CN104072398A - 一种合成依折麦布的方法 - Google Patents
一种合成依折麦布的方法 Download PDFInfo
- Publication number
- CN104072398A CN104072398A CN201410313888.4A CN201410313888A CN104072398A CN 104072398 A CN104072398 A CN 104072398A CN 201410313888 A CN201410313888 A CN 201410313888A CN 104072398 A CN104072398 A CN 104072398A
- Authority
- CN
- China
- Prior art keywords
- compound
- reaction
- fluorophenyl
- chiral
- ezetimibe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410313888.4A CN104072398B (zh) | 2014-07-03 | 2014-07-03 | 一种合成依折麦布的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410313888.4A CN104072398B (zh) | 2014-07-03 | 2014-07-03 | 一种合成依折麦布的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104072398A true CN104072398A (zh) | 2014-10-01 |
CN104072398B CN104072398B (zh) | 2016-02-03 |
Family
ID=51594048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410313888.4A Active CN104072398B (zh) | 2014-07-03 | 2014-07-03 | 一种合成依折麦布的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104072398B (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104940153A (zh) * | 2015-07-23 | 2015-09-30 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗高血脂症的药物依折麦布组合物片剂 |
CN104958261A (zh) * | 2015-08-05 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗心脑血管疾病的药物依折麦布组合物干混悬剂 |
CN104983713A (zh) * | 2015-07-23 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗心脑血管系统疾病的药物依折麦布组合物胶囊 |
CN105439929A (zh) * | 2015-12-16 | 2016-03-30 | 上海恒晟药业有限公司 | 一种依泽麦布中间体的合成工艺 |
CN115960054A (zh) * | 2022-12-15 | 2023-04-14 | 南通常佑药业科技有限公司 | 一种依泽替米贝中间体的制备方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997045406A1 (en) * | 1996-05-31 | 1997-12-04 | Schering Corporation | 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones |
US5886171A (en) * | 1996-05-31 | 1999-03-23 | Schering Corporation | 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones |
US5919672A (en) * | 1998-10-02 | 1999-07-06 | Schering Corporation | Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone |
WO2009157019A2 (en) * | 2008-06-23 | 2009-12-30 | Ind-Swift Laboratories Limited | Process for preparing ezetimibe using novel allyl intermediates |
CN103204795A (zh) * | 2012-01-11 | 2013-07-17 | 重庆华邦胜凯制药有限公司 | 一种手性氮杂环丁酮类化合物的制备方法 |
CN103435525A (zh) * | 2013-07-25 | 2013-12-11 | 凯莱英医药集团(天津)股份有限公司 | 一种制备依折麦布的方法 |
-
2014
- 2014-07-03 CN CN201410313888.4A patent/CN104072398B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997045406A1 (en) * | 1996-05-31 | 1997-12-04 | Schering Corporation | 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones |
US5886171A (en) * | 1996-05-31 | 1999-03-23 | Schering Corporation | 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones |
US5919672A (en) * | 1998-10-02 | 1999-07-06 | Schering Corporation | Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone |
WO2009157019A2 (en) * | 2008-06-23 | 2009-12-30 | Ind-Swift Laboratories Limited | Process for preparing ezetimibe using novel allyl intermediates |
