CN214408322U - Automatic drop dyeing mounting equipment with human-computer interaction function - Google Patents

Abstract

The utility model provides an automatic drip-dyeing mounting equipment with human-computer interaction function, which comprises a frame, the carrier dish, the module is transferred in the delivery, heat treatment module, automatic drip-dyeing module, automatic mounting module, human-computer interaction module and control unit, the carrier dish is transported to the module in the delivery in the frame, heat treatment module, automatic drip-dyeing module and automatic mounting module establish in the carrier dish of frame transport route, the carrier dish carries the slide glass, heat treatment module heats the slide glass, automatic drip-dyeing module drips the slide glass and dyes, automatic mounting module carries out the mounting to the slide glass, control unit control each module's operation flow and processing procedure, human-computer interaction module includes the human-computer interaction interface, it is connected to the control unit, be used for the input of control command and the output of processing information. The equipment can carry out automatic drip dyeing and mounting treatment operation on the glass slide, also provides a human-computer interaction function, realizes a user-defined treatment mode, and can carry out supervision and feedback while treating the tissue section.

Description

Automatic drop dyeing mounting equipment with human-computer interaction function

Technical Field

The utility model relates to a be used for automatic mounting technique of dying that drips of biological tissue sample section, especially relate to an automatic mounting equipment of dying that drips with human-computer interaction function.

Background

The automatic staining treatment technology of biological tissue sample slices is an important step in the whole automatic staining, drying and sealing process of the biological tissue sample, and is an indispensable step, so that the treated biological tissue sample has a convenient observed appearance, the consistency and the high efficiency of the treatment process can be kept, and the staining step is an object which must be strictly controlled in the treatment process of the biological tissue sample.

The purpose of staining is to make different structures within the tissue appear differently colored for easy viewing. The classic Hematoxylin and Eosin staining method is the conventional staining of histological specimens and pathological section specimens, referred to as HE staining for short. After staining, the nuclei were stained violet-blue with hematoxylin, and most of the cytoplasmic and acellular components were stained pink with eosin.

Various techniques may be used to analyze biological samples. Examples of analytical techniques include microscopy, microarray analysis (e.g., protein and nucleic acid microarray analysis), and mass spectrometry. Preparing samples for these and other types of analysis typically includes: the sample is contacted with a series of treatment liquids. Some of these treatment liquids (e.g., staining and counterstaining reagents) may add color and, in contrast or otherwise, alter the visual characteristics of sample components (e.g., at least some types of cells and intracellular structures) that are not visible or difficult to see. Other treatment liquids (e.g., de-paraffinized liquids) may be used to achieve other treatment objectives. If multiple processing liquids are used to process the sample, the application and subsequent removal of the various processing liquids may be important to produce a sample suitable for analysis. In some cases, treating the sample with a plurality of treatment liquids comprises: the processing liquid is manually applied to the microscope slides that each carry a sample. This method of processing samples tends to be labor intensive and inaccurate.

The pathological section staining process by manual work is often characterized by large time consumption, easy error, difficult batch processing and the like, and the pathological section samples can be automatically processed in batches by using an automatic staining machine.

Most automatic dyeing machines are large in size, sample slides are fixed, all modules are operated alternately corresponding to the same number of three-dimensional moving machines, mechanical control is complex, the types of liquid reagents cannot be excessive, or alternative nozzles are adopted, but cleaning is time-consuming and liquid drops of the last operation remain. The human-computer interaction is poor, biological tissue slices can only be processed according to a fixed mode, the oriented setting accuracy or high-efficiency or batch mode and the like cannot be selected according to requirements, different dyeing programs cannot be selected corresponding to different tissue materials, and real-time supervision and feedback in the dyeing process are lacked.

It is to be noted that the information disclosed in the above background section is only for understanding the background of the present application and thus may include information that does not constitute prior art known to a person of ordinary skill in the art.

SUMMERY OF THE UTILITY MODEL

The utility model discloses a main aim at overcomes the problem that above-mentioned background art exists, provides an automatic mounting equipment that drips and dyes with human-computer interaction function.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

an automatic drip-dyeing mounting device with a human-computer interaction function comprises a rack, a carrier disc, a carrying and transferring module, a heat treatment module, an automatic drip-dyeing module, an automatic mounting module, a human-computer interaction module and a control unit, wherein the carrying and transferring module is used for conveying the carrier disc on the rack, the heat treatment module, the automatic drip-dyeing module and the automatic mounting module are arranged on a carrier disc conveying route on the rack, a glass slide is loaded on the carrier disc, the heat treatment module is used for carrying out dewaxing heating treatment and mounting reagent heating and curing treatment on the glass slide, the automatic drip-dyeing module is used for carrying out drip-dyeing treatment on the glass slide, the automatic mounting module is used for carrying out cover glass mounting treatment on the glass slide, the control unit controls the operation flow and the treatment process of each module, and the human-computer interaction module comprises a human-computer interaction interface, the man-machine interaction module is connected to the control unit and used for controlling the input of instructions and the output of processing information.

The utility model discloses following beneficial effect has:

the utility model provides an automatic mounting equipment that dyes that drips of biological tissue sample section with human-computer interaction function can carry out the automation to the slide glass that bears biological tissue sample and drip the mounting and handle the operation, still provides the human-computer interaction function, realizes self-defined processing mode, and can supervise and feed back when handling tissue section.

Further, the utility model provides the high dyeing treatment efficiency of sample has reduced labour intensive, has also reduced cross contamination's between the sample possibility simultaneously effectively, makes the sample treatment process have uniformity and controllability. The utility model discloses be favorable to realizing automatic dyeing of batchization, high efficiency, simple and easy, accurate full-automatic biological tissue sample and handle.

In an optimal scheme, the automatic drop dyeing mounting equipment has an all-in-one machine structure, wherein a rack is provided with a heat treatment module, an automatic drop dyeing module and an automatic mounting module in a distributed layout mode, the rack is provided with a carrying and transferring module with an X-axis guide rail and a Y-axis guide rail, the carrying and transferring module is matched with the space operation mode of each module distributed on the rack, and a carrying and transferring module conveys a carrier disc to each module for automatic flow treatment, so that the drop dyeing mounting treatment efficiency is effectively improved, and the volume and the occupation of the whole set of process treatment equipment are also obviously reduced. Through the relative motion mechanism that the conveying module moves the sample glass slides among the processing modules on the rack, the complex mechanical alternate operation caused by conveying the glass slides among the modules is reduced, and the complexity of mechanical control is effectively reduced. Through the structural automatic distributed assembly line that realizes at an all-in-one, reached the directional, batch processing, accurate, high-efficient, pollution-free, save the effect of reagent, and can also realize customization and the adjustment of artifical directional processing route as required simply conveniently.

