CN103889930B - 用于制备68Ga络合物的工艺 - Google Patents

用于制备68Ga络合物的工艺 Download PDF

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Publication number
CN103889930B
CN103889930B CN201280039304.8A CN201280039304A CN103889930B CN 103889930 B CN103889930 B CN 103889930B CN 201280039304 A CN201280039304 A CN 201280039304A CN 103889930 B CN103889930 B CN 103889930B
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vial
formate
chelator
reaction
acid
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CN103889930A (zh
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洛伦扎·佛卡夏
玛丽亚·阿苏拉·费拉尼诺
毛里齐奥·弗兰科·马里亚尼
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Advanced Catalyst Applications International Ltd
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Advanced Accelerator Applications SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280039304.8A 2011-08-12 2012-08-10 用于制备68Ga络合物的工艺 Active CN103889930B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITFI2011A000180 2011-08-12
IT000180A ITFI20110180A1 (it) 2011-08-12 2011-08-12 Processo per la preparazione di complessi di 68ga.
PCT/EP2012/065659 WO2013024013A2 (en) 2011-08-12 2012-08-10 Process for the preparation of complexes of 68ga.

Publications (2)

Publication Number Publication Date
CN103889930A CN103889930A (zh) 2014-06-25
CN103889930B true CN103889930B (zh) 2017-03-29

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US (2) US9375498B2 (enExample)
EP (3) EP3718991A1 (enExample)
JP (1) JP6161610B2 (enExample)
CN (1) CN103889930B (enExample)
AU (1) AU2012297008B2 (enExample)
BR (2) BR122020011908B1 (enExample)
CA (2) CA3045484C (enExample)
CO (1) CO7020857A2 (enExample)
DK (1) DK2742017T3 (enExample)
ES (2) ES2835581T3 (enExample)
IL (3) IL230904B (enExample)
IN (1) IN2014CN01897A (enExample)
IT (1) ITFI20110180A1 (enExample)
MX (1) MX370081B (enExample)
PL (1) PL2742017T3 (enExample)
PT (1) PT2742017E (enExample)
RU (2) RU2605090C2 (enExample)
WO (1) WO2013024013A2 (enExample)
ZA (1) ZA201401789B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11027030B2 (en) 2014-08-29 2021-06-08 Anmi S.A. Kit for radiolabelling
BE1021191B1 (fr) * 2014-08-29 2015-10-27 Anmi S.A. Kit pour radiomarquage.
ES2892034T3 (es) * 2015-01-30 2022-02-01 Advanced Accelerator Applications Int S A Proceso para la purificación de Ga-68 a partir del eluato derivado de generadores de 68Ge/ 68Ga
IL237525A (en) 2015-03-03 2017-05-29 Shalom Eli Method for labeling a prostate-specific membrane antigen with a radioactive isotope
GB201504064D0 (en) * 2015-03-10 2015-04-22 Accretion Biotechnology Ltd Method and kits for preparing radionuclide complexes
IL297323A (en) * 2020-04-29 2022-12-01 Novartis Ag Methods for radiological labeling of psma-binding ligands and their kits
RU2760273C1 (ru) * 2020-11-02 2021-11-23 Федеральное государственное бюджетное учреждение науки Ордена Трудового Красного Знамени Институт химии силикатов им. И.В. Гребенщикова Российской академии наук (ИХС РАН) Способ получения комплексов на основе изотопа галлий-68
CN117500772A (zh) 2021-05-31 2024-02-02 泰利克斯制药(创新)私人有限公司 改进的前列腺特异性膜抗原靶向放射性药物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092114A1 (en) * 2009-02-13 2010-08-19 Guerbet Use of buffers for radionuclide complexation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
AU2002365649A1 (en) * 2001-11-28 2003-06-17 Immunomedics, Inc. Anti-dota antibody
GB0308408D0 (en) * 2003-04-11 2003-05-21 Amersham Plc Microwave activation
BRPI0412824A (pt) * 2003-07-24 2006-09-26 Bracco Imaging Spa composições radiofarmacêuticas estáveis e métodos para suas preparações
CN1874792A (zh) 2003-09-03 2006-12-06 布里斯托尔-迈尔斯.斯奎布制药公司 包含基质金属蛋白酶底物的化合物及其使用方法
DE102004057225B4 (de) * 2004-11-26 2006-10-12 Johannes-Gutenberg-Universität Mainz Verfahren und Vorrichtung zur Isolierung eines chemisch und radiochemisch gereinigten 68Ga-Radionuklids und zum Markieren eines Markierungsvorläufers mit dem 68Ga-Radionuklid
US20100233082A1 (en) * 2006-08-28 2010-09-16 Bengt Langstrom 68GA-Labeled Peptide-Based Radiopharmaceuticals
WO2010141833A2 (en) * 2009-06-05 2010-12-09 The General Hospital Corporation Vital fluorochrome conjugates and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092114A1 (en) * 2009-02-13 2010-08-19 Guerbet Use of buffers for radionuclide complexation

Also Published As

Publication number Publication date
EP3718991A1 (en) 2020-10-07
AU2012297008A1 (en) 2014-03-20
CA2844145A1 (en) 2013-02-21
IL230904A0 (en) 2014-03-31
WO2013024013A3 (en) 2013-05-02
JP2014524423A (ja) 2014-09-22
PT2742017E (pt) 2016-02-26
RU2016144237A3 (enExample) 2019-10-10
NZ708281A (en) 2016-01-29
CA2844145C (en) 2019-07-30
CA3045484A1 (en) 2013-02-21
CO7020857A2 (es) 2014-08-11
NZ622071A (en) 2015-07-31
RU2014109381A (ru) 2015-09-20
US9907868B2 (en) 2018-03-06
US20160263259A1 (en) 2016-09-15
RU2605090C2 (ru) 2016-12-20
ES2560231T3 (es) 2016-02-18
US9375498B2 (en) 2016-06-28
CN103889930A (zh) 2014-06-25
ZA201401789B (en) 2015-01-28
IL275979A (en) 2020-08-31
PL2742017T3 (pl) 2016-04-29
DK2742017T3 (da) 2016-02-08
EP2955168B1 (en) 2020-09-23
IL275979B2 (en) 2023-02-01
MX2014001691A (es) 2014-11-13
WO2013024013A2 (en) 2013-02-21
IL245849A0 (en) 2016-07-31
IN2014CN01897A (enExample) 2015-05-29
AU2012297008B2 (en) 2016-12-08
CA3045484C (en) 2022-10-11
IL275979B (en) 2022-10-01
ITFI20110180A1 (it) 2013-02-13
BR122020011908B1 (pt) 2022-07-05
ES2835581T3 (es) 2021-06-22
EP2742017A2 (en) 2014-06-18
BR112014003336A2 (pt) 2017-03-14
IL245849B (en) 2021-03-25
EP2742017B1 (en) 2015-10-28
JP6161610B2 (ja) 2017-07-12
IL230904B (en) 2019-01-31
US20140171637A1 (en) 2014-06-19
EP2955168A1 (en) 2015-12-16
MX370081B (es) 2019-11-29
RU2016144237A (ru) 2018-12-18
BR112014003336B1 (pt) 2021-03-09
RU2020120802A (ru) 2021-12-23

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