CN103204795A (zh) * | 2012-01-11 | 2013-07-17 | 重庆华邦胜凯制药有限公司 | 一种手性氮杂环丁酮类化合物的制备方法 |
CN103435525A (zh) * | 2013-07-25 | 2013-12-11 | 凯莱英医药集团(天津)股份有限公司 | 一种制备依折麦布的方法 |
Non-Patent Citations (1)
Title |
---|
谭祖磊: "新型降胆固醇药物依折麦步的合成工艺研究进展", 《中国医药技术经济与管理》 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104940153A (zh) * | 2015-07-23 | 2015-09-30 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗高血脂症的药物依折麦布组合物片剂 |
CN104983713A (zh) * | 2015-07-23 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗心脑血管系统疾病的药物依折麦布组合物胶囊 |
CN104958261A (zh) * | 2015-08-05 | 2015-10-07 | 青岛蓝盛洋医药生物科技有限责任公司 | 一种治疗心脑血管疾病的药物依折麦布组合物干混悬剂 |
CN105439929A (zh) * | 2015-12-16 | 2016-03-30 | 上海恒晟药业有限公司 | 一种依泽麦布中间体的合成工艺 |
CN105439929B (zh) * | 2015-12-16 | 2018-08-21 | 江苏恒盛药业有限公司 | 一种依泽麦布中间体的合成工艺 |
CN115960054A (zh) * | 2022-12-15 | 2023-04-14 | 南通常佑药业科技有限公司 | 一种依泽替米贝中间体的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN104072398B (zh) | 2016-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104072398B (zh) | 一种合成依折麦布的方法 | |
CN103333942B (zh) | 左旋吡喹酮的合成方法 | |
Jia et al. | Catalytic Asymmetric Decarboxylative Mannich Reaction of Malonic Acid Half Esters with Cyclic Aldimines: Access to Chiral β-Amino Esters and Chroman-4-amines | |
CN104557572A (zh) | 左旋沙丁胺醇中间体及左旋沙丁胺醇盐酸盐的合成方法 | |
CN102659919B (zh) | 一种硼替佐米的合成方法 | |
CN102675135B (zh) | 一种合成α-氨基酸酯的方法 | |
CN106365986A (zh) | 化合物及其制备方法和在合成布瓦西坦中的用途 | |
CN103664896A (zh) | 一种新的抗肿瘤分子靶向药物克里唑替尼的合成工艺方法 | |
CN104628622A (zh) | 一种沙格列汀中间体的制备方法 | |
CN104086419B (zh) | 取代3-羟基联苯-2,4-二羧酸二乙酯类化合物及其合成方法 | |
CN103242171A (zh) | 反式-(1r,2s)-2-(3,4-二氟苯基)环丙胺的制备方法 | |
CN102391128B (zh) | 一种抗生素医药中间体丙二酸单对硝基苄酯的生产方法 | |
US20140200355A1 (en) | Method for Preparing Optically Pure (-)-Clausenamide Compound | |
CN101130520B (zh) | 经非对映异构体盐的外消旋体拆分制备天然(-)-石杉碱甲和非天然(+)-石杉碱甲的新方法 | |
CN104860980A (zh) | 一种用于合成依折麦布的中间体及其制备方法和应用 | |
CN105646285A (zh) | 一种维兰特罗中间体及其制备方法和应用 | |
CN100387586C (zh) | 手性2-胺基-1-(6-氟-3,4-二氢苯并吡喃基)乙醇的合成方法 | |
CN101575298A (zh) | 一种制备手性医药中间体2-氨基-1-苯乙醇的方法 | |
CN102010345B (zh) | 一种动态动力学拆分制备d-苯丙氨酸的方法 | |
CN107266311B (zh) | 一种利用微流体芯片反应器连续制备α-酮酸酯的方法 | |
CN101747252A (zh) | R构诺普利兰的合成方法 | |
CN102757390B (zh) | 一种制备2-甲氧基-4-肼基-5-氟嘧啶的方法 | |
CN104745550A (zh) | 一种非水相催化制备(r)-3-取代戊二酸单烷基酯类化合物的calb突变体 | |
CN103923040A (zh) | 一种制备呋喃肟酸的方法 | |
CN105330550A (zh) | 一种光学活性的1-环己基乙胺的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Fan Yange Inventor after: Li Wenfeng Inventor after: Zhao Junhong Inventor after: Xue Baoyu Inventor after: Duan Xianying Inventor after: Xu Xiaobing Inventor after: Ruijin Na Naidoo. Inventor before: Fan Yange Inventor before: Li Wenfeng Inventor before: Zhao Junhong Inventor before: Xue Baoyu Inventor before: Duan Xianying Inventor before: Xu Xiaobing |
|
COR | Change of bibliographic data | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant |