC(*3=C*3)=CC**2OC(*C(O)=C([C@]2C=C(*O)[C@](C(O)=C(C(O)=C)O)O)O)=C(C)C2O)OC)C1=O)=O)O)(O)O)cc1)c1OC(O)(O)O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Surgery (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261596417P | 2012-02-08 | 2012-02-08 | |
| US61/596,417 | 2012-02-08 | ||
| PCT/EP2013/000215 WO2013117299A1 (fr) | 2012-02-08 | 2013-01-24 | Analogues de thiazolidinone deutériés utilisés comme agonistes du récepteur de l'hormone folliculo-stimulante |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104114544A true CN104114544A (zh) | 2014-10-22 |
Family
ID=47666083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380008413.8A Pending CN104114544A (zh) | 2012-02-08 | 2013-01-24 | 用作卵泡刺激素受体激动剂的氘化噻唑烷酮类似物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20150111933A1 (fr) |
| EP (1) | EP2812320B1 (fr) |
| JP (1) | JP6386382B2 (fr) |
| KR (1) | KR20140120903A (fr) |
| CN (1) | CN104114544A (fr) |
| AU (1) | AU2013218368B2 (fr) |
| BR (1) | BR112014019351A8 (fr) |
| CA (1) | CA2860489C (fr) |
| ES (1) | ES2672326T3 (fr) |
| HK (1) | HK1201837A1 (fr) |
| IL (1) | IL233983B (fr) |
| MX (1) | MX2014009416A (fr) |
| RU (1) | RU2014136334A (fr) |
| SG (1) | SG11201403540RA (fr) |
| WO (1) | WO2013117299A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015196335A1 (fr) | 2014-06-23 | 2015-12-30 | Tocopherx, Inc. | Composés de pyrazole utilisés comme modulateurs de fshr et leurs utilisations |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002009706A1 (fr) * | 2000-07-27 | 2002-02-07 | Smithkline Beecham Corporation | Agoniste d'activite hormonale stimulant un follicule |
| WO2009045476A1 (fr) * | 2007-10-02 | 2009-04-09 | Concert Pharmaceuticals, Inc. | Dérivés de pyrimidinedione |
| WO2010136438A1 (fr) * | 2009-05-27 | 2010-12-02 | N.V. Organon | (dihydro)imidazo-iso(5,1-a)quinoléines en tant qu'agonistes du récepteur de la fsh pour le traitement de troubles de la fertilité |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| PT1102763E (pt) | 1998-08-07 | 2005-01-31 | Applied Research Systems | Mimeticos fsh para o tratamento da infertilidade |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| US6426357B1 (en) | 1999-07-27 | 2002-07-30 | Affymax, Inc. | Antagonists of follicle stimulating hormone activity |
| DE60001623T2 (de) * | 1999-12-03 | 2003-12-18 | Pfizer Products Inc., Groton | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| US7598273B2 (en) * | 2005-10-06 | 2009-10-06 | Auspex Pharmaceuticals, Inc | Inhibitors of the gastric H+, K+-ATPase with enhanced therapeutic properties |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JP2012502038A (ja) * | 2008-09-03 | 2012-01-26 | テバ ファーマシューティカル インダストリーズ リミティド | 免疫機能の２−オキソ−１，２−ジヒドロ−キノリンモジュレーター |
-
2013
- 2013-01-24 JP JP2014555967A patent/JP6386382B2/ja not_active Expired - Fee Related
- 2013-01-24 CA CA2860489A patent/CA2860489C/fr not_active Expired - Fee Related
- 2013-01-24 ES ES13702741.3T patent/ES2672326T3/es active Active
- 2013-01-24 CN CN201380008413.8A patent/CN104114544A/zh active Pending
- 2013-01-24 RU RU2014136334A patent/RU2014136334A/ru unknown
- 2013-01-24 US US14/372,102 patent/US20150111933A1/en not_active Abandoned
- 2013-01-24 EP EP13702741.3A patent/EP2812320B1/fr not_active Not-in-force
- 2013-01-24 BR BR112014019351A patent/BR112014019351A8/pt not_active IP Right Cessation
- 2013-01-24 KR KR20147021930A patent/KR20140120903A/ko not_active Application Discontinuation
- 2013-01-24 AU AU2013218368A patent/AU2013218368B2/en not_active Ceased
- 2013-01-24 SG SG11201403540RA patent/SG11201403540RA/en unknown
- 2013-01-24 WO PCT/EP2013/000215 patent/WO2013117299A1/fr active Application Filing
- 2013-01-24 MX MX2014009416A patent/MX2014009416A/es unknown
-
2014
- 2014-08-06 IL IL233983A patent/IL233983B/en active IP Right Grant
-
2015
- 2015-03-10 HK HK15102455.7A patent/HK1201837A1/xx unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002009706A1 (fr) * | 2000-07-27 | 2002-02-07 | Smithkline Beecham Corporation | Agoniste d'activite hormonale stimulant un follicule |
| WO2009045476A1 (fr) * | 2007-10-02 | 2009-04-09 | Concert Pharmaceuticals, Inc. | Dérivés de pyrimidinedione |
| WO2010136438A1 (fr) * | 2009-05-27 | 2010-12-02 | N.V. Organon | (dihydro)imidazo-iso(5,1-a)quinoléines en tant qu'agonistes du récepteur de la fsh pour le traitement de troubles de la fertilité |
Non-Patent Citations (2)
| Title |
|---|
| B. BELLEAU ET AL.: "Effect of Deuterium Substitution in Sympathomimetic Amines on Adrenergic Responses", 《SCIENCE》 * |
| 江文峰 等.: "氘代作用在药物研究中的应用", 《齐鲁药事》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2672326T3 (es) | 2018-06-13 |
| HK1201837A1 (en) | 2015-09-11 |
| EP2812320A1 (fr) | 2014-12-17 |
| US20150111933A1 (en) | 2015-04-23 |
| MX2014009416A (es) | 2014-11-10 |
| IL233983A0 (en) | 2014-09-30 |
| AU2013218368B2 (en) | 2017-09-07 |
| AU2013218368A1 (en) | 2014-07-17 |
| WO2013117299A1 (fr) | 2013-08-15 |
| RU2014136334A (ru) | 2016-04-10 |
| BR112014019351A8 (pt) | 2017-07-11 |
| EP2812320B1 (fr) | 2018-03-07 |
| JP2015511943A (ja) | 2015-04-23 |
| JP6386382B2 (ja) | 2018-09-05 |
| KR20140120903A (ko) | 2014-10-14 |
| SG11201403540RA (en) | 2014-07-30 |
| BR112014019351A2 (fr) | 2017-06-20 |
| IL233983B (en) | 2019-12-31 |
| CA2860489A1 (fr) | 2013-08-15 |
| CA2860489C (fr) | 2019-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1201837 Country of ref document: HK |
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