CN103974964B - β-C-芳基葡糖苷的制备方法 - Google Patents
β-C-芳基葡糖苷的制备方法 Download PDFInfo
- Publication number
- CN103974964B CN103974964B CN201280054691.2A CN201280054691A CN103974964B CN 103974964 B CN103974964 B CN 103974964B CN 201280054691 A CN201280054691 A CN 201280054691A CN 103974964 B CN103974964 B CN 103974964B
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- aryl
- arylation
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC=*C(C(OC1)O[C@]1[C@]1*)C1*=C Chemical compound CC=*C(C(OC1)O[C@]1[C@]1*)C1*=C 0.000 description 7
- BZSGSMQXTYWEMN-YTPWUJHKSA-N C=[O]=C([C@@H]([C@@H]1OC2OC1)O)[C@H]2O Chemical compound C=[O]=C([C@@H]([C@@H]1OC2OC1)O)[C@H]2O BZSGSMQXTYWEMN-YTPWUJHKSA-N 0.000 description 1
- SPHHCXWEMHUBRC-BNDIWNMDSA-N CO[C@@H]([C@@H]([C@@H](CO)O[C@H]1c2ccccc2)O)[C@H]1O Chemical compound CO[C@@H]([C@@H]([C@@H](CO)O[C@H]1c2ccccc2)O)[C@H]1O SPHHCXWEMHUBRC-BNDIWNMDSA-N 0.000 description 1
- LZXUKQVSZZUYKP-YZJMRIMCSA-N OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)OC1[AlH2] Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)OC1[AlH2] LZXUKQVSZZUYKP-YZJMRIMCSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161556780P | 2011-11-07 | 2011-11-07 | |
| US61/556,780 | 2011-11-07 | ||
| US201261661793P | 2012-06-19 | 2012-06-19 | |
| US61/661,793 | 2012-06-19 | ||
| PCT/IB2012/002894 WO2013068850A2 (en) | 2011-11-07 | 2012-11-07 | PROCESS FOR THE PREPARATION OF β-C-ARYL GLUCOSIDES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103974964A CN103974964A (zh) | 2014-08-06 |
| CN103974964B true CN103974964B (zh) | 2016-03-23 |
Family
ID=48290709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280054691.2A Expired - Fee Related CN103974964B (zh) | 2011-11-07 | 2012-11-07 | β-C-芳基葡糖苷的制备方法 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2776449B1 (https=) |
| JP (1) | JP6144686B2 (https=) |
| KR (1) | KR101756772B1 (https=) |
| CN (1) | CN103974964B (https=) |
| AU (1) | AU2012335280B2 (https=) |
| BR (1) | BR112014010997A2 (https=) |
| CA (1) | CA2854591A1 (https=) |
| IL (1) | IL232418A (https=) |
| IN (1) | IN2014CN04050A (https=) |
| TW (1) | TWI488861B (https=) |
| WO (1) | WO2013068850A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104557894A (zh) * | 2013-10-18 | 2015-04-29 | 上海信谊药厂有限公司 | 坎格列汀晶型及其制备方法 |
| WO2015155739A1 (en) * | 2014-04-11 | 2015-10-15 | Scinopharm Taiwan, Ltd. | Process for the preparation of beta-c-arylglucosides |
| CN105017237A (zh) * | 2014-04-29 | 2015-11-04 | 嘉实（湖南）医药科技有限公司 | 一种卡格列净的制备工艺 |
| EP2947077A1 (en) | 2014-05-19 | 2015-11-25 | LEK Pharmaceuticals d.d. | Stereoselective synthesis of intermediates in the preparation of ß-C-arylglucosides |
| US10370365B2 (en) | 2015-09-16 | 2019-08-06 | Optimus Drugs (P) Limited | Process for the preparation of Canagliflozin |
| CN105294624B (zh) * | 2015-11-16 | 2018-01-12 | 山东罗欣药业集团股份有限公司 | 一种达格列净的制备方法 |
| CN105486767B (zh) * | 2015-12-03 | 2018-03-13 | 上海应用技术学院 | 一种达格列净及其α‑异构体的分离方法 |
| CN105541815B (zh) * | 2015-12-24 | 2018-07-13 | 寿光富康制药有限公司 | 一种卡格列净的制备方法 |
| EP4114365A1 (en) | 2020-03-05 | 2023-01-11 | KRKA, d.d., Novo mesto | Pharmaceutical composition comprising sglt2 inhibitor |
| CN115867538A (zh) | 2020-06-05 | 2023-03-28 | 新梅斯托克公司 | 高纯的无定形达格列净的制备 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007031548A2 (en) * | 2005-09-15 | 2007-03-22 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5872599A (ja) * | 1981-10-27 | 1983-04-30 | Kanto Ishi Pharma Co Ltd | 複合糖質誘導体 |
| JP2006516257A (ja) * | 2003-01-03 | 2006-06-29 | ブリストル−マイヤーズ スクイブ カンパニー | Ｃ−アリールグルコシドｓｇｌｔ２阻害剤の製造法 |
| CN102762583A (zh) | 2009-11-24 | 2012-10-31 | 南非医学研究院 | 合成阿司巴汀及其类似物的方法 |
-
2012
- 2012-11-07 TW TW101141390A patent/TWI488861B/zh not_active IP Right Cessation
- 2012-11-07 AU AU2012335280A patent/AU2012335280B2/en not_active Ceased
- 2012-11-07 BR BR112014010997A patent/BR112014010997A2/pt not_active Application Discontinuation
- 2012-11-07 IN IN4050CHN2014 patent/IN2014CN04050A/en unknown
- 2012-11-07 JP JP2014539427A patent/JP6144686B2/ja not_active Expired - Fee Related
- 2012-11-07 EP EP12847376.6A patent/EP2776449B1/en not_active Not-in-force
- 2012-11-07 CN CN201280054691.2A patent/CN103974964B/zh not_active Expired - Fee Related
- 2012-11-07 KR KR1020147015420A patent/KR101756772B1/ko not_active Expired - Fee Related
- 2012-11-07 CA CA2854591A patent/CA2854591A1/en not_active Abandoned
- 2012-11-07 WO PCT/IB2012/002894 patent/WO2013068850A2/en not_active Ceased
-
2014
- 2014-05-01 IL IL232418A patent/IL232418A/en not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007031548A2 (en) * | 2005-09-15 | 2007-03-22 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted (ethynyl-benzyl)-benzene derivatives and intermediates thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013068850A8 (en) | 2013-10-10 |
| CN103974964A (zh) | 2014-08-06 |
| IL232418A (en) | 2016-10-31 |
| EP2776449B1 (en) | 2017-08-02 |
| CA2854591A1 (en) | 2013-05-16 |
| AU2012335280B2 (en) | 2016-09-29 |
| KR20140089427A (ko) | 2014-07-14 |
| IL232418A0 (en) | 2014-06-30 |
| KR101756772B1 (ko) | 2017-07-26 |
| WO2013068850A2 (en) | 2013-05-16 |
| TW201335175A (zh) | 2013-09-01 |
| BR112014010997A2 (pt) | 2017-06-06 |
| WO2013068850A3 (en) | 2013-08-22 |
| EP2776449A2 (en) | 2014-09-17 |
| JP6144686B2 (ja) | 2017-06-07 |
| AU2012335280A1 (en) | 2014-05-22 |
| JP2014532690A (ja) | 2014-12-08 |
| TWI488861B (zh) | 2015-06-21 |
| EP2776449A4 (en) | 2015-10-07 |
| IN2014CN04050A (https=) | 2015-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160323 Termination date: 20181107 |