WO2015165019A1

WO2015165019A1 - Smear preparation device, smear preparation method and glass slide basket drying module

Info

Publication number: WO2015165019A1
Application number: PCT/CN2014/076412
Authority: WO
Inventors: 陈良清; 向愿; 李为公; 李学荣; 印帅; 李乐昌; 董丽芳; 汪云飞
Original assignee: 深圳迈瑞生物医疗电子股份有限公司
Priority date: 2014-04-28
Filing date: 2014-04-28
Publication date: 2015-11-05
Also published as: CN111337321A; CN111337323A; CN111337324A; CN111337322A; CN105960584A; CN111366429A

Abstract

The present invention relates to the technical field of medical devices. Disclosed are a smear preparation device, smear preparation method and glass slide basket drying module. The smear preparation device comprises a glass slide carrying module, a printing module, a sample dripping module, a smearing module, a turn over module and a staining module, all arranged along a work line. The smear preparation method comprises the following steps: laying the glass slide flat and moving the glass slide along a work line; cleaning the glass slide with a cleaning module; printing sample information by using the printing module; dripping the sample by using the sample dripping module; smearing the sample by using the smearing module; turning the glass slide by using the turn over module to change from horizontal to vertical; and staining the glass slide by using the staining module. The glass slide basket drying module comprises a casing having an air inlet and an air outlet. With the smear preparation device, smear preparation method and glass slide basket drying module provided in the present invention the smear preparation device has a compact structure, and also high efficiency and high reliability of smear preparation, thus ensuring the accuracy of diagnosis results.

Description

Smear preparation device, smear preparation method and slide basket drying module

Technical field

The invention belongs to the technical field of medical equipment, and in particular relates to a smear preparation device, a smear preparation method and a slide basket drying module.

Background technique

At present, a fully automated blood smear or other tissue smear preparation instrument, as a smear preparation device, is generally divided into three important functions of push film preparation, push film and dyeing. In the prior art, some smear preparation devices divide the two functions of pushing and dyeing into two instruments, wherein after the blood smear is completed, manual intervention is required, and the blood smear is completed. Go to the staining instrument. In the manual transfer process, both the labor cost and the risk of the blood smear being damaged are increased, which easily affects the accuracy of the diagnosis result.

technical problem

The object of the present invention is to overcome the deficiencies of the prior art described above, and to provide a smear preparation device, a smear preparation method and a slide basket drying module, which have high reliability in preparing a smear and are advantageous for ensuring the accuracy of the diagnosis result.

Technical solution

The technical solution of the present invention is: a smear preparation device comprising a sampling module for extracting a sample, a slide loading module for moving the slide to the working line, a printing module for printing information on the slide, a drip module for dropping a sample onto a slide, a pusher module for smoothing a sample on the slide, a flip module for flipping the slide, and dyeing for dyeing the slide The module, the slide loading module, the printing module, the dropping module, the pushing module, the inverting module, and the dyeing module are arranged along the working line.

Specifically, the smear preparation apparatus further includes a cleaning module for cleaning the slide, the cleaning module being disposed along the work line.

In particular, the smear preparation apparatus further includes a sample drying module for drying the sample on the slide, the sample drying module being disposed along the working line.

Specifically, the smear preparation apparatus further includes a slide output module for carrying a slide basket and outputting the slide basket to a set position.

Specifically, the smear preparation apparatus further includes a slide basket drying module for drying the dyed slide.

Specifically, the drip sample module includes a blood drop needle connected to the sampling module; one side of the blood drop needle is provided with a micro-input for moving a priority sample under the blood drop needle Sample module.

Specifically, the lancet includes a needle body and a guide sleeve, and an elastic structure is disposed between the needle body and the guide sleeve.

Specifically, the working line includes a first working line and a second working line; the slide loading module, the cleaning module, the printing module, the dropping module, the pushing piece module and the turning module are arranged along the first working line, The inverting module is located at an intersection of the first working line and the second working line; the sample drying module and the dyeing module are arranged along the second working line.

Specifically, the first working line is provided with a first linear slide rail, and the first linear slide rail is slidably connected with a pusher cart for carrying a slide; the second working line is provided with a second straight line a slide rail, the second linear slide rail is slidably connected with a robot module for clamping and moving the slide; the first working line and the second working line are arranged perpendicularly or perpendicularly.

Specifically, the smear preparation device further includes a sample auto-injection module, the sample auto-injection module is disposed adjacent to the sampling module; the sample auto-injection module includes a test tube rack feeding component, and the sample is mixed. component.

Specifically, the slide loading module includes a slide storage sub-module for accommodating a slide, a cutter sub-module for pushing the slide from the slide storage sub-module to the working line, and a pair of slides Or the cutter head sub-module performs the limit in place blocking sub-module.

Specifically, the pusher module includes a pusher blade submodule for smearing the sample, and a flipping module for flipping the slide from a flat to an upright.

Specifically, the smear preparation apparatus has a control member for controlling a grip of a robot to manually insert a slide inserted at the sample drying module to the dyeing module.

Specifically, the dyeing module comprises a turntable sub-module, a needle tray module and a dyeing box; the dyeing module has a slide entry station and a slide take-out station, and the slide enters a station, a slide take-out station, The flip module, the sample drying module, and the slide output module are arranged along the same straight line.

Specifically, the slide basket drying module includes a housing provided with a blow port for blowing an air flow and an air suction port for sucking the air flow.

The present invention also provides a slide basket drying module comprising a housing provided with a blow port for blowing an air flow and an air suction port for drawing in the air flow.

The invention also provides a method for preparing a smear comprising the steps of: laying a slide flat and moving the slide along a working line, and performing the slide on the slide through the cleaning module during the movement of the slide along the working line Cleaning, then printing the sample information on the slide through the printing module, and then dropping the sample collected from the sampling module on the slide through the drop module, and then smoothing the sample of the slide through the push module. Then, the slide piece is turned from the flat state to the erect state by the flipping module, and the inverted slide piece is dyed by the dyeing module.

Specifically, the flipping module flips the slide to tilt and stays for a set length of time during the process of flipping the slide from the flat state to the upright state.

Specifically, the sample information printed on the slide is inspected by the detection module after the sample is printed on the slide and before the sample is dropped on the slide.

Beneficial effect

The smear preparing device, the smear preparing method and the slide basket drying module provided by the invention, the slide loading module, the printing module, the dropping sample module, the pushing piece module, the turning module and the dyeing module are arranged along the working line, The smear preparation device has a compact structure, and the preparation efficiency of the smear is high, and the reliability of preparing the smear is high, which is favorable for ensuring the accuracy of the diagnosis result.

DRAWINGS

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings to be used in the embodiments will be briefly described below. It is obvious that the drawings in the following description are only some embodiments of the present invention. Those skilled in the art can also obtain other drawings based on these drawings without paying any creative work.

1 is a schematic perspective view of a smear preparation apparatus according to an embodiment of the present invention;

2 is a schematic perspective view of a smear preparing device according to an embodiment of the present invention;

3 is a schematic view showing the arrangement of each station in the working line of the smear preparing device according to the embodiment of the present invention;

4 is a schematic perspective view of a slide loading module in a smear preparation device according to an embodiment of the present invention;

5 is a schematic plan view of a pusher module in a smear preparation device according to an embodiment of the present invention;

6 is a schematic perspective view of a push-pull module in a smear preparation device according to an embodiment of the present invention;

7 is a schematic perspective view of a sample drying module in a smear preparing device according to an embodiment of the present invention;

8 is a schematic perspective view of a second slide rail and a robot module in a smear preparation device according to an embodiment of the present invention;

9 is a schematic perspective view showing a three-dimensional assembly of a dyeing module in a smear preparing device according to an embodiment of the present invention;

FIG. 10 is a perspective view of a three-dimensional assembly of a middle glass basket drying module according to an embodiment of the present invention; FIG.

FIG. 11 is a perspective view of a three-dimensional assembly of a middle slide output module according to an embodiment of the invention.

Embodiments of the invention

The present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It is understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

It is to be noted that when an element is referred to as being "fixed" or "in" another element, it can be directly on the other element or the central element. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or the central element.

It should also be noted that the terms of the left, right, up, and down orientations in this embodiment are merely relative concepts or reference to the normal use state of the product, and should not be considered as limiting.

As shown in FIG. 1 to FIG. 6 , a smear preparation device provided by an embodiment of the present invention can be used for smear preparation of blood, body fluid and the like. The above smear preparation apparatus includes a sampling module for extracting a sample, a slide loading module 3 for moving a slide to a working line, a printing module 4 for printing information on a slide, and a sample for dropping the sample a drop module 5 of the slide, a pusher module 6 for smoothing the sample on the slide, a flip module 64 (not shown) for flipping the slide, and for the slide a dyeing module 9 for dyeing, the slide loading module 3, the printing module 4, the dropping module 5, the pushing module 6, the inverting module 64 and the dyeing module 9 are arranged along the working line, and the structure is compact, and the smear is The preparation efficiency is high, the reliability of preparing the smear is high, and the accuracy of the diagnosis result is ensured. There are various stations on the working line, the sampling module is the sampling station, the slide loading module 3 is the slide loading station, the printing module 4 is the printing station, and the dropping module 5 is the printing station. For the blood dropping station and the pushing module 6, the pushing station is the turning station, the turning module 64 is the turning station, and the dyeing module 9 is the dyeing station. It should be noted that the glass slides in this embodiment are not limited to glass materials, and other suitable materials may be used, which are all within the protection scope of the present invention.

