SG11201403540RA - Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor - Google Patents

Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor

Info

Publication number
SG11201403540RA
SG11201403540RA SG11201403540RA SG11201403540RA SG11201403540RA SG 11201403540R A SG11201403540R A SG 11201403540RA SG 11201403540R A SG11201403540R A SG 11201403540RA SG 11201403540R A SG11201403540R A SG 11201403540RA SG 11201403540R A SG11201403540R A SG 11201403540RA
Authority
SG
Singapore
Prior art keywords
agonists
stimulating hormone
hormone receptor
follicle stimulating
analogues
Prior art date
Application number
SG11201403540RA
Other languages
English (en)
Inventor
Henry Yu
Marianne Donnelly
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11201403540RA publication Critical patent/SG11201403540RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SG11201403540RA 2012-02-08 2013-01-24 Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor SG11201403540RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261596417P 2012-02-08 2012-02-08
PCT/EP2013/000215 WO2013117299A1 (fr) 2012-02-08 2013-01-24 Analogues de thiazolidinone deutériés utilisés comme agonistes du récepteur de l'hormone folliculo-stimulante

Publications (1)

Publication Number Publication Date
SG11201403540RA true SG11201403540RA (en) 2014-07-30

Family

ID=47666083

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201403540RA SG11201403540RA (en) 2012-02-08 2013-01-24 Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor

Country Status (15)

Country Link
US (1) US20150111933A1 (fr)
EP (1) EP2812320B1 (fr)
JP (1) JP6386382B2 (fr)
KR (1) KR20140120903A (fr)
CN (1) CN104114544A (fr)
AU (1) AU2013218368B2 (fr)
BR (1) BR112014019351A8 (fr)
CA (1) CA2860489C (fr)
ES (1) ES2672326T3 (fr)
HK (1) HK1201837A1 (fr)
IL (1) IL233983B (fr)
MX (1) MX2014009416A (fr)
RU (1) RU2014136334A (fr)
SG (1) SG11201403540RA (fr)
WO (1) WO2013117299A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015196335A1 (fr) 2014-06-23 2015-12-30 Tocopherx, Inc. Composés de pyrazole utilisés comme modulateurs de fshr et leurs utilisations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
IL141063A (en) 1998-08-07 2005-06-19 Applied Research Systems Derivatives of pyrrolidine-2-carboxylic acid and piperidine-2-carboxylic acids and pharmaceutical compositions comprising said derivatives for treating infertility
US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
US6426357B1 (en) 1999-07-27 2002-07-30 Affymax, Inc. Antagonists of follicle stimulating hormone activity
PT1104760E (pt) * 1999-12-03 2003-06-30 Pfizer Prod Inc Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
JP2004505051A (ja) * 2000-07-27 2004-02-19 スミスクライン　ビーチャム　コーポレーション 卵胞刺激ホルモン活性のアゴニスト
TW200413273A (en) * 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
CA2624179A1 (fr) * 2005-10-06 2007-04-12 Auspex Pharmaceuticals, Inc. Inhibiteurs deuteries d'atpase h+,k+ gastrique ayant des proprietes therapeutiques renforcees
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
WO2009045476A1 (fr) * 2007-10-02 2009-04-09 Concert Pharmaceuticals, Inc. Dérivés de pyrimidinedione
CN104311486A (zh) * 2008-09-03 2015-01-28 泰华制药工业有限公司 2-羰基-1,2-二氢喹啉免疫功能调节剂
TWI461426B (zh) 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類

Also Published As

Publication number Publication date
RU2014136334A (ru) 2016-04-10
EP2812320A1 (fr) 2014-12-17
IL233983B (en) 2019-12-31
MX2014009416A (es) 2014-11-10
CA2860489A1 (fr) 2013-08-15
ES2672326T3 (es) 2018-06-13
AU2013218368B2 (en) 2017-09-07
JP2015511943A (ja) 2015-04-23
EP2812320B1 (fr) 2018-03-07
KR20140120903A (ko) 2014-10-14
US20150111933A1 (en) 2015-04-23
IL233983A0 (en) 2014-09-30
BR112014019351A2 (fr) 2017-06-20
BR112014019351A8 (pt) 2017-07-11
HK1201837A1 (en) 2015-09-11
CA2860489C (fr) 2019-11-12
AU2013218368A1 (en) 2014-07-17
WO2013117299A1 (fr) 2013-08-15
JP6386382B2 (ja) 2018-09-05
CN104114544A (zh) 2014-10-22

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