CN114383916B - Sample slide conveying method and conveying system - Google Patents
Sample slide conveying method and conveying system Download PDFInfo
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- CN114383916B CN114383916B CN202111672977.4A CN202111672977A CN114383916B CN 114383916 B CN114383916 B CN 114383916B CN 202111672977 A CN202111672977 A CN 202111672977A CN 114383916 B CN114383916 B CN 114383916B
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- 238000000034 method Methods 0.000 title claims abstract description 39
- 238000004043 dyeing Methods 0.000 claims abstract description 30
- 238000001514 detection method Methods 0.000 claims description 74
- 230000005540 biological transmission Effects 0.000 claims description 45
- 238000003780 insertion Methods 0.000 claims description 22
- 230000037431 insertion Effects 0.000 claims description 22
- 238000001035 drying Methods 0.000 claims description 15
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 238000002347 injection Methods 0.000 description 12
- 239000007924 injection Substances 0.000 description 12
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 230000032258 transport Effects 0.000 description 8
- 238000009971 piece dyeing Methods 0.000 description 6
- 238000010186 staining Methods 0.000 description 4
- 241001510071 Pyrrhocoridae Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G37/00—Combinations of mechanical conveyors of the same kind, or of different kinds, of interest apart from their application in particular machines or use in particular manufacturing processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G43/00—Control devices, e.g. for safety, warning or fault-correcting
- B65G43/08—Control devices operated by article or material being fed, conveyed or discharged
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
- B65G2203/00—Indexing code relating to control or detection of the articles or the load carriers during conveying
- B65G2203/02—Control or detection
- B65G2203/0208—Control or detection relating to the transported articles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Mechanical Engineering (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The application discloses a method and a system for conveying a sample slide, wherein the conveying method comprises the following steps: providing a conveying system, wherein the conveying system comprises a conveying rail capable of conveying sample baskets, and an putting-in station, a plugging station and a sample moving-out station which are sequentially arranged on a conveying path of the conveying rail; conveying the sample basket loaded with the sample slide to a plugging station along a conveying track; taking out the sample slide from the inserting station for dyeing, and inserting the dyed sample slide into the sample basket; the sample basket is transported along the transport track to a sample removal station. The application can complete automatic dyeing and collection of sample slide, simplify the structure of the slide-pushing dyeing machine and reduce the space occupied by the equipment.
Description
Technical Field
The application relates to the field of in-vitro diagnosis, in particular to a method and a system for conveying a sample slide applied to sample analysis equipment.
Background
A push-piece staining machine is a device capable of automatically preparing and staining blood smears. In some special cases such as emergency, the manually prepared blood smear can be independently dyed by using a push-piece dyeing machine.
For the blood smear of manual preparation, current pushing piece dyeing machine adopts independent sampling channel more, and the sampling channel of independent setting not only occupation space makes equipment structure more complicated moreover, and the user need look for independent sampling channel when putting into manual smear, and experience is relatively poor.
Disclosure of Invention
The embodiment of the application provides a method and a system for conveying a sample slide, which aim to solve the problems of inconvenient sample introduction and space occupation of the sample slide.
In one aspect, an embodiment of the present application provides a method for transferring a sample slide, including: providing a conveying system, wherein the conveying system comprises a conveying rail capable of conveying sample baskets, and an putting-in station, a plugging station and a sample moving-out station which are sequentially arranged on a conveying path of the conveying rail; conveying the sample basket loaded with the sample slide to a plugging station along a conveying track; taking out the sample slide from the inserting station for dyeing, and inserting the dyed sample slide into the sample basket; the specimen basket with the inserted stained specimen slide is transported along a transport track to a specimen removal station.
According to the foregoing embodiment of the first aspect of the present application, the step of transferring the specimen basket loaded with the specimen slides to the loading station comprises: sample slide placement information within the sample basket is obtained, and if the sample placement information is that the sample basket is loaded with sample slides, the sample basket is transferred to the insert station.
According to any of the foregoing embodiments of the first aspect of the present application, the step of acquiring sample slide placement information within the sample basket, and if the sample placement information is that the sample slide is loaded in the sample basket, then transferring the sample basket to the insert station comprises: after detecting a sample basket placed in the station, acquiring first sample slide placement information in the sample basket, and if the first sample placement information is that the sample slide is placed in the sample basket, conveying the sample basket from the placing station to an inserting sheet detection station which is arranged on a conveying path of a conveying track and is positioned at the upstream of the inserting sheet station; and acquiring second sample slide placement information in the sample basket reaching the insert detection station, and if the second sample placement information is that the sample basket is loaded with the sample slide, conveying the sample basket from the insert detection station to the insert station.