In preferred scheme, the utility model provides a heat treatment module for automizing drip-dyeing mounting equipment still, can form a semi-closed cavity of closed cavity jointly after agreeing with mutually through setting up and the carrier dish that bears a plurality of slide glass to along circumference distribution set up a plurality of heating resistor and air-blower flabellum, heat in the cavity in the time of the air in the cavity, the drive the air-blower flabellum is rotatory with form cyclic annular heat convection in the cavity, thus it is right a plurality of slide glass on the carrier dish carry out even convection current heating, so, the utility model discloses can realize carrying out high-efficiently heating with even, stable temperature simultaneously to a plurality of slide glass on the carrier dish.

The utility model discloses constructed the automatic processing system who carries out one or more slide glass processing operation to the slide glass that bears biological sample, can carry out the processing of directional batch to multiple biological tissue sample section, reached accurate, high-efficient, pollution-free, save the effect of reagent. The system can provide high sample throughput while also maximizing the possibility of reducing or limiting slide cross-contamination.

Drawings

Fig. 1A is a front view of an integrated machine for an automatic drip-dyeing processing system for biological tissue sample slices according to an embodiment of the present invention;

fig. 1B is a left side view of an integrated machine structure for an automatic drip-dyeing processing system for biological tissue sample slices according to an embodiment of the present invention;

fig. 1C is a top view of an integrated machine structure for an automatic drip-dyeing processing system for biological tissue sample slices according to an embodiment of the present invention;

fig. 2A is a structural view of a carrying and transferring module according to an embodiment of the present invention;

fig. 2B is a bottom view of the carrying and transferring module according to an embodiment of the present invention;

fig. 2C is a top view of a carrying and transferring module according to an embodiment of the present invention;

fig. 2D is a schematic view of a carrier plate transporting method for transporting a transfer module according to an embodiment of the present invention;

fig. 3A is a top view of a carrier tray according to an embodiment of the present invention;

fig. 3B is a bottom view of a carrier plate according to an embodiment of the present invention;

fig. 4 is a structural view of an entrance carrying and transferring module according to an embodiment of the present invention;

fig. 5 is a block diagram of a part of a human-computer interaction module according to an embodiment of the present invention:

fig. 6 is a three-dimensional structure diagram of an automatic drop dyeing module according to an embodiment of the present invention.

Fig. 7A is an isometric view of a fluid middle-end assembly according to an embodiment of the present invention.

Fig. 7B is a top view of a fluid middle-end device according to an embodiment of the invention.

Fig. 7C is an isometric view of a central common chamber according to an embodiment of the present invention.

Figure 7D is a top view of a central common chamber of an embodiment of the present invention.

Fig. 7E is a B-B cross-sectional view of a central common chamber of an embodiment of the present invention.

Fig. 7F is an isometric view of a fluid tip device according to an embodiment of the present invention.

Fig. 7G is a bottom view of a fluid tip device according to an embodiment of the present invention.

Fig. 7H is a front view of a fluid tip device according to an embodiment of the present invention.

Fig. 7I is a stepped cross-sectional view G-G in an elevation view of a fluid tip device according to an embodiment of the present invention.

Fig. 7J is a cross-sectional view of a fluid tip device at the center of an embodiment of the present invention.

Fig. 8A is an isometric view of a dyeing module portion apparatus according to an embodiment of the present invention.

Fig. 8B is an isometric view of a carrier tray receiving tray and power device according to an embodiment of the invention.

Fig. 8C is a front view of a carrier tray receiving tray and a power device according to an embodiment of the present invention.

FIG. 9A is a block diagram of a thermal processing module according to an embodiment of the present invention;

fig. 9B is a front view of a thermal treatment module according to an embodiment of the present invention;

fig. 9C is a diagram illustrating an inner structure of a semi-cavity of a heat treatment module according to an embodiment of the present invention;

fig. 9D is a structural view of a heating portion in a heat treatment module according to an embodiment of the present invention;

fig. 9E is a structural view of a heating portion in a heat treatment module according to an embodiment of the present invention;

fig. 9F is a schematic diagram of the operation of the holder in the thermal treatment module according to an embodiment of the present invention;

fig. 10 is a block diagram illustrating the overall structure of an automated drop dyeing system for biological tissue sample slices according to an embodiment of the present invention;

fig. 11 is a block diagram of a human-computer interaction control system according to an embodiment of the present invention;

fig. 12 is a schematic diagram of a human-computer interaction control biological tissue sample slice automatic drop dyeing processing system according to an embodiment of the present invention.

Detailed Description

The embodiments of the present invention will be described in detail below. It should be emphasized that the following description is merely exemplary in nature and is not intended to limit the scope of the invention or its application.

Human-computer interaction module and automatic drop dyeing mounting equipment with same

Referring to fig. 1A to 1C and fig. 10 to 12, an embodiment of the present invention further provides an automatic dispensing and sealing apparatus with a human-computer interaction function, including a frame, a carrier tray, a carrying and transferring module, a heat treatment module, an automatic dispensing and sealing module, a human-computer interaction module, and a control unit, wherein the carrying and transferring module is used for conveying the carrier tray on the frame, the heat treatment module, the automatic dispensing and sealing module and the automatic sealing module are arranged on a carrier tray conveying route on the frame, the carrier tray is loaded with a slide, the heat treatment module is used for dewaxing and heating and curing a slide and a sealing reagent, the automatic dispensing and sealing module is used for dispensing and sealing the slide, the automatic sealing module is used for sealing the slide, the control unit controls the operation flow and the processing process of each module, the human-computer interaction module comprises a human-computer interaction interface, and is connected to the control unit and used for controlling the input of instructions and the output of processing information.

In a preferred embodiment, the automated drop-dye mounting apparatus further comprises a surveillance recognition system comprising one or more of: the camera is arranged on the rack and used for monitoring each module, and monitoring images are transmitted to the human-computer interaction interface for display; the infrared scanner is arranged on the rack and used for scanning the two-dimensional code on the glass slide to acquire sample information and processing flow information of a tissue section corresponding to the glass slide and transmitting the acquired information to the control unit, and the control unit controls the operation flow and the processing process of each module according to the acquired information; and the photosensitive sensor is arranged on the rack and used for detecting whether the glass slide is correctly placed or not, transmitting a detection signal to the control unit and processing or giving an alarm by the control unit.

Specific embodiments are described further below.

The human-computer interaction module comprises a human-computer interaction interface, interacts with a control host, adjusts the operation flow and the processing process of the bio-tissue sample section staining mounting by inputting a control instruction to the microprocessor, and comprises the steps of moving a two-dimensional platform, stopping, moving and closing liquid drops, adding a liquid drop reagent sequence, finely adjusting a micro two-dimensional sliding table, monitoring and identifying signals, operating and designing the processing of different bio-tissue sample sections through the human-computer interaction interface, carrying out directional batch processing on various bio-tissue sample sections, and selecting a staining flow according to the requirements through a human-computer interaction system, thereby achieving the effects of accuracy, high efficiency, no pollution and reagent saving. The man-machine interaction interface comprises a display and an input device, and is used for controlling the input of instructions and the output of information. A pair of miniature cameras are arranged on the upper portion of a rack of the all-in-one machine and used for monitoring all modules in the all-in-one machine, and images are transmitted to a human-computer interaction interface to be displayed. The infrared scanner is used for scanning the two-dimensional code on the glass slide to obtain the sample information (such as basic information of a patient) of the tissue section and the processing flow information of the tissue section, transmitting the data to the host, judging whether the glass slide is correctly placed or not by judging whether the signal is received or not by the photosensitive sensor, and transmitting the data to the man-machine interaction system.

Automatic drip dyeing mounting equipment with all-in-one machine structure

Referring to fig. 1A to 12, an embodiment of the present invention further provides an automatic dispensing and dyeing mounting apparatus with an all-in-one machine structure, including a frame 700, a carrier tray 401, a carrying and transferring module 500, a heat treatment module 100, 900, an automatic dispensing and dyeing module 200, and an automatic mounting module 300, wherein the heat treatment module 100, 900, the automatic dispensing and dyeing module 200, and the automatic mounting module 300 are disposed on the frame 700, the carrying and transferring module 500 includes an X-axis guide 503, a Y-axis guide 504, and a carrier tray carrying mechanism, the Y-axis guide 504 is mounted on the frame 700, the X-axis guide is movably mounted on the Y-axis guide 504, the carrier tray carrying mechanism is used for carrying the carrier tray 401, the carrier tray carrying mechanism is movably mounted on the X-axis guide 503, the carrier tray carrying mechanism and the X-axis guide 503 are respectively driven by a driving mechanism (such as a motor), and thus the carrier tray 401 carrying the slide glass is carried to the heat treatment module 100, 900 for dewaxing heat treatment, then carried to the automatic drip-dyeing module 200 for drip-dyeing treatment, then carried to the automatic cover slip module 300 for cover slip mounting treatment, and then carried to the heat treatment module 100, 900 for cover slip reagent heat-curing treatment. The automatic drip-dyeing module 200 may be the automatic drip-dyeing module 200 provided by the present invention.

In a preferred embodiment, the rack 700 is a vertical structure, the X-axis guide 503 is disposed along a horizontal direction, the Y-axis guide 504 is disposed along a vertical direction, and the heat treatment modules 100 and 900, the automatic drip-dyeing module 200, and the automatic mounting module 300 are distributed on different height positions of the rack 700 or on different horizontal positions of the same height.

In a preferred embodiment, the heat treatment modules 100 and 900 include first to second heat treatment modules, the automatic drip-dyeing module 200 includes first to third drip-dyeing modules 200, the first heat treatment module 900 is used for dewaxing heating treatment, the second heat treatment module 100 is used for mounting reagent heating and curing treatment, and the first to third drip-dyeing modules 200 can each perform drip-dyeing treatment on one carrier tray 401 at the same time.

In a preferred embodiment, the X-axis guide 503 is slidably mounted on the Y-axis guide 504 via a first slider 505, and the carrier disk carrier mechanism is slidably mounted on the X-axis guide 503 via a second slider 502.

In a preferred embodiment, the automatic drip-dyeing system further comprises a carrier tray temporary storage module 600, wherein the carrier tray temporary storage module 600 is disposed on the rack 700 and is used for receiving and temporarily storing the dewaxed and heat-treated carrier tray 401 carried by the carrier transfer module 500 when the automatic drip-dyeing module 200 has no empty space temporarily.

In a preferred embodiment, the carrier plate carrying mechanism includes a fork-shaped structure 506 extending outward in a cantilever manner, the bottom of the carrier plate 401 is provided with a positioning structure matching with the fork-shaped structure 506, and the carrier plate 401 is carried on the fork-shaped structure 506 through the coupling of the positioning structure 408 and the fork-shaped structure 506. Preferably, the positioning structure 408 protrudes from the bottom surface of the carrier plate 401, and is embedded in the middle of the fork-shaped structure 506 when coupled with the fork-shaped structure 506 so as to position the carrier plate 401. The fork-type structure may be, but is not limited to, a U-shaped structure.

In a preferred embodiment, the rack 700 further comprises a carrier tray access module, the carrier tray access module is a retractable structure 406 disposed at the carrier tray access, the retracted position of the retractable structure is located above the initial position of the carrier tray carrying mechanism, two notches aligned with the extending fingers of the fork-shaped structure 506 are disposed on the retractable structure 406, at least a part of the two notches is covered when the carrier tray 401 is located on the retractable structure 406, and the fork-shaped structure 506 passes through the two notches to transfer the carrier tray 401 from the retractable structure 406 to the carrier tray carrying mechanism when the carrier tray carrying mechanism moves upward; and/or

In a preferred embodiment, the rack 700 further includes a carrier tray receiving module, the carrier tray receiving module is a retractable structure 406 disposed at the carrier tray outlet, the retracted position of the carrier tray receiving module is located below the end position of the carrier tray carrying mechanism, two notches aligned with the extending fingers of the fork-shaped structure 506 are disposed on the retractable structure 406, at least a part of the two notches is covered when the carrier tray 401 is located on the retractable structure 406, and when the carrier tray carrying mechanism moves downward, the fork-shaped structure 506 passes through the two notches to transfer the carrier tray 401 from the carrier tray carrying mechanism to the retractable structure 406.

In a preferred embodiment, the carrier plate 401 is provided with positioning holes 404, and the retractable structure 406 is provided with positioning protrusions 407 for matching with the positioning holes.

In a preferred embodiment, the automatic drip-dyeing module 200 includes a drip-dyeing device, a carrier tray receiving tray for receiving the carrier tray 401 conveyed by the carrying and transferring module 500, a receiving tray lifting mechanism for lifting and moving the carrier tray receiving tray between the receiving position of the carrier tray 401 and a drip-dyeing processing position, and a receiving tray rotation driving mechanism for driving the carrier tray receiving tray to rotate so that the drip-dyeing device can perform drip-dyeing processing on different slides on the carrier tray 401; preferably, the carrier plate 401 is provided with a positioning hole, and the carrier plate receiving holder is provided with a positioning protrusion matched with the positioning hole.

In a preferred embodiment, the heat treatment module 100, 900 includes a heating device for providing a heat source for heat treatment, a carrier tray receiving tray for receiving the carrier tray 401 carried by the carrying and transferring module 500, and a receiving tray lifting mechanism for lifting and moving the carrier tray receiving tray between a receiving position for the carrier tray 401 and a heat treatment position; preferably, the carrier plate 401 is provided with a positioning hole, and the carrier plate receiving holder is provided with a positioning protrusion matched with the positioning hole.

In a preferred embodiment, the automatic drip-dyeing machine further comprises a liquid storage module arranged on the rack 700 and used for supplying liquid to the automatic drip-dyeing module 200 and a waste liquid collecting module used for collecting waste liquid from the automatic drip-dyeing module 200.

Specific embodiments are described further below.

Referring to fig. 1A to 1C, in one embodiment, the rack 700, the carrier tray 401, the carrier tray access module 400, the carrying and transferring module 500, the automatic drip dyeing module 200, the liquid storage module 800, the heat treatment modules 100 and 900 (the constant temperature heating and curing system and the drying and dewaxing system), the waste liquid collection module, the automatic sealing module 300, and the human-computer interaction control system are integrated into a whole. The automatic dripping and dyeing treatment system all-in-one machine for the biological tissue sample slices adopts a distributed layout, and can accelerate the treatment efficiency.

Optionally, the automatic drip-staining processing system for biological tissue sample slices further comprises: the device comprises an anti-pollution module and an alarm processing module.

Referring to fig. 1A, in a preferred embodiment the housing 700 is vertical. Optionally, the integrated machine of the automatic staining and dripping processing system for biological tissue sample slices can be in a horizontal box type or an off-box type.

Referring to fig. 1A, in a preferred embodiment, three drop dyeing modules 200 and two heat treatment modules 100, 900 are provided in order to improve the efficiency of the parallel process according to dyeing time and heat treatment time.

Referring to fig. 2 and 4, in a preferred embodiment, the carrier transfer module 500 includes a two-dimensional guide 504 and moving sliders 505 and 502 to move the carrier plate 401 among the modules of the automatic drip-dyeing module 200, the thermal processing modules 100 and 900, and the automatic cover sealing module 300, and the process thereof includes:

the transport carrier plate 401 moves among the automatic drip dyeing module 200, the heat treatment modules 100 and 900 and the automatic cover sealing module 300;

the circular hole 404 at the bottom of the carrier disc 401 is coupled and fixed with the convex structure 407 of the telescopic structure 406, the telescopic structure 406 is contracted, the motor controls the motion of the motion sliding block 502, so that the fork-shaped structure 506 is coupled and fixed with the U-shaped positioning structure 408 at the bottom of the carrier disc 401, and the motion sliding blocks 505 and 502 are controlled by the motor to drive the carrier disc 401 to move;

conveying the carrier disc 401 into the all-in-one machine from an inlet of the all-in-one machine, and conveying the carrier disc 401 to an outlet of the all-in-one machine from the all-in-one machine;

the automatic drip-dyeing module 200 moves the carried carrier disc 401 into the module for processing, and moves out after processing;

the heat treatment module 100, 900 moves the carried carrier plate 401 into the module for processing, and moves out after processing;

the automated cover module 300 moves the incoming carrier plate 401 into the module for processing and then moves out after processing.

Referring to fig. 3, in a preferred embodiment, a carrier plate 401 may hold slides 402 via removable slots 405, the slides 402 may be removable from the carrier plate 401, and multiple slides 402 may be held on the carrier plate 401 at the same time. The two-dimensional code on the slide 402 can be recognized by the recognition device.

Referring to fig. 3, in a preferred embodiment, the carrier plate 401 is a circular or rectangular symmetrical shape, and the slides 402 are regularly distributed on the carrier plate 401, which is beneficial to streamline processing.

Referring to fig. 5, in a preferred embodiment, a pair of miniature cameras is arranged at the upper part of the all-in-one machine, each module in the all-in-one machine is monitored, images are transmitted to a human-computer interaction interface for display, an infrared scanner scans two-dimensional codes 403 on a glass slide 402 to obtain basic information of a patient and tissue slice processing flow information, data are transmitted to and transmitted into a host, a photosensitive sensor judges whether the glass slide 402 is correctly placed or not according to whether signals are received or not, and the data are transmitted to a human-computer interaction system

Referring to fig. 6-8C, the automatic drip dye module 200 of the preferred embodiment is described in detail below.

Referring to fig. 9A-9F, the preferred embodiment thermal processing module 100, 900 is described in detail below.

Automatic drip dyeing module and automatic drip dyeing mounting equipment with same

Referring to fig. 6 to 8C, in one embodiment, an automatic drop staining mounting apparatus includes an automatic drop staining module for automatically staining a biological tissue sample slide and an automatic mounting module for mounting stained slides, the automatic drop staining module includes a fluid middle device 2200, fluid end devices 2300A to 2300D, a carrier tray 401 and a carrier tray receiving tray 2401, the carrier tray 401 is used for carrying slides, the carrier tray 401 is held by the carrier tray receiving tray 2401, the fluid middle device 2200 is connected with the fluid end devices 2300A to 2300D through fluid pipelines, the fluid middle device 2200 serves as a fluid splitter for distributing externally input staining liquid to the fluid end devices 2300A to 2300D, the fluid end devices 2300A to 2300D have a liquid outlet and a waste liquid recovery hole 2304, the staining liquid is applied to the slides carried by the carrier tray 401 from the liquid outlet and is recovered to a negative pressure chamber (not shown) through the effluent collection well 2304 by negative pressure suction after staining of the samples on the slides is completed.

In a preferred embodiment, a power device is further included, the power device including a take-up tray rotational drive mechanism 2400 and a take-up tray lift mechanism 2500, the take-up tray rotational drive mechanism 2400 coupled to the carrier tray take-up tray 2401 for driving the carrier tray take-up tray 2401 to rotate in a working position to position a slide to be stained relative to the fluid end device 2300A-2300D; preferably, the receiving tray lifting mechanism 2500 is further used for moving the carrier tray receiving tray 2401 up and down between the receiving position of the carrier tray and the drip dyeing processing position.

In a preferred embodiment, the fluid end unit 2300A-2300D comprises a liquid inlet header 2301 and a high pressure gas connector 2303 connected to the liquid outlet via a common manifold 2308, the liquid inlet header 2301 is connected to the fluid middle unit 2200 via a fluid line, the high pressure gas connector 2303 is used for introducing high pressure gas during waste liquid recovery, and a plurality of waste liquid recovery holes 2304 are distributed around the liquid outlet. The high pressure gas forces liquid on the slide to spread from the exit port toward effluent port 2304 and forces liquid in the channel to exit fluid tip assembly 2300A-2300D from inlet header 2301 and back to fluid tip assembly 2200.

In a preferred embodiment, the liquid outlet comprises a dropping needle 2305, and a plurality of waste liquid recovery holes 2304 are distributed in a row on both sides of the dropping needle 2305.

In a preferred embodiment, pumps 2800A-2800D are also included between the fluid middle end device 2200 and the fluid end devices 2300A-2300D to apply motive forces to the liquid.

In a preferred embodiment, the fluid middle-end device 2200 includes a liquid storage chamber (e.g., a central common chamber 2202) that provides a fluid inlet for inputting a staining liquid, a fluid outlet for dispensing liquid to the fluid end device 2300A-2300D, and at least one of: a negative pressure suction port for forming a negative pressure in the liquid storage chamber to input a staining liquid, a liquid overflow port for overflowing the liquid when the liquid input is excessive, an atmospheric connection port for communicating the atmosphere when the liquid is dispensed to the fluid end device 2300A-2300D, and a discharge port for discharging the liquid after the staining of the sample is completed, preferably, the negative pressure suction port, i.e., the discharge port.

In a preferred embodiment, the liquid storage chamber is provided with a plurality of fluid inlets.

In a preferred embodiment, one or more of said fluid inlets is provided with a fluid switch.

In the preferred embodiment, the fluid middle-end device 2200 comprises a combination of a top 2203, at least one waist 2204 and a bottom 2205 stacked together in a square shape, the fluid storage chamber is formed by the combination, a plurality of sides of the top 2203 and a bottom connected with the waist 2204 are respectively provided with openings, a plurality of sides of the at least one waist 2204 are respectively provided with openings, a top surface of the waist 2204 connected with the top 2203 is provided with an opening, a bottom surface of the waist 2204 connected with the bottom 2205 is provided with an opening, namely a fluid outlet 2206A, a plurality of sides of the bottom 2205 and a top surface connected with the waist 2204 are respectively provided with openings, an opening of the top 2203 is used for liquid or air, and an opening of the waist 2204 and an opening of the bottom 2205 are used for liquid.

In a preferred embodiment, the fluid middle-end 2200 is provided with a negative pressure conduit 2207, and the negative pressure conduit 2207 is connected with the negative pressure suction port and extends to the bottom of the liquid storage chamber.

In a preferred embodiment, a temperature maintenance device 2900 is also included for maintaining the temperature within the dyeing device at a set temperature range or value.

Specific embodiments are described in further detail below.

An automatic drip staining module for a section of a biological tissue sample comprising: fluid lines (not shown), fluid middle end device 2200, fluid end devices 2300A-2300D, fluid switches, carrier tray receiving holder 2401, receiving holder rotational drive mechanism 2400, receiving holder lift mechanism 2500, temperature maintenance device 2900, pumps 2800A-2800E, and rack 2600. Fluid lines connect an external source of liquid (e.g., a liquid storage device) to the fluid end-device 2200, the fluid lines connect the fluid end-device 2200 to the fluid end-devices 2300A-2300D, and pumps 2800A-2800D are included between the fluid end-device 2200 and the fluid end-devices 2300A-2300D. The fluid line includes a liquid conduit (preferably a flexible, corrosion resistant conduit), a fluid switch, and a port. The fluidic medium device 2200 includes a fluidic switch, a central common chamber, and an interface. The end-of-fluid device 2200 can store and dispense liquids. Fluid end devices 2300A-2300D include a plurality of ports, waste recovery apertures 2304, and a plurality of manifolds, enabling liquid application, waste recovery, and blowing operations. The carrier tray receiving holder 2401 can drive the carrier tray to rotate and translate. The temperature maintaining device can maintain the temperature in the dyeing device to be approximately constant, and the best dyeing effect is realized. The frame holds the various sections.

The dyeing main process comprises the following steps: the fluid middle-end device 2200 dispenses externally inflowing liquids to the fluid end-devices 2300A-2300D. The liquid is delivered to the slides of carrier disk 401 held by carrier disk receiving tray 2401 by fluid end devices 2300A-2300D. After the task of the fluid is completed, the fluid is again recovered by the fluid end devices 2300A-2300D. The positions of the fluid lines, fluid middle end device 2200, and fluid end devices 2300A-2300D are typically held stationary relative to the floor, and the carrier tray receiving holder 2401 rotates the carrier tray 401 to effect a one-by-one staining of the specimen on each slide. The carrier tray receiving tray 2401 can receive the carrier tray 401 when opened and is in an operating state when closed. The temperature maintaining device keeps the temperature in the dyeing device approximately constant.

In FIG. 6, 2200 shows a fluid medium-end device, and 2300A-2300D show a fluid end device. The dyeing module can be provided with a plurality of fluid pipelines, and each fluid pipeline only contains one liquid. The fluid pipeline is inserted with a fluid switch which can be a solenoid valve and controls the liquid to enter the fluid middle-end device. The dyeing module can be provided with a fluid middle-end device, a plurality of fluid inlets are distributed on the device to receive liquid from the outside, and a fluid switch is arranged on each inlet and can be an electromagnetic valve; the device has at least one fluid outlet, which may be provided without a switch. The fluid middle-end device can be regarded as a liquid transfer station. The fluid middle-end device is provided with a liquid storage chamber. The staining module has at least one fluid end device therein. The fluid end device is connected with the fluid middle end device through a fluid pipeline. The fluid end device is in fluid communication with the fluid middle device. When a switch in a fluid pipeline in which a certain liquid exists is opened, the liquid flows into the fluid middle-end device, so that the storage cavity of the fluid middle-end device is filled with the liquid. To allow liquid to flow into the fluidic medium device, the air pressure in the storage chamber of the fluidic medium device may be reduced in some way. This may be done by using a pump 2800E to draw air away from the chamber. When the liquid amount in the storage chamber reaches a certain standard, the switch in the fluid pipeline where the liquid exists is closed, and the liquid is stopped from entering. In order to prevent the fluid middle-end device from sucking excessive liquid, a liquid overflow outlet is arranged in the fluid middle-end device. When the fluid end device is activated, liquid in the storage chamber flows out of the outlet of the fluid end device through the fluid end device onto a slide carried by the carrier plate 401. In order to make the liquid have certain power, a pump is arranged on a pipeline between the fluid middle-end device and the fluid end device to apply power to the liquid. During this process, the air pressure in the fluid storage chamber of the fluid center device is maintained equal to atmospheric pressure by some means. When the amount of liquid on the slide reaches a desired level, the fluid end device changes operating conditions to move the fluid end device and the liquid in the fluid line between the fluid end device and the fluid middle device into the storage chamber of the fluid middle device. The liquid in the storage chamber is discharged by a tube. After a certain period of time, the fluid end device removes the liquid from the slides carried by the carrier tray 401 and delivers it to a waste collection (e.g., waste reservoir). When the task of the liquid is finished, the liquid middle-end device discharges the liquid which finishes the task out of the storage chamber, and the liquid is discharged out of the dyeing module through the corresponding fluid pipeline.

Fig. 7A is an isometric view and fig. 7B is a top view of a fluid center device. 2201A-2201L are fluid switches, which may be solenoid valves. 2202 is a central common chamber. The central common chamber has one or more inlets and one or more outlets, and several tributary channels are connectable by means of respective fluid switches. The fluid switch is connected with each fluid pipeline and/or the negative pressure generating device (which can be a vacuum pump) and/or the atmospheric pressure.

Figure 7C is an isometric view of a central common chamber. The central common chamber may consist of a top, a waist and a bottom, each part carrying a different function. The central common chamber has a bottom and a waist, but may have one or more waists. The central common chamber has a top, a waist, and a bottom. The top of the device is provided with 5 openings, four openings of which are connected with the fluid switch, and one opening of which is connected with the waist. The waist has 6 openings, of which four are connected to the fluid switch, and of which the other two openings can be connected to the top, waist or bottom. The bottom can have 5 openings or 9 openings, wherein 4 openings are necessary for the fluid outlet, and one opening is necessary to be connected with the waist. In this example, 2203 is the top of the central common chamber, 2204 is the waist of the central common chamber, and 2205 is the bottom of the central common chamber. 2206A is a liquid outlet at the bottom 2205 of the central common chamber that is connected to a fluid line leading to a fluid terminal device. The central common chamber top 2205 has two ports for connection to a negative pressure generating device and one may be a liquid overflow port and one needs to be connected to atmosphere. The central common chamber waist 2204 is typically in fluid communication with a fluid line for the liquid. When a certain liquid is required, the fluid switch on the fluid line for this liquid is opened, and at the same time the switch connected to the negative pressure is also opened, so that the liquid enters the central common chamber. If the liquid enters too much, the liquid will flow out of the liquid overflow outlet. When it is desired to deliver liquid from the central common chamber to the fluid end fitting, the switch to the port for atmospheric connection is opened, the pump is started and liquid flows out of the central common chamber 2202.

Figure 7D is a top view of the central common chamber. Figure 7E is a cross-sectional view B-B of the central common chamber. 2207 is a conduit which is part of the top of the central common chamber. One end of the pipe is connected to the top and its length is such that its other end is just below the bottom of the central common chamber. This conduit is connected through the top of the central common chamber to an external gas pressure controller, which may be a vacuum pump. The fluid middle-end device changes the gas pressure in the liquid storage chamber through the pipeline. Meanwhile, the fluid middle-end device can also discharge the liquid in the storage cavity which is used for completing the task out of the storage cavity through the pipeline. When it is desired to drain the liquid from the central common chamber, a negative pressure is created in conduit 2207 and the port to atmosphere is opened and the liquid in the central common chamber can be drained from the fluid center.

Fig. 7F is an isometric view of a fluid tip device. Fig. 7G is a bottom view of the fluid tip device. Fig. 7H is a front view of the fluid tip device. Fig. 7I is a stepped cross-sectional view G-G in an elevation view of the fluid tip assembly. Fig. 7J is a cross-sectional view at the center of the fluid tip device. 2301 is a liquid inlet head of a fluid terminal device, and 2301 is connected to a fluid middle device through a fluid pipeline. When a switch in a fluid pipeline in which a certain liquid exists is opened, the liquid flows into the fluid middle-end device, so that the storage cavity of the fluid middle-end device is filled with the liquid. When the liquid amount in the storage chamber reaches a certain standard, the switch in the fluid pipeline where the liquid exists is closed, and the liquid is stopped from entering. Subsequently, the fluid end device is operated and the liquid in the storage chamber flows out of the outlet of the fluid end device through the fluid line to the fluid end device inlet header 2301 into the fluid end device. The reagent is introduced into the common manifold 2308 and the lower pipe in sequence through the inlet header 2301, and then flows out from the outlet 809 of the lower pipe after a certain amount of liquid is accumulated in the lower pipe to prevent air bubbles. 2302 is the waste outlet head of the fluid end set. The task-performed liquid recovered from the slide eventually exits the fluidic terminal device through a waste outlet header 2302 of the fluidic terminal device. 2303 is a high pressure gas connection of the fluid end unit, through which high pressure gas enters. The conduits of the inlet header 2301 and the conduits of the high pressure gas connection 2303 merge into a common manifold 2308. Attached to the end of the common manifold is a drip needle 2305. In FIG. 7G, 2304 are effluent collecting wells. Waste recovery holes 2304 are distributed in rows on both sides of dropping needles 2305. The number of each row of waste liquid recovery holes is between 5 and 15. The waste liquid recovery hole is connected with the negative pressure chamber. The negative pressure chamber is connected to a negative pressure source through waste outlet header 2302, which can draw negative pressure via tubing to draw fluid out of the negative pressure chamber. When liquid is distributed, the waste liquid recovery hole 2304 and the high-pressure gas connector 2303 are in a non-operating state, and the liquid passes through the liquid inlet head 2301 and the common manifold 2308 and finally goes out of the dropping needle 2305 to reach the slide glass. After the liquid finishes the coloring task, the waste liquid recovery hole 2304 and the high pressure gas joint 2303 start to work. High pressure gas enters the common manifold 2308 from the high pressure gas connection 2303 and then travels in both directions. And upward, to displace liquid in the conduit from the inlet header 2301 out of the fluid end device to the fluid middle device. Flows downward, out of common manifold 2308 to drip needle 2305, and blows liquid onto the slide. The high pressure forces the liquid on the slide to spread from the center to the two sides of the waste liquid recovery hole. At the same time, the low air pressure in the waste liquid recovery hole sucks the liquid into the negative pressure chamber, thereby completing the waste liquid removal work.

When the fluid tip device dispenses reagent liquid onto the surface of the slide 402, the two-dimensional code 403 disposed on the slide 402 can be recognized by the recognition device, processed for marking, and passed information to the human-computer interaction system.

Figure 8A is an isometric view of a portion of an apparatus of a staining module. Fig. 8B is an isometric view of the carrier tray receiving tray and power device. Fig. 8C is a front view of the carrier tray receiving tray and power device. In fig. 8A, 2900 denotes a temperature maintaining device which can radiate or radiate heat to the outside to maintain the temperature inside the dyeing apparatus at a set temperature range or value. 401 denotes a carrier plate carrying slides circumferentially distributed on the carrier plate with their long side axis aligned with the center of the tray. The central region of the carrier plate 401 has a convex spatial geometry with corresponding draft features on the bottom surface of the carrier plate corresponding to these shapes. The fluid end devices 2300A-2300D can precisely align slides carried on carrier trays during the staining process. After one staining process is finished, the carrier tray receiving holder 2401 drives the carrier tray 401 to rotate a certain angle, so that the next slide adjacent to the slide which finishes the staining process can be properly aligned with the fluid end device 2300A-2300D. The carrier plate 401 is combined with the carrier plate receiving tray in a certain manner and can maintain the relative position unchanged. 2401 in fig. 8B shows a carrier tray receiving tray. The carrier tray receiving receptacles 2401 also have raised dimensional geometries that can be precisely matched to the pattern drawing features on the bottom surface of the carrier tray. In one embodiment, the carrier plate 401 has a circular hole 404 that is coupled to a protrusion structure of the carrier plate receiving holder 2401. The power device is provided with a bearing support rotary driving mechanism 2400 to drive the carrier plate bearing support 2401 to rotate. The carrier rotation driving mechanism 2400 may be a motor. The carrier holder rotation driving mechanism 2400 and the carrier tray holder 2401 may be connected to a timing belt pulley by a timing belt. The carrying tray lifting mechanism 2500 and the carrier tray carrying tray 2401 can also be connected through a screw rod, so that the lifting linear motion of the carrier tray carrying tray 2401 is realized.

In fig. 8C, 2400 denotes a carrier tray receiving tray, 2500 denotes a receiving tray lifting mechanism, and 2600 denotes a frame of the dyeing apparatus. The carrier plate receiving tray has at least a lifting linear motion relative to the frame of the dyeing apparatus and a circular motion relative to the frame of the dyeing apparatus. The carrier tray receiving tray has two states of open and working. In the open state, the carrier tray receiving tray does not perform circular motion. In the opening process and the return process, the carrier plate bearing support only moves linearly. In the operating state, the carrier plate carrying holder only performs circular motion. In fig. 6, the carrier tray receiving tray is in an operative state. In the operating state, after each circular motion of the carrier plate receiving tray is stopped, at least one slide glass on the carrier plate receiving tray can be opposite to the fluid end device. Meanwhile, a device is arranged on a rack of the dyeing device to detect whether the position of the carrier plate for bearing the supporting device is accurate or not. The power device provides power for the carrier tray bearing support. In fig. 8C, the carrier tray receiving tray is in an open state.

Heat treatment module and automatic drop dyeing mounting equipment with same

Referring to fig. 9A to 9F, the embodiment of the present invention further provides a heat treatment module, which can be used in the aforementioned automatic dispensing and mounting apparatus to perform heat treatment on a slide. The heat treatment module comprises a semi-closed cavity 901, a plurality of heating resistors 907, a blower fan blade 912 and a blower driving mechanism, wherein the heating resistors 907 and the blower fan blade 912 are arranged in the semi-closed cavity 901, the heating resistors 907 are circumferentially distributed in the semi-closed cavity 901, the upper end of the semi-closed cavity 901 is closed and is provided with a bottom opening, a carrier disc 401 carrying a plurality of glass slides can be matched with the semi-closed cavity 901 at the bottom opening to form a closed cavity, the heating resistors 907 heat air in the cavity when being electrified, and the blower driving mechanism is used for driving the blower fan blade 912 to rotate so as to form annular heat convection in the cavity, so that the glass slides on the carrier disc 401 are subjected to uniform convection heating.

In a preferred embodiment, the plurality of heating resistors 907 are uniformly distributed in a ring shape.

In a preferred embodiment, the heat treatment module further comprises a plurality of heating partitions 906 arranged in the semi-closed cavity 901 and vertically distributed in a ring shape, the plurality of heating partitions 906 extend radially outwards around the center of the cavity and are connected to a fixed outer ring, and the plurality of heating resistors 907 are respectively mounted on different heating partitions 906.

In a preferred embodiment, the heat treatment module further comprises a plurality of temperature sensors 908 uniformly arranged in the cavity to generate feedback signals for adjusting the operating states of one or more heating resistors 907 at corresponding positions when the plurality of temperature sensors 908 detect that the temperature in the cavity is not uniform or too high, so as to keep the temperature in the cavity uniform and stable.

In a preferred embodiment, the plurality of temperature sensors 908 are disposed on different heating partitions 906 corresponding to the plurality of heating resistors 907, respectively.

In a preferred embodiment, the thermal treatment module further includes the rotating bracket 911 disposed in the cavity, the rotating bracket 911 includes a rotating shaft 913 and an upper bracket plate and a lower bracket plate coupled to the rotating shaft 913, the blower fan 912 includes a plurality of fan blade units distributed in a vortex shape around a center of the rotating bracket 911, the plurality of fan blade units are vertically fixed between the upper bracket plate and the lower bracket plate, the rotating bracket 911 is disposed on an upper side or a lower side of the plurality of heating partitions 906, or an upper layer and a lower layer of the plurality of heating partitions 906 are disposed in the cavity, and the rotating bracket 911 is disposed between the upper layer of the plurality of heating partitions 906 and the lower layer of the plurality of heating partitions 906.

In a preferred embodiment, the blower driving mechanism comprises a motor 903, a transmission belt 904, and a transmission gear 905, and the motor 903 is coupled to the rotating shaft through the transmission gear 905 and the transmission belt 904.

In a preferred embodiment, the thermal processing module further comprises a carrier tray receiving tray 909 and a receiving tray lifting mechanism 910, wherein the carrier tray receiving tray 909 is configured to receive the transported carrier tray 401, and the receiving tray lifting mechanism 910 is configured to lift and move the carrier tray receiving tray 909 between a receiving position of the carrier tray 401 and the bottom opening of the semi-enclosed cavity 901.

In a preferred embodiment, the carrier plate 401 has a positioning hole, such as a circular hole 404, and the carrier plate receiving holder 909 has a protrusion 914 that matches the positioning hole.

In the preferred embodiment, the semi-enclosed cavity 901 is formed by a cylindrical housing that is open at the bottom and covers the plurality of heating resistors 907 and the blower fan blades.

Specific embodiments are described further below.

Referring to fig. 9A to 9F, in a preferred embodiment, the thermal treatment module 100, 900 includes a semi-enclosed cavity 901, a motor 903, a transmission belt 904, a transmission gear 905, a heating partition 906, a heating resistor 907, a temperature sensor 908, a carrier tray supporting device 909, a thermal treatment module vertical telescopic device 910, a rotating bracket 911, and a blower fan blade 912.

A plurality of layers of heating resistors 907 distributed annularly are arranged in the semi-closed cavity 901 and are connected with the driving circuit integrated module. The semi-enclosed cavity 901 is a cylindrical shell, and the heating part is embedded in the cylindrical shell. Also uniformly disposed within the cylindrical housing are temperature sensors 908 whose values are fed back to the drive circuit integrated module. The heating resistors 907 distributed in a ring shape are matched with the built-in rotating bracket 911, and the rotating bracket 911 is provided with fan blades 912 distributed in a ring-shaped radiation manner. The semi-enclosed cavity 901 may cooperate with the carrier plate 401 to form an enclosed cavity.

The working mode is as follows: the heating resistor 907 works, the motor 903 drives the transmission belt 904 to drive the rotating support 911 to rotate, so that the fan blades 912 of the air blower are driven to rotate, annular heat convection is formed, and the temperature in the semi-closed cavity is uniformly heated and increased. The temperature sensor 908 feeds back the temperature to the driver circuit integrated module, and for the part with uneven temperature or too high temperature, the heating resistor 907 is adjusted to finally keep the heating temperature distribution uniform and stable.

The carrier plate 401 may be carried to the heat treatment module 100, 900 by the carrier transfer module. Under the transportation of the carrier tray 401 by the carrying and transferring module 500, the circular hole 404 at the bottom of the carrier tray 401 is coupled and fixed with the protrusion structure 914 of the carrier tray receiving holder 909 in the heat treatment module 100, 900, then the receiving holder lifting mechanism 910 of the heat treatment module is lifted to lift the carrier tray receiving holder 909 carrying tray 401, the carrier tray 401 is matched with the bottom opening of the semi-closed cavity 901 to form a closed cavity, the carrier tray 401 carries the slide glass 402, and the slide glass 402 is heated and processed in the closed cavity for a certain time by annular heat convection. Before the slide 402 is drip stained, the thermal processing module 900 is used for carrying out the convection baking dewaxing treatment at 140 ℃ for 4 minutes, after the slide 402 is dewaxed, the slide 402 is drip stained and mounted, and then the slide is conveyed to the thermal processing module 100 to be carried out the mounting curing treatment at 70 ℃ for 5 minutes.

In the convection baking process, the paraffin covering on the surface of the biological tissue sample of the slide 402 on the carrier plate 401 is heated to a liquid state and dropped under the action of gravity. After the slide 402 is drop-stained by the automatic drop staining module, a coverslipping reagent is added to the surface of the slide 402 by the automatic coverslipping module, and the slide is covered. In the curing treatment, the mounting reagent can be rapidly cured by heating treatment at 70 ℃ for 5 minutes. The mounting agent is a liquid agent such as cyanoacrylate adhesive or a photocurable adhesive polymer.

Claims (10)

1. An automatic drip-dyeing mounting device with a human-computer interaction function is characterized by comprising a rack, a carrier disc, a carrying and transferring module, a heat treatment module, an automatic drip-dyeing module, an automatic mounting module, a human-computer interaction module and a control unit, wherein the carrying and transferring module is used for conveying the carrier disc on the rack, the heat treatment module, the automatic drip-dyeing module and the automatic mounting module are arranged on a carrier disc conveying route on the rack, a glass slide is loaded on the carrier disc, the heat treatment module is used for carrying out dewaxing heating treatment and mounting reagent heating and curing treatment on the glass slide, the automatic drip-dyeing module is used for carrying out drip-dyeing treatment on the glass slide, the automatic mounting module is used for carrying out cover glass mounting treatment on the glass slide, the control unit controls the operation flow and the treatment process of each module, and the human-computer interaction module comprises a human-computer interaction interface, the man-machine interaction module is connected to the control unit and used for controlling the input of instructions and the output of processing information.

2. The automated drop dye mounting apparatus of claim 1, further comprising a surveillance recognition system comprising one or more of:

the camera is arranged on the rack and used for monitoring each module, and monitoring images are transmitted to the human-computer interaction interface for display;

the infrared scanner is arranged on the rack and used for scanning the two-dimensional code on the glass slide to acquire sample information and processing flow information of a tissue section corresponding to the glass slide and transmitting the acquired information to the control unit, and the control unit controls the operation flow and the processing process of each module according to the acquired information;

and the photosensitive sensor is arranged on the rack and used for detecting whether the glass slide is correctly placed or not, transmitting a detection signal to the control unit, and controlling operation processing or alarming by the control unit.

3. The automated dip dyeing mounting apparatus according to claim 1 or 2, wherein the carrying and transferring module includes an X-axis guide rail, a Y-axis guide rail and a carrier disc carrying mechanism, the Y-axis guide rail is mounted on the frame, the X-axis guide rail is movably mounted on the Y-axis guide rail, the carrier disc carrying mechanism is used for carrying a carrier disc, the carrier disc carrying mechanism is movably mounted on the X-axis guide rail, and the carrier disc carrying mechanism and the X-axis guide rail are respectively driven by a driving mechanism to carry out the transportation of the carrier disc.

4. The automatic drop dyeing mounting device according to claim 3, characterized in that the frame is a vertical structure, the X-axis guide rail is arranged along the horizontal direction, the Y-axis guide rail is arranged along the vertical direction, and the heat treatment module, the automatic drop dyeing module and the automatic mounting module are distributed on different height positions on the frame or on different horizontal positions on the same height.

5. The automated drop-dye mounting apparatus of claim 4, wherein the thermal processing module comprises first to second thermal processing modules, the automatic drop-dye module comprises first to third drop-dye modules, the first thermal processing module is used for dewaxing heat treatment, the second thermal processing module is used for mounting reagent heat curing treatment, and the first to third drop-dye modules are capable of simultaneously performing drop-dye treatment on one carrier tray respectively.

6. The automated drop-dye mounting apparatus according to any one of claims 1 to 2, further comprising a carrier tray temporary storage module provided on the rack for receiving and temporarily storing the dewaxed and heat-treated carrier tray carried by the carrier transfer module when the automatic drop-dye module is temporarily empty.

7. The automated dispensing and mounting apparatus of any one of claims 1 to 2, wherein the carrier tray carrying mechanism comprises a fork-shaped structure extending outwardly in a cantilever manner, a bottom of the carrier tray is provided with a positioning structure matching with the fork-shaped structure, and the carrier tray is carried on the fork-shaped structure by coupling the positioning structure and the fork-shaped structure.

8. The automated dispensing and mounting apparatus of claim 7, further comprising a carrier plate access module, wherein the rack is provided with a carrier plate entrance, the carrier plate access module is a retractable structure disposed at the carrier plate entrance, the retractable structure is located above the initial position of the carrier plate carrying mechanism, the retractable structure is provided with two notches aligned with the extending fingers of the fork-shaped structure, the carrier plate is located on the retractable structure, at least a portion of the two notches is covered, and when the carrier plate carrying mechanism moves upward, the fork-shaped structure passes through the two notches to transfer the carrier plate from the retractable structure to the carrier plate carrying mechanism; and/or

The carrier disc receiving module is arranged on the rack and is a telescopic structure arranged at the carrier disc outlet, the retraction position of the carrier disc receiving module is located below the termination position of the carrier disc bearing mechanism, two notches aligned with the extension interdigital of the fork-shaped structure are arranged on the telescopic structure, when the carrier disc is located on the telescopic structure, at least one part of the two notches is covered, and when the carrier disc bearing mechanism moves downwards, the fork-shaped structure penetrates through the two notches and transfers the carrier disc from the carrier disc bearing mechanism to the telescopic structure.

9. The automated drop dyeing mounting apparatus according to any one of claims 1 to 2, wherein the automatic drop dyeing module comprises a drop dyeing device, a carrier tray receiving tray for receiving a carrier tray conveyed by the carrying and transferring module, a receiving tray lifting mechanism for lifting and moving the carrier tray receiving tray between a receiving position of the carrier tray and a drop dyeing processing position, and a receiving tray rotary driving mechanism for driving the carrier tray receiving tray to rotate so that the drop dyeing device performs drop dyeing processing on different slides on the carrier tray.

10. The automated dip dyeing and mounting apparatus according to any one of claims 1 to 2, wherein the heat treatment module comprises a heating device for providing a heat source for heat treatment, a carrier tray receiving tray for receiving the carrier tray carried by the carrier transfer module, and a receiving tray lifting mechanism for lifting and moving the carrier tray receiving tray between a receiving position for the carrier tray and a heat treatment position.

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