Specifically, the smear preparation apparatus further includes a cleaning module (not shown) for cleaning the slide, the cleaning module being disposed along the working line, and the cleaning module is a cleaning station. In the step before the dropping module 5 performs blood dropping, for example, the slide can be cleaned by the cleaning module before printing the sample information, for example, by blowing, or the like.

Specifically, as shown in FIGS. 1 to 3, the smear preparation apparatus further includes a sample drying module 8 for drying a sample on a slide, and the sample drying module 8 can be used for drying a sample such as a blood film. The sample drying module 8 is arranged along the working line, and the sample drying module 8 is a slide drying station to dry the blood sample in time.

Specifically, as shown in FIGS. 1 to 3, the smear preparing device further includes a slide output module 10 for carrying a slide basket and outputting the slide basket to a set position, and the slide output module 10 The slide output station is the place.

Specifically, as shown in FIG. 1 to FIG. 3, the smear preparation device further includes a slide basket drying module for drying the dyed slide, and the slide basket drying module 12 is a slide basket drying. Station.

Specifically, as shown in FIG. 1 to FIG. 3, the drop module 5 includes a lancet 501, and the lancet 501 is connected to the sampling module 1; one side of the lancet 501 is provided for The priority sample is moved to the micro-injection module 2 below the lancet 501. The micro-injection module 2 can directly move the test tube placed by the operator in the direction of the lancet 501, and at the same time, the lancet 501 can also move in the direction of the test tube placed by the operator, since it is not necessary to draw blood through the sampling module 1. , can reduce the need for blood samples, thus achieving micro and priority injection. Moreover, the same blood drop 501 can be shared by batch injection and micro-preferred injection.

Specifically, as shown in FIG. 1 to FIG. 3, the lancet 501 includes a needle body and a guide sleeve, and an elastic structure is disposed between the needle body and the guide sleeve to prevent the lancet 501 from rigidly impacting the glass. sheet.

Specifically, as shown in FIG. 1 to FIG. 6 , the working line includes a first working line 101 and a second working line 102; the slide loading module 3, the cleaning module, the printing module 4, the dropping module 5, and the pushing The sheet module 6 and the inversion module 64 are arranged along the first working line 101, the inversion module 64 is located at the intersection of the first working line 101 and the second working line 102; the sample drying module 8 and the dyeing module 9 Arranged along the second working line 102, the first working line 101 and the second working line 102 are arranged perpendicularly to each other or arranged in a straight line or at other suitable angles.

Specifically, as shown in FIG. 1 to FIG. 11 , the first working line 101 is provided with a first linear slide rail 111 , and the first linear slide rail 111 is slidably connected with a pusher cart for carrying a slide. The second working line 102 is provided with a second linear slide 112, and the second linear slide 112 is slidably connected with a robot module 113 for clamping and moving the slide; the first working line 101 and the The second working lines 102 are arranged perpendicularly or vertically. For example, in this embodiment, the first working line 101 and the second working line 102 are arranged in a “T” shape, and the inversion module 64 is located at the intersection of the first working line 101 and the second working line 102, wherein The sample drying module 8 and the dyeing module 9 are disposed on the left and right sides of the inversion module 64. The slide loading module 3, the cleaning module, the printing module 4, the dropping module 5, and the pushing module 6 are located on the same side of the inversion module 64.

Specifically, as shown in FIG. 1 to FIG. 11 , the smear preparation device further includes a sample auto-injection module 114, the sample auto-injection module 114 is disposed adjacent to the sampling module 1 , and the sample auto-injection module 114 The test tube rack can be sent to the sampling module 1; the sample autosampler module 114 includes a test tube rack feed member, and a sample mixing member.

Specifically, as shown in FIGS. 1 to 11, the slide loading module 3 serves as a sheet storage and distribution module including a slide storage sub-module 31 for accommodating a slide for using the slide from the The slide storage sub-module 31 is pushed to the bit sub-module 33 of the working line, the in-position blocking sub-module 32 for limiting the slide or the bit sub-module 33.

Specifically, as shown in FIGS. 1 to 11, the pusher module 6 includes a pusher blade submodule 61 for smoothing the sample, and a flip module 64 for flipping the slide from the flat to the upright.

Specifically, as shown in FIGS. 1 to 11, the smear preparation apparatus has a control member for controlling a grip of a robot to manually insert the slide inserted at the sample drying module 8 to the dyeing module 9. When only the slide having the blood sample has been dyed, the slide having the blood sample can be directly placed at the sample drying module 8, and the control member can cause the robot to grip the slide at the sample drying module 8. And the slide is sent to the dyeing module 9. The control unit can be a button or the like. The sample drying module 8 has a first receiving groove 81 and a second receiving groove 82 for receiving the slide coated with the sample, and the inside of the first receiving groove 81 and the second receiving groove 82 can flow out a dry air flow to dry the sample. The second receiving groove 82 can be used as a slide for manually inserting. Through the control component, the robot module 113 can take a slide in the second receiving groove 82 and put it into the dyeing station. The first receiving groove 81 and the second receiving groove 82 correspond to the first drying station and the second drying station, respectively.

Specifically, as shown in FIG. 1 to FIG. 11 , the dyeing module 9 includes a turntable sub-module, a needle tray module and a dyeing box; the dyeing module 9 has a slide entering station 901 (dyeing station 1) and a slide. The station 902 (dyeing station 4) is taken out, and the slide entering station 901, the slide take-out station 902, the flipping module 64, the sample drying module 8, and the slide output module 10 are arranged along the same straight line, thus, one The robot that can move in a straight line can move the slide to each corresponding station.

Specifically, as shown in FIG. 1 to FIG. 11 , the slide basket drying module 12 includes a housing 120 provided with a blowing port 1201 for blowing out airflow and an air inlet 1202 for sucking airflow, such that It can form a better convection effect, which is beneficial to the rapid drying of the slide in the slide basket 11. The housing 120 can have two air flow passages, that is, one air outlet passage and one air suction passage. An outlet fan may be provided at the outlet passage, and an intake fan may be provided at the suction passage. Alternatively, there may be only one circulation passage in the casing 120. The two ends of the circulation passage are respectively a blowing port 1201 and an air suction port 1202, and a circulation fan may be disposed in the circulation passage or/and the air outlet 1201 or/and the suction opening 1202.

In this embodiment, as shown in FIG. 1 to FIG. 11, all the working positions can be designed as two working lines that intersect perpendicularly, including: the first working line 101 from the right side of the smear preparation device to the left side (pushing piece) Work line), a second working line 102 (dyeing and output working line) that intersects the push line perpendicularly. On the push line, there are loading, printing, dripping, pushing and flipping work positions from left to right. The slide output, blood film drying and blood film unfolding are distributed from front to back on the dyeing and output working line. , flip, staining station 1 (slide insert), staining station 4 (slide removal). The two station lines intersect at the flip station and switch the slide placement state (horizontal to vertical) at the flip station. This layout can ensure that the whole machine can always be in an accurate position control state under the premise that the functions can be realized, and the number of times of the slides can be minimized, and the slides are solved during the operation of the instrument. Card failure. At the same time, because the station design is on the two working station lines, it also plays an important role in reducing the volume of the whole machine.

In the work station design of the working line, considering that the printing is easily affected by the quality of the external input slide, there are many faults, and the blood dropping station design of the sample is arranged after the printing station. This scheme can effectively avoid the sample collection and blood dropping due to the glitch of the printing, which is necessary for the sample with a small amount. Especially for the sample with a small amount, such a design is necessary. At the same time, in order to reduce the influence of free foreign matter on the surface of the slide on the print quality, a special cleaning station is designed between the slide storage and distribution module and the slide information printing module 4. The special cleaning module is used to clean the free foreign matter on the surface of the slide, so that when the slide is printed, there is no foreign matter on the surface in the printing area, which minimizes the failure of printing due to the surface quality of the slide.

In this embodiment, the sample auto-injection module 114 is mainly composed of an injection sub-module and a sampling sub-module, and can automatically perform sample collection processing on a closed test tube that is continuously or discontinuously arranged on the test tube rack. The injection sub-module and the sampling sub-module structure are relatively independent, and can be used according to different application environments (such as using an automatic blood smear preparation instrument alone or using a fully automatic blood smear preparation instrument on a fully automatic assembly line) It is very convenient to install and disassemble without affecting the integrity of the sampling sub-module function. The automatic blood smear preparation instrument can be quickly configured into different scenarios, and independent or high-speed, automatic re-checking functions can be realized as needed.