According to any of the foregoing embodiments of the first aspect of the present application, between the step of providing a transfer system and the step of transferring the specimen basket loaded with specimen slides from the insertion station to the insertion station, further comprises: receiving transfer request information for a sample slide; acquiring the working state of a transmission system; the transfer system is set to a specimen slide transfer mode according to an operation state of the transfer system.
According to any of the foregoing embodiments of the first aspect of the present application, the step of setting the transfer system to the specimen slide transfer mode according to an operation state of the transfer system includes: the working state of the conveying system is an idle state, and the conveying system is set into a sample slide conveying mode; the operating state of the transfer system is a sample basket circulation state, and then the sample basket on the transfer rail is emptied first, and then the transfer system is set to a sample slide transfer mode.
According to any one of the foregoing embodiments of the first aspect of the present application, in the step of receiving transfer request information of the specimen slide, the transfer request information of the specimen slide includes type information of the specimen slide; the step of evacuating the sample basket on the transfer rail comprises: when the type information is that the sample slide is a label-free slide, all sample baskets on the conveying track are emptied; the type information is that when the sample slide is a marked slide, the sample basket on the conveying track positioned at the downstream of the inserting station is emptied.
According to any of the foregoing embodiments of the first aspect of the present application, the step of inserting the stained specimen slide into the specimen basket and the step of transporting the specimen basket along the transport track to the specimen removal station further comprises: conveying the sample basket to a drying station which is arranged on a conveying path of the conveying rail and is positioned at the downstream of the inserting station along the conveying rail; the stained specimen slide was dried.
According to any of the foregoing embodiments of the first aspect of the present application, the step of transporting the sample basket along the transport rail to the sample removal station further comprises: and detecting whether the sample basket is loaded with the sample slide or not, and if the sample slide is not detected, conveying the sample basket from the sample moving-out station to the sample placing station.
In another aspect, an embodiment of the present application provides a system for transporting a specimen slide, the system comprising: the conveying rail is used for conveying the sample basket, and a placing station, an inserting station and a sample moving-out station are sequentially arranged on a conveying path of the conveying rail; the manipulator module is used for taking out the sample slide from the sample basket at the inserting station for dyeing and inserting the dyed sample slide into the sample basket; and the control module is used for controlling the operation of the conveying track and the manipulator module.
According to the foregoing embodiment of the second aspect of the present application, the sample basket detection module further includes a sample basket detection module and a sample detection module, the sample basket detection module includes a first sample basket detector, the first sample basket detector is used for detecting whether a sample basket exists at the placement station, the first sample detector is used for detecting whether a sample slide exists in the sample basket located at the placement station, and the control module is used for controlling whether the conveying track conveys the sample basket from the placement station to the direction of the insertion station according to the detection result of the first sample detector.
According to any one of the foregoing embodiments of the second aspect of the present application, an insertion sheet detection station is further provided on the conveying path of the conveying rail, the insertion sheet detection station being located between the insertion station and the insertion sheet station; the sample basket detection module comprises a second sample basket detector, the sample detection module further comprises a second sample detector, the second sample basket detector is used for detecting whether a sample basket exists at the insert detection station, the second sample detector is used for detecting whether a sample slide exists in the sample basket located at the insert detection station, and the control module is further used for controlling whether the conveying track conveys the sample basket from the insert detection station to the insert station according to the detection result of the second sample detector.
According to any of the foregoing embodiments of the second aspect of the application, the transfer system includes a specimen slide transfer mode in which the transfer rail transfers the specimen basket from the drop-in station toward the insert station when the first specimen detector detects a specimen slide, and a specimen basket circulation mode in which the transfer rail transfers the specimen basket from the drop-in station toward the insert station when the first specimen detector does not detect a specimen slide.
According to any one of the foregoing embodiments of the second aspect of the present application, the control module includes a receiver for receiving transmission request information, a processor for acquiring operation state information of the transmission system, and a controller for controlling setting of an operation mode of the transmission system according to the transmission request information and the operation state information, the transmission request information includes a transmission sample slide and a transmission sample basket, and the operation state information includes an idle state, a sample basket circulation state, and a sample slide transmission state.
According to any one of the foregoing embodiments of the second aspect of the present application, when the transfer request information is to transfer a sample slide and the operation state information is in an idle state, the controller sets the transfer system to a sample slide transfer mode, and when the transfer request information is to transfer a sample slide and the operation state information is in a sample basket circulation state, the controller firstly controls the transfer rail to empty a sample basket on its transfer path, and then sets the transfer system to the sample slide transfer mode.
According to any of the foregoing embodiments of the second aspect of the present application, a drying station is further provided on the conveying path of the conveying rail, the drying station being located between the insertion station and the sample removal station.
