CN109443889B - Full-automatic push-piece dyeing system - Google Patents
Full-automatic push-piece dyeing system Download PDFInfo
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- CN109443889B CN109443889B CN201811525084.5A CN201811525084A CN109443889B CN 109443889 B CN109443889 B CN 109443889B CN 201811525084 A CN201811525084 A CN 201811525084A CN 109443889 B CN109443889 B CN 109443889B
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- dyeing
- slide
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- liquid
- push
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- 238000009971 piece dyeing Methods 0.000 title claims abstract description 17
- 238000004043 dyeing Methods 0.000 claims abstract description 84
- 238000004140 cleaning Methods 0.000 claims abstract description 64
- 238000005070 sampling Methods 0.000 claims abstract description 54
- 210000004369 blood Anatomy 0.000 claims abstract description 30
- 239000008280 blood Substances 0.000 claims abstract description 30
- 239000007788 liquid Substances 0.000 claims description 93
- 230000002572 peristaltic effect Effects 0.000 claims description 61
- 239000002699 waste material Substances 0.000 claims description 43
- 239000011521 glass Substances 0.000 claims description 24
- 238000002347 injection Methods 0.000 claims description 12
- 239000007924 injection Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000010241 blood sampling Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- 238000007599 discharging Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 241001552669 Adonis annua Species 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000010339 medical test Methods 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
Abstract
The invention discloses a full-automatic push-piece dyeing system, and belongs to the field of medical appliances. The device comprises a whole machine chassis, an upper sheet sampling triaxial module, a pushing sheet module, a dyeing sheet bin module, a sample feeding and sheet taking triaxial module, a collecting module, a sample position, a slide position, a sample feeding needle cleaning groove and a push-type cutter cleaning groove. The invention adopts a set of triaxial mechanical arm to perform the action of loading and sampling, uses the shaft of the pushing piece to perform angle adjustment, and uses a second set of triaxial mechanical arm to collect the blood smear into the dyeing piece with the chute and dye, and then cleans and collects the blood smear. The invention adopts a brand new angle adjusting structure and a dyeing piece bin structure with a chute, has reasonable design, good repeatability and high reliability, can process a plurality of samples simultaneously, improves the efficiency, avoids the uncertainty of manual pushing, and provides convenience for medical staff to diagnose rapidly.
Description
Technical Field
The invention relates to a full-automatic push-piece dyeing system, and belongs to the field of medical bioengineering.
Background
In the field of medical bioengineering, microscopic examination of blood smears is a fundamental method of blood cytology, and has wide application, particularly great value for diagnosis of various blood diseases. However, the preparation and staining of blood smears are often manually operated by medical staff, the consistency is not good enough, the influence of human factors is large, and the cell identification is often difficult. The thickness of the blood film is influenced by the angle of the pushing sheet, the speed of the pushing sheet and the viscosity of blood, white blood cells are not uniform enough, and the dyeing effect is poor, which are all the problems of the preparation and dyeing of the blood smear at present.
Push-piece dyeing equipment popular in the market at present is as follows in China patent publication No.: CN107782597a, publication date: 2018-03-09, invention name: the invention relates to a full-automatic medical test blood push-piece dyeing machine, which can carry out push-piece dyeing on a sample and adjust the height of a placing plate, but can not automatically adjust the push-piece angle on the blood sample, and has poor push-out effect consistency due to different blood viscosities of different samples. Such as Chinese patent publication No.: CN103364251a, publication date: 2013-10-23, invention name: the dyeing device of the push-piece dyeing machine and the dyeing method of the push-piece dyeing machine are high in cost, complex in structure and poor in stability.
Disclosure of Invention
Aiming at the problems, the invention provides a full-automatic push-piece dyeing system which is simple in mode and can automatically adjust the push-piece angle and the push-piece speed.
The technical scheme adopted for achieving the purposes of the invention is as follows:
a full-automatic push-piece dyeing system, said full-automatic push-piece dyeing machine system comprising: the device comprises a whole machine chassis, an upper sheet sampling triaxial module, a pushing sheet module, a sheet taking and dyeing triaxial module, a dyeing sheet bin, a collecting module, a sample position, a slide position, a sample injection needle cleaning tank and a pushing cutter cleaning tank.
