CN103884565B - A kind of pathological staining machine - Google Patents
A kind of pathological staining machine Download PDFInfo
- Publication number
- CN103884565B CN103884565B CN201410132100.XA CN201410132100A CN103884565B CN 103884565 B CN103884565 B CN 103884565B CN 201410132100 A CN201410132100 A CN 201410132100A CN 103884565 B CN103884565 B CN 103884565B
- Authority
- CN
- China
- Prior art keywords
- slide frame
- cylinder
- cylinder cap
- casing
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of pathological staining machine, including casing, be positioned at multiple reagent tanks of casing, slide frame and for moving the mechanical arm of described slide frame, it is characterised in that: also include control system and man-machine interactive system；Described man-machine interactive system is used for receiving the staining reagent access times of user's input and dyeing time relation curve or staining reagent access times and divergaence time relation curve, and sends described control system to；Described control system includes dyeing counting how many times unit and mechanical arm control unit；Described dyeing counting how many times unit is used for adding up staining reagent access times；Described mechanical arm control unit calculates dyeing time or divergaence time for the relation curve according to user's input and described stain access times, and moves described slide frame according to result of calculation control mechanical arm.Compared with prior art, distribute bright staining machine and there is more excellent Color.
Description
Technical field
The present invention relates to tissue section strain technical field, especially relate to a kind of pathological staining machine.
Background technology
At present after the Pathology Deparment of hospital or all kinds of institute or biomedical company all need exfoliative cyte (such as cervix uteri examination) or biological tissue's (local organization such as animal or human's body) are carried out section statining, doctor is by carrying out accurate diagnosis to all kinds of diseases after in-house nucleus and cytoplasmic variation situation are carried out microscope observation, for instance judge such as whether have inflammation, be benign tumor or malignant tumor etc..Being manually operate to carry out tissue staining at present mostly in dyeing link, presently, there are drawback: consuming time, effort, operational consistency is poor, method disunity, and human body is had injury by reagent, big for environment pollution etc..
The patent No. be 201210030113.7 Chinese patent literature propose a kind of pathological staining machine, this machine has X, the movable two dimensional motion mechanical arm in bis-directions of Z, it includes mainframe, is used for fixing the mechanical arm of two dimensional motion, and machine frame inside is cavity, (reagent mainly has: ethanol to be mainly used to place classes of agents cylinder, dimethylbenzene, the stain of various brands, hydrochloride alcohol etc.).But it is not high that this pathological staining machine yet suffers from dyeing quality, staining efficiency, to defects such as the protection of operator are not enough.
Summary of the invention
The technical problem to be solved is, it is proposed to a kind of pathological staining machine is to overcome the defect of prior art.
The present invention solves aforementioned technical problem by following technological means:
A kind of pathological staining machine, including casing, is positioned at multiple reagent tanks of casing, slide frame and for moving the mechanical arm of described slide frame；
Also include control system and man-machine interactive system；
Described man-machine interactive system is used for receiving the staining reagent access times of user's input and dyeing time relation curve or staining reagent access times and divergaence time relation curve, and sends described control system to；
Described control system includes dyeing counting how many times unit and mechanical arm control unit；Described dyeing counting how many times unit is used for adding up staining reagent access times；Described mechanical arm control unit calculates dyeing time or divergaence time for the relation curve according to user's input and described stain access times, and moves described slide frame according to result of calculation control mechanical arm.
After deliberation, the inventors discovered that, Color is had very important impact by the access times of reagent, increase with tinction number of times, the Color of same time is gradually lowered, thus the present invention adjusts dyeing time or divergaence time according to the access times of staining reagent, such as: can when staining reagent access times are higher proper extension dyeing time or shorten divergaence time, so that the Color of dyeing every time all disclosure satisfy that expection, relative to prior art, there is more excellent Color.
Preferably: also include water bath, described water bath is arranged on described box bottom, and at least part of described reagent tank is positioned at described water bath.
Preferably: described reagent tank includes multiple water washing cylinder, is provided with water inlet in described water washing cylinder；This pathological staining machine also includes liquid-way system, and described liquid-way system includes water supply connector, pressure regulator valve, diverter and multiple electromagnetic valve；Described water supply connector is used for receiving outside water supply；The input of described pressure regulator valve is connected with described water supply connector, export the input with described diverter is connected, for regulating hydraulic pressure to predetermined value；Multiple outputs of described diverter are respectively connecting to described water bath and each described water washing cylinder；The plurality of electromagnetic valve is respectively used to control the pipeline break-make between diverter and described water bath and each described water washing cylinder；Described control system also includes control unit of electromagnetic valve, and described control unit of electromagnetic valve is for controlling the break-make of described electromagnetic valve.This preferred version is capable of automatic watering, and the pressure regulation effect of pressure regulator flows through the tissue on havoc slide it can be avoided that enter water water.
More preferably: described liquid-way system also includes rhone, and described water washing cylinder is provided with overfall；Described rhone connects with described overfall, for being collected from the liquid that described overfall overflows.This preferred version is capable of the automatic water-replacing of water washing cylinder, it is ensured that water washing effect, when can avoid artificial changing water simultaneously operator by reagent murder by poisoning.
More preferably: described water bath is provided with upper limit level sensor, bottom limit level sensor and draining pump, described upper limit level sensor, bottom limit level sensor and draining pump are connected with described control system respectively, and described control system controls the electromagnetic valve between described draining pump and described water bath and described diverter for the signal transmitted according to upper limit level sensor and bottom limit level sensor.
Also including the baking box being positioned at described casing, this baking box includes: slide frame containing cavity: be provided with air inlet and air outlet, and for slide frame accommodating when baking, wherein, described air inlet is opened in the bottom of described slide frame containing cavity one sidewall；Wind sector: for supplying hot blast by described air inlet to described slide frame containing cavity；Drip cake wax: be positioned over the bottom of described slide frame containing cavity, for collecting the wax of drippage from slide；Described cake wax forms the first wind-guiding tract in the bottom of described slide containing cavity, the top of described first wind-guiding tract is provided with air guide hole, the side of described first wind-guiding tract connects with described air inlet, so that after the hot blast described first wind-guiding tract of entrance of air inlet, blow to the slide being positioned at described slide frame containing cavity from described air guide hole；The opening of described air guide hole is at least some of to be gradually reduced to the side away from described air inlet near the side of described air inlet.This preferred version provides a containing cavity to be used for placing slide frame, multiple tissue slice can be fixed by slide frame and carry out baking dewaxing, and the air outlet of this preferred version arranges and experiments verify that the degree of being heated evenly that can improve the slide being positioned at containing cavity diverse location, so that the multiple section dewaxing effects dewaxed reach unanimity simultaneously.
Preferably also include: Box Cover, for by the plurality of reagent cylinder cap in described casing completely cut off reagent tank and casing outside atmosphere；Reload cylinder, for placing slide frame that is to be dyed and/or that dyeed；Drawer, this drawer includes the cylinder accommodation space that reloads for the cylinder that reloads described in placing, and described drawer has to be sent into the described cylinder accommodation space that reloads the first working position in described casing and the cylinder accommodation space that reloads described at least partly is pulled out the second working position outside described casing；When described first working position, described drawer can reload cylinder and described reagent tank is enclosed in described casing by described jointly with described Box Cover；When described second working position, described reagent tank jointly can be enclosed in described casing by described drawer with described Box Cover.The staining machine of this preferred version is additionally arranged reload cylinder and drawer, coordinated by drawer and Box Cover make in the process of charging and feeding reagent tank all with casing external atmosphere, efficiently avoid reagent and volatilize pollution surrounding air；And reload cylinder owing to increasing, disposable can being put into by multiple slide holding frame is reloaded in cylinder, controls staining machine twice or repeatedly feeding from the cylinder that reloads automatically, it is achieved the section simultaneously difference cut into slices on frame is dyeed, and provides basis for improving staining efficiency.
Preferably: described man-machine interactive system includes data interaction unit, and described data interaction unit includes radio receiving transmitting module, described radio receiving transmitting module is for carrying out data interaction with network-side.This preferred version is checked by network side equipment for user and controlled staining machine provides basis, conveniently realizes the work of staining machine unmanned.
Preferably: also include the cylinder cap for covering the plurality of reagent tank；Described mechanical arm includes slide frame clamp assemblies and cylinder cap clamp assemblies；Described slide frame clamp assemblies includes the fixing plate of slide frame clamp assemblies, slide frame grip unit and about the first driver element；Described about first driver element is fixed on the fixing plate of described slide frame clamp assemblies, is used for driving described slide frame grip unit to move up and down；Described slide frame grip unit is used for clamping described slide frame；Described cylinder cap clamp assemblies includes the fixing plate of cylinder cap clamp assemblies, cylinder cap grip unit and rotary drive unit；The fixing plate of described cylinder cap clamp assemblies and the fixing plate of described slide frame clamp assemblies are to installation；Described rotary drive unit is arranged on the fixing plate of described cylinder cap clamp assemblies, described cylinder cap grip unit is arranged on described rotary drive unit, and described rotary drive unit is used for driving the rotation of described cylinder cap grip unit to pick and place working position and a skew working position to produce at least one；At the described working position that picks and places, described cylinder cap grip unit is positioned at the underface of described slide grip unit；At described skew working position, described cylinder cap grip unit deviates the underface of described slide grip unit, so that described slide grip unit can move down maybe the slide frame of clamping is put into reagent tank with gripping slide frame in reagent tank.Compared with prior art, this preferred version arrange be oppositely arranged for gripping slide frame and for gripping two mechanical arms of cylinder cap, slide frame grip unit moves up and down and grips, and cylinder cap grip unit realizes gripping by rotary motion, and cylinder cap grip unit is in the underface of slide grip unit when clamping, such setting, on the one hand, cylinder cap grip unit adopts the mode rotated to be operated, the slide frame grip unit being not only able to and move up and down realizes multiplexing spatially, save space and reduce the overall volume of mechanical arm, realize cost low；On the other hand, the working position that picks and places of cylinder cap grip unit is in the underface of slide grip unit, thus, in the whole process of gripping cylinder cap-pick and place slide frame-cover cylinder cap, mechanical arm is overall without moving, it is easy to control.
Preferably: the plurality of reagent tank is arranged in two rows in described casing.