According to the sample slide conveying method and system, the sample basket carrying the sample slide is conveyed to the inserting station through the conveying track, the sample slide is taken out of the inserting station for dyeing and then is inserted back into the sample basket, and then the sample slide is conveyed to the sample moving-out station along the conveying track, so that automatic conveying, dyeing and collecting of the sample slide are realized. When the existing push piece dyeing machine performs single dyeing treatment on a manually prepared blood smear, an independent sample injection channel is required to be arranged to realize sample injection of the manual slide, the independently arranged sample injection channel not only occupies space, but also makes the equipment structure more complex, and a user needs to search the independent sample injection channel when putting the manual slide, so that the experience is poor; in the method and the device for conveying the sample slide, the original sample basket conveying system in the slide dyeing machine can be used for conveying the manually prepared sample slide, so that automatic dyeing and collection of the sample slide are completed, the structure of the slide dyeing machine can be simplified, the occupied space of equipment is reduced, and the utilization efficiency of the conveying system is improved.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading the following detailed description of non-limiting embodiments, taken in conjunction with the accompanying drawings, in which like reference characters designate the same or similar features, and in which the figures are not to scale.
FIG. 1 is a flow chart of a method of transferring a specimen slide according to an embodiment of the present application;
FIG. 2 is a flow chart of a method of transferring a specimen slide according to another embodiment of the present application;
FIG. 3 is a flow chart of a method of transferring a specimen slide according to yet another embodiment of the present application;
FIG. 4 is a flow chart of a method of transferring a specimen slide according to yet another embodiment of the present application;
FIG. 5 is a schematic view of a sample slide transport system according to an embodiment of the present application;
fig. 6 is a schematic structural view of a conveying track of a conveying system for a sample slide according to an embodiment of the present application.
Detailed Description
Features and exemplary embodiments of various aspects of the present application will be described in detail below, and in order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be described in further detail below with reference to the accompanying drawings and the detailed embodiments. It should be understood that the specific embodiments described herein are merely configured to illustrate the application and are not configured to limit the application. It will be apparent to one skilled in the art that the present application may be practiced without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the application by showing examples of the application.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising … …" does not exclude the presence of other like elements in a process, method, article or apparatus that comprises the element.
It will be understood that when a layer, an area, or a structure is described as being "on" or "over" another layer, another area, it can be referred to as being directly on the other layer, another area, or another layer or area can be included between the layer and the other layer, another area. And if the component is turned over, that layer, one region, will be "under" or "beneath" the other layer, another region.
Fig. 1 is a flowchart of a method for transferring a slide glass according to an embodiment of the present application. Embodiments of the present application provide a method of transferring a specimen slide, which may include steps S100 to S400.
In step S100, a transfer system is provided.
The conveying system comprises a conveying rail capable of conveying the sample basket, and a placing station, a plugging station and a sample moving-out station which are sequentially arranged on a conveying path of the conveying rail. The sample basket is used to load a sample slide.
It will be appreciated that the conveyor system may be a specimen basket conveyor system in a slide stainer that conveys specimen baskets through a conveyor track of the conveyor system for collection of automatically prepared and stained specimen slides in the slide stainer. When the sample basket is required to be used for collecting the sample slide, the empty sample basket can be placed to the conveying track by the placing station, then the sample basket is conveyed to the inserting station along the conveying track, the stained sample slide is collected, and then the sample basket is conveyed to the sample moving-out station along the conveying track, so that a user can take out the sample slide conveniently.
In step S200, a specimen basket loaded with specimen slides is transported along a transport rail to a slide insertion station. It will be appreciated that the specimen slide may be a manually prepared specimen slide (having blood film coated thereon) or a separately prepared specimen slide (having blood film coated thereon) using a machine.
In step S300, the specimen slide is removed from the slide insertion station for staining, and the stained specimen slide is inserted into the specimen basket.
In step S400, a specimen basket into which the stained specimen slide is inserted is transferred along a transfer rail to a specimen removal station.
When the sample slide which is separately prepared is required to be dyed, the sample slide can be placed into the sample basket, the sample basket loaded with the sample slide is placed onto the conveying track by the placing station, then the sample slide is conveyed to the inserting station by the conveying track, the sample slide is taken out from the inserting station to be dyed, is inserted back into the sample basket after being dyed, and is conveyed to the sample moving-out station along the conveying track.
According to the method for conveying the sample slide, disclosed by the embodiment of the application, the sample slide is conveyed by the conveying system, so that the sample slide can be automatically dyed and collected.