The upper sampling triaxial module is fixedly arranged above the chassis of the whole machine and positioned at the right end of the chassis of the whole machine, and comprises a three-dimensional moving platform, a sample injection needle, a plunger pump, a three-way liquid valve, a waste discharge peristaltic pump, a cleaning peristaltic pump, a sucking disc, a positive pressure three-way air valve, a negative pressure three-way air valve, a vacuum pump and a T-shaped three-way joint; the three-dimensional moving platform comprises a sampling X-direction moving platform, a sampling Y-direction moving platform and a sampling Z-direction moving platform, wherein a slide position, a sample position and a sample needle cleaning groove are positioned below the three-dimensional moving platform, the sample needle cleaning groove is positioned between the sample position and the X-direction moving platform, the sample position is positioned between the slide position and the three-dimensional moving platform, and the slide position is parallel to the slide groove; the sucking disc and the sampling needle are fixed at two ends of a belt pulley of the sampling Z-direction moving table, the sucking disc and the sampling needle synchronously run, the sampling needle is connected with a liquid inlet at the side end of the plunger pump through a liquid pipeline, a liquid outlet at the top end of the plunger pump is connected with a normally closed end of a three-way liquid valve through a liquid pipeline, a normally open end of the three-way liquid valve is connected with a liquid inlet at the side end of a cleaning tank of the sampling needle through a liquid pipeline, a liquid outlet at the bottom end of the cleaning tank of the sampling needle is connected with an inlet of a waste discharge peristaltic pump through a liquid pipeline, an outlet of the waste discharge peristaltic pump is connected with a waste liquid barrel through a liquid pipeline, a public end of the three-way liquid valve is connected with an inlet of a cleaning peristaltic pump through a liquid pipeline, and an outlet of the cleaning peristaltic pump is connected with a cleaning liquid barrel through a liquid pipeline; the vacuum pump is connected to the positive pressure three-way air valve common end through the air pipe, the positive pressure three-way air valve normally closed end is connected with the T-shaped three-way joint through the air pipe, the vacuum pump is connected to the negative pressure three-way air valve common end through the air pipe, the negative pressure three-way air valve normally open end is connected with the T-shaped three-way joint, and the T-shaped three-way joint common end is connected with the sucker top end interface through the air pipe.
The pushing sheet module is fixedly arranged above the chassis of the whole machine and positioned between the upper sheet sampling triaxial module and the sheet taking and dyeing triaxial module, and comprises a Z-direction moving table, a steering engine fixing frame, a steering engine, a baffle sheet, a push knife, an X-direction moving table, a slide groove, a cleaning push knife sample injection pump and a cleaning push knife waste discharge pump; the Z-direction moving table is fixed on the whole machine chassis, the steering engine fixing frame is fixed on the Z-direction moving table, the steering engine is fixed on the steering engine fixing frame, the steering engine arm is vertical to the steering engine fixing frame, the push-type cutter and the baffle are respectively sleeved on the steering engine arm, the baffle is fixed through bolts and the steering engine arm, the X-direction moving table is fixed on the whole machine chassis, the slide groove is fixed on the X-direction moving table, the width direction of the slide groove is parallel to the steering engine arm, the length direction of the slide groove is vertical to the steering engine arm, the push-type cutter cleaning tank is fixed on the whole machine bottom plate and is positioned under the push-type cutter, the push-type cutter cleaning tank is arranged between the X-direction moving table and the Z-direction moving table, a push-type cutter cleaning tank side sampling interface is connected with an outlet of a cleaning push-type cutter sampling pump through a liquid pipeline, an inlet of the cleaning push-type cutter sampling pump is externally connected with an inlet of a cleaning push-type cutter waste discharging pump through a liquid pipeline, and an outlet of the push-type cutter waste discharging pump is connected with a system waste liquid barrel.
The three-axis dyeing module for taking the sheet is fixedly arranged above the chassis of the whole machine and is positioned at the left end of the chassis of the whole machine, and comprises a moving table for taking the sheet in the X direction, a moving table for taking the sheet in the Y direction, a moving table for taking the sheet in the Z direction, a sucking disc for taking the sheet, 4 paths of sample injection needles, a water inlet peristaltic pump, a liquid peristaltic pump for dyeing A, a liquid peristaltic pump for dyeing B and a waste discharge peristaltic pump for a dyeing tank; the dyeing piece bin is positioned below the piece taking and dyeing triaxial module, the direction of the dyeing piece bin is the same as that of the glass groove, the piece taking suction cup and the 4 paths of sample needles are respectively fixed on a belt pulley on a piece taking Z-direction moving table, the 4 paths of sample needles are arranged in parallel and run synchronously with the piece taking suction cup, a port at the top end of the piece taking suction cup is connected with a public end of a T-shaped three-way joint through an air pipe, an outlet of a water inlet peristaltic pump is connected with a first sample needle from the right end of the 4 paths of sample needles, an outlet of a dyeing A liquid peristaltic pump is connected with a second sample needle from the right end of the 4 paths of sample needles, an outlet of a dyeing B liquid peristaltic pump is connected with a third sample needle from the right end of the 4 paths of sample needles, an inlet of a waste discharge peristaltic pump of the dyeing groove is connected with a sample needle from the left end of the 4 paths of sample needles, and inlets of the water inlet peristaltic pump, the dyeing A liquid peristaltic pump and the dyeing B liquid peristaltic pump are connected into corresponding reagent barrels through liquid pipelines, and outlets of the waste discharge peristaltic pumps of the dyeing groove are connected into the waste liquid barrels through liquid pipelines;
the collecting module is fixedly arranged above the chassis of the whole machine and positioned at the left end of the chassis of the whole machine, and comprises a slide conveying platform, a slide collecting frame, a slide bin fixing plate and a slide bin lifting moving platform; the slide conveying platform is arranged between the slide taking and dyeing triaxial module and the dyeing slide bin, the slide collecting frame is fixed on the slide conveying platform, the slide collecting frame is parallel to the direction of the dyeing slide bin, the slide bin is fixed on the slide bin fixing plate, the slide bin is parallel to the direction of the slide collecting frame, and the slide bin fixing plate is fixed on the slide bin lifting moving platform.
The dyeing piece bin is provided with a dyeing groove group, and the bottom of the dyeing groove is inclined.
By adopting the technology, the invention has the following advantages: the blood viscosity can be judged, the pushing plate angle is adjusted through the pushing plate module, the pushing plate speed depends on the natural sagging of the bottom end of the pushing knife, so that the blood can be uniformly coated on a glass slide, the quality of blood smear preparation is improved, and the consistency is good; multiple samples can be processed efficiently, and the efficiency is improved; the chute type dyeing position is adopted, so that the dyeing reagent can be paved on the smear part of the glass slide, the adsorption part of the sucker is not affected, and the sucker is not polluted; because of the automatic control, medical staff only needs to put in the sample, can take out the sheet bin after waiting for operation, and take out the prepared dyed blood smear from the sheet bin, so that manual contact is avoided, and the safety level is improved.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Detailed Description
The invention is described in further detail below with reference to the accompanying drawings.
A full-automatic push-piece dyeing system, said full-automatic push-piece dyeing machine system comprising: the whole machine chassis 41, the upper sheet sampling triaxial module, the pushing sheet module, the sheet taking and dyeing triaxial module, the dyeing sheet bin 32, the collecting module, the sample position 39, the slide 38, the sample needle cleaning tank 37 and the pushing cutter cleaning tank 34.
The upper sampling triaxial module is fixedly arranged above the whole machine chassis 41 and positioned at the right end of the whole machine chassis 41, and comprises a three-dimensional moving platform, a sample injection needle 11, a plunger pump 8, a three-way liquid valve 7, a waste discharge peristaltic pump 1, a cleaning peristaltic pump 2, a sucker 36, a positive pressure three-way air valve 42, a negative pressure three-way air valve 43, a vacuum pump 40 and a T-shaped three-way joint 44; the three-dimensional moving platform comprises a sampling X-direction moving platform 5, a sampling Y-direction moving platform 6 and a sampling Z-direction moving platform 9, a slide position 38, a sample position 39 and a sample needle cleaning groove 37 are positioned below the three-dimensional moving platform, the sample needle cleaning groove 37 is positioned between the sample position 39 and the X-direction moving platform 33, the sample position 39 is positioned between the slide position 38 and the three-dimensional moving platform, and the slide position 38 is parallel to the slide groove 18; the sucking disc 36 and the sampling needle 11 are fixed at two ends of a belt pulley 10 of the sampling Z-direction moving table 9, the sucking disc 36 and the sampling needle 11 synchronously run, the sampling needle 11 is connected with a liquid inlet at the side end of the plunger pump 8 through a liquid pipeline, a liquid outlet at the top end of the plunger pump 8 is connected with a normally closed end of the three-way liquid valve 7 through a liquid pipeline, a normally open end of the three-way liquid valve 7 is connected with a liquid inlet at the side end of a sampling needle cleaning tank 37 through a liquid pipeline, a liquid outlet at the bottom end of the sampling needle cleaning tank 37 is connected with an inlet of the waste discharge peristaltic pump 1 through a liquid pipeline, an outlet of the waste discharge peristaltic pump 1 is connected with a waste liquid barrel through a liquid pipeline, a public end of the three-way liquid valve 7 is connected with an inlet of the cleaning peristaltic pump 2 through a liquid pipeline, and an outlet of the cleaning peristaltic pump 2 is connected with a cleaning liquid barrel through a liquid pipeline; the air outlet of the vacuum pump 40 is connected to the public end of the positive pressure three-way air valve 42 through an air pipe, the normally closed end of the positive pressure three-way air valve 42 is connected with the public end of the T-shaped three-way joint 44 through an air pipe, the air suction port of the vacuum pump 40 is connected to the public end of the negative pressure three-way air valve 43 through an air pipe, the normally open end of the negative pressure three-way air valve 43 is connected with the T-shaped three-way joint 44, the public end of the T-shaped three-way joint 44 is connected with the top end of the suction cup 36 through an air pipe, the waste peristaltic pump 1, the cleaning peristaltic pump 2, the vacuum pump 40, the positive pressure three-way air valve 42, the T-shaped three-way joint 44 and the negative pressure three-way air valve 43 are fixed on the whole machine bottom plate 41, the suction cup 36 of the upper sampling module can transfer a slide from the slide position 38 to the slide groove 18, and suck blood into the sampling needle 11 from the sampling tube in the sample position 39 through the plunger pump 8, drop blood of the sampling needle 11 onto the slide of the slide groove 18, and then clean the sampling needle 11.
The pushing sheet module is fixedly arranged above the whole machine chassis 41 and positioned between the upper sheet sampling triaxial module and the sheet taking and dyeing triaxial module, and comprises a Z-direction moving table 14, a steering engine fixing frame 15, a steering engine 13, a baffle sheet 12, a pushing cutter 35, an X-direction moving table 33, a glass slide groove 18, a cleaning pushing cutter sample injection pump 3 and a cleaning pushing cutter waste discharge pump 4; the Z-direction moving table 14 is fixed on the whole machine chassis 41, the steering engine fixing frame 15 is fixed on the Z-direction moving table 14, the steering engine 13 is fixed on the steering engine fixing frame 15, the steering engine 13 arm is perpendicular to the steering engine fixing frame 15, the push-type cutter 35 and the baffle 12 are respectively sleeved on the steering engine 13 arm, the baffle 12 is fixed through bolts and the steering engine 13 arm, the X-direction moving table 33 is fixed on the whole machine chassis 41, the slide groove 18 is fixed on the X-direction moving table 33, the width direction of the slide groove 18 is parallel to the steering engine 13 arm, the length direction of the slide groove 18 is perpendicular to the steering engine 13 arm, the push-type cutter cleaning tank 34 is fixed on the whole machine chassis 41 and is located right below the push-type cutter 35, the push-type cutter cleaning tank is installed between the X-direction moving table 33 and the Z-direction moving table 14, a side end sample inlet of the push-type cutter cleaning tank 34 is connected with an outlet of the cleaning push-type cutter sample pump 3 through a liquid pipeline, a bottom end liquid outlet interface of the push-type cutter cleaning tank 34 is connected with an inlet of the cleaning push-type cutter waste pump 4 through a liquid pipeline, an outlet of the cleaning push-type waste pump 4 is connected with a system barrel, and the cleaning push-type waste liquid discharge pump 4 is fixed on the whole machine chassis 41. The moving table 33 in the X direction moves to scrape the bottom of the push-broach 35 on the surface of the slide in the slide groove 18, blood drops on the surface of the slide can be uniformly coated on the slide, the slide groove 18 is removed, the steering engine 13 is rotated, the baffle plate 12 follows to rotate, the push-broach 35 freely hangs down, the moving table 14 in the Z direction moves downwards, the push-broach 35 can be cleaned in the push-broach cleaning groove 34, the cleaning push-broach sample injection pump 3 feeds liquid into the push-broach cleaning groove 34, and the cleaning push-broach waste discharge pump 4 discharges waste liquid from the push-broach cleaning groove 34.
The three-axis dyeing module for taking the sheet is fixedly arranged above the whole machine chassis 41 and is positioned at the left end of the whole machine chassis 41, and comprises a sheet taking X-direction moving table 22, a sheet taking Y-direction moving table 21, a sheet taking Z-direction moving table 20, a sheet taking sucker 17, 4 paths of sample injection needles 16, a water inlet peristaltic pump 24, a dyeing A liquid peristaltic pump 25, a dyeing B liquid peristaltic pump 26 and a dyeing tank waste discharge peristaltic pump 27; the dyeing sheet bin 32 is positioned below the sheet taking and dyeing triaxial module, a dyeing groove group is arranged on the dyeing sheet bin 32, the bottom of the dyeing groove is inclined, the direction of the dyeing sheet bin 32 is the same as that of the glass groove 18, the sheet taking suction cup 17 and the 4 paths of sample needles 16 are respectively fixed on a belt pulley 19 on the sheet taking Z-direction moving table 20, the 4 paths of sample needles 16 are arranged in parallel and synchronously run with the sheet taking suction cup 17, the top end interface of the sheet taking suction cup 17 is connected with the public end of the T-shaped three-way joint 44 through an air pipe, the outlet of the water inlet peristaltic pump 24 is connected with a first sample needle from the right end in the 4 paths of sample needles 16, the outlet of the dyeing A liquid peristaltic pump 25 is connected with a second sample needle from the right end in the 4 paths of sample needles 16, the outlet of the dyeing B liquid peristaltic pump 26 is connected with a third sample needle from the right end in the 4 paths of sample needles 16, the inlet of the waste discharge peristaltic pump 27 is connected with the left end sample needles in the 4 paths of sample needles 16, the inlets of the water inlet peristaltic pump 24, the dyeing A liquid peristaltic pump 25 and the inlet of the dyeing B liquid peristaltic pump 26 are connected with the corresponding reagent barrels through liquid pipelines, and the outlet of the waste liquid discharge peristaltic pump 27 is connected with the waste liquid outlet of the waste liquid pump. The three-axis slide-taking and dyeing module takes out the prepared blood smear from the slide groove 18 by utilizing the slide-taking sucking disc 17, puts the prepared blood smear into the dyeing slide groove 32, sequentially adds the dyeing agent A, the dyeing agent B by using the water inlet peristaltic pump 24, the dyeing A liquid peristaltic pump 25, the dyeing B liquid peristaltic pump 26 and the waste discharge peristaltic pump 27 of the dyeing groove respectively, finally discharges all waste liquid by using the water, takes out the dyed blood smear from the dyeing slide groove, and puts the blood smear into the slide-collecting frame 28.
The collecting module is fixedly arranged above the whole machine chassis 41 and positioned at the left end of the whole machine chassis 41, and comprises a slide conveying platform 23, a slide collecting frame 28, a slide cabin 29, a slide cabin fixing plate 30 and a slide cabin lifting moving platform 31; the slide conveying platform 23 is arranged between the three-axis slide taking and dyeing module and the dyeing slide bin 32, the slide collecting frame 28 is fixed on the slide conveying platform 23, the slide collecting frame 28 is parallel to the dyeing slide bin 32, the slide bin 29 is fixed on the slide bin fixing plate 30, the slide bin 29 is parallel to the slide collecting frame 28, and the slide bin fixing plate 30 is fixed on the slide bin lifting moving table 31.
The working principle of the invention is as follows:
in the experiment preparation stage, an operator puts a blood sample to be detected into a sample frame, checks whether a sufficient amount of glass slides exist on a glass slide position, stains whether a glass slide exists on a glass slide bin, and whether a sufficient space is reserved in the glass slide bin.
After the experimental process is started, a glass slide is taken out from a glass slide position by a sampling triaxial module and placed in a glass slide groove by a sucker, then the sample is sucked out from a blood sampling tube on a sample frame by a sampling needle, the sample is dripped on the glass slide in the glass slide groove, the sampling needle is cleaned at a sampling needle cleaning position, a picture angle is calculated by a pushing sheet module according to blood viscosity, the pushing sheet speed is started, the pushing sheet is started, after the pushing sheet is completed, the glass slide groove moves into a movement range of a sheet taking and dyeing triaxial module, a pushing sheet is cleaned in a pushing sheet cleaning tank, the prepared blood smear is taken out from the glass slide groove by the sheet taking and dyeing triaxial module, the prepared blood smear is placed in a dyeing sheet bin, a dyeing reagent A, a dyeing reagent B and clear water are added by a peristaltic pump, waste is discharged, the blood smear is taken out from the dyeing sheet bin by the sheet taking and placing the sample into a glass collecting frame by the glass slide collecting frame, and the blood smear is sent into the sheet bin. And the medical staff takes out the sheet bin, performs microscopic examination on the blood smear in the sheet bin, and collects the sample information of the patient.
Claims (2)
1. A full-automatic push-piece dyeing system is characterized in that: the full-automatic push piece dyeing machine system comprises: the device comprises a whole machine chassis (41), an upper sheet sampling triaxial module, a pushing sheet module, a sheet taking and dyeing triaxial module, a dyeing sheet bin (32), a collecting module, a sample position (39), a slide position (38), a sample injection needle cleaning tank (37) and a pushing cutter cleaning tank (34);
the upper sampling triaxial module is fixedly arranged above a whole machine chassis (41) and positioned at the right end of the whole machine chassis (41), and comprises a three-dimensional moving platform, a sample injection needle (11), a plunger pump (8), a three-way liquid valve (7), a waste discharge peristaltic pump (1), a cleaning peristaltic pump (2), a sucker (36), a positive pressure three-way air valve (42), a negative pressure three-way air valve (43), a vacuum pump (40) and a T-shaped three-way joint (44); the three-dimensional moving platform comprises a sampling X-direction moving platform (5), a sampling Y-direction moving platform (6) and a sampling Z-direction moving platform (9), a slide position (38), a sample position (39) and a sample needle cleaning groove (37) are positioned below the three-dimensional moving platform, the sample needle cleaning groove (37) is positioned between the sample position (39) and the X-direction moving platform (33), the sample position (39) is positioned between the slide position (38) and the three-dimensional moving platform, and the slide position (38) and the slide groove (18) are parallel in direction; the suction cup (36) and the sampling needle (11) are fixed at two ends of a belt pulley (10) of a sampling Z-direction moving table (9), the suction cup (36) and the sampling needle (11) synchronously run, the sampling needle (11) is connected with a liquid inlet at the side end of a plunger pump (8) through a liquid pipeline, a liquid outlet at the top end of the plunger pump (8) is connected with a normally closed end of a three-way liquid valve (7) through a liquid pipeline, a normally open end of the three-way liquid valve (7) is connected with a liquid inlet at the side end of a sampling needle cleaning tank (37) through a liquid pipeline, a liquid outlet at the bottom end of the sampling needle cleaning tank (37) is connected with an inlet of a waste discharge peristaltic pump (1) through a liquid pipeline, an outlet of the waste discharge peristaltic pump (1) is connected with a waste liquid barrel through a liquid pipeline, and a common end of the three-way liquid valve (7) is connected with an inlet of a cleaning peristaltic pump (2) through a liquid pipeline; the air outlet of the vacuum pump (40) is connected to the public end of the positive pressure three-way air valve (42) through an air pipe, the normally closed end of the positive pressure three-way air valve (42) is connected with the public end of the negative pressure three-way air valve (43) through an air pipe, the normally open end of the negative pressure three-way air valve (43) is connected with the public end of the T-shaped three-way joint (44), and the public end of the T-shaped three-way joint (44) is connected with the top end interface of the sucker (36) through an air pipe;
the waste discharge peristaltic pump (1), the cleaning peristaltic pump (2), the vacuum pump (40), the positive pressure three-way air valve (42), the T-shaped three-way joint (44) and the negative pressure three-way air valve (43) are fixed on a bottom plate (41) of the whole machine, a suction disc (36) of the upper sheet sampling module can transfer a slide from a slide position (38) to a slide groove (18), blood is sucked into a sampling needle (11) from a blood sampling tube in a sample position (39) by utilizing a plunger pump (8), the blood of the sampling needle (11) is dripped onto the slide of the slide groove (18), and then the sampling needle (11) is cleaned;
the pushing piece module is fixedly arranged above the whole machine chassis (41) and positioned between the upper piece sampling triaxial module and the piece taking dyeing triaxial module, and comprises a Z-direction moving table (14), a steering engine fixing frame (15), a steering engine (13), a baffle piece (12), a push knife (35), an X-direction moving table (33), a slide groove (18), a cleaning push knife sample injection pump (3) and a cleaning push knife waste discharge pump (4); the Z-direction moving table (14) is fixed on a whole machine chassis (41), the steering engine fixing frame (15) is fixed on the Z-direction moving table (14), the steering engine (13) is fixed on the steering engine fixing frame (15), the steering engine (13) arm is perpendicular to the steering engine fixing frame (15), the push-type cutter (35) and the baffle (12) are respectively sleeved on the steering engine (13) arm, the baffle (12) is fixed through bolts and the steering engine (13) arm, the X-direction moving table (33) is fixed on the whole machine chassis (41), the glass slide groove (18) is fixed on the X-direction moving table (33), the width direction of the glass slide groove (18) is parallel to the steering engine (13) arm, the length direction of the glass slide groove (18) is perpendicular to the steering engine (13) arm, the push-type cutter cleaning groove (34) is fixed on the whole machine chassis (41), the push-type cutter (35) is arranged right below the push-type cutter (33) and in the middle of the Z-direction moving table (14), a sample inlet of the push-type cutter (34) side end sample inlet is connected with an outlet of a cleaning push-type cutter pump (3) through a liquid pipeline, the glass slide groove (18) is connected with a sample outlet of the cleaning liquid outlet of the cleaning push-type cutter pump (4), and a sample outlet of the cleaning liquid outlet of the push-type cutter pump (4 is connected with a sample outlet of the push-type waste liquid pump (4;
the three-axis dyeing module for taking the sheet is fixedly arranged above a chassis (41) of the whole machine and is positioned at the left end of the chassis (41) of the whole machine, and comprises a sheet taking X-direction moving table (22), a sheet taking Y-direction moving table (21), a sheet taking Z-direction moving table (20), a sheet taking sucker (17), 4 paths of sample injection needles (16), a water inlet peristaltic pump (24), a dyeing A liquid peristaltic pump (25), a dyeing B liquid peristaltic pump (26) and a dyeing tank waste discharge peristaltic pump (27); the dyeing piece bin (32) is positioned below the piece taking and dyeing triaxial module, the direction of the dyeing piece bin (32) is the same as that of the glass groove (18), the piece taking suction cup (17) and the 4 paths of sample needles (16) are respectively fixed on a belt pulley (19) on a piece taking Z-direction moving table (20), the 4 paths of sample needles (16) are arranged in parallel and synchronously run with the piece taking suction cup (17), a top end interface of the piece taking suction cup (17) is connected with a public end of a T-shaped three-way joint (44) through an air pipe, an outlet of a water inlet peristaltic pump (24) is connected with a first sample needle from the right end of the 4 paths of sample needles (16), an outlet of a dyeing A liquid peristaltic pump (25) is connected with a second sample needle from the right end of the 4 paths of sample needles (16), an outlet of a dyeing B liquid peristaltic pump (26) is connected with a third sample needle from the right end of the 4 paths of sample needles (16), an inlet of a waste dyeing tank pump (27) is connected with a left end sample needle in the 4 paths of sample needles (16), and a dyeing A liquid peristaltic pump (25) and a dyeing liquid peristaltic pump (26) is connected with a corresponding waste liquid outlet of a waste liquid through a waste liquid peristaltic pump (27) through a corresponding peristaltic pump inlet;
the collecting module is fixedly arranged above the whole machine chassis (41) and is positioned at the left end of the whole machine chassis (41), and comprises a slide conveying platform (23), a slide collecting frame (28), a slide bin (29), a slide bin fixing plate (30) and a slide bin lifting moving platform (31); the slide conveying platform (23) is arranged between the slide taking and dyeing triaxial module and the dyeing slide bin (32), the slide collecting frame (28) is fixed on the slide conveying platform (23), the slide collecting frame (28) is parallel to the direction of the dyeing slide bin (32), the slide bin (29) is fixed on the slide bin fixing plate (30), the slide bin (29) is parallel to the slide collecting frame (28), and the slide bin fixing plate (30) is fixed on the slide bin lifting moving table (31).
2. A fully automated push-piece dyeing system as set forth in claim 1, wherein: the dyeing piece bin (32) is provided with a dyeing groove group, and the bottom of the dyeing groove is inclined.
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| WO2020258169A1 (en) * | 2019-06-27 | 2020-12-30 | 深圳迈瑞生物医疗电子股份有限公司 | Method for dyeing sample, device for preparing smear, and dye solution combination |
| WO2020258158A1 (en) * | 2019-06-27 | 2020-12-30 | 深圳迈瑞生物医疗电子股份有限公司 | Slide maker and control method therefor |
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