CN103958474B - 作为lsd1抑制剂的(杂)芳基环丙基胺化合物 - Google Patents
作为lsd1抑制剂的(杂)芳基环丙基胺化合物 Download PDFInfo
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- CN103958474B CN103958474B CN201280051318.1A CN201280051318A CN103958474B CN 103958474 B CN103958474 B CN 103958474B CN 201280051318 A CN201280051318 A CN 201280051318A CN 103958474 B CN103958474 B CN 103958474B
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- cyclopropyl
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- diamidogen
- nitrae
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- 0 CC1CCC(*)CC1 Chemical compound CC1CCC(*)CC1 0.000 description 30
- CZGIEJXGCLWRPY-UHFFFAOYSA-N CNC1CN(C)CC1 Chemical compound CNC1CN(C)CC1 CZGIEJXGCLWRPY-UHFFFAOYSA-N 0.000 description 1
- VIKCPUKEURRAHA-UHFFFAOYSA-N NC(CC1)CCC1NCC1=CC1c1ccccc1 Chemical compound NC(CC1)CCC1NCC1=CC1c1ccccc1 VIKCPUKEURRAHA-UHFFFAOYSA-N 0.000 description 1
- RDWRYLVZMRPAAI-ZZVGESKWSA-N OC(CC1)CCC1N[C@@H](C1)[C@H]1c1ccc(-c2cccc(C(F)(F)F)c2)nc1 Chemical compound OC(CC1)CCC1N[C@@H](C1)[C@H]1c1ccc(-c2cccc(C(F)(F)F)c2)nc1 RDWRYLVZMRPAAI-ZZVGESKWSA-N 0.000 description 1
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| BR112012006572A2 (pt) | 2009-09-25 | 2016-04-26 | Oryzon Genomics Sa | inibidores de demetilase-1 de lisina específicos e seu uso |
| EP2486002B1 (en) | 2009-10-09 | 2019-03-27 | Oryzon Genomics, S.A. | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
| WO2011106106A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae |
| US9616058B2 (en) | 2010-02-24 | 2017-04-11 | Oryzon Genomics, S.A. | Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use |
| JP5868948B2 (ja) | 2010-04-19 | 2016-02-24 | オリゾン・ジェノミックス・ソシエダッド・アノニマOryzon Genomics S.A. | リジン特異的脱メチル化酵素1阻害薬およびその使用 |
| US9006449B2 (en) | 2010-07-29 | 2015-04-14 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as LSD1 inhibitors |
| ES2674747T3 (es) | 2010-07-29 | 2018-07-03 | Oryzon Genomics, S.A. | Inhibidores de demetilasa LSD1 basados en arilciclopropilamina y sus usos médicos |
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| EP3981395A1 (en) * | 2011-02-08 | 2022-04-13 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| RU2668952C2 (ru) * | 2011-10-20 | 2018-10-05 | Оризон Дженомикс, С.А. | (гетеро)арилциклопропиламины в качестве ингибиторов lsd1 |
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| WO2014058071A1 (ja) | 2012-10-12 | 2014-04-17 | 武田薬品工業株式会社 | シクロプロパンアミン化合物およびその用途 |
| EP2740474A1 (en) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
| WO2015021128A1 (en) | 2013-08-06 | 2015-02-12 | Imago Biosciences Inc. | Kdm1a inhibitors for the treatment of disease |
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