Accompanying drawing explanation
Fig. 1 is the control circuit block diagram of the staining machine of specific embodiment；
Fig. 2 is the structure chart after the staining machine of specific embodiment covers Box Cover；
Fig. 3 is that the staining machine of Fig. 2 is removed Box Cover and drawer and is positioned at the cut-away view of the first working position；
Fig. 4 is the structural representation of the water bath of specific embodiment；
Fig. 5 is the liquid-way system block diagram of the staining machine of specific embodiment；
Fig. 6 is that the staining machine of Fig. 2 is removed Box Cover and drawer and is positioned at the cut-away view of the second working position；
Fig. 7 is the external structure schematic diagram of the baking box of specific embodiment；
The top view after section frame removed by the baking box of Fig. 8 Fig. 7；
The internal structure schematic diagram of the baking box of Fig. 9 Fig. 7；
Figure 10 is the structural scheme of mechanism dripping cake wax of Fig. 9.
Figure 11 is the structure chart of the mechanical arm of the staining machine of specific embodiment；
Figure 12 is the structure chart of the slide frame clamp assemblies of the staining machine of Figure 11；
The cylinder cap clamp assemblies that Figure 13 is the staining machine of Figure 11 is positioned at structure chart when picking and placeing working position；
Figure 14 is the cylinder cap clamp assemblies of the staining machine of Figure 11 structure chart when being disposed offset from working position；
Figure 15 is the structure chart of the cam clamping machine mechanical arm of the dyeing mechanism of specific embodiment；
Figure 16 is the STRUCTURE DECOMPOSITION figure of the cam clamping machine mechanical arm of Figure 15；
Figure 17 is the structural representation of the cam of Figure 15；
Figure 18 is state diagram during mechanical arm gripping slide frame；
Figure 19 is state diagram during mechanical arm gripping cylinder cap.
Detailed description of the invention
Below in conjunction with preferred embodiment the invention will be further described.
A kind of pathological staining machine, including casing, is positioned at multiple reagent tanks of casing, slide frame and for moving the mechanical arm of described slide frame, as it is shown in figure 1, the pathological staining machine of the present embodiment also includes control system and man-machine interactive system；Man-machine interactive system is connected with controlling system, is used for receiving the staining reagent access times of user's input and dyeing time relation curve or staining reagent access times and divergaence time relation curve, and sends described control system to；Control system includes dyeing counting how many times unit and mechanical arm control unit；Dyeing counting how many times unit is used for adding up staining reagent access times；Mechanical arm control unit calculates dyeing time or divergaence time for the relation curve according to user's input and described stain access times, and moves described slide frame according to result of calculation control mechanical arm.Owing to the access times of reagent can affect Color, and the access times of different reagent are also different on the impact of Color, the present embodiment can realize the access times according to staining reagent and control dyeing time or divergaence time, the staining reagent that user uses according to reality, staining reagent access times and dyeing time relation curve or staining reagent access times and divergaence time relation curve is inputted by man-machine interactive system, the pathological staining machine of the present embodiment, dyeing time or divergaence time then can be calculated according to this curve, then pass through mechanical arm and move slide frame entrance next step when dyeing time or divergaence time reach requirement.In preferred embodiment, man-machine interactive system includes data interaction unit, and data interaction unit includes radio receiving transmitting module, for carrying out data interaction with network-side, the running state information of staining machine sends to network-side or accepts the control instruction of network-side.
As in Figure 2-4, in specific embodiment more, pathological staining machine includes casing 100, is positioned at multiple reagent tanks 200 of casing, drawer 300, the cylinder 210 that reloads, mechanical arm 400, Box Cover 500, baking box 600, liquid-way system 600, water bath 800 and slide frame 900.
As shown in Figure 3-4, water bath 800 is arranged on the bottom of casing 100, and portion of reagent cylinder is positioned at water bath 800, and the function of water bath 800 is in that the reagent tank 200 in groove is heated and constant temperature.Water bath is provided with the electromagnetic valve 803 of upper limit level sensor 801, bottom limit level sensor 802, draining pump 804, water inlet, described upper limit level sensor 801, bottom limit level sensor 802, draining pump 804, electromagnetic valve 803 are connected with described control system respectively, described control system controls described draining pump and electromagnetic valve for the signal transmitted according to upper limit level sensor 801 and bottom limit level sensor 802, draining pump is used for regularly carrying out draining in water bath, to avoid bacteria breed in water；Electromagnetic valve coordinates upper and lower liquid level sensor to be used for ensureing that during water-bath, the too high spilling water of liquid level or liquid level are too low.
As it is shown in figure 5, reagent tank 200 includes multiple water washing cylinder, each water washing cylinder is equipped with water inlet and overfall, and liquid-way system 600 includes water supply connector, pressure regulator valve, diverter, multiple electromagnetic valve and rhone, and water supply connector is used for receiving outside water supply；The input of pressure regulator valve is connected with water supply connector, export the input with diverter is connected, for regulating hydraulic pressure to predetermined value；Multiple outputs of diverter are respectively connecting to water bath and each described water washing cylinder；Multiple electromagnetic valves are respectively used to control the pipeline break-make between diverter and described water bath and each water washing cylinder；Described control system also includes control unit of electromagnetic valve, and described control unit of electromagnetic valve is for controlling the break-make of described electromagnetic valve, thus controlling the water supply of water washing cylinder and water bath.Liquid-way system also includes rhone, and rhone connects with the overfall of water washing cylinder, for collecting the liquid that sub-overfall overflows, collects heel row and to outside waste water collection device or drains into and carry out subsequent treatment in the Mead-Bauer recovery system that hospital is special.
As shown in Figure 3, reload cylinder 210 for placing the slide frame equipped with slide that is to be dyed and/or that dyeed, its shape and structure can be identical with reagent tank 200, the cylinder 210 that reloads can include one or more, for instance can comprise for placed dyeing slide frame special cylinder and for placing the special cylinder of slide frame to be dyed.Drawer 300 includes the cylinder accommodation space that reloads for placing the cylinder that reloads, and the cylinder 210 that reloads is placed on the reloading in accommodation space of this drawer 300.Drawer 300 pushes in casing for the cylinder 210 that will reload or outside pull-out casing, it includes the first working position as shown in Figure 3 and the second working position as shown in Figure 6.At described first working position, the accommodation space that reloads is admitted in casing completely, and as shown in Figure 1, at this working position, after Box Cover 500 covers, drawer 300 and Box Cover 500 will reload cylinder 210 jointly and reagent tank 200 is enclosed in casing 100, make box house and extraneous air isolation, even if the reagent volatilization in reagent tank 200 is without entering contaminated air in extraneous air, air exhauster now preferably can be set and box house is carried out convulsion to be collected the reagent of volatilization processing, for instance pass through activated carbon adsorption；As shown in Figure 6, when the second working position, drawer 300 is drawn to outside casing 100, now, the cylinder 210 that reloads is positioned at outside casing, and the sidewall of drawer 300 has blocked the drawer installing port on casing 100 such that it is able to jointly reagent tank 200 is enclosed in casing with Box Cover 500, at this working position, operator can be taken off being complete the slide frame of dyeing or adding the slide frame of new needs dyeing, without the volatilization reagent in inlet box body, after having operated, drawer is pushed in casing.Automatically dye from cylinder feeding of reloading during staining machine work, and the tissue slice dyeed is put into the cylinder that reloads.The pull mode that is installed on of the drawer 300 of the present embodiment adopts existing known mode, it may be assumed that between the bottom and the bottom of casing of drawer, installation guide rail and slide block realize the relative motion of drawer and casing.
As it is shown in fig. 7, the staining machine of the present embodiment also includes baking box 600, this baking box mainly includes section frame containing cavity 6100, wind sector 6200, drips cake wax 6500 and temperature sensing device 6700.Section frame containing cavity 6100 is used for placing slide frame 900, and it is provided with air inlet 6101 and air outlet 6103, and air inlet 6101 is opened in the bottom of section frame containing cavity 6,100 1 sidewall, and the slide 901 on section frame carries out toasting, dewaxing in section frame containing cavity 6100；Wind sector 6200 is for providing the hot blast of baking tissue slice；Dripping cake wax 6500 and be positioned at the bottom of section frame containing cavity 6100, the wax for collecting the toasted rear drippage of tissue slice drips.
After a cake wax 6500 of the present embodiment is positioned over the bottom of section containing cavity 6100, the first wind-guiding tract 6501 is formed in the bottom of containing cavity 6100, the top of this first wind-guiding tract 6501 is provided with air guide hole 6503, side connects with the air inlet 6101 of section frame containing cavity 6100, after the hot blast that air inlet 6101 enters initially enters the first wind-guiding tract 6501, blow to the tissue slice 901 in section frame containing cavity from the air guide hole 6503 at top；Air guide hole 6503 extends certain length on the axial direction of the first wind-guiding tract 6501, and at least some of side from close described air inlet of the opening of air guide hole 6503 is gradually reduced to the side away from described air inlet.Such as Fig. 8-10, in specific embodiment more, drip the overall box shaped cuboid of cake wax 6500, the internal cavities of this cuboid is described first wind-guiding tract 6501, air guide hole 6503 is the opening being opened in cuboid top, flare openings part 5011 and the strip open part extended to the side away from air inlet from flare openings part that this opening contours includes being located close to air inlet 6101 side divide 5013, and namely this flare openings part 5011 is constituted from the opening portion being gradually reduced to the side away from described air inlet near the side of described air inlet.
As shown in Figure 9, in a preferred embodiment, being provided with the first wind-guiding baffle plate 6505 in first wind-guiding tract 6501, this first wind-guiding baffle plate 6505 is near the side of air inlet 6101 to the side away from air inlet 6101 progressively upwards, thus being acute angle relation with the axis of the first wind-guiding tract 6501.In more excellent embodiment, the first wind-guiding baffle plate 6505 original position near the side of air inlet 6101 is higher than the bottom of the first wind-guiding tract 6501, thus a part of hot blast at least from air inlet flows through between the first wind-guiding baffle plate 6505 and the bottom of the first wind-guiding tract 6501；And temperature sensing device 6700 is arranged between the first wind-guiding baffle plate 6505 and the bottom of the first wind-guiding tract 6501, so, the temperature that temperature sensing device 6700 is surveyed be more nearly tissue slice by air temperature, and temperature sensing device 6700 blocking due to the first wind-guiding baffle plate 6505, without being dripped to wax.
The baking box of the present embodiment also includes the second wind-guiding tract 6110, and the two ends of this second wind-guiding tract 6110 are respectively communicated with wind sector 6200 and air inlet 6101, for the hot blast guiding air inlet 6101 supplied by wind sector 6200.This second wind-guiding tract 6110 includes a second wind-guiding baffle plate 6111 extended obliquely from air inlet 6101, angle between this second wind-guiding baffle plate 6111 and air-out direction of wind sector is obtuse angle, this the second wind-guiding baffle plate 6111 is for entering air inlet by least some of part hot blast along the direction with the first wind-guiding tract axis being acute angle, thus being advantageously obtained in that enough hot blasts in the section near air inlet so that each section is uniformly heated.
As shown in Figure 9, the wind sector of the present embodiment includes air feed fan 6201 and heater 6203, it is introduced into air port 6101 through the second wind-guiding tract after air heater via 6203 heating that air feed fan 6201 blasts, heater 6201 can adopt various heater well known in the art, such as add heat pipe, add hot plate etc., it is preferable to employ controllable silicon carries out power control, to realize temperature control accurately.
The air outlet of this example is arranged on section frame containing cavity 6100 away from the side of described air inlet 6101 and outside being positioned at described first wind-guiding tract, and is gone out by tympanites due to wind by air-out fan 6107.
As it is shown on figure 3, the reagent tank of the present embodiment lines up two rows in casing, thus mechanical arm preferably employs the mechanical arm of three-dimensional motion, it is achieved arranges the movement between reagent tanks, the alignment of same row's difference reagent tank two and moves up and down and carry out picking and placeing action.The implementation of mechanical arm can adopt existing known technical scheme.
In preferred embodiment, staining machine also includes cylinder cap, and for covering the cylinder mouth of reagent tank, it is to avoid reagent volatilizees, and it is as follows to realize moving up and down the part-structure carrying out picking and placeing the mechanical arm of work:
As figs 11-13, it includes slide frame clamp assemblies 410 and cylinder cap clamp assemblies 420.Wherein, slide frame clamp assemblies 410 includes the fixing plate 411 of slide frame clamp assemblies, slide frame grip unit 412 and about the first driver element 413；About first driver element fixes 413 on the fixing plate 411 of slide frame clamp assemblies, is used for driving slide frame grip unit 412 to move up and down；Slide frame grip unit 412 is used for clamping slide frame 003；Cylinder cap clamp assemblies 420 includes the fixing plate 421 of cylinder cap clamp assemblies, cylinder cap grip unit 422 and rotary drive unit 423；The fixing plate 421 of cylinder cap clamp assemblies and the fixing plate 411 of slide frame clamp assemblies are to installation；Rotary drive unit 423 is arranged on the fixing plate 421 of cylinder cap clamp assemblies, is used for driving cylinder cap grip unit 422 to rotate to produce at least one and picks and places working position and a skew working position.When picking and placeing working position, cylinder cap grip unit 422 is positioned at the underface of slide grip unit 412；At skew working position, cylinder cap grip unit 422 deviates the underface of slide grip unit 412, so that slide grip unit 412 can move down maybe the slide frame 900 of clamping is put into reagent tank with gripping slide frame 900 in reagent tank.
As shown in figure 12, about first driver element 413 of the present embodiment, including drive motor 4130, synchronizing wheel (not shown), Timing Belt 4131, contiguous block 4132 and line slideway 4133.Drive motor 4130 drives synchronizing wheel to drive Timing Belt 4131 to move, contiguous block 4132 is fixed on Timing Belt 4131, can under the drive of Timing Belt 4131 linearly guide rail 4133 move up and down, slide frame grip unit 412 is fixed on contiguous block 4132, slide frame grip unit 412 can be driven to move up and down thereby through drive motor 4130.
As shown in figure 13, the rotary drive unit 423 of the present embodiment includes rotary drive motor 4230, synchronizing wheel 4231 and 4233 and Timing Belt 4232.Drive motor 4230 drives synchronizing wheel 4231 to rotate, and synchronizing wheel 4231 drives synchronizing wheel 4233 to rotate by Timing Belt 4232, synchronizing wheel 4233 and rotating shaft 4222 transmission, axle 4222 is rotated and rotates.The cylinder cap clamping machine mechanical arm 4221 of cylinder cap grip unit 422 rotates the fixing connection of axle 4222, rotates under the drive of rotating shaft 4222.In the present embodiment, cylinder cap clamp assemblies also includes about the second driver element 424, its structure is identical with about the first driver element, do not repeat them here, the effect of about the second driver element 424 is for driving rotary drive unit 423 to move up and down and then drive cylinder cap grip unit to move up and down, concrete: rotary drive unit 423 is fixed on the connecting plate 4241 of about the second driver element 424, with connecting plate 4241 together linearly guide rail move up and down.Such as Figure 14, in the present embodiment, the cylinder cap clamping machine mechanical arm 4221 of cylinder cap grip unit 422 rotates has predetermined distance to form a cavity 4223 between axle 4222, as shown in Figure 5, when when described second working position, slide grip unit 412 can move down through cavity 4223 and maybe the slide frame of clamping be put into reagent tank with gripping slide frame in reagent tank.
