CN206862721U - A kind of histopathology sample processing system - Google Patents
A kind of histopathology sample processing system Download PDFInfo
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- CN206862721U CN206862721U CN201720510695.7U CN201720510695U CN206862721U CN 206862721 U CN206862721 U CN 206862721U CN 201720510695 U CN201720510695 U CN 201720510695U CN 206862721 U CN206862721 U CN 206862721U
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Abstract
The utility model provides a kind of histopathology sample processing system, belongs to technical field of medical instruments.Including removable grip unit, dehydration waxdip unit, section unit, slide glass dye unit, image scanning display unit and main control unit.Pass through each unit of the system, the fixation from the histopathology sample after materials, dehydration can be automatically performed, embedding, section, drift piece, dyed and this series of processing steps of taking pictures, so as to reduce the amount of labour of technical staff, avoid technical staff from contacting poisonous and harmful substance, shorten the histopathology sample disposal time.
Description
Technical field
It the utility model is related to technical field of medical instruments, and in particular to a kind of histopathology sample processing system.
Background technology
The premise of accurate pathological diagnosis is realized, is the processing tissue Pathologic specimen (hereinafter referred to as sample) of science, specification,
Making turns into qualified pathological section, there is provided to pathologist.The processing procedure of sample, including draw materials, fix, being dehydrated, embedding,
Several key steps such as section, drift piece, dyeing, mounting.Wherein, dyeing can be divided into haematoxylin eosin stains, specific enzymes systematism
Learn dyeing, immunohistochemical staining, in situ hybridization etc..The implementation of these steps using a variety of with volatile, it is necessary to be had
Malicious reagent, there is different degrees of harm to the health of technical staff.This just needs a kind of supermatic equipment to reduce
Manual operation, so as to the health of safeguards technique personnel.
Pathological diagnosis is, it is necessary to not only accurate, and in time, more early acquisition pathological diagnosis, the disease for being more advantageous to patient is examined
Control.Traditional sample disposal process is, it is necessary to undergo 3-5 days, and even more long, its reason is：On the one hand it is each of sample
Step has clear and definite processing time to require that the time will not enough influence chipping qualities, so as to influence to diagnose；On the other hand it is each
Individual step is accomplished into before next step, and the time is wasted because of the factor such as the work handover of technical staff, rest.Cause
This is, it is necessary to a kind of supermatic equipment handles sample, on the premise of ensureing that each enough step process time, section
The time being connected between different step is saved, avoids the artificial time from wasting, shortens the time completed required for sample disposal, so as to
Patient is allowed to obtain pathological diagnosis earlier.
All processing procedures are undergone in sample, are made into as that after qualified histotomy, will be carried out by pathologist
Read, propose diagnosis.If desired other pathologists carry out remote medical consultation with specialists, then need that histotomy manually is put into digital pathology
IMAQ is carried out in slice scanner, digitized image is obtained, in order to remote transmission.It is if straight after the completion of microsection manufacture
Connecing scanning turns into digitized image, will save manual operation, saves the time.
At present, there are substantial amounts of automatic dehydrator, automatic staining machine, automatic mounting machine and Full automatic digital pathological section
The equipment such as scanner are applied in real work, but these equipment only substitute staff and complete wherein some step, it is impossible to even
Continuous property completes all steps, stills need manually to be connected between different step, and some steps at present can only be by manually grasping
Make, such as section and drift piece.
If it can realize that complete dynamicization of the steps such as piece, dyeing and IMAQ is fixed, be dehydrated, embedding, cutting into slices, being floated to sample
Operation, it disclosure satisfy that the simpler reliable, requirement of higher efficiency of sample disposal.
Utility model content
Technical problem of the utility model for solution in above-mentioned, there is provided one kind can be automatically performed tissue specimen processing stream successively
The histopathology sample processing system of journey.
Technical scheme is used by the utility model：
A kind of histopathology sample processing system, including,
- grip unit is may move, for gripping sample and mobile tissue specimen or the carrier for being equipped with sample, including machinery
Hand and the guide rail for manipulator movement, the end of the manipulator for rotary part and are provided with clamping jaw；
- dehydration waxdip unit, for being washed, being dehydrated by sample, transparent, waxdip and embedding, realize and load sample
In wax stone Riker mount and make and turn into wax stone, including dehydration waxdip mechanism, be dehydrated fluid cylinder group, for wax mechanism, the 3rd pipettor and
First thermoregulation mechanism；The dehydration waxdip mechanism is provided with some independent clamp dog cavitys, is provided with clamp dog cavity some
Wax stone Riker mount；The dehydration fluid cylinder group is used to deposit sample dehydration liquid and provided to dehydration waxdip mechanism, described to supply wax machine
Structure is used to deposit liquid paraffin and provided to dehydration waxdip mechanism, and the 3rd pipettor is used to shift tissue specimen dehydration liquid；
First thermoregulation mechanism is used for the melting and solidification for adjusting paraffin；
- section unit, for piece to be cut into slices and floated to the sample being embedded in wax stone Riker mount, acquisition comes from wax stone
The section of middle specimen embedding, including slicer pedestal, wax stone Riker mount clamping mechanism, section groove mechanism, the first travel mechanism and
Second travel mechanism；The forwardly convex formation boss in slicer pedestal stage casing, and be provided with for the longitudinally reciprocal shifting of the boss
The first dynamic travel mechanism, the boss surface are provided with wax stone clamping mechanism；The slicer pedestal bottom extends forward
Boss section platform formed below is stated, the section platform is provided with section groove mechanism, cuts into slices and also pacifies between groove mechanism and platform surface
Equipped with the second travel mechanism for section groove mechanism transverse reciprocating movement；
- slide glass dye unit, for the tissue specimen slide glass that section is completed in above-mentioned section unit to be carried out into roasting piece, taken off
Wax and dyeing, including the first dyeing group and the second dyeing group；The first dyeing group includes the first dyeing chamber, second temperature regulation
Mechanism, the first dyeing fluid cylinder group and the first pipettor；The second dyeing group include second dyeing chamber, second dyeing fluid cylinder group and
Second pipettor；
- image scanning display unit, for gathering the image of pathological section；
- Main Control Unit, for control and the above-mentioned each unit of tissue treatment in electric device operation, and with it is outer
Control acquisition terminal connection, including Master control chip and outer end connector.