When the existing push piece dyeing machine performs single dyeing treatment on a manually prepared blood smear, an independent sample injection channel is required to be arranged to realize sample injection of the manual slide, the independently arranged sample injection channel not only occupies space, but also makes the equipment structure more complex, and a user needs to search the independent sample injection channel when putting the manual slide, so that the experience is poor; the method for conveying the sample slide can utilize the original sample basket conveying system in the slide-pushing dyeing machine to convey the manually prepared sample slide, complete automatic dyeing and collection of the sample slide, simplify the structure of the slide-pushing dyeing machine, reduce the occupied space of equipment and improve the utilization efficiency of the conveying system.
In the method for transferring a sample slide provided by the embodiment of the present application, the sample basket is transferred by the transfer rail, and in order to transfer the sample slide effectively, in some optional embodiments, in step S200, sample slide placement information in the sample basket may be obtained first, and if the sample placement information is that the sample basket is loaded with the sample slide, the sample basket is transferred to the insert station.
Optionally, the sample slide placement information in the sample basket can be obtained by detecting whether a sample slide in the sample basket is present or not by the sample detection module, if the sample detection module detects the sample slide, the sample slide placement information indicates that the sample basket is loaded with the sample slide, the sample basket is transmitted to the inserting station by the control transmission track, if the sample detection module does not detect the sample slide, the sample slide placement information indicates that the sample basket is not loaded with the sample slide, and at the moment, the transmission of the sample basket can be stopped, so that the ineffective transmission of the empty sample basket by the transmission track can be avoided.
Fig. 2 is a flowchart of a method for transferring a specimen slide according to another embodiment of the present application.
In some alternative embodiments, the transfer system may further include a tab detection station disposed on a transfer path of the transfer rail, the tab detection station being positioned between the insertion station and the tab station, the transfer rail being configured to transfer the sample basket from the insertion station to the tab detection station and from the tab detection station to the tab station as the transfer rail transfers the sample basket.
Alternatively, as shown in fig. 2, step S200 may include step S210 and step S220.
In step S210, after detecting the sample basket of the loading station, first sample slide placement information in the sample basket is acquired, and if the first sample placement information is that the sample slide is loaded in the sample basket, the sample basket is transferred from the loading station to the insert detection station.
In step S220, second sample slide placement information within the sample basket arriving at the insert detection station is acquired, and if the second sample placement information is that the sample basket is loaded with a sample slide, the sample basket is transferred from the insert detection station to the insert station.
Alternatively, the first sample slide placement information may be obtained by detecting the presence or absence of a sample slide in a sample basket located at the insertion station by a first sample detector, and the second sample slide placement information may be obtained by detecting the presence or absence of a sample slide in a sample basket located at the insertion sheet detection station by a second sample detector. The double detection of the sample slide is carried out at the placing station and the inserting sheet detection station, so that the ineffective transmission of the empty sample basket can be further avoided.
In some alternative embodiments, the conveyor system may further comprise a drying station disposed on the conveyor path of the conveyor track, the drying station being located between the tab station and the sample removal station. When the conveying system conveys the sample slide, the sample basket loaded with the sample slide is firstly conveyed to the inserting station from the placing station through the conveying track, then the sample slide is taken out from the inserting station for dyeing and then is inserted back into the sample basket, then the sample basket is conveyed to the drying station through the conveying track, the dyed sample slide is dried at the drying station, and the dried sample slide is conveyed to the sample moving-out station along the conveying track.
Fig. 3 is a flowchart of a method for transferring a specimen slide according to still another embodiment of the present application.
Optionally, the method for transferring a sample slide provided in the embodiment of the present application may further include steps S010 and S020 between step S300 and step S400.
In step S010, the sample basket is transported from the tab station to the drying station along the transport track.
In step S020, the stained specimen slide is dried.
Optionally, in the method for transferring a sample slide according to the embodiment of the present application, after the sample basket is transferred to the sample removal station along the transfer track, whether the sample basket is loaded with the sample slide may be further detected, and if the sample slide is not detected, the sample basket is transferred from the sample removal station to the placement station.
After the sample basket loaded with the stained sample slides is conveyed to the sample removal station through the conveying track, whether the sample slides exist in the sample basket positioned at the sample removal station or not can be detected through the third sample detection module, if the sample slides are not detected, the user is indicated that the sample slides are taken out of the sample basket, and at the moment, the sample basket can be conveyed from the sample removal station to the placement station for loading the next batch of sample slides to be stained.
Of course, when the sample basket loaded with the dyed sample slide is conveyed to the sample removing station through the conveying track, the sample basket can be removed from the sample removing station to the conveying track, after the dyed sample slide is taken out from the sample basket, the next batch of sample slides to be dyed are placed in the sample basket, and the sample basket is placed on the conveying track from the placing station.