As shown in figure 11, about first driver element of the present embodiment, the second driver element and rotary drive unit are respectively positioned between the fixing plate of the fixing plate of the described slide frame clamp assemblies installed and described cylinder cap clamp assemblies.Mechanical arm compact overall structure, it is appreciated that in the space saved in casing.
Cylinder cap grip unit and the slide frame grip unit of the present embodiment all adopt cam clamping machine mechanical arm 4600, as shown in Figure 15,16,17, this cam clamping machine mechanical arm includes: motor 4601, left fixing plate 4602, right fixing plate 4603, motor fixing plate 4604, cam 4605, left grip block 4606, right grip block 4607, driven shaft 4608 and 4609 and guide rod 4610.Left fixing plate 4602, right fixing plate 4603 are separately fixed at the two ends of motor fixing plate 4604, motor 4601 is fixed on motor fixing plate 4604, motor fixing plate 4604 is provided with mean for the hole of the power transmission shaft traverse of motor 4601, the power transmission shaft of motor 4601 is connected with cam 4605 through this hole and rotates with band moving cam 4605, cam 4605 offers two cam paths 6051, cam path 6051 is arcuate groove, and one end of this arcuate groove is relative to the other end rotating shaft near cam；Guide rod 4610 two ends are separately fixed on the fixing plate 4603 of left fixing plate 4602 and the right side, being respectively equipped with the hole for guide rod 4610 traverse on left grip block 4606, right grip block 4607, left grip block 4606, right grip block 4607 are coordinated with guide rod 4610 by this hole and move along guide rod 4610；Left grip block 4606, right grip block 4607 further respectively have the driven shaft 4608 and 4609 that the cam path with cam 4605 coordinates, driven shaft 4608 and 4609 lays respectively in two cam paths 6051, when cam 4605 rotates, driven shaft 4608 and 4609 drives left grip block 4606, right grip block 4607 to move respectively, thus clamping or decontroling held slide frame or cylinder cap.
Above-described embodiment to pick and place work process as follows: mechanical arm moves the surface to slide frame；Slide frame grip unit moves downward, and clamps slide frame (as shown in figure 18)；Slide frame grip unit moves up to topmost；Mechanical arm moves to place directly over the reagent tank of slide frame, and cylinder cap grip unit is from skew working position rotary motion to picking and placeing working position；Cylinder cap grip unit moves down and clamps cylinder cap 005 (as shown in figure 19)；Cylinder cap grip unit moves up to top, and then from picking and placeing working position rotation to skew working position, now slide frame grip unit can move downward placement slide frame in reagent tank.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, it is impossible to assert that specific embodiment of the invention is confined to these explanations.For those skilled in the art, without departing from the inventive concept of the premise, it is also possible to make some equivalent replacements or obvious modification, and performance or purposes are identical, all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. a pathological staining machine, including casing, is positioned at multiple reagent tanks of casing, slide frame and for moving the mechanical arm of described slide frame, it is characterised in that:
Also include control system and man-machine interactive system；
Described man-machine interactive system is used for receiving the staining reagent access times of user's input and dyeing time relation curve or staining reagent access times and divergaence time relation curve, and sends described control system to；
Described control system includes dyeing counting how many times unit and mechanical arm control unit；Described dyeing counting how many times unit is used for adding up staining reagent access times；Described mechanical arm control unit calculates dyeing time or divergaence time for the relation curve according to user's input and described stain access times, and moves described slide frame according to result of calculation control mechanical arm.
2. pathological staining machine according to claim 1, it is characterised in that: also including water bath, described water bath is arranged on described box bottom, and at least part of described reagent tank is positioned at described water bath.
3. pathological staining machine according to claim 2, it is characterised in that: described reagent tank includes multiple water washing cylinder, is provided with water inlet in described water washing cylinder；
This pathological staining machine also includes liquid-way system, and described liquid-way system includes water supply connector, pressure regulator valve, diverter and multiple electromagnetic valve；Described water supply connector is used for receiving outside water supply；The input of described pressure regulator valve is connected with described water supply connector, export the input with described diverter is connected, for regulating hydraulic pressure to predetermined value；Multiple outputs of described diverter are respectively connecting to described water bath and each described water washing cylinder；The plurality of electromagnetic valve is respectively used to control the pipeline break-make between diverter and described water bath and each described water washing cylinder；
Described control system also includes control unit of electromagnetic valve, and described control unit of electromagnetic valve is for controlling the break-make of described electromagnetic valve.
4. pathological staining machine according to claim 3, it is characterised in that: described liquid-way system also includes rhone, and described water washing cylinder is provided with overfall；Described rhone connects with described overfall, for being collected from the liquid that described overfall overflows.
5. pathological staining machine according to claim 3, it is characterized in that: described water bath is provided with upper limit level sensor, bottom limit level sensor and draining pump, described upper limit level sensor, bottom limit level sensor and draining pump are connected with described control system respectively, and described control system controls the electromagnetic valve between described draining pump and described water bath and described diverter for the signal transmitted according to upper limit level sensor and bottom limit level sensor.
