CN103998536B - 用于药物递送的具有二氧化钛纳米管膜的装置 - Google Patents

用于药物递送的具有二氧化钛纳米管膜的装置 Download PDF

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Publication number
CN103998536B
CN103998536B CN201280059539.3A CN201280059539A CN103998536B CN 103998536 B CN103998536 B CN 103998536B CN 201280059539 A CN201280059539 A CN 201280059539A CN 103998536 B CN103998536 B CN 103998536B
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titania nanotube
titania
titanium
nanotube film
based material
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CN103998536A (zh
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亚当·D·孟德尔索恩
凯瑟琳·E·菲舍尔
彭浩怡
威廉·G·菲舍尔
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Nano Precision Medical Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
    • C25D11/02—Anodisation
    • C25D11/26—Anodisation of refractory metals or alloys based thereon
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
    • C25D11/02—Anodisation
    • C25D11/34—Anodisation of metals or alloys not provided for in groups C25D11/04 - C25D11/32
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D5/00—Electroplating characterised by the process; Pretreatment or after-treatment of workpieces
    • C25D5/48—After-treatment of electroplated surfaces
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D5/00—Electroplating characterised by the process; Pretreatment or after-treatment of workpieces
    • C25D5/48—After-treatment of electroplated surfaces
    • C25D5/50—After-treatment of electroplated surfaces by heat-treatment
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
    • F04C2270/00—Control; Monitoring or safety arrangements
    • F04C2270/04—Force
    • F04C2270/041—Controlled or regulated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Metallurgy (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
CN201280059539.3A 2011-12-05 2012-12-05 用于药物递送的具有二氧化钛纳米管膜的装置 Active CN103998536B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161566810P 2011-12-05 2011-12-05
US61/566,810 2011-12-05
PCT/US2012/067868 WO2013085951A1 (en) 2011-12-05 2012-12-05 Device having titania nanotube membrane for drug delivery

Publications (2)

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CN103998536A CN103998536A (zh) 2014-08-20
CN103998536B true CN103998536B (zh) 2017-09-15

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Country Link
US (1) US9814867B2 (cg-RX-API-DMAC10.html)
EP (1) EP2788439A4 (cg-RX-API-DMAC10.html)
JP (2) JP6564187B2 (cg-RX-API-DMAC10.html)
KR (1) KR102055772B1 (cg-RX-API-DMAC10.html)
CN (1) CN103998536B (cg-RX-API-DMAC10.html)
WO (1) WO2013085951A1 (cg-RX-API-DMAC10.html)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2857499A1 (en) 2010-10-01 2015-04-08 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2831613A1 (en) 2011-03-31 2012-10-04 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PT3682905T (pt) 2011-10-03 2022-04-07 Modernatx Inc Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
CN103998536B (zh) * 2011-12-05 2017-09-15 纳诺精密医疗有限公司 用于药物递送的具有二氧化钛纳米管膜的装置
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
WO2013151664A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
PT2922554T (pt) 2012-11-26 2022-06-28 Modernatx Inc Arn modificado nas porções terminais
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
KR20160067219A (ko) 2013-10-03 2016-06-13 모더나 세라퓨틱스, 인코포레이티드 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드
WO2015112811A1 (en) 2014-01-23 2015-07-30 Nano Precision Medical, Inc. Implant device for drug delivery
KR101458486B1 (ko) * 2014-02-26 2014-11-07 재단법인대구경북과학기술원 다공성 한방침 및 이의 제조방법
US12071516B2 (en) 2014-09-04 2024-08-27 Nano Precision Medical, Inc. Polymeric stabilizing formulations
US10479868B2 (en) 2014-09-04 2019-11-19 Nano Precision Medical, Inc. Polymeric stabilizing formulations
US12582607B2 (en) 2014-11-02 2026-03-24 Nano Precision Medical, Inc. Implantable medical devices for extended release of therapeutic agents
CN107106499B (zh) * 2014-11-02 2021-09-17 纳诺精密医疗有限公司 用于延长释放治疗剂的可植入医药装置
WO2016123027A1 (en) * 2015-01-26 2016-08-04 Nano Precision Medical, Inc. Apparatus and method for promoting fluid uptake into an implant
US20160367677A1 (en) * 2015-06-19 2016-12-22 Board Of Regents, The University Of Texas System Lipid nanodiscs and nanorods as modulators of clotting factor function in vivo
WO2017218354A1 (en) 2016-06-13 2017-12-21 Nano Precision Medical, Inc. Drug delivery device
WO2018067535A1 (en) 2016-10-04 2018-04-12 Nano Precision Medical, Inc. Implant delivery system with hydration promotor capability
KR101946703B1 (ko) * 2017-03-10 2019-04-29 성균관대학교산학협력단 친수성의 나노 필름 구조물을 이용한 무동력 액츄에이터 및 상기 무동력 액츄에이터를 제작하는 방법
EP3760241B1 (en) 2018-03-01 2024-04-17 Titanium Textiles AG Tension-free titanium metal warp knit fabric for surgically shaping soft tissues
DE112018000126B4 (de) 2018-03-01 2020-01-16 Elastic Titanium Implants, LLC. Titanmatrix auf der Basis von spannungsfreiem Metallgestrick für eine gerichtete Geweberegeneration
CN109692695B (zh) * 2018-12-27 2022-02-01 东北大学 一种近红外光响应型纳米二氧化钛复合材料及其制备方法
CN109686594B (zh) * 2019-01-18 2020-11-24 三峡大学 钴基双金属硫化物负极材料的制备方法及其应用
KR20230024874A (ko) 2020-02-28 2023-02-21 나노 프리시전 메디컬, 인코포레이티드 이식형 약물 전달 장치용 중합성 안정화제
BR112022025658A2 (pt) 2020-07-08 2023-01-17 Nano Prec Medical Inc Método para controlar uma taxa de liberação de um agente terapêutico, dispositivo implantável para liberação de um agente terapêutico, e, formulação de um agente terapêutico
WO2023107950A1 (en) * 2021-12-06 2023-06-15 Case Western Reserve University Implant medical devices
WO2023235302A1 (en) 2022-06-01 2023-12-07 Nano Precision Medical, Inc. Devices, methods and formulations to control release of therapeutic agents from implantable devices
WO2023235298A1 (en) 2022-06-01 2023-12-07 Nano Precision Medical, Inc. Methods and devices to control release of therapeutic agents from implantable devices
CA3255297A1 (en) * 2022-06-03 2023-12-07 Nano Precision Medical, Inc. DEVICES AND METHODS TO IMPROVE THE BIOAVAILABILITY OF THERAPEUTIC AGENTS
EP4646187A1 (en) 2023-01-06 2025-11-12 Nano Precision Medical, Inc. Formulations, devices and methods for a glp-1 agonist
WO2025147462A1 (en) 2024-01-04 2025-07-10 Nano Precision Medical, Inc. Implantable devices, formulations and methods for body weight management
WO2025147459A1 (en) 2024-01-04 2025-07-10 Nano Precision Medical, Inc. Stabilization of peptides and proteins in implantable devices and formulations

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101191248A (zh) * 2006-12-01 2008-06-04 西南交通大学 在钛基底材料表面制备二氧化钛纳米管阵列层的方法
CN101550581A (zh) * 2009-04-03 2009-10-07 西北有色金属研究院 一种双通大面积TiO2纳米管阵列膜的制备方法
CN101717984A (zh) * 2009-11-05 2010-06-02 兰州大学 一种二氧化钛纳米管薄膜的制备方法
CN101896643A (zh) * 2007-07-26 2010-11-24 宾州研究基金会 高度有序的二氧化钛纳米管阵列
CN102220616A (zh) * 2011-05-26 2011-10-19 东南大学 二氧化钛纳米管阵列的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0883788A (ja) * 1994-09-14 1996-03-26 Oki Electric Ind Co Ltd ドライエッチング方法
ATE246489T1 (de) 1997-03-31 2003-08-15 Alza Corp Implantierbares diffusionabgabesystem
CA2460334A1 (en) * 2001-09-14 2003-03-27 Francis J. Martin Microfabricated nanopore device for sustained release of therapeutic agent
WO2005039668A2 (en) * 2003-10-21 2005-05-06 Boiarski Anthony A Implantable drug delivery device for sustained release of therapeutic agent
KR100937167B1 (ko) 2007-06-05 2010-01-15 재단법인서울대학교산학협력재단 나노 포어 어레이를 이용한 나노 구조체의 제조방법
US20090232870A1 (en) 2008-03-13 2009-09-17 Richmond Chemical Corporation Apparatus and method of retaining and releasing molecules from nanostructures by an external stimulus
KR101043584B1 (ko) * 2008-08-20 2011-06-22 한국과학기술원 질소 원자가 선택적으로 도핑된 TiO2-xNx 나노튜브 및 그의 제조방법
KR101063761B1 (ko) 2008-11-19 2011-09-08 경원대학교 산학협력단 마개가 형성된 나노튜브를 제조하는 방법 및 이에 의해 제조된 나노튜브
US20100213046A1 (en) * 2009-01-06 2010-08-26 The Penn State Research Foundation Titania nanotube arrays, methods of manufacture, and photocatalytic conversion of carbon dioxide using same
CA2792484C (en) * 2009-03-12 2017-10-31 Delpor, Inc. Implantable device for long-term delivery of drugs
US20100269894A1 (en) * 2009-04-28 2010-10-28 Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The University Of Nevada Titanium dioxide nanotubes and their use in photovoltaic devices
NL2003250C2 (en) * 2009-07-20 2011-01-24 Metal Membranes Com B V Method for producing a membrane and such membrane.
JP2011111660A (ja) * 2009-11-27 2011-06-09 National Institute Of Advanced Industrial Science & Technology チタニアナノチューブアレイ及びその形成方法
CN103998536B (zh) * 2011-12-05 2017-09-15 纳诺精密医疗有限公司 用于药物递送的具有二氧化钛纳米管膜的装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101191248A (zh) * 2006-12-01 2008-06-04 西南交通大学 在钛基底材料表面制备二氧化钛纳米管阵列层的方法
CN101896643A (zh) * 2007-07-26 2010-11-24 宾州研究基金会 高度有序的二氧化钛纳米管阵列
CN101550581A (zh) * 2009-04-03 2009-10-07 西北有色金属研究院 一种双通大面积TiO2纳米管阵列膜的制备方法
CN101717984A (zh) * 2009-11-05 2010-06-02 兰州大学 一种二氧化钛纳米管薄膜的制备方法
CN102220616A (zh) * 2011-05-26 2011-10-19 东南大学 二氧化钛纳米管阵列的制备方法

Also Published As

Publication number Publication date
EP2788439A1 (en) 2014-10-15
CN103998536A (zh) 2014-08-20
JP6564187B2 (ja) 2019-08-21
EP2788439A4 (en) 2015-09-02
JP2018109236A (ja) 2018-07-12
WO2013085951A1 (en) 2013-06-13
KR102055772B1 (ko) 2019-12-13
US9814867B2 (en) 2017-11-14
KR20140106660A (ko) 2014-09-03
US20140371687A1 (en) 2014-12-18
JP2015500288A (ja) 2015-01-05

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