CN103800268B - A kind of Enteromorpha Crude polysaccharides protective skin cream and its preparation method - Google Patents
A kind of Enteromorpha Crude polysaccharides protective skin cream and its preparation method Download PDFInfo
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- CN103800268B CN103800268B CN201410069099.0A CN201410069099A CN103800268B CN 103800268 B CN103800268 B CN 103800268B CN 201410069099 A CN201410069099 A CN 201410069099A CN 103800268 B CN103800268 B CN 103800268B
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Abstract
The invention belongs to cosmetic field, in particular to a kind of Enteromorpha Crude polysaccharides protective skin cream and its preparation method, this Enteromorpha Crude polysaccharides protective skin cream comprises the raw material of following weight percent number meter, Enteromorpha Crude polysaccharides 2.5-5%, wetting Agent for Printing Inks 4-6%, sanitas 0.05-0.1%, nutritional additive 0.5-1.5%, oiliness raw material 5-7.5%, thickening material 1-2%, anti-allergic agent 0.05-0.1%, freshener 0.5-1%, solubilizing agent 0.5-1.5%, surplus is deionized water. Through test, the total antioxidant capacity of this protective skin cream is more than 40mM/g; After using six days continuously, skin moisture content increases by more than 60%, and skin collagen fibre content increases by more than 120%, and skin elasticity improves more than 230%, is that a kind of cosmetic result is remarkable, the skin care product that price is cheap.
Description
Technical field
The invention belongs to cosmetic field, in particular to a kind of Enteromorpha Crude polysaccharides protective skin cream and its preparation method.
Background technology
Protective skin cream is a kind of cosmetics and skincare product spreading on face, is form natural sebum film at the epidermis of skin, keeps the skin wet to skin and nutritive ingredient, can repair the damaged cell of epiderm skin simultaneously, it is to increase the elasticity of skin, pliability and luminance brightness. The kind of protective skin cream is a lot, and wherein marine alga Crude polysaccharides protective skin cream adds marine alga Crude polysaccharides composition, it is provided that moisturizing, anti-oxidant, the effects such as radioprotective, makes skin remain fine and smooth glossy.
Enteromorpha is a kind of common large ocean green alga, and it belongs to the Chlorophyta in marine alga, green alga guiding principle, sea lettuce order, Ulvaceae. The Crude polysaccharides of Enteromorpha have reduce cholesterol, antibacterial and antiviral, anti-oxidant, strengthen the pharmacological actions such as immunologic function, antitumor, anti-inflammatory. And Enteromorpha also has multiple biological activity, cosmetic applications mainly shows as anti-oxidant, radioprotective, antiviral, the aspects such as moisture retention. In recent years, along with that is studied by its chemical composition progressively gos deep into, its medical mechanism is also illustrated gradually, and the step of drug development is constantly accelerated.
Utilize Enteromorpha Crude polysaccharides to prepare protective skin cream, existing document and report in not yet have described in. If effect of Enteromorpha Crude polysaccharides can constantly be researched and developed by people, utilize that it is anti-oxidant, the characteristic of radioprotective, moisture retention etc., it is developed to the protective skin cream with anti-oxidant, moisturizing and anti-ageing effect of waiting for a long time, has opened up the new Application Areas of Enteromorpha.
Summary of the invention
It is an object of the invention to provide a kind of Enteromorpha Crude polysaccharides protective skin cream, this protective skin cream can improve skin oxidation-resistance, obvious Glycerin, increases skin elasticity, slows down skin aging.
It is a further object to provide the preparation method of a kind of above-mentioned Enteromorpha Crude polysaccharides protective skin cream.
The object of the present invention can be achieved through the following technical solutions:
A kind of Enteromorpha Crude polysaccharides protective skin cream, it is characterised in that, comprise the raw material of following weight percent number meter:
Enteromorpha Crude polysaccharides 2.5-5%, wetting Agent for Printing Inks 4-6%, sanitas 0.05-0.1%, nutritional additive 0.5-1.5%, oiliness raw material 5-7.5%, thickening material 1-2%, anti-allergic agent 0.05-0.1%, freshener 0.5-1%, solubilizing agent 0.5-1.5%, surplus is deionized water.
