CA2844145C - Process for the preparation of complexes of 68ga - Google Patents
Process for the preparation of complexes of 68ga Download PDFInfo
- Publication number
- CA2844145C CA2844145C CA2844145A CA2844145A CA2844145C CA 2844145 C CA2844145 C CA 2844145C CA 2844145 A CA2844145 A CA 2844145A CA 2844145 A CA2844145 A CA 2844145A CA 2844145 C CA2844145 C CA 2844145C
- Authority
- CA
- Canada
- Prior art keywords
- vial
- formate
- process according
- chelator
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3045484A CA3045484C (en) | 2011-08-12 | 2012-08-10 | Process for the preparation of complexes of 68ga |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000180A ITFI20110180A1 (it) | 2011-08-12 | 2011-08-12 | Processo per la preparazione di complessi di 68ga. |
| ITFI2011A000180 | 2011-08-12 | ||
| PCT/EP2012/065659 WO2013024013A2 (en) | 2011-08-12 | 2012-08-10 | Process for the preparation of complexes of 68ga. |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3045484A Division CA3045484C (en) | 2011-08-12 | 2012-08-10 | Process for the preparation of complexes of 68ga |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2844145A1 CA2844145A1 (en) | 2013-02-21 |
| CA2844145C true CA2844145C (en) | 2019-07-30 |
Family
ID=44898621
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2844145A Active CA2844145C (en) | 2011-08-12 | 2012-08-10 | Process for the preparation of complexes of 68ga |
| CA3045484A Active CA3045484C (en) | 2011-08-12 | 2012-08-10 | Process for the preparation of complexes of 68ga |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3045484A Active CA3045484C (en) | 2011-08-12 | 2012-08-10 | Process for the preparation of complexes of 68ga |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US9375498B2 (enExample) |
| EP (3) | EP2742017B1 (enExample) |
| JP (1) | JP6161610B2 (enExample) |
| CN (1) | CN103889930B (enExample) |
| AU (1) | AU2012297008B2 (enExample) |
| BR (2) | BR112014003336B1 (enExample) |
| CA (2) | CA2844145C (enExample) |
| CO (1) | CO7020857A2 (enExample) |
| DK (1) | DK2742017T3 (enExample) |
| ES (2) | ES2835581T3 (enExample) |
| IL (3) | IL230904B (enExample) |
| IN (1) | IN2014CN01897A (enExample) |
| IT (1) | ITFI20110180A1 (enExample) |
| MX (1) | MX370081B (enExample) |
| PL (1) | PL2742017T3 (enExample) |
| PT (1) | PT2742017E (enExample) |
| RU (2) | RU2605090C2 (enExample) |
| WO (1) | WO2013024013A2 (enExample) |
| ZA (1) | ZA201401789B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1021191B1 (fr) | 2014-08-29 | 2015-10-27 | Anmi S.A. | Kit pour radiomarquage. |
| US11027030B2 (en) | 2014-08-29 | 2021-06-08 | Anmi S.A. | Kit for radiolabelling |
| MX373709B (es) * | 2015-01-30 | 2020-05-08 | Advanced Accelerator Applications Int S A | Proceso para la purificacion de ga-68 a partir del eluato que se deriva de generadores de 68ge/ 68ga y columnas cromatograficas para usarse en dicho proceso. |
| IL237525A (en) | 2015-03-03 | 2017-05-29 | Shalom Eli | Method for labeling a prostate-specific membrane antigen with a radioactive isotope |
| GB201504064D0 (en) * | 2015-03-10 | 2015-04-22 | Accretion Biotechnology Ltd | Method and kits for preparing radionuclide complexes |
| IL297323A (en) * | 2020-04-29 | 2022-12-01 | Novartis Ag | Methods for radiological labeling of psma-binding ligands and their kits |
| RU2760273C1 (ru) * | 2020-11-02 | 2021-11-23 | Федеральное государственное бюджетное учреждение науки Ордена Трудового Красного Знамени Институт химии силикатов им. И.В. Гребенщикова Российской академии наук (ИХС РАН) | Способ получения комплексов на основе изотопа галлий-68 |
| CA3217589A1 (en) | 2021-05-31 | 2022-12-08 | Frederik Giesel | Improved prostate-specific membrane antigen targeting radiopharmaceuticals and uses thereof |
| FR3130840B1 (fr) * | 2021-12-16 | 2023-11-03 | Univ Bordeaux | Procédé de séquestration de méthionine contenue dans un liquide et matériau convenant à la mise en œuvre d’un tel procédé |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6056939A (en) * | 1998-08-28 | 2000-05-02 | Desreux; Jean F. | Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals |
| WO2003048207A2 (en) * | 2001-11-28 | 2003-06-12 | Immunomedics, Inc. | Anti-dota antibody |
| GB0308408D0 (en) * | 2003-04-11 | 2003-05-21 | Amersham Plc | Microwave activation |
| CN100418585C (zh) * | 2003-07-24 | 2008-09-17 | 伯拉考成像股份公司 | 稳定的放射性药物组合物及制备方法 |
| CN1874792A (zh) | 2003-09-03 | 2006-12-06 | 布里斯托尔-迈尔斯.斯奎布制药公司 | 包含基质金属蛋白酶底物的化合物及其使用方法 |
| DE102004057225B4 (de) * | 2004-11-26 | 2006-10-12 | Johannes-Gutenberg-Universität Mainz | Verfahren und Vorrichtung zur Isolierung eines chemisch und radiochemisch gereinigten 68Ga-Radionuklids und zum Markieren eines Markierungsvorläufers mit dem 68Ga-Radionuklid |
| CN101528270A (zh) * | 2006-08-28 | 2009-09-09 | 通用电气健康护理有限公司 | 基于68Ga标记的肽的放射性药物 |
| FR2942227B1 (fr) * | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
| WO2010141833A2 (en) * | 2009-06-05 | 2010-12-09 | The General Hospital Corporation | Vital fluorochrome conjugates and methods of use |
-
2011
- 2011-08-12 IT IT000180A patent/ITFI20110180A1/it unknown
-
2012
- 2012-08-10 JP JP2014524396A patent/JP6161610B2/ja active Active
- 2012-08-10 EP EP12756391.4A patent/EP2742017B1/en active Active
- 2012-08-10 WO PCT/EP2012/065659 patent/WO2013024013A2/en not_active Ceased
- 2012-08-10 DK DK12756391.4T patent/DK2742017T3/da active
- 2012-08-10 MX MX2014001691A patent/MX370081B/es active IP Right Grant
- 2012-08-10 BR BR112014003336-6A patent/BR112014003336B1/pt active IP Right Grant
- 2012-08-10 CA CA2844145A patent/CA2844145C/en active Active
- 2012-08-10 US US14/237,728 patent/US9375498B2/en active Active
- 2012-08-10 RU RU2014109381/04A patent/RU2605090C2/ru active
- 2012-08-10 IN IN1897CHN2014 patent/IN2014CN01897A/en unknown
- 2012-08-10 AU AU2012297008A patent/AU2012297008B2/en active Active
- 2012-08-10 EP EP15174234.3A patent/EP2955168B1/en active Active
- 2012-08-10 CN CN201280039304.8A patent/CN103889930B/zh active Active
- 2012-08-10 CA CA3045484A patent/CA3045484C/en active Active
- 2012-08-10 PT PT127563914T patent/PT2742017E/pt unknown
- 2012-08-10 PL PL12756391T patent/PL2742017T3/pl unknown
- 2012-08-10 ES ES15174234T patent/ES2835581T3/es active Active
- 2012-08-10 ES ES12756391.4T patent/ES2560231T3/es active Active
- 2012-08-10 EP EP20177270.4A patent/EP3718991A1/en active Pending
- 2012-08-10 BR BR122020011908-0A patent/BR122020011908B1/pt active IP Right Grant
-
2014
- 2014-02-10 IL IL230904A patent/IL230904B/en active IP Right Grant
- 2014-03-10 CO CO14050755A patent/CO7020857A2/es unknown
- 2014-03-11 ZA ZA2014/01789A patent/ZA201401789B/en unknown
-
2016
- 2016-05-24 US US15/163,484 patent/US9907868B2/en active Active
- 2016-05-25 IL IL245849A patent/IL245849B/en active IP Right Grant
-
2020
- 2020-06-23 RU RU2020120802A patent/RU2020120802A/ru unknown
- 2020-07-12 IL IL275979A patent/IL275979B2/en unknown
Also Published As
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| US9907868B2 (en) | Process for the preparation of complexes of 68Ga | |
| JP6543343B2 (ja) | 放射標識用キット | |
| JP7315004B2 (ja) | ジルコニウム錯体の合成方法 | |
| WO2020099398A1 (en) | Chelating aazta conjugates and complexes thereof | |
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| EP4501353A1 (en) | Method for producing complex | |
| NZ708281B2 (en) | Process for the preparation of complexes of 68ga | |
| RU2779132C2 (ru) | СПОСОБ ПОЛУЧЕНИЯ КОМПЛЕКСОВ 68Ga | |
| NZ622071B2 (en) | Process for the preparation of complexes of 68ga. | |
| RU2760273C1 (ru) | Способ получения комплексов на основе изотопа галлий-68 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MPN | Maintenance fee for patent paid |
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| U11 | Full renewal or maintenance fee paid |
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