It will be appreciated that the transfer system may include a specimen slide transfer mode and a specimen basket circulation mode. When the conveying system is in a sample slide conveying mode, the sample basket loaded with the sample slide can be conveyed through the conveying track, so that automatic dyeing and collection of the manually prepared sample slide are realized; the conveying system is in a sample basket circulation mode, and can convey empty sample baskets through the conveying track, so that automatic preparation and collection of stained sample slides in the push-piece staining machine are realized.
When the manually prepared sample slide is required to be dyed, in order to realize smooth conveying of the sample slide, conveying request information of the sample slide can be sent to a conveying system, and when the conveying system is in a sample slide conveying mode, a sample basket loaded with the sample slide is placed on a conveying track by a placing station.
Fig. 4 is a flowchart of a method for transferring a specimen slide according to still another embodiment of the present application. As shown in fig. 4, in some alternative embodiments, the method for transferring a sample slide according to the embodiment of the present application may further include steps S001 to S003 between step S100 and step S200.
In step S001, receiving transfer request information of a specimen slide;
in step S002, the operation state of the conveying system is acquired;
in step S003, the conveyance system is set to the specimen slide conveyance mode according to the operation state of the conveyance system.
In step S003, if the working state of the transfer system is an idle state, the transfer system is directly set to a sample slide transfer mode; if the operating state of the transfer system is a sample basket circulation state, the sample basket on the transfer rail is emptied first, and then the transfer system is set to a sample slide transfer mode.
It will be appreciated that when the transfer system includes a specimen slide transfer mode and a specimen basket circulation mode, the transfer system has three operating states, an idle state, a specimen slide transfer state, and a specimen basket circulation state. When the conveying system is in an idle state, the conveying track is not provided with a sample basket, and the conveying system can directly convey the sample slide; when the conveying system is in a sample basket circulation state, the conveying track is in a running state and conveys the sample basket, and after the sample basket on the conveying track is emptied, the conveying system is set into a sample slide conveying mode, so that the problem of collection operation of automatically preparing and dyeing the sample slide can be avoided.
Alternatively, in step S001, the received transfer request information of the specimen slide may include type information of the specimen slide. When the sample slide is the unmarked slide, in order to avoid confusion between the sample slide to be conveyed and the sample slide collected in the sample basket circulation mode, all the sample baskets on the conveying track can be emptied, and then the conveying system is set into a sample slide conveying mode; when the specimen slide is a labeled slide, the transfer system can be set to the specimen slide transfer mode after the specimen basket on the transfer track downstream of the loading station is emptied.
In addition, the embodiment of the application also provides a conveying system for the sample slide, which can be used for conveying the sample slide and can realize automatic dyeing and collection of the manually prepared sample slide.
FIG. 5 is a schematic view of a sample slide transport system according to an embodiment of the present application; fig. 6 is a schematic structural view of a conveying track of a conveying system for a sample slide according to an embodiment of the present application.
The sample slide transfer system provided by embodiments of the present application may include a transfer rail 100, a robot module 200, and a control module 300. The conveying rail 100 is used for conveying sample baskets, and a placing station 110, an inserting station 130 and a sample removing station 150 are sequentially arranged on a conveying path of the conveying rail 100; the manipulator module 200 is used for taking out the sample slide from the sample basket at the inserting station 130 for dyeing, and inserting the dyed sample slide into the sample basket; the control module 300 is used to control the operation of the transfer rail 100 and the robot module 200.
When it is desired to stain a specimen slide, the specimen slide can be placed into a specimen basket, which is loaded with the specimen slide by the placement station 110 onto the transfer rail 100; the transfer rail 100 then transports the sample basket along its own transfer path; when the sample basket is conveyed to the inserting station 130, the control module 300 controls the manipulator module 200 to operate, the manipulator module 200 takes out the sample slide from the sample basket for dyeing, and the sample slide is inserted back into the sample basket through the manipulator module 200 after dyeing; the transfer rail 100 then conveys the specimen basket loaded with the stained specimen slides to the specimen removal station 150 for convenient removal by the user. According to the sample slide conveying system provided by the embodiment of the application, automatic dyeing and collection of the sample slide can be realized.
Optionally, a drying station 140 may be further disposed on the conveying path of the conveying track 100, where the drying station 140 is located between the inserting station 130 and the sample removing station 150; in operation of the transfer system, the specimen slide is transferred along the transfer rail 100 from the loading station 110 to the insertion station 130, stained, then transferred from the insertion station 130 to the drying station 140, dried at the drying station 140, and then transferred along the transfer rail 100 to the specimen removal station 150.
In order to achieve efficient transfer of the sample slide, in some optional embodiments, the sample slide transfer system provided in the embodiments of the present application may further include a sample basket detection module 400 and a sample detection module 500, where the sample basket detection module 400 is used to detect whether a sample basket is located at a position of at least one of the loading station 110, the inserting station 130, and the sample removing station 150, and the sample detection module 500 is used to detect whether a sample is located in the sample basket at a position of at least one of the loading station 110, the inserting station 130, and the sample removing station 150.
Optionally, the sample basket detecting module 400 includes a first sample basket detector, the sample detecting module 500 includes a first sample basket detector, the first sample basket detector is used for detecting whether a sample basket exists at the placement station 110, the first sample detector is used for detecting whether a sample slide exists in the sample basket located at the placement station 110, and the control module 300 can control whether the conveying track 100 conveys the sample basket from the placement station 110 to the direction of the insert station 130 according to the detection result of the first sample detector.
When the first sample basket detector detects the sample basket placed at the station 110, the first sample detector detects whether the sample basket is loaded with a sample slide, and when the first sample detector detects the sample slide, the control module 300 controls the conveying track 100 to convey the sample basket from the station 110 to the direction of the inserting station 130; when the first sample detector does not detect a sample slide, indicating that the sample basket is not loaded with a sample slide, the control module 300 controls the transfer rail 100 to stop the transfer of the sample basket, so that ineffective transfer of the empty sample basket by the transfer rail 100 can be avoided.
In some alternative embodiments, the transfer path of the transfer rail 100 may further be provided with a tab detection station 120, where the tab detection station 120 is located between the loading station 110 and the tab station 130, and the transfer rail 100 conveys the sample basket from the loading station 110 to the tab detection station 120 and from the tab detection station 120 to the tab station 130.
Optionally, the sample basket detection module 400 may further include a second sample basket detector, where the sample detection module 500 further includes a second sample detector, where the second sample basket detector is configured to detect whether a sample basket is located at the insert detection station 120, and the second sample detector is configured to detect whether a sample slide is located in the sample basket located at the insert detection station 120, and the control module 300 is further configured to control whether the transfer rail 100 transfers the sample basket from the insert detection station 120 to the insert station 130 according to a detection result of the second sample detector.
When the second sample basket detector detects the sample basket at the insert detection station 120, the second sample detector detects whether the sample basket is loaded with a sample slide, and when the second sample detector detects the sample slide, the control module 300 controls the conveying track 100 to convey the sample basket from the insert detection station 120 to the insert station 130; when the second sample detector does not detect a sample slide, indicating that the sample basket is not loaded with a sample slide, the control module 300 controls the transfer rail 100 to stop the transfer of the sample basket. The dual detection of the specimen slide at the loading station 110 and the tab detection station 120 can further avoid inefficient transfer of empty specimen baskets.
In some alternative embodiments, the sample slide transfer system provided by embodiments of the present application may include a sample slide transfer mode and a sample basket circulation mode. When the transfer system is in the specimen slide transfer mode, the control module 300 controls the transfer rail 100 to transfer the specimen basket from the insertion station 110 toward the tab station 130 when the first specimen detector detects a specimen slide; when the transfer system is in the sample basket circulation mode, the control module 300 controls the transfer rail 100 to transfer the sample basket from the insertion station 110 toward the tab station 130 when the first sample detector does not detect a sample slide.
When the conveying system is in a sample slide conveying mode, a sample basket loaded with sample slides can be conveyed through the conveying track 100, so that automatic dyeing and collection of manually prepared sample slides are realized; the transfer system is in a sample basket circulation mode and is capable of transporting empty sample baskets through the transfer rail 100 to effect collection of automatically prepared and stained sample slides in a slide stainer.
When the existing push piece dyeing machine performs single dyeing treatment on a manually prepared blood smear, an independent sample injection channel is required to be arranged to realize sample injection of the manual slide, the independently arranged sample injection channel not only occupies space, but also makes the equipment structure more complex, and a user needs to search the independent sample injection channel when putting the manual slide, so that the experience is poor; the sample slide conveying system provided by the embodiment of the application can utilize the original sample basket conveying system in the slide-pushing dyeing machine to convey the manually prepared sample slide, complete automatic dyeing and collection of the sample slide, simplify the structure of the slide-pushing dyeing machine, reduce the occupied space of equipment and improve the utilization efficiency of the conveying system.