Above-mentioned Enteromorpha Crude polysaccharides is prepared by the following method,
Enteromorpha is immersed in the ethanol that mass concentration is 90%-95% 12-24 hour, filters, dry; The Enteromorpha dried and distilled water are soaked 2-4 hour according to the proportioning of 1g:25-45mL, smash to pieces rear 95 DEG C thermostatically heating 10-20 minute, cooling, filters and gets filtrate, filtrate heating concentrated (filtrate concentrates to 95% water content) afterwards centrifugation get supernatant liquor; Filtering after ethanol alcohol precipitation 24-28h, taking precipitate freeze-drying, obtains Enteromorpha Crude polysaccharides. Preferably, described Enteromorpha is the one in bar Enteromorpha, edge pipe Enteromorpha or bent Enteromorpha.
Described wetting Agent for Printing Inks is the mixture of one or more in glycerine, amino acid humectant, propylene glycol, butyleneglycol. Preferably, described wetting Agent for Printing Inks is the mixture of glycerine, amino acid humectant, propylene glycol, butyleneglycol, and wherein, the weight ratio of glycerine, amino acid humectant, propylene glycol, butyleneglycol is 2-4:1:2-4:2-4.
Described sanitas is one or both the mixture in Phenoxyethanol or Sang Pu K15; Preferably, described sanitas is Phenoxyethanol and the mixture of Sang Pu K15, and wherein, the weight ratio of Phenoxyethanol and Sang Pu K15 is 1-2:1.
Described anti-allergic agent is one or both the mixture in water-soluble a-Hydagen B or Rizinsan K2 A2. Preferably, described anti-allergic agent is the mixture in water-soluble a-Hydagen B and Rizinsan K2 A2, and wherein, the weight ratio of water-soluble a-Hydagen B and Rizinsan K2 A2 is 1-2:1.
Described nutritional additive is the mixture of one or more in collagen protein powder, ceramide, silk fibroin powder and snail mucus extract. Preferably, described nutritional additive is the mixture of collagen protein powder, ceramide and snail mucus extract, and wherein, the weight ratio of described collagen protein powder, ceramide and snail mucus extract is 1-2:1-2:1.
Described oiliness raw material is one or both the mixture in jojoba oil, Isopropyl myristate (IPM). Preferably, described oiliness raw material is the mixture of jojoba oil, IPM, and wherein, the weight ratio of jojoba oil and IPM is 2-3:1.
Described thickening material is one or both mixture of high molecular cellulose or xanthan gum. Preferably, described thickening material is the mixture of high molecular cellulose and xanthan gum, and wherein, the weight ratio of high molecular cellulose and xanthan gum is 1-2:1.
Described freshener is lemon quintessence oil, Flos Rosae Rugosae quintessence oil, lavender essence oil, Fructus Citri Sarcodactylis essence oil, rosemary ethereal oil, the mixture of one or more in Geranium Essential.
Described solubilizing agent is essence emulsifier.
The preparation method of above-mentioned Enteromorpha Crude polysaccharides protective skin cream, its step comprises:
(1), by Enteromorpha it is immersed in the ethanol that mass concentration is 90%-95% 12-24 hour, filters, dry; The Enteromorpha dried and distilled water are soaked 2-4 hour according to the proportioning of 1g:25-45mL, smash to pieces rear 95 DEG C thermostatically heating 10-20 minute, cooling, filters and gets filtrate, and after filtrate heating is concentrated, supernatant liquor is got in centrifugation; Filtering after ethanol alcohol precipitation 24-28h, taking precipitate freeze-drying, obtains Enteromorpha Crude polysaccharides; Preferably, described Enteromorpha is the one in bar Enteromorpha, edge pipe Enteromorpha or bent Enteromorpha.
(2), good various raw material is weighed according to formula;
(3), by Enteromorpha Crude polysaccharides adding constantly to stir in deionized water makes it swelling, dissolves under adding glycerine post-heating to 70 DEG C-90 DEG C of temperature; Oiliness raw material is heating for dissolving under 70 DEG C of-90 DEG C of conditions, then both is mixed, adds solubilizing agent, and homogenizing emulsifying is stirred; Emulsion is cooled to 50-60 DEG C, stirs after adding wetting Agent for Printing Inks, antioxidant, sanitas, anti-allergic agent, nutritional additive; Emulsion is cooled to 40-45 DEG C, adds viscosity increaser, freshener stirs; The weight ratio of described Enteromorpha Crude polysaccharides and glycerine is 1-3:1.
In described step (1), the mass concentration of ethanolic soln used in ethanol alcohol precipitation is 75-80%.
Compared with prior art, the useful effect of the present invention is:
1, described Enteromorpha Crude polysaccharides protective skin cream can significantly improve that skin is anti-oxidant, moisturizing and anti-ageing ability, wherein, the total antioxidant capacity of Enteromorpha Crude polysaccharides protective skin cream is more than 40mM/g; After using six days continuously, skin moisture content increases by more than 60%, and skin collagen fibre content increases by more than 120%, and skin elasticity improves more than 230%.
2, the preparation method of described Enteromorpha Crude polysaccharides protective skin cream is simply, easily operate, and raw material is easy to get, cost is low, price is cheap, and skin is not only injured by the medicine added in preparation process, and environmentally safe, green, environmental protection.
Accompanying drawing explanation
Fig. 1 is the FRAP method typical curve in embodiment 1.
Fig. 2 is the Enteromorpha Crude polysaccharides skin cream water content detection result in embodiment 1.
Fig. 3 is the Enteromorpha Crude polysaccharides skin cream collagen fabric detected result in embodiment 1.
Fig. 4 is the Enteromorpha Crude polysaccharides skin cream elastomeric check result in embodiment 1.
Embodiment
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1
(1) preparation of Enteromorpha Crude polysaccharides
Filter after the fresh edge pipe Enteromorpha ethanolic soln (mass concentration is 95%) gathered is soaked 12 hours, dry, Enteromorpha after oven dry adds in distilled water, wherein, the amount ratio of Enteromorpha and distilled water is 1g:40mL, thermostatically heating 15 minutes at 95 DEG C will be soaked after the Enteromorpha tissue mashing of 2 hours, cooled and filtered; Supernatant liquor is got in filtrate concentrated (filtrate concentrates to 95% water content) centrifugation afterwards under 70 DEG C of heating, filters with after ethanolic soln (mass concentration is 80%) alcohol precipitation 24h, obtains Enteromorpha Crude polysaccharides after taking precipitate freeze-drying.
(2) preparation of protective skin cream
A, according to weighing (weight percent) of filling a prescription as follows:
Enteromorpha Crude polysaccharides: 2.5%;
Wetting Agent for Printing Inks: 5%(wherein, glycerine: 1.5%, amino acid humectant: 0.5%, propylene glycol 1.5%, butyleneglycol: 1.5%);
Sanitas: 0.06%(wherein, Phenoxyethanol: 0.03%, Sang Pu K15:0.03%);
Anti-allergic agent: 0.06%(wherein, water-soluble a-Hydagen B: 0.03%, Rizinsan K2 A2: 0.03%);
Nutritional additive: 1.5%(wherein, collagen protein powder: 0.5%, ceramide: 0.5%, snail mucus extract: 0.5%);
Oiliness raw material: 7.5%(wherein, jojoba oil: 5%, IPM:2.5%);
Thickening material: 1.25%(wherein, high molecular cellulose: 0.75%, xanthan gum: 0.5%);
Flos Rosae Rugosae quintessence oil: 0.7%;
Essence emulsifier: 1%;
Surplus is deionized water.
B, joining Enteromorpha Crude polysaccharides in deionized water constantly to stir and make it swelling, and then add glycerine, wherein, the weight ratio of Enteromorpha Crude polysaccharides and glycerine is 5:3, is heated to 70 DEG C of dissolvings; Both, 70 DEG C of heating for dissolving, are then mixed, add essence emulsifier by oiliness raw material, and homogenizing emulsifying is stirred; Emulsion is cooled to 50-60 DEG C, stirs 3 minutes after adding wetting Agent for Printing Inks, antioxidant, sanitas, anti-allergic agent, nutritional additive; Emulsion is cooled to 40-45 DEG C, adds viscosity increaser, Flos Rosae Rugosae quintessence oil stirs.
(3) detected result
A, total antioxidation are tested
Measuring total antioxidant capacity by FRAP method, test procedure is as follows:
By specification requires configuration FRAP working fluid, hatches for 37 DEG C. Configuration 100mmol/LFeSO4 standardized solution, and it is diluted with distilled water into 0.15,0.3,0.6,0.9,1.2 and 1.5mmol/L. Take Enteromorpha Crude polysaccharides protective skin cream 0.015g obtained in above-mentioned steps (2), add 0.3mL distilled water diluting and dissolve. Each detect aperture of 96 orifice plates adds 180 and micro-rises FRAP working fluid. Blank hole adds 5 and micro-rises distilled water; Adding 5 micro-liters in typical curve detect aperture respectively, concentration is the FeSO4 standardized solution of 0.15,0.3,0.6,0.9,1.2 and 1.5mmol/L concentration, if 3 repetitions; