CN1040755C - 杂环化合物的制备方法 - Google Patents

杂环化合物的制备方法 Download PDF

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Publication number
CN1040755C
CN1040755C CN92105152A CN92105152A CN1040755C CN 1040755 C CN1040755 C CN 1040755C CN 92105152 A CN92105152 A CN 92105152A CN 92105152 A CN92105152 A CN 92105152A CN 1040755 C CN1040755 C CN 1040755C
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CN
China
Prior art keywords
group
phenyl
compound
methyl
alkyl
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Expired - Fee Related
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CN92105152A
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English (en)
Chinese (zh)
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CN1067890A (zh
Inventor
仲建彦
稻田义行
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of CN1067890A publication Critical patent/CN1067890A/zh
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Publication of CN1040755C publication Critical patent/CN1040755C/zh
Anticipated expiration legal-status Critical
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN92105152A 1991-06-27 1992-06-26 杂环化合物的制备方法 Expired - Fee Related CN1040755C (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP157194/91 1991-06-27
JP15719491 1991-06-27
JP157194/1991 1991-06-27
JP18888291 1991-07-29
JP188882/91 1991-07-29
JP192054/91 1991-07-31
JP19205491 1991-07-31
JP28821791 1991-08-12
JP288217/91 1991-08-12
JP239764/91 1991-09-19
JP23976491 1991-09-19
JP239764-91 1991-09-19

Publications (2)

Publication Number Publication Date
CN1067890A CN1067890A (zh) 1993-01-13
CN1040755C true CN1040755C (zh) 1998-11-18

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Family Applications (1)

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CN92105152A Expired - Fee Related CN1040755C (zh) 1991-06-27 1992-06-26 杂环化合物的制备方法

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CN (1) CN1040755C (enExample)
TW (1) TW251288B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102731408A (zh) * 2012-07-20 2012-10-17 江苏先声药物研究有限公司 一种阿齐沙坦中间体及其制备方法
CN103408500A (zh) * 2013-07-25 2013-11-27 上海博志研新药物技术有限公司 一种血管紧张素ⅱ受体拮抗剂及其关键中间体的制备方法
CN104072490A (zh) * 2013-03-28 2014-10-01 江苏柯菲平医药有限公司 一种阿奇沙坦关键中间体的制备方法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200709002B (en) * 2005-03-30 2009-01-28 Takeda Pharmaceutical Benzimidazole derivative and use as angiotensin II antagonist
CN103788097B (zh) * 2009-01-30 2016-03-30 武田药品工业株式会社 稠环化合物和其用途
WO2011063764A1 (zh) * 2009-11-30 2011-06-03 江苏豪森医药集团有限公司 阿齐沙坦有机胺盐及其制备方法和用途
CZ306650B6 (cs) * 2011-03-04 2017-04-19 Zentiva, K.S. Způsob výroby 2-ethoxy-1-((2´-((hydroxyamino)iminomethyl)bifenyl-4-yl)methyl)-1H-benzo[d]imidazol-7-karboxylové kyseliny a jejích esterů, klíčových intermediátů syntézy azilsartanu
CN102827153B (zh) * 2011-06-14 2016-10-05 江苏豪森药业集团有限公司 阿齐沙坦的晶型及其制备方法
US9174973B2 (en) 2011-09-30 2015-11-03 Sunshine Lake Pharma Co., Ltd. Crystalline forms of azilsartan and preparation and uses thereof
CN102731491B (zh) * 2012-07-04 2015-03-18 北京科莱博医药开发有限责任公司 一种阿齐沙坦中间体的制备方法
CN102766139B (zh) * 2012-08-14 2014-09-17 江苏先声药物研究有限公司 阿齐沙坦的多晶型物及其制备方法
CN103113364B (zh) * 2012-08-27 2015-11-18 南京华威医药科技开发有限公司 阿齐沙坦多晶型的制备方法
CN103664920B (zh) * 2012-09-24 2016-03-09 上海医药工业研究院 阿奇沙坦中间体及其与阿奇沙坦的制备方法
CN103880830B (zh) * 2013-03-22 2017-01-18 江西同和药业股份有限公司 一种阿齐沙坦的合成方法
CN104119326B (zh) * 2013-04-25 2017-04-26 正大天晴药业集团股份有限公司 一种阿齐沙坦的制备方法
CN103242305B (zh) * 2013-05-11 2018-02-27 迪沙药业集团有限公司 一种阿齐沙坦的制备方法
CN103372017A (zh) * 2013-07-04 2013-10-30 丁圣雨 Chukrasone A在制备治疗动脉粥样硬化药物中的应用
CN104418807A (zh) * 2013-09-09 2015-03-18 天津药物研究院 一种2-乙氧基-1-[[2`-(羟基脒基)-联苯基]-4-基]甲基-1h-苯并咪唑-7-羧酸及其酯衍生物的制备方法
CN106032378B (zh) * 2015-03-20 2019-10-25 武汉启瑞药业有限公司 新型arb化合物及其用途
CN106478515B (zh) * 2016-10-13 2018-11-23 艾美科健（中国）生物医药有限公司 一种阿齐沙坦中间体的制备方法
CN110194749B (zh) * 2019-07-08 2022-04-26 福州大学 3-三氟(二氟)甲基-1,2,4-三氮唑-5-酮类化合物的合成方法
CN112745302A (zh) * 2019-10-31 2021-05-04 上海中医药大学附属龙华医院 苯并咪唑类化合物及其医药用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149543A1 (en) * 1984-01-16 1985-07-24 Warner-Lambert Company Cardiotonic and antihypertensive oxadiazinone compounds
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
EP0411766A1 (en) * 1989-07-03 1991-02-06 Merck & Co. Inc. Substituted quinazolinones as angiotensin II antagonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149543A1 (en) * 1984-01-16 1985-07-24 Warner-Lambert Company Cardiotonic and antihypertensive oxadiazinone compounds
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
EP0411766A1 (en) * 1989-07-03 1991-02-06 Merck & Co. Inc. Substituted quinazolinones as angiotensin II antagonists

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102731408A (zh) * 2012-07-20 2012-10-17 江苏先声药物研究有限公司 一种阿齐沙坦中间体及其制备方法
CN104072490A (zh) * 2013-03-28 2014-10-01 江苏柯菲平医药有限公司 一种阿奇沙坦关键中间体的制备方法
CN103408500A (zh) * 2013-07-25 2013-11-27 上海博志研新药物技术有限公司 一种血管紧张素ⅱ受体拮抗剂及其关键中间体的制备方法
CN103408500B (zh) * 2013-07-25 2016-03-16 上海博志研新药物技术有限公司 一种血管紧张素ⅱ受体拮抗剂及其关键中间体的制备方法

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TW251288B (enExample) 1995-07-11
CN1067890A (zh) 1993-01-13

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 19981118

Termination date: 20100626