The micro-injection module 2 can also be used as an open injection module. When the sample size is relatively small, or after a push-push is initiated, it is necessary to preferentially intervene to process a certain sample, and the micro-injection module 2 can be used. The micro-injection module 2 can automatically collect and process a single sample placed in the tube adapter. It can include sample feed and sample unloading functions. In the micro-injection module 2, the sampling needle used for sample collection and the lancet 501 used by the drip-type module 5 use the same needle, which can minimize the requirement for the sample size; and because the same needle is used, the sample is used. The short distance of transportation can effectively reduce the deformation effect of the sample on the tangible cells of the sample during transportation in the instrument.

As shown in FIG. 1 to FIG. 4, the slide loading module 3 (slide storage and distribution module) is mainly composed of a slide box module 31, a cutter sub-module 33, and an in-position blocking sub-module 32, and can be loaded into the user here. The horizontal slide of the stack is automatically loaded by the slide storage and distribution module to the pusher carriage of the pusher module 6 one by one according to the sample requirements. The slide box can be designed with a relatively independent structure, but is different from the easy-to-remove structure. Under normal working conditions, the slide box is locked by a special locking mechanism. By locking, the accuracy of the relative position of the slide box and the slide distribution guide can be reliably ensured, and the slide box of the easy-disassembled structure is prevented from being shaken by external disturbance, and the slide distribution failure is caused. In the process of troubleshooting and instrument maintenance, the operator can easily remove the slide box by opening a special locking mechanism for independent disassembly.

The printing module 4 can use a thermal transfer method to print pre-set information (possibly number, time, type, etc.) of the user on the frosted area of the slide for identifying the slide. The ribbon and the slide are stationary, and the print head is moved relative to the ribbon to achieve absolute rest of the ribbon and the slide, maximally avoiding the breakage of the ribbon during printing due to ribbon and slide movement.

The drop sample module 5 is mainly divided into a sample suction sub-module and a blood drop sub-module. The lancet 501 adopts a structure in which the guide sleeve is elastic. The lancet 501 is moved downward, and when the slide is touched, the lancet 501 is restricted from moving downward. Because the guide sleeve has an elastic structural design, the fixed bracket of the lancet 501 can continue to move downward. A small buffer distance. In this way, the blood drop needle 501 can be used for dripping blood without very precise position control, that is, the bottom end surface of the blood drop needle 501 can always contact the surface of the slide surface, and the shape of the blood drop on the surface of the slide surface can be consistent.

As shown in FIGS. 1 to 11, the pusher module 6 is mainly divided into a pusher car sub-module 62, a pusher blade sub-module 61, a blade cleaning sub-module 63, and a flip module 64. Including: slide clamping, push film parameter control, slide unloading, slide flip, blade cleaning function. The pusher car sub-module 62 utilizes the power of its own motion to achieve the fixation and release of the slide on the trolley. And through a single clamping, the slides are loaded, printed, dripped, pushed, and flipped, which effectively prevents the slide from being damaged and reduces the troubles that occur during the transport of the slide. The flip module 64 adopts a single-piece flip structure, which realizes a simple structure and reliable flipping. During the flipping process, the slide is first flipped at a small angle, waiting for the preset time of the system, and then flipped to the vertical position. This can effectively solve the problem of blood stasis caused by the blood film being too thick after the completion of the push film.

As shown in FIG. 1 to FIG. 11 , the manipulator module 113 serves as a main bearing mechanism for the dyeing and output working line, and realizes the slide output, the blood film drying, the blood film unfolding detection, the turning, the dyeing in the vertical placement state of the slide. Transfer between bit 1 (slide placement), staining station 4 (slide removal). Slide output station, slide drying station (blood film drying station), push station (blood film unfolding inspection station), flip station, dyeing station 4, dyeing station 1 The linear design allows the robot to easily perform all station movements in a straight line. The sample drying module 8 may also be referred to as a blood film drying module to perform the function of drying the slide on the slide, and at the same time, providing an interface to the unstained slide as an external input in the entire machine interface. When the user needs to perform a single-stained scene, the slide piece completed by the user is manually placed into the blood film drying module. The sample drying module 8 serves as both a blood film drying module and an externally input unstained glass slide in the whole structure, and simplifies the structure of the whole machine without reducing the function of the instrument, thereby realizing the streamlining of the whole machine. At the same time, the module controls the relative humidity of the drying medium, the drying temperature and the flow rate of the drying medium, which greatly improves the drying speed, and completely solves other products in the market due to low ambient temperature and low air humidity. In case the blood film can not be completely dry. Moreover, the module proposes a blowing drying method in which the dry air flow flows along the direction in which the sample (blood film) is deployed, which can ensure that the cell shape does not change under the drying of the micro airflow, and solves other products in the air drying process. The resulting cellular deformation gives the problem of a wrong diagnosis.

The staining module 9 dyes the slides that have been pushed by the user according to a pre-selected staining process. Mainly divided into: turntable sub-module, needle plate module and blocking sub-module 32, dyeing box. The rotating plate module, together with the dyeing box, provides the location required for the dyed slides and completes the dyeing process. The needle plate module carries all the adding and discharging needles, and all the needles are inserted and lifted off the dyeing box along with the up and down movement of the dial to realize the liquid filling and discharging of the dyeing liquid. In the dyeing module 9, there is at least one and more barrier sub-modules 32, and the blocking sub-module 32 switches between the dyeing station and the next dyeing station. The dyeing module 9 adopts a disc structure in structure, and realizes a compact structure. The use of a dial with all the liquid-filling and liquid-discharging needles as a whole prevents the problem of requiring a set of power mechanisms for each of the dyeing stations. The dyeing box uses the friction between the dyeing box and the turntable on the turntable, and is transferred along with the turntable. The blocking mechanism is used to control the time point of the dyeing box transfer, and the user-defined coloring process is realized.

As shown in FIG. 1 to FIG. 11, the slide output module 10 is mainly a slide basket loading sub-module 115, a slide basket feeding sub-module 116, a slide drying sub-module (a slide basket drying module 12) and a slide. The basket unloading sub-module 117 includes loading, slide basket transport, slide storage, and slide basket drying. The slide basket loading sub-module 115 can be designed with a double belt feeding mechanism, and can accurately detect and display the number of slide baskets available inside the instrument, and can load the slide basket at any time and continuously, and alarm when the number is insufficient. Meet the needs of users to add slide baskets under any circumstances. The application of the freely retractable finger mechanism enables the number of empty slide baskets to be increased by 50% without taking up space. The application of the slide basket pressing mechanism in the slide basket feeding sub-module 116 ensures the movement precision of the slide basket and improves the reliability of the slide collection. The slide basket drying module 12 is dried by blowing hot air on the slide, and the water on the surface of the slide is evaporated by heating, and the moisture is taken away by the flowing air to achieve the drying effect. The air outlet 1201 has a large area, and a plurality of slides can be placed at one time to provide work efficiency. At the same time, the slide basket drying module 12 is designed with a blow port 1201 and an air suction port 1202 so that the slide basket passage is between the air outlet 1201 and the air passage of the suction port 1202. When the slide basket loaded with the slide reaches the designated dry position, the slide basket drying module 12 blows a constant temperature, a constant speed of strong wind from the air outlet 1201, and at the same time, the flow rate from the suction port 1202 is much larger than the flow rate of the air outlet 1201. The fan draws air and creates effective convection at the slide basket. At the same time, with the hollow design around the slide basket, the drying time is greatly reduced under the influence of temperature and air convection.

As shown in FIG. 1 and FIG. 10, the embodiment further provides a slide basket drying module 12, comprising a casing 120, the casing 120 is provided with a blowing port 1201 for blowing airflow and a suction for sucking airflow. Tuyere 1202. In this way, a better convection effect can be formed, which facilitates rapid drying of the slide in the slide basket. The air outlet 1201 can face the top of the slide basket, and the air inlet 1202 can face the side wall of the slide basket. The housing 120 can have two air flow passages, that is, one air outlet passage and one air suction passage. At least one air outlet fan may be disposed at the air outlet passage, and at least one air suction fan may be disposed at the air suction passage. Alternatively, there may be only one circulation passage in the casing 120. The two ends of the circulation passage are respectively a blowing port 1201 and an air suction port 1202, and a circulation fan may be disposed in the circulation passage or/and the air outlet 1201 or/and the suction opening 1202. The slide basket drying module 12 allows the slide basket passage to be between the air outlet 1201 and the air passage of the suction port 1202. When the slide basket loaded with the slide reaches the designated drying station, the slide basket drying module 12 blows a constant temperature, a constant speed of strong wind from the air outlet 1201, and at the same time, the flow rate from the suction port 1202 is much larger than the flow rate of the air outlet 1201. The fan draws air and creates effective convection at the slide basket. At the same time, with the hollow design around the slide basket, the drying time is greatly reduced under the influence of temperature and air convection.

As shown in FIG. 1 to FIG. 11 , an embodiment of the present invention further provides a method for preparing a smear, which can be applied to the above smear preparation device, and the smear preparation method comprises the following steps, and the sampling module 1 and the slide are arranged. Loading the working line of the module 3, the printing module 4, the dropping module 5, the pushing module 6, the inverting module 64 and the dyeing module 9, laying the slide flat and moving the slide along the working line, along the slide During the movement of the working line, the slide is cleaned by the cleaning module, then the sample information is printed on the slide by the printing module 4, and the sample collected from the sampling module 1 is dropped onto the slide by the drop module 5 Then, the sample of the slide is smoothed by the pusher module 6, and then the slide is flipped from the flat state to the upright state by the flipping module 64, and the inverted slide is dyed by the dyeing module 9.

Specifically, in the process of flipping the slide piece from the flat state to the upright state, the flipping module 64 flips the slide to tilt and stays for a set length of time, so that the sample is dried to a certain extent and then turned into a standing state to ensure Diagnostic accuracy.

In a specific application, the front end of the smear preparation device may be a sample auto-injection module 114, where the user puts the sample to be tested, or the other workstation device (such as a cascade pipeline) automatically transmits the sample. In this module, the functions including tube injection, test tube presence, barcode scanning, sample mixing, and puncture aspiration are completed. For special samples (such as body fluids) or open-top samples, the micro/open injection module can be used for aspiration, which ensures that the tablet can be dyed at a lower sample size. At the same time, the sample auto-injection module 114 and the micro/open sampling module respectively transmit the sample information collected by the sample to the drip sample module 5 for processing to extract the sample characteristics related to the push film for subsequent push.

The right side of the smear preparation device can be a slide storage and distribution module, where the user loads a stack of horizontal slides, and the slide storage and distribution module automatically loads the slides one by one according to the sample requirements. The pusher car of the pusher module 6 is fixed in the horizontal state on the trolley. In the slide storage and distribution module, a special slide cleaning station is designed, and a special cleaning module is used to clean the free foreign matter on the surface of the slide surface, so that when the slide is printed, there is no surface free foreign matter in the printing area. Minimizes the failure of printing due to the quality of the surface of the slide. The slide is then moved along the trolley of the pusher module 6 along with the trolley to the left side of the smear preparation device. The trolley in this embodiment first arrives at the printing position, and cooperates with the slide information printing module 4 to complete the printing of the sample information; after confirming that the printing operation is successfully completed, the blood dropping station is reached again; and the sample automatic sampling module is matched with the dropping module 5 114 or the sample collected by the micro/open injection module is dropped onto the slide; reaching the push position, according to the sample characteristics extracted by the drop module 5, the push parameters are intelligently adjusted, so that the sample is applied to the glass in an optimal state. On-chip, the push action is completed; then, the slide is finally flipped from the horizontal state to the vertical state by the flip module 64 of the push module 6.

The manipulator module 113 on the left side of the smear preparation device runs through the front and rear direction of the whole instrument, and connects the flipping position of the slide in the vertical state, the blood film drying position, the dyeing station 1, the dyeing station 4, and the slide output position. The robot module 113 transfers the slides that have completed the push to the blood film drying module at the inversion position of the pusher module 6, and the sample is sufficiently dried in the blood film drying module to ensure that the blood film does not fall off during the subsequent dyeing process. After a fixed period of time, the robot module 113 rotates the slides of the sample dried to the dyeing box in the station 1 of the dyeing module 9, each of which corresponds to a dyeing box. The slides are dyed in the dyeing box according to the dyeing process set by the user (the dyeing process can be customized by the user within a certain range), and the instrument automatically absorbs and discharges the dyeing solution for each dyeing box, thereby realizing the staining of the slides. . The dyed finished slide along with the dyeing box will be transferred from the dyeing station 1 to the dyeing station 4 in the dyeing module 9. The robot module 113 takes the dyed slide from the dyeing box from the dyeing station 4, and the dye box automatically enters the next dyeing cycle.

The robot module 113 transfers the slides from the dyeing station 4 of the dyeing module 9 to the bottom sealed, hollowed-out slide basket 11 on the slide output module 10, one by one, with a gap arranged. The slide output module 10 counts the loaded slides in the slide basket. When the slide basket 11 is full or the entire push print process is completed, the slide output module 10 transports the slide basket 11 to the slide output. At the drying mechanism of the slide basket drying module 12 of the module 10, the drying mechanism blows a strong temperature at a constant temperature and a constant speed to dry the dyed slide. After a fixed time of strong wind drying, all the slides were sufficiently dried. The slide output module 10 pushes the slide together with the slide basket 11 onto the unloading platform of the slide output module 10, at which time the entire push dyeing process is completed.

The above is only the preferred embodiment of the present invention, and is not intended to limit the present invention. Any modifications, equivalent substitutions or improvements made within the spirit and principles of the present invention, such as work for each work line. The bit order is adjusted, or the number of stations is combined or decomposed, and the corresponding matching adjustment process is included in the protection scope of the present invention.

Claims

A smear preparation apparatus comprising: a sampling module for extracting a sample, a slide loading module for moving the slide to the working line, a printing module for printing information on the slide, for a drop module for dropping a sample onto a slide, a pusher module for smoothing a sample on the slide, a flip module for flipping the slide, and a dyeing module for dyeing the slide, The slide loading module, the printing module, the dropping module, the pushing module, the flipping module, and the dyeing module are arranged along the working line.
The smear preparation apparatus according to claim 1, wherein the smear preparing apparatus further comprises a cleaning module for cleaning the slide, the cleaning module being disposed along the work line.
The smear preparation apparatus according to claim 2, wherein the smear preparing apparatus further comprises a sample drying module for drying the sample on the slide, the sample drying module being disposed along the working line.
A smear preparation apparatus according to claim 3, wherein said smear preparing apparatus further comprises a slide output module for carrying a slide basket and outputting said slide basket to a set position.
The smear preparation apparatus according to claim 4, wherein the smear preparing apparatus further comprises a slide basket drying module for drying the dyed slide.
The smear preparation apparatus according to claim 1, wherein the drips module comprises a lancet, the lancet is connected to the sampling module; and one side of the lancet is provided for The priority sample is moved to the micro-injection module below the lancet.
The smear preparation apparatus according to claim 6, wherein the lancet comprises a needle body and a guide sleeve, and an elastic structure is disposed between the needle body and the guide sleeve.
The smear preparation apparatus according to claim 3, wherein the working line comprises a first working line and a second working line; the slide loading module, the cleaning module, the printing module, the dropping module, and the pushing piece The module and the flipping module are arranged along the first working line, the flipping module is located at the intersection of the first working line and the second working line; the sample drying module and the dyeing module are arranged along the second working line.
The smear preparation apparatus according to claim 8, wherein the first working line is provided with a first linear slide rail, and the first linear slide rail is slidably coupled with a push piece for carrying a slide The second working line is provided with a second linear slide rail, and the second linear slide rail is slidably coupled with a robot module for clamping and moving the slide; the first working line and the second working Lines are vertically intersected or lined up.
The smear preparation apparatus according to any one of claims 1 to 9, wherein the smear preparing apparatus further comprises a sample auto-injection module, the sample auto-injection module being adjacent to the sampling module The sample auto-injection module includes a test tube rack feeding component and a sample mixing component.
The smear preparation apparatus according to any one of claims 1 to 9, wherein the slide loading module includes a slide storage submodule for accommodating a slide for using the slide from the The slide storage sub-module is pushed to the cutter head sub-module of the working line, and the in-position blocking sub-module for limiting the slide or the cutter sub-module.
The smear preparation apparatus according to any one of claims 1 to 9, wherein the pusher module includes a pusher blade submodule for smearing a sample, for flipping the slide from flat to Upright flip module.
A smear preparation apparatus according to claim 9, wherein said smear preparation apparatus has a control member for controlling a grip of a robot to manually insert a slide inserted at said sample drying module to a dyeing module.
The smear preparation apparatus according to claim 4, wherein the dyeing module comprises a turntable sub-module, a needle tray module and a dyeing box; the dyeing module has a slide entry station and a slide take-out station, The slide into the station, the slide take-out station, the flip module, the sample drying module, and the slide output module are arranged along the same straight line.
A smear preparation apparatus according to claim 5, wherein said slide basket drying module comprises a casing provided with a vent opening for blowing an air flow and an air suction port for sucking the air flow.
A slide basket drying module characterized by comprising a casing provided with a blow port for blowing an air flow and an air suction port for sucking air.
A smear preparation method, comprising the steps of: laying a slide flat and moving the slide along a working line, and cleaning the slide through the cleaning module during movement of the slide along the working line And then printing the sample information on the slide through the printing module, and then dropping the sample collected from the sampling module on the slide through the drop module, and then smoothing the sample of the slide through the push module, and then The slide is flipped from the flat state to the upright state by the flipping module, and the inverted slide is dyed by the dyeing module.
The smear preparation method according to claim 17, wherein the flipping module flips the slide to tilt and stays for a set length of time during the process of flipping the slide from the flat state to the erect state.
The smear preparation method according to claim 17, wherein the sample information printed on the slide is inspected by the detecting module after the sample is printed on the slide and before the sample is dropped on the slide.