It will be appreciated that the transfer path of the transfer rail 100 may be provided with a tab detection station 120, the tab detection station 120 being located between the drop-in station 110 and the tab station 130, the sample basket detection module 400 may include a second sample basket detector for detecting the presence or absence of a sample basket at the tab detection station 120, and the sample detection module 500 may be used to detect the presence or absence of a second sample detector for a sample slide within a sample basket located at the tab detection station 120. On this basis, when the transfer system is in a sample slide transfer mode, the transfer rail 100 transfers the sample basket from the loading station 110 to the insert detection station 120 when the first sample detector detects a sample slide, and transfers the sample basket from the insert detection station 120 to the insert station 130 when the second sample detector detects a sample slide; when the transfer system is in sample basket circulation mode, the transfer rail 100 transfers sample baskets from the insertion station 110 to the tab detection station 120 when no sample slide is detected by the first sample detector and transfers sample baskets from the tab detection station 120 to the tab station 130 when no sample slide is detected by the second sample detector.
In order to enable the transfer system to smoothly switch between the specimen slide transfer mode and the specimen basket circulation mode, the control module 300 may optionally include a receiver for receiving the transfer request information, a processor for acquiring the operation state information of the transfer system, and a controller for controlling setting of the operation mode of the transfer system according to the transfer request information and the operation state information.
It is understood that the transfer request information may include transfer of a specimen slide and transfer of a specimen basket, and the operational status information includes an idle status, a specimen basket cycle status, and a specimen slide transfer status. When the manually prepared sample slide is required to be dyed, the transmission system receives transmission request information of which the transmission content is the transmission sample slide, and when the push-piece dyeing machine is required to automatically prepare and collect the dyed sample slide, the transmission system receives the transmission request information of which the transmission content is the transmission sample basket.
Optionally, when the transfer request information is to transfer a sample slide and the working state information is in an idle state, indicating that there is no sample basket on the transfer track 100, the controller may directly set the transfer system to the sample slide transfer mode; when the transmission request information is for transmitting the sample slide and the working state information is in a sample basket circulation state, the transmission track 100 is in a running state and is used for transmitting the sample basket, and at the moment, the controller controls the transmission track 100 to empty the sample basket on the transmission path, and then sets the transmission system into a sample slide transmission mode.
It should be noted that, to ensure smooth transfer of the sample slide, after the transfer system is in the sample slide transfer mode, the sample basket loaded with the sample slide is placed on the transfer rail 100 from the placement station 110.
Alternatively, when the transfer request information is a transfer of a specimen slide, the transfer request information may further include type information of the specimen slide including both types of unlabeled slide and labeled slide.
When the transmission request information is to transmit the unmarked sample slide and the working state information is the sample basket circulation state, in order to avoid confusion between the sample slide to be transmitted and the sample slide collected in the sample basket circulation mode, all the sample baskets on the transmission track 100 can be emptied, and then the transmission system is set into the sample slide transmission mode; when the transfer request information is a sample slide with a mark transferred and the working state information is a sample basket circulation state, the transfer system can be set to a sample slide transfer mode after the sample basket on the transfer rail 100 located downstream of the insertion station 130 is emptied, so that the utilization rate of the transfer system can be improved.
Of course, the transmission request information may not include the type information of the sample slide, and if the working state information of the transmission system is the sample basket circulation state when the sample slide is required to be transmitted, the transmission system is set to the sample slide transmission mode after all the sample baskets on the transmission track 100 are emptied, which is also within the protection scope of the present application.
These embodiments are not exhaustive or to limit the application to the precise embodiments disclosed, and according to the application described above. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the application and the practical application, to thereby enable others skilled in the art to best utilize the application and various modifications as are suited to the particular use contemplated. The application is limited only by the claims and the full scope and equivalents thereof.
Claims (15)
1. A method of transferring a specimen slide, the method comprising:
providing a conveying system, wherein the conveying system comprises a conveying rail capable of conveying sample baskets, an inserting station and a sample removing station, wherein the inserting station, the inserting station and the sample removing station are sequentially arranged on a conveying path of the conveying rail;
transferring a sample basket loaded with a sample slide at the placing station to the inserting station along the transfer rail;
taking out the sample slide from the inserting station for dyeing, and inserting the dyed sample slide into a sample basket;
and conveying the sample basket inserted with the stained sample slide to the sample removing station along the conveying track.
2. The method of claim 1, wherein the step of transferring the specimen basket loaded with specimen slides to the tab station comprises:
and acquiring sample slide placement information in the sample basket, and if the sample placement information is that the sample basket is loaded with the sample slide, conveying the sample basket to the inserting station.
3. The method of claim 2, wherein the step of acquiring sample slide placement information within the sample basket and, if the sample placement information is that the sample basket is loaded with a sample slide, transferring the sample basket to the insert station comprises:
after the sample basket of the placing station is detected, first sample slide placing information in the sample basket is obtained, and if the first sample placing information is that the sample basket is loaded with the sample slide, the sample basket is transmitted from the placing station to an inserting sheet detection station which is arranged on a transmission path of the transmission track and is positioned at the upstream of the inserting sheet station;
and acquiring second sample slide placement information in the sample basket reaching the insert detection station, and if the second sample placement information is that the sample basket is loaded with the sample slide, conveying the sample basket from the insert detection station to the insert station.
4. The transfer method of claim 1, further comprising, between the step of providing a transfer system and the step of transferring the specimen basket loaded with specimen slides from the insertion station to the tab station:
receiving transfer request information for a sample slide;
acquiring the working state of a transmission system;
the transfer system is set to a specimen slide transfer mode according to an operation state of the transfer system.
5. The method of claim 4, wherein the step of setting the transfer system to the specimen slide transfer mode according to an operation state of the transfer system comprises:
the working state of the conveying system is an idle state, and the conveying system is set into a sample slide conveying mode;
and the working state of the conveying system is a sample basket circulating state, so that the sample basket on the conveying track is emptied, and then the conveying system is set into a sample slide conveying mode.
6. The transfer method according to claim 5, wherein in the step of receiving transfer request information of the specimen slide, the transfer request information of the specimen slide includes type information of the specimen slide;
the step of evacuating the sample basket on the transfer rail comprises:
when the type information is that the sample slide is a label-free slide, all sample baskets on the conveying track are emptied;
and when the type information is that the sample slide is a marked slide, evacuating a sample basket positioned on the conveying track and downstream of the inserting station.
7. The method of claim 1, wherein the step of inserting the stained specimen slide into a specimen basket and the step of transferring the specimen basket along the transfer track to the specimen removal station further comprises:
conveying the sample basket along the conveying track to a drying station which is arranged on a conveying path of the conveying track and is positioned downstream of the inserting sheet station;
the stained specimen slide was dried.
8. The method of claim 1, wherein the step of transporting the specimen basket along the transport track to the specimen removal station further comprises:
and detecting whether a sample slide is loaded in the sample basket, and if the sample slide is not detected, conveying the sample basket from the sample moving-out station to the placing station.
9. A system for transporting a specimen slide, the system comprising:
the conveying track is used for conveying the sample basket, and a placing station, an inserting station and a sample moving-out station are sequentially arranged on a conveying path of the conveying track and are used for conveying the sample basket loaded with the sample slide at the placing station to the inserting station;
the manipulator module is used for taking out the sample slide from the sample basket at the inserting station for dyeing and inserting the dyed sample slide into the sample basket;
and the control module is used for controlling the operation of the conveying track and the manipulator module.
10. The transfer system of claim 9, further comprising a sample basket detection module and a sample detection module, the sample basket detection module comprising a first sample basket detector for detecting the presence of a sample basket at the loading station, the first sample detector for detecting the presence of a sample slide within a sample basket at the loading station, the control module for controlling whether the transfer rail transfers a sample basket from the loading station to the tab station based on a detection result of the first sample detector.
11. The conveyor system of claim 10, wherein the conveyor track is further provided with a tab detection station on the conveyor path, the tab detection station being located between the insertion station and the tab station;
the sample basket detection module comprises a second sample basket detector, the sample detection module further comprises a second sample detector, the second sample basket detector is used for detecting whether a sample basket exists at the insert detection station or not, the second sample detector is used for detecting whether a sample slide exists in the sample basket located at the insert detection station or not, and the control module is further used for controlling whether the conveying track conveys the sample basket from the insert detection station to the insert station according to the detection result of the second sample detector.
12. The transfer system of claim 10, wherein the transfer system includes a sample slide transfer mode and a sample basket circulation mode, wherein the transfer rail transfers sample baskets from the loading station toward the loading station when a sample slide is detected by the first sample detector, and wherein the transfer rail transfers sample baskets from the loading station toward the loading station when a sample slide is not detected by the first sample detector when the transfer system is in the sample basket circulation mode.
13. The transmission system according to claim 12, wherein the control module includes a receiver for receiving transmission request information, a processor for acquiring operation state information of the transmission system, and a controller for controlling setting of an operation mode of the transmission system according to the transmission request information and the operation state information,
the transfer request information includes transfer of a specimen slide and transfer of a specimen basket, and the operational state information includes an idle state, a specimen basket cycle state, and a specimen slide transfer state.
14. The transfer system of claim 13, wherein the controller sets the transfer system to a specimen slide transfer mode when the transfer request information is to transfer a specimen slide and the operational status information is in an idle state, and sets the transfer system to a specimen slide transfer mode after the transfer rail is controlled to empty a specimen basket on its transfer path when the transfer request information is to transfer a specimen slide and the operational status information is in a specimen basket circulation state.
15. The transfer system of claim 9, wherein a drying station is further disposed on the transfer path of the transfer rail, the drying station being located between the tab station and the sample removal station.
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