Manipulator, guide rail and jaw shaped in the removable grip unit turn into six axis robot.
The clamping jaw pawl heart of the six axis robot is additionally provided with identification (mrfid) reader.
The wax stone Riker mount includes box body and sample carries groove, and the sample carries groove outwardly convex, by separable sample
Carry groove water jacket and sample carries groove inside groove and forms and mutually coincide, the groove face of the two is provided with fine and closely woven through hole, the tissue specimen
Lay between sample carries groove water jacket and sample carries groove inside groove, and it treats that section is affixed to the water jacket that sample carries groove.
In the clamp dog cavity of the dehydration waxdip mechanism, axial order is provided with wax stone Riker mount carrier strip, the wax stone mark
This box order is installed on wax stone Riker mount carrier strip surface.
The wax stone Riker mount carrier strip is provided with preceding connection end and rear connection end, the two front frame with the clamp dog cavity respectively
It is rotatably connected with after-frame, and the preceding connection end forms rotating shaft to outer frame is prominent, the rotating shaft is provided with gear, adjacent wax stone mark
The gear intermeshing of this box carrier strip, and be provided with the gear positioned at the wax stone Riker mount carrier strip of first place for band moving gear
The stepper motor of rotation.
The confession wax mechanism includes, air compressor, electrically-controlled valve, wax storage and wax conveying tube, described in the wax conveying tube UNICOM
The clamp dog cavity and wax storage of waxdip mechanism are dehydrated, liquid paraffin flows between clamp dog cavity and wax storage.
The wax stone clamping mechanism includes clamping mouth and push rod, and the clamping mouth side is provided with opening, the wax stone sample
Box is inserted in clamping mouth through the opening, and the clamping mouth is longitudinally interference fit, the clamping mouth and wax stone with wax stone Riker mount
Riker mount laterally coordinates for gap；The opposite side of the clamping mouth is closing frame, is connected with push rod on the outside of the closing frame, institute
Closing frame is stated to be connected by elastomer with push rod.
The section groove mechanism, its groove face is ramp-like in dipping down, in addition to,
- blade apparatus, it is described section groove mechanism front end upper surface be horizontally arranged with blade and blade upward, together
The front end of Shi Suoshu section groove mechanisms is located at the cutter groove for taking blade dress；
- left cut piece chamber, left cut piece chamber are provided with separable section fragment drawer；
- right cut piece chamber, separated with the left cut piece chamber by dividing plate and separate, while the right cut piece chamber is divided into
Chamber and cavity of resorption are simultaneously separated by dividing plate, and slide platform is provided with the left of the epicoele, and slide glass folder, the load are equipped with the right side of the epicoele
Piece folder is the cavity-like of intraformational bed, and its front surface is provided with the scanning window for contaminating, and its side is provided with the jaws for supplying slide to enter；
The jaws of the slide glass folder is corresponding with the slide platform surface slide lateral attitude；Slide scraper plate is provided with the left of the slide platform,
For the slide for being loaded with histotomy to be pushed into the right in the slide glass folder.- liquid bleeder, including the first flow export and
Second flow export, by solenoid valve control, the first flow export is in the dividing plate between epicoele and cavity of resorption, for by the liquid of epicoele
It is evacuated in cavity of resorption, the second flow export is located at cavity of resorption bottom side, for the liquid of cavity of resorption to be released；
- intracavity liquid EGR, including feed tube, filter, water pump and drain pipe, the feed tube mouth of pipe are located at
Lower intracavitary, for by water pump extract cavity of resorption in liquid, the filter be used for will enter feed tube liquid filter, it is described go out
The liquid pipe mouth of pipe is in the dividing plate between epicoele and cavity of resorption, for the liquid extracted in cavity of resorption to be flowed out into epicoele by water pump
In；
- the three thermoregulation mechanism, the heating for liquid in the epicoele；
- slice probing device, including detection mouth, the detection mouth is above the section groove mechanism.
The top and bottom of the slide scraper plate are fixing end, and its top and bottom is symmetrically connected with slide plate, and slide plate passes through
The slide rail transverse reciprocating movement of bottom；The slide platform bottom is additionally provided with slide shell fragment, for being upspring after top layer slide is pushed open
Next piece of new slide；Pinch roller is provided with above the slide platform, the pinch roller wheel bottom is bonded with slide, for being promoted in slide scraper plate
Slide is avoided to be moved perpendicular to slide direction during slide.
The cutter groove is electromagnet cutter groove.
Rule is provided with dye liquor tank in the first dyeing chamber, and slide glass folder is inserted in staining trough, the second temperature regulation
Mechanism includes calandria, for adjusting the first dyeing intracavity liquid temperature and roasting piece.
Slide glass folder mounting bar is provided with the second dyeing chamber, slide glass folder mounting bar is sequentially with some slide glass folder installations
Mouthful.
Described image scans display unit, including sweep mechanism and image display.
First pipettor, the second pipettor or the 3rd pipettor, including liquid-transfering gun and liquid relief guide rail, the liquid relief are led
Rail is made up of X-axis liquid relief guide rail and Y-axis liquid relief guide rail.
A kind of histopathology sample processing system of the present utility model, can be automatically performed tissue specimen handling process successively,
It is advantageous that：
1st, the fixation from the histopathology sample after materials, dehydration, embedding, section, drift piece, dyeing and figure can be automatically performed
As gathering this series of processing steps, and the utility model eliminates mounting the step, directly slide glass folder is scanned and
Digital picture is obtained, is advantageous to save the time；
2nd, full automation operates, and avoids technical staff from contacting poisonous and harmful reagent；
3rd, whole flow process standardizes, and avoids the difference between different slicing experiments, improves tissue pathological slice quality；
4th, each flow is closely connected, and shortens the histopathology sample disposal time；
5th, the pathological section digital picture finally obtained scan transfer at once, is easy to remote medical consultation with specialists.
Brief description of the drawings
Figure of description
Fig. 1 is the overall structure diagram of Tthe utility model system；
Fig. 2 is the structural representation of six axis robot；
Fig. 3 is the structural representation of dehydration waxdip mechanism；
Fig. 4 is the structural representation of wax stone Riker mount；
Fig. 5 is the structural representation for wax mechanism；
Fig. 6 is the overall structure diagram of section unit；
Fig. 7 is the structural representation of wax stone Riker mount clamping mechanism；
Fig. 8 is the structural representation of section groove mechanism；
Fig. 9 is the structural representation of right cut piece intracavitary liquid circulation；
Figure 10 is the structural representation of the first dyeing chamber；
Figure 11 is the structural representation of the second dyeing chamber；
Figure 12 is the structural representation of first (second, third) pipettor；
Figure 13 is the annexation figure of Main Control Unit.
Illustrate：
In Fig. 1,1-1 six axis robots, 2-1 dehydration waxdips unit, 3-1 sections unit, 4-1 slide glasses dye unit, 5-1
Sweep mechanism, 5-2 displays, the pipettors of 6-1 first, the pipettors of 6-2 second, the pipettors of 6-3 the 3rd, 7-1 dehydration fluid cylinders group, 7-
2 first dyeing fluid cylinder groups, 7-3 second dye fluid cylinder group；
In Fig. 2,1-1 six axis robots, 1-2 clamping jaws, 1-3 identification (mrfid) readers；
In Fig. 3,2-2 dehydration waxdips mechanism, 2-3 clamp dogs cavity, 2-4 wax stone Riker mounts carrier strip, 2-5 gears, 2-6 steppings electricity
Machine, 2-7 wax stone Riker mounts；
In Fig. 4,2-7 wax stones Riker mount, 2-8 box bodys, 2-9 samples carry groove water jacket, 2-10 samples carry groove inside groove；
In Fig. 5,2-11 air compressors, 2-12 electrically-controlled valves, 2-13 wax storages, 2-14 wax conveying tubes；
In Fig. 6,3-1 sections unit, 3-2 slicers pedestal, 3-3 wax stone Riker mounts clamping mechanism, the moving machines of 3-4 first
Structure, 3-5 sections groove mechanism, the travel mechanisms of 3-6 second, 3-27 slice probing devices；
In Fig. 7,3-3 wax stone Riker mounts clamping mechanism, 3-7 clampings mouth, 3-8 push rods, 3-9 springs；
In Fig. 8,3-5 sections groove mechanism, 3-10 blades, 3-11 electromagnet cutter groove, 3-12 left cuts piece chamber, 3-13 section fragments
Drawer, 3-14 right cuts piece chamber, 3-15 epicoeles, 3-16 cavity of resorptions, 3-17 slides platform, 3-18 slide glasses folder, 3-19 slides scraper plate, 3-20 pressure
Wheel；
In Fig. 9, the flow exports of 3-21 first, the flow exports of 3-22 second, 3-23 feed tubes, 3-24 filters, 3-25 water pumps,
3-26 drain pipes；
In Figure 10,4-2 first dyes chamber, 4-3 dye liquor tanks, 3-18 slide glasses folder；
In Figure 11,4-4 slide glasses folder mounting bar, 4-5 slide glasses folder installing port, 3-18 slide glasses folder；
In Figure 12,6-4 liquid-transfering guns, 6-5X axle liquid reliefs guide rail, 6-6Y axle liquid relief guide rails.
Embodiment
Below in conjunction with the accompanying drawings, utility model is further described.
Referring to Fig. 1, the utility model Fig. 1 provides a kind of histopathology sample processing system, including removable folder
Hold unit, dehydration waxdip unit 2-1, section unit 3-1, slide glass dye unit 4-1, image scanning collecting unit and main control
Unit.Removable grip unit is used to grip sample and mobile tissue specimen or the carrier for being equipped with sample, dehydration waxdip unit 2-1
For sample being washed, being dehydrated, transparent, waxdip and embedding, realize and sample be fitted into wax stone Riker mount 2-7 and made
As wax stone.Section unit 3-1 is used for piece that the sample being embedded in wax stone Riker mount 2-7 is cut into slices and floated, and is come from
The section of specimen embedding in wax stone.Slide glass dye unit 4-1 carries in by the tissue specimen that section is completed in above-mentioned section unit 3-1
Piece carries out roasting piece, dewaxing and dyeing.Image scanning collecting unit is used for the image for gathering the histotomy after dyeing.Main control list
Member is used to control the operation with electric device in the above-mentioned each unit of tissue treatment, and is connected with outer control acquisition terminal, including
The control annexation of Master control chip and outer end connector, its control chip and other each units is as shown in Figure 13.
Removable grip unit as depicted in figs. 1 and 2, the unit are pressed from both sides using six axis robot 1-1 to section, slide glass
3-18 etc. is clamped and shifted, each position that six axis robot 1-1 may extend in processing system as shown in Figure 1.
Meanwhile tissue specimen is being dehydrated, waxdip, during embedding, code mark can be identified to forming wax stone Riker mount 2-7
Note, so, in six axis robot 1-1 claw, identification (mrfid) reader 1-3 is additionally provided with, coming for each tissue specimen is identified for reading
The information such as source, it is easy to record and the tracking of information.
Waxdip unit is dehydrated, by dehydration waxdip mechanism 2-2, dehydration fluid cylinder group 7-1, for wax mechanism, the 3rd pipettor 6-3
Formed with the first thermoregulation mechanism.Dehydration waxdip mechanism 2-2 as shown in Figure 3, waxdip mechanism 2-2 is dehydrated in the present embodiment
Provided with three independent clamp dog cavity 2-3, adjacent clamp dog cavity 2-3 is separated by dividing plate.In each clamp dog cavity 2-3, axially
Order is provided with wax stone Riker mount carrier strip 2-4, is sequentially set with wax stone Riker mount carrier strip 2-4 for filling wax stone Riker mount 2-7
Depression, the shape and size of depression and sample carry groove water jacket 2-9 and matched.Wax stone Riker mount carrier strip 2-4 is provided with preceding connection end
With rear connection end, the two is rotatably connected with clamp dog cavity 2-3 front frame and after-frame respectively, and the preceding connection end is dashed forward to outer frame
Going out to form rotating shaft, the rotating shaft is provided with gear 2-5, adjacent wax stone Riker mount carrier strip 2-4 gear 2-5 intermeshings, and in position
Stepper motor 2-6 for being rotated with moving gear 2-5 is installed at the wax stone Riker mount carrier strip 2-4 of first place gear 2-5.
Wax stone Riker mount 2-7 as shown in Figure 4, including box body 2-8 and sample carry groove, and wax stone Riker mount 2-7 includes box body
2-8 and sample carry groove, and sample carries groove outwardly convex, carry groove water jacket 2-9 by separable sample and sample carries groove inside groove 2-10 groups
Into and mutually coincide, the groove face of the two is provided with fine and closely woven through hole, and tissue specimen is laid carries groove water jacket 2-9 and sample carries in sample
Between groove inside groove 2-10, and it treats that section is affixed to the water jacket that sample carries groove.Wax stone Riker mount 2-7 is made of plastic, is contacting
Do not occur significantly to deform after handling the reagent of sample, the blade 3-10 that sample load slot part can be sliced machine is cut off easily；
After being put into sample, sample carries groove inside groove 2-10 and compliance caves inward, so as to accommodate sample.
Dehydration fluid cylinder group 7-1 is made up of multiple equipped with tissue specimen dehydration with the band mouth container of liquid, and sequentially proper alignment
Located at dehydration waxdip mechanism 2-2 sides, be dehydrated in tissue specimen, transparent step when, will be corresponding by the 3rd pipettor 6-3
Dehydration liquid suck and be transferred in dehydration waxdip mechanism 2-2 clamp dog cavity 2-3 to submerge each wax stone mark from place container
This box 2-7.
As shown in Figure 5 supplies wax mechanism, including air compressor 2-11, electrically-controlled valve 2-12 and wax conveying tube 2-14, wax conveying tube
2-14 UNICOMs dehydration waxdip mechanism 2-2 clamp dog cavity 2-3 and wax storage 2-13, liquid paraffin is in clamp dog cavity 2-3 and storage wax
Flowed between tank 2-13.Liquid paraffin enter clamp dog cavity 2-3 in submerge the wax stone Riker mount carrier strip 2-4 after, wax stone Riker mount
Carrier strip 2-4 is rotated to horizontal position, so can be after most of paraffin in making clamp dog cavity 2-3 returns to wax storage 2-13, still
There is part paraffin to retain in wax stone Riker mount carrier strip 2-4 depression, when temperature is reduced into below the melting point of paraffin, be then recessed
In paraffin, so as to which wax stone be made.Paraffin recycles, and is manually added in time when paraffin deficiency in wax storage 2-13.
Dehydration and transparent stage in tissue specimen, when wax stone Riker mount carrier strip 2-4 is in horizontal inclination position, wax is installed
Depression corresponding to block Riker mount 2-7 will not residual liquid, i.e., each liquid effects after tissue specimen certain time, it is necessary to complete
Remove entirely, can just add a kind of lower liquid, wax stone Riker mount carrier strip 2-4 is tilted, wax stone Riker mount 2-7 sample carries groove not
A kind of dehydration liquid of addition can be remained.When entering waxdip, embedding stage, wax stone Riker mount carrier strip 2-4 is in horizontal stroke
To horizontal position, the liquid with its volume respective amount can be retained in depression, now passes through and adds paraffin to wax stone mark for wax mechanism
This box 2-7 sample is carried in groove, is flow back into wax storage 2-13 making the paraffin in addition to depression leave clamp dog cavity 2-3, is passed through
First thermoregulation mechanism reduces clamp dog cavity 2-3 temperature, solidifies wax, so as to be successfully made the wax containing tissue specimen
Block, wax stone then will be molded by six axis robot 1-1 and clamp and be transferred in the unit 3-1 of cutting into slices.
Section unit 3-1 as shown in figures 1 to 6, by slicer pedestal 3-2, wax stone Riker mount clamping mechanism 3-3, cut
Piece groove mechanism 3-5, the first travel mechanism 3-4 and the second travel mechanism 3-6 compositions.As shown in fig. 7, in slicer pedestal 3-2
The forwardly convex formation boss of section, the first travel mechanism 3-4 for longitudinal direction can position limiting slide block and sliding surface, be installed on the boss and slicer
Pedestal 3-2 joint, boss is set longitudinally to reciprocatingly move.Boss surface is provided with wax stone clamping mechanism, wax stone clamping machine
Structure includes clamping mouth 3-7 and push rod 3-8, and clamping mouth 3-7 sides are provided with opening.During work, by six axis robot 1-1 by wax stone
Riker mount 2-7 is moved in opening insertion clamping mouth 3-7 from clamp dog cavity 2-3, clamping mouth 3-7 and wax stone Riker mount 2-7 longitudinal directions
For interference fit, the clamping mouth 3-7 and wax stone Riker mount 2-7 laterally coordinates for gap, can both make wax stone Riker mount 2-7 upper
It will not be moved during lower section, can also be easy to wax stone Riker mount 2-7 is horizontal to pick and place.Clamping mouth 3-7 opposite side is closing frame,
Push rod 3-8 is connected with the outside of the closing frame, closing frame is connected by a pair of symmetrical spring 3-9 with push rod 3-8, worked
In, when changing wax stone Riker mount 2-7, six axis robot 1-1 raps push rod 3-8, can be by wax stone Riker mount 2-7 from wax stone clamping
A part is ejected in mechanism, six axis robot 1-1 easily can take out wax stone box.
Slicer pedestal 3-2 bottom extends forward above-mentioned boss section platform formed below, is set on the section platform
Have section groove mechanism 3-5, the second travel mechanism 3-6 for laterally can position limiting slide block and sliding surface, be installed on the section platform and section
Groove mechanism 3-5 joint, section groove mechanism 3-5 is set laterally to reciprocatingly move.Section groove mechanism 3-5 as shown in Figure 8, its
Groove face slightly tilts down, and the mechanism includes blade 3-10 more changing devices, left cut piece chamber 3-12, right cut piece chamber 3-14, liquid flow
Go out device, intracavity liquid EGR, the 3rd thermoregulation mechanism and slice probing device 3-27.Before section groove mechanism 3-5
End upper surface be horizontally arranged with blade 3-10 and blade upward (one piece of blade of left cut piece chamber and each correspondence of right cut piece chamber), together
When cut into slices groove mechanism 3-5 front end be located at the electromagnet cutter groove 3-11 for taking blade 3-10 dresses.During more allowing blade replacement 3-10, electromagnetism
Iron cutter groove 3-11 powers off degaussing, is taken out old blade 3-10 by six axis robot 1-1, then new blade 3-10 is placed on into electricity
In magnet cutter groove 3-11；During work, electromagnet cutter groove 3-11 is powered and sucks blade 3-10, so as to carry out section work.Electricity
Magnet powers off degaussing, and manipulator removes the blade of left cut piece chamber, and the blade of right cut piece chamber is placed on to the cutter groove of left cut piece chamber
Interior, six axis robot takes out new blade in the cutter groove of right cut piece chamber from new blade receiver, and now electromagnet is powered
Installation will be held with the blade changed at two.It is less demanding to blade because left cut piece chamber is used to slightly repair wax stone, and right cut piece chamber is used
In obtaining histotomy, high is required to blade, it is necessary to sharp, N/D, therefore, in more allowing blade replacement, by the knife of right cut piece chamber
Piece is put into left cut piece chamber recycling, plays and saves blade effect.
Left cut piece chamber 3-12 and right cut piece chamber 3-14 by dividing plate separate and it is separate.Wax stone Riker mount 2-7 is loaded
After in section groove mechanism 3-5, before to its formal section, the sample in wax stone Riker mount 2-7 need to be repaired, i.e. wax stone mark
This box 2-7 protrusion outer layer excision, it is complete to be switched to the tissue surface of tissue specimen, so left cut piece chamber 3-12 be provided with it is separable and
The section fragment drawer 3-13 of replacing, when the sample in wax stone Riker mount 2-7 is repaired, the fragment cut will directly fall
Enter to cut into slices fragment drawer 3-13, section fragment drawer 3-13 cleanings or will be changed in cleaning, will not cause to cut broken
It is in disorder scattered, it is difficult to clean out.3-14 points of right cut piece chamber is separated for epicoele 3-15 and cavity of resorption 3-16 and by dividing plate.Epicoele 3-
15 left side, which is provided with the right side of slide platform 3-17, epicoele 3-15, is equipped with slide glass folder 3-18, and slide glass folder is the cavity of intraformational bed
Shape, its front surface, which is provided with, to be used to contaminate the scanning window with IMAQ, and slide glass folder 3-18 uses transparent plastic material or glass
Material, with avoid next enter staining procedure when because the effect of dyeing liquor and may caused by burn into deformation etc., load intermediate plate
3-18 scanning basis rest of the window towards epicoele, its side be provided with for slide enter jaws, slide glass folder 3-18 jaws with
Slide platform 3-17 surfaces slide lateral attitude is corresponding.Slide scraper plate 3-19 is provided with the left of slide platform 3-17, slide scraper plate 3-19's
Top and bottom are fixing end, and its top and bottom is symmetrically connected with slide plate, and slide plate is moved by the slide rail transverse reciprocating of bottom,
For the slide for being loaded with histotomy to be pushed into the right in the slide glass folder 3-18；Pinch roller 3- is provided with above the slide platform 3-17
20, pinch roller 3-20 are made up of 4 rubber wheels and are arranged with slide corner, and the wheel bottom of each rubber wheel is bonded with surface of glass slide, are used
Slide is avoided to be moved perpendicular to slide direction when in slide scraper plate 3-19 promotion slides；Slide platform 3-17 bottoms are additionally provided with slide
Shell fragment, for next piece of new slide of being upspring after top layer slide is pushed open.
As shown in figure 9, liquid bleeder includes the first flow export 3-21 and the second flow export 3-22, by magnetic valve control
System, the first flow export 3-21 is in the dividing plate between epicoele 3-15 and cavity of resorption 3-16, for epicoele 3-15 liquid to be evacuated to down
In chamber 3-16, the second flow export 3-22 is located at cavity of resorption 3-16 bottom sides, for cavity of resorption 3-16 liquid to be released.Intracavity liquid circulates
Device includes feed tube 3-23, filter 3-24, water pump 3-25 and drain pipe 3-26, and the feed tube 3-23 mouths of pipe are located at cavity of resorption 3-
In 16, for extracting liquid in cavity of resorption 3-16 by water pump 3-25, filter 3-24 is used to that feed tube 3-23 liquid will to be entered
Filtering, the drain pipe 3-26 mouths of pipe are in the dividing plate between epicoele 3-15 and cavity of resorption 3-16, for will be extracted in cavity of resorption 3-16
Liquid flowed out to by water pump 3-25 in epicoele 3-15.The calandria of 3rd thermoregulation mechanism is located in epicoele 3-15.With
The heating of liquid in for epicoele 3-15.Whether the drift piece that slice probing device 3-27 is used to detect and judge to cut into slices reaches will
Ask, be camera device, it detects mouth and camera above section groove mechanism 3-5, and slice picture is shot and transmitted point
Analysis.
During formal section, section groove is moved to left, right cut film trap be located at wax stone clamping mechanism underface, and by right cut piece chamber
After 3-14 epicoele 3-15 is full of water (controlling epicoele 3-15 water temperatures at 45 DEG C by the 3rd thermoregulation mechanism), soak liquid level
Do not have blade 3-10 below blade 1mm part.After wax stone Riker mount 2-7 histotomy is cut, water can be directly floated to
In, multiple histotomies of section are joined end to end, and the afterbody of finally cut a histotomy is ined succession blade.The tissue cut
The detected device monitoring of section, when the gauffer disappearance for finding histotomy, that is, controls the first flow export 3-21 to make epicoele 3-15's
The water surface slowly declines, and the now histotomy dampening that will have some setbacks flows away, but is attached on slide downwards, then passes through six axis robot 1-
1 promotion slide scraper plate 3-19 pushes away to the right the slide with histotomy, in insertion slide glass folder 3-18, controls six axis robot 1-1
Take out slide glass folder 3-18 to be transferred in slide glass dye unit 4-1, and the slide glass more renewed by six axis robot 1-1 presss from both sides 3-
18.Now liquid circulating apparatus in transit chamber, the water conservancy that will transfer to cavity of resorption 3-16 enter feed tube 3-23 simultaneously with water pump 3-25
Come back in epicoele 3-15 after filter 3-24 filterings, then by drain pipe 3-26, now changed by slide shell fragment
New slide, repeat above-mentioned section work.
Slide glass dye unit 4-1 is by the first dyeing group and the second dyeing group, wherein the first dyeing group is progress normal dyeing
Step and the dyeing group used, the second dyeing group is need to carry out specific stain (such as special enzyme staining, immuning tissue
Learn dyeing, in situ hybridization etc.) step and the dyeing group that uses.
First dyeing group as shown in Figure 10, including the first dyeing chamber 4-2, second temperature governor motion, the first dyeing liquor
Cylinder group 7-2 and the first pipettor 6-1.Rule is provided with multiple dye liquor tank 4-3 in first dyeing chamber 4-2, slide glass press from both sides 3-18 insert in
In staining trough, second temperature governor motion includes calandria, should for adjusting fluid temperature and roasting piece in the first dyeing chamber 4-2
Calandria is the Resistant heating aluminium flake located at the first dyeing chamber 4-2.Slide glass folder 3-18 is gripped and inserted by six axis robot 1-1
It is placed in different dye liquor tank 4-3, dyeing liquor draws corresponding dyeing by the first pipettor 6-1 from the first dyeing fluid cylinder group 7-2
Liquid is simultaneously delivered in corresponding dye liquor tank 4-3 slide glass folder 3-18, and the dyeing liquor after use is passed through into first again after the completion of conveying
Pipettor 6-1 is sucked back and is delivered to the first dyeing fluid cylinder group 7-2 original place, recycling, is sequentially completed dyeing in this way.
Second dyeing group as shown in figure 11, including the second dyeing chamber, the second dyeing fluid cylinder group 7-3 and the second pipettor 6-
2.As shown in figure 12, slide glass folder mounting bar 4-4 is provided with the second dyeing chamber, slide glass folder mounting bar 4-4 is sequentially with some loads
Piece press from both sides installing port 4-5, due to the second dyeing group for carry out specific stain when use, general frequency of use with respect to the first dyeing group compared with
It is low, so slide glass folder mounting bar 4-4 slide glass folder 3-18 can be fitted into that quantity can be less than slide glass folder 3-18 in the first dyeing group can
Load quantity.When second dyeing group is dyed, the liquid for being added to slide glass folder progress tissue treatment does not return again to dyeing liquor cylinder group
7-3, but the vacuum suction hole pressed from both sides by being arranged at slide glass on mounting bar 4-4 will complete the liquid sucking-off after staining procedure, flow
To waste liquid cylinder.
Figure 12 is the first pipettor 6-1, the second pipettor 6-2, the 3rd pipettor 6-3 structural representation, by liquid relief
Rifle 6-4 and liquid relief guide rail composition, wherein liquid relief guide rail is made up of X-axis liquid relief guide rail 6-5 and Y-axis liquid relief guide rail 6-6, makes liquid-transfering gun
The top of any position of unit, is picked and placeed to related liquid where 6-4 is movable to.
As shown in figure 1, image scanning display unit, including sweep mechanism 5-1 and image display 5-2, and sweep mechanism
5-1 is provided with slide glass folder 3-18 delivery ports.The slide glass folder 3-18 after dyeing is completed, can be by adding cedar oil in final step, can
The mounting step in conventional procedures is omitted, directly slide glass folder 3-18 is scanned and obtains respective image, and is shown in image
Shown in device 5-2.
Described above only to express preferred embodiment of the present utility model, its description is more specific and detailed, but not
Therefore the limitation to the utility model patent scope can be interpreted as.It should be pointed out that the ordinary skill people for this area
For member, without departing from the concept of the premise utility, some deformations can also be made, improves and substitutes, these all belong to
In the scope of protection of the utility model.Therefore, the protection domain of the utility model patent should be determined by the appended claims.
Claims (15)
- A kind of 1. histopathology sample processing system, it is characterised in that：Including,- removable grip unit, for gripping sample and mobile tissue specimen or the carrier for being equipped with sample, including manipulator and For the guide rail of manipulator movement, the end of the manipulator for rotary part and is provided with clamping jaw；- dehydration waxdip unit, for being washed, being dehydrated by sample, transparent, waxdip and embedding, realize and sample is loaded into wax stone In Riker mount and making turns into wax stone, including is dehydrated waxdip mechanism, dehydration fluid cylinder group, for wax mechanism, the 3rd pipettor and first Thermoregulation mechanism；The dehydration waxdip mechanism is provided with some independent clamp dog cavitys, and some wax stones are provided with clamp dog cavity Riker mount；The dehydration fluid cylinder group is used to deposit sample dehydration liquid and provided to dehydration waxdip mechanism, described for wax mechanism There is provided in storage liquid paraffin and to dehydration waxdip mechanism, the 3rd pipettor is used to shift tissue specimen dehydration liquid；It is described First thermoregulation mechanism is used for the melting and solidification for adjusting paraffin；- section unit, for piece to be cut into slices and floated to the sample being embedded in wax stone Riker mount, acquisition is wrapped from wax stone Bury the section of sample, including slicer pedestal, wax stone Riker mount clamping mechanism, section groove mechanism, the first travel mechanism and second Travel mechanism；The forwardly convex formation boss in slicer pedestal stage casing, and be provided with for the longitudinally reciprocal movement of the boss First travel mechanism, the boss surface are provided with wax stone clamping mechanism；The slicer pedestal bottom extends forward above-mentioned convex Platform section platform formed below, the section platform are provided with section groove mechanism, cut into slices and are also equipped between groove mechanism and platform surface For the second travel mechanism of section groove mechanism transverse reciprocating movement；- slide glass dye unit, for by the tissue specimen slide glass that section is completed in above-mentioned section unit carry out roasting piece, dewaxing and Dyeing, including the first dyeing group and the second dyeing group；The first dyeing group includes the first dyeing chamber, second temperature regulation machine Structure, the first dyeing fluid cylinder group and the first pipettor；The second dyeing group includes the second dyeing chamber, the second dyeing fluid cylinder group and the Two pipettors；- image scanning display unit, for gathering the image of pathological section；- Main Control Unit, for controlling the operation with electric device in the above-mentioned each unit of tissue treatment, and and outer control Acquisition terminal connects, including Master control chip and outer end connector.
- A kind of 2. histopathology sample processing system according to claim 1, it is characterised in that：The removable clamping is single Manipulator, guide rail and jaw shaped in member turn into six axis robot.
- A kind of 3. histopathology sample processing system according to claim 2, it is characterised in that：The six axis robot The clamping jaw pawl heart is additionally provided with identification (mrfid) reader.
- A kind of 4. histopathology sample processing system according to claim 1, it is characterised in that：The wax stone Riker mount bag Include box body and sample carries groove, the sample carries groove outwardly convex, carries groove water jacket by separable sample and sample carries groove inside groove group Into and mutually coincide, the groove face of the two is provided with fine and closely woven through hole, and the tissue specimen is laid carries groove water jacket and sample in sample Between carrying groove inside groove, and it treats that section is affixed to the water jacket that sample carries groove.
- A kind of 5. histopathology sample processing system according to claim 4, it is characterised in that：The dehydration waxdip mechanism Clamp dog cavity in, axial order is provided with wax stone Riker mount carrier strip, and the wax stone Riker mount order is installed on wax stone Riker mount Carrier strip surface.
- A kind of 6. histopathology sample processing system according to claim 5, it is characterised in that：The wax stone Riker mount carries Bar is provided with preceding connection end and rear connection end, and the two is rotatably connected with the front frame and after-frame of the clamp dog cavity respectively, and described Preceding connection end forms rotating shaft to outer frame is prominent, and the rotating shaft is provided with gear, and the gear of adjacent wax stone Riker mount carrier strip is intermeshed, And the stepper motor for driving pinion rotation is installed at the gear positioned at the wax stone Riker mount carrier strip of first place.
- A kind of 7. histopathology sample processing system according to claim 1, it is characterised in that：It is described to supply wax mechanism bag Include, air compressor, electrically-controlled valve, wax storage and wax conveying tube, the clamp dog cavity of waxdip mechanism is dehydrated described in the wax conveying tube UNICOM And wax storage, liquid paraffin flow between clamp dog cavity and wax storage.
- A kind of 8. histopathology sample processing system according to claim 1, it is characterised in that：The wax stone clamping mechanism Including clamping mouth and push rod, the clamping mouth side is provided with opening, and the wax stone Riker mount is inserted in clamping mouth through the opening, institute It is longitudinally interference fit that clamping mouth, which is stated, with wax stone Riker mount, and the clamping mouth laterally coordinates with wax stone Riker mount for gap；It is described The opposite side of clamping mouth is closing frame, and push rod is connected with the outside of the closing frame, and the closing frame passes through elastomer with push rod Connection.
- A kind of 9. histopathology sample processing system according to claim 1, it is characterised in that：The section groove mechanism, Its groove face is ramp-like in dipping down, in addition to,- blade apparatus, the front end upper surface of the section groove mechanism be horizontally arranged with blade and blade upward, while institute The front end for stating section groove mechanism is located at the cutter groove for taking blade dress；- left cut piece chamber, left cut piece chamber are provided with separable section fragment drawer；- right cut piece chamber, with the left cut piece chamber by dividing plate separate and it is separate, while the right cut piece chamber be divided into epicoele and Cavity of resorption is simultaneously separated by dividing plate, and slide platform is provided with the left of the epicoele, and slide glass folder, slide glass folder are equipped with the right side of the epicoele For the cavity-like of intraformational bed, its front surface, which is provided with, to be used to contaminate the scanning window with IMAQ, and its side is provided with to be entered for slide Jaws；The jaws of the slide glass folder is corresponding with the slide platform surface slide lateral attitude；Glass is provided with the left of the slide platform Piece scraper plate, for the slide for being loaded with histotomy to be pushed into the right in the slide glass folder；- liquid bleeder, including the first flow export and the second flow export, by solenoid valve control, the first flow export is embedded in upper In dividing plate between chamber and cavity of resorption, for the liquid of epicoele to be evacuated in cavity of resorption, the second flow export is located at cavity of resorption bottom side, for by under The liquid of chamber is released；- intracavity liquid EGR, including feed tube, filter, water pump and drain pipe, the feed tube mouth of pipe are located at cavity of resorption It is interior, for by water pump extract cavity of resorption in liquid, the filter be used for will enter feed tube liquid filter, it is described go out liquid The pipe mouth of pipe is in the dividing plate between epicoele and cavity of resorption, for the liquid extracted in cavity of resorption to be flowed out into epicoele by water pump In；- the three thermoregulation mechanism, the heating for liquid in the epicoele；- slice probing device, including detection mouth, the detection mouth is above the section groove mechanism.
- A kind of 10. histopathology sample processing system according to claim 9, it is characterised in that：The slide scraper plate Top and bottom are fixing end, and its top and bottom is symmetrically connected with slide plate, and slide plate is moved by the slide rail transverse reciprocating of bottom； The slide platform bottom is additionally provided with slide shell fragment, for next piece of new slide of being upspring after top layer slide is pushed open；The slide Pinch roller is provided with above platform, the pinch roller wheel bottom is bonded with slide, for avoiding slide perpendicular to glass when slide scraper plate promotes slide Move in piece direction.
- A kind of 11. histopathology sample processing system according to claim 9, it is characterised in that：The cutter groove is electromagnetism Iron cutter groove.
- A kind of 12. histopathology sample processing system according to claim 1, it is characterised in that：The first dyeing chamber Middle rule is provided with dye liquor tank, and slide glass folder is inserted in staining trough, and the second temperature governor motion includes calandria, for adjusting The first dyeing intracavity liquid temperature and roasting piece.
- A kind of 13. histopathology sample processing system according to claim 1, it is characterised in that：The second dyeing chamber In be provided with slide glass folder mounting bar, slide glass folder mounting bar is sequentially with some slide glasses folder installing ports.
- A kind of 14. histopathology sample processing system according to claim 1, it is characterised in that：Described image scanning is aobvious Show unit, including sweep mechanism and image display.
- A kind of 15. histopathology sample processing system according to claim 1, it is characterised in that：First pipettor, Second pipettor or the 3rd pipettor, including liquid-transfering gun and liquid relief guide rail, the liquid relief guide rail are moved by X-axis liquid relief guide rail and Y-axis Liquid guide rail forms.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720510695.7U CN206862721U (en) | 2017-05-09 | 2017-05-09 | A kind of histopathology sample processing system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720510695.7U CN206862721U (en) | 2017-05-09 | 2017-05-09 | A kind of histopathology sample processing system |
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| Publication Number | Publication Date |
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| CN206862721U true CN206862721U (en) | 2018-01-09 |
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| CN201720510695.7U Expired - Fee Related CN206862721U (en) | 2017-05-09 | 2017-05-09 | A kind of histopathology sample processing system |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106979878A (en) * | 2017-05-09 | 2017-07-25 | 南昌德漫多科技有限公司 | A kind of histopathology sample processing system |
| CN109342154A (en) * | 2018-10-25 | 2019-02-15 | 广州金域医学检验中心有限公司 | Tissue specimen dehydration management method, apparatus, computer equipment and storage medium |
| CN109991066A (en) * | 2019-05-16 | 2019-07-09 | 兰州大学 | Pathological paraffin sample slicing treatment device |
| CN110608936A (en) * | 2019-10-24 | 2019-12-24 | 广州江元医疗科技有限公司 | Multi-slide clamp |
| CN111281443A (en) * | 2020-03-12 | 2020-06-16 | 西安瑞丰仪器设备有限责任公司 | ESD sample automatic processing equipment and method |
| CN111795879A (en) * | 2020-07-14 | 2020-10-20 | 青岛大学附属医院 | Application of pathological specimen manufactured by dehydration set in digital evaluation system |
| CN112268770A (en) * | 2020-10-29 | 2021-01-26 | 山东第一医科大学附属省立医院(山东省立医院) | Anti-pollution pathology sample floats piece, drags for piece and dyeing all-in-one |
| US20220074911A1 (en) * | 2019-02-07 | 2022-03-10 | Thyssenkrupp Industrial Solutions Ag | Method for handling melt samples in a steelworks laboratory, and steelworks laboratory |
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2017
- 2017-05-09 CN CN201720510695.7U patent/CN206862721U/en not_active Expired - Fee Related
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018205691A1 (en) * | 2017-05-09 | 2018-11-15 | 南昌德漫多科技有限公司 | System for processing histopathological specimen |
| CN106979878A (en) * | 2017-05-09 | 2017-07-25 | 南昌德漫多科技有限公司 | A kind of histopathology sample processing system |
| CN106979878B (en) * | 2017-05-09 | 2023-12-15 | 贵阳德漫多医疗科技有限公司 | Histopathological specimen processing system |
| CN109342154A (en) * | 2018-10-25 | 2019-02-15 | 广州金域医学检验中心有限公司 | Tissue specimen dehydration management method, apparatus, computer equipment and storage medium |
| US20220074911A1 (en) * | 2019-02-07 | 2022-03-10 | Thyssenkrupp Industrial Solutions Ag | Method for handling melt samples in a steelworks laboratory, and steelworks laboratory |
| CN109991066A (en) * | 2019-05-16 | 2019-07-09 | 兰州大学 | Pathological paraffin sample slicing treatment device |
| CN109991066B (en) * | 2019-05-16 | 2021-11-23 | 长春赛斯医疗生物工程有限公司 | Pathological paraffin specimen section processing device |
| CN110608936A (en) * | 2019-10-24 | 2019-12-24 | 广州江元医疗科技有限公司 | Multi-slide clamp |
| CN110608936B (en) * | 2019-10-24 | 2024-03-22 | 广州江元医疗科技有限公司 | Multi-slide clamp |
| CN111281443A (en) * | 2020-03-12 | 2020-06-16 | 西安瑞丰仪器设备有限责任公司 | ESD sample automatic processing equipment and method |
| CN111281443B (en) * | 2020-03-12 | 2022-07-05 | 西安瑞丰仪器设备有限责任公司 | ESD sample automatic processing equipment and method |
| CN111795879A (en) * | 2020-07-14 | 2020-10-20 | 青岛大学附属医院 | Application of pathological specimen manufactured by dehydration set in digital evaluation system |
| CN112268770A (en) * | 2020-10-29 | 2021-01-26 | 山东第一医科大学附属省立医院(山东省立医院) | Anti-pollution pathology sample floats piece, drags for piece and dyeing all-in-one |
| CN112268770B (en) * | 2020-10-29 | 2023-02-03 | 山东第一医科大学附属省立医院(山东省立医院) | Anti-pollution pathology sample floats piece, drags for piece and dyeing all-in-one |
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