6. pathological staining machine according to claim 1, it is characterised in that: also including the baking box being positioned at described casing, this baking box includes:
Slide frame containing cavity: be provided with air inlet and air outlet, for slide frame accommodating when baking, wherein, described air inlet is opened in the bottom of described slide frame containing cavity one sidewall；
Wind sector: for supplying hot blast by described air inlet to described slide frame containing cavity；
Drip cake wax: be positioned over the bottom of described slide frame containing cavity, for collecting the wax of drippage from slide；
Described cake wax forms the first wind-guiding tract in the bottom of described slide containing cavity, the top of described first wind-guiding tract is provided with air guide hole, the side of described first wind-guiding tract connects with described air inlet, so that after the hot blast described first wind-guiding tract of entrance of air inlet, blow to the slide being positioned at described slide frame containing cavity from described air guide hole；The opening of described air guide hole is at least some of to be gradually reduced to the side away from described air inlet near the side of described air inlet.
7. pathological staining machine according to claim 1, it is characterised in that: also include:
Box Cover, for by the plurality of reagent cylinder cap in described casing completely cut off reagent tank and casing outside atmosphere；
Reload cylinder, for placing slide frame that is to be dyed and/or that dyeed；
Drawer, this drawer includes the cylinder accommodation space that reloads for the cylinder that reloads described in placing, and described drawer has to be sent into the described cylinder accommodation space that reloads the first working position in described casing and the cylinder accommodation space that reloads described at least partly is pulled out the second working position outside described casing；When described first working position, described drawer can reload cylinder and described reagent tank is enclosed in described casing by described jointly with described Box Cover；When described second working position, described reagent tank jointly can be enclosed in described casing by described drawer with described Box Cover.
8. pathological staining machine according to claim 1, it is characterised in that: described man-machine interactive system includes data interaction unit, and described data interaction unit includes radio receiving transmitting module, and described radio receiving transmitting module is for carrying out data interaction with network-side.
9. pathological staining machine according to claim 1, it is characterised in that: also include the cylinder cap for covering the plurality of reagent tank；
Described mechanical arm includes slide frame clamp assemblies and cylinder cap clamp assemblies；
Described slide frame clamp assemblies includes the fixing plate of slide frame clamp assemblies, slide frame grip unit and about the first driver element；Described about first driver element is fixed on the fixing plate of described slide frame clamp assemblies, is used for driving described slide frame grip unit to move up and down；Described slide frame grip unit is used for clamping described slide frame；
Described cylinder cap clamp assemblies includes the fixing plate of cylinder cap clamp assemblies, cylinder cap grip unit and rotary drive unit；The fixing plate of described cylinder cap clamp assemblies and the fixing plate of described slide frame clamp assemblies are to installation；Described rotary drive unit is arranged on the fixing plate of described cylinder cap clamp assemblies, described cylinder cap grip unit is arranged on described rotary drive unit, and described rotary drive unit is used for driving the rotation of described cylinder cap grip unit to pick and place working position and a skew working position to produce at least one；
At the described working position that picks and places, described cylinder cap grip unit is positioned at the underface of described slide grip unit；At described skew working position, described cylinder cap grip unit deviates the underface of described slide grip unit, so that described slide grip unit can move down maybe the slide frame of clamping is put into reagent tank with gripping slide frame in reagent tank.
10. pathological staining machine according to claim 1, it is characterised in that: the plurality of reagent tank is arranged in two rows in described casing, and described mechanical arm is three-dimensional machinery arm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410132100.XA CN103884565B (en) | 2014-04-02 | 2014-04-02 | A kind of pathological staining machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410132100.XA CN103884565B (en) | 2014-04-02 | 2014-04-02 | A kind of pathological staining machine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103884565A CN103884565A (en) | 2014-06-25 |
| CN103884565B true CN103884565B (en) | 2016-07-06 |
Family
ID=50953584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410132100.XA Active CN103884565B (en) | 2014-04-02 | 2014-04-02 | A kind of pathological staining machine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103884565B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6527177B2 (en) * | 2014-06-30 | 2019-06-05 | ベンタナ メディカル システムズ， インコーポレイテッド | Automated sample processing system and method |
| CN106568624A (en) * | 2016-10-18 | 2017-04-19 | 东莞市鸥翼实业有限公司 | A pathological specimen pretreatment device |
| CN106959238B (en) * | 2017-05-13 | 2023-09-26 | 遵义医学院附属医院 | Piece dyeing box |
| CN108195655B (en) * | 2018-01-30 | 2019-11-19 | 武汉呵尔医疗科技发展有限公司 | A kind of cell smear overflow dyeing machine structure |
| CN108918237A (en) * | 2018-07-02 | 2018-11-30 | 昆明金域医学检验所有限公司 | A method of improving full-automatic dyeing machine dyeing quality |
| CN109855941A (en) * | 2019-03-12 | 2019-06-07 | 上海皓信生物科技有限公司 | Dip dyeing formula dyeing instrument |
| CN110595857A (en) * | 2019-09-11 | 2019-12-20 | 宁波江丰生物信息技术有限公司 | Freezing slice dyeing machine and slice dyeing method thereof |
| CN112945684B (en) * | 2019-12-10 | 2022-11-29 | 镇江蓝勃医疗器械有限公司 | Pathological section dyeing machine |
| CN111537317B (en) * | 2020-05-10 | 2023-03-24 | 浙江省金华市科迪仪器设备有限公司 | Dyeing machine |
| CN112611620A (en) * | 2020-12-15 | 2021-04-06 | 成都朴华科技有限公司 | Automatic change sperm staining equipment |
| CN114167797B (en) * | 2022-02-11 | 2022-04-26 | 江苏美克医学技术有限公司 | Dyeing machine control system with parallel time sequences |
| CN117538128B (en) * | 2024-01-10 | 2024-03-15 | 苏州大学附属第二医院 | Pathology department's sample section dyeing equipment |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102560929A (en) * | 2012-02-10 | 2012-07-11 | 湖北泰维科技实业有限公司 | Staining machine |
| CN203502277U (en) * | 2013-08-22 | 2014-03-26 | 武汉兰丁医学高科技有限公司 | Low-pollution cellular tissue dyeing machine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10041229A1 (en) * | 2000-08-22 | 2002-03-07 | Leica Microsystems | Handling apparatus for cytological or histological preparations has region which receives modular processing stations |
| DE10041230A1 (en) * | 2000-08-22 | 2002-03-07 | Leica Microsystems | Handling apparatus for cytological or histological preparations has feed stations and/or removal stations allocated to several processing stations |
-
2014
- 2014-04-02 CN CN201410132100.XA patent/CN103884565B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102560929A (en) * | 2012-02-10 | 2012-07-11 | 湖北泰维科技实业有限公司 | Staining machine |
| CN203502277U (en) * | 2013-08-22 | 2014-03-26 | 武汉兰丁医学高科技有限公司 | Low-pollution cellular tissue dyeing machine |
Non-Patent Citations (1)
| Title |
|---|
| 研制改造全自动病理组织染色机;胡维维等;《诊断病理学杂志》;20001231;第7卷(第4期);313 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103884565A (en) | 2014-06-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103884565B (en) | A kind of pathological staining machine | |
| CN206862721U (en) | A kind of histopathology sample processing system | |
| CN106334701A (en) | Automatic Cleaning and Drying Device for Test Tube and Its Using Methods | |
| CN105960584A (en) | Smear preparation device, smear preparation method and glass slide basket drying module | |
| CN103551215A (en) | Pipetting device and pipetting method | |
| CN105628477B (en) | The full-automatic device for quickly preparing cell block | |
| CN109844523A (en) | Egg check device | |
| CN112505042B (en) | Biological sample imaging apparatus | |
| CN112747991A (en) | Full-automatic drop dyeing device for tissue slices | |
| CN206038393U (en) | Cell dyeing pelleter | |
| CN104170903A (en) | Low-temperature deep frying device and method for deep frying food | |
| CN103293034B (en) | Full-automatic pathological tissue moviemaking system | |
| CN109443889B (en) | Full-automatic push-piece dyeing system | |
| CN112781962B (en) | Automatic drip dyeing and sealing piece equipment with integrated machine structure | |
| CN112730000B (en) | Automatic change drop dyeing sealing piece equipment | |
| CN212451387U (en) | Automatic chromosome harvesting device | |
| CN204988839U (en) | Novel automatic dyeing machine | |
| CN210136123U (en) | Slide flat dyeing device | |
| CN213068417U (en) | Full-automatic immunohistochemical dyeing equipment | |
| CN212174961U (en) | Fluorescent quantitative PCR instrument | |
| CN206832556U (en) | One kind dye piece case | |
| CN112763294B (en) | Heat treatment module and automatic drop dyeing sealing piece equipment with same | |
| CN214408322U (en) | Automatic drop dyeing mounting equipment with human-computer interaction function | |
| CN214408321U (en) | Automatic change and drip dyeing mounting equipment | |
| CN215374755U (en) | Heat treatment module and automatic drop dyeing mounting equipment with same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160316 Address after: Baoan District Xixiang Huang Tian street community of Shenzhen city in Guangdong province 518000 Yang back industrial zone three Heng Rong High-tech Industrial Park eleven Building 5 floor A District Applicant after: Dakewe (Shenzhen) medical equipment Co., Ltd. Address before: 518000, 203B building, building A, No. 43, building 1, Shenzhen, Nanshan District, Guangdong Applicant before: SHENZHEN DAKEWE MEDICAL TECHNOLOGY CO., LTD. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Pathological staining machine Effective date of registration: 20200630 Granted publication date: 20160706 Pledgee: Shenzhen small and medium-sized micro enterprise financing re Guarantee Co.,Ltd. Pledgor: DAKEWE (SHENZHEN) MEDICAL EQUIPMENTS Co.,Ltd. Registration number: Y2020980003629 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20211013 Granted publication date: 20160706 Pledgee: Shenzhen small and medium-sized micro enterprise financing re Guarantee Co.,Ltd. Pledgor: DAKEWE (SHENZHEN) MEDICAL EQUIPMENT Co.,Ltd. Registration number: Y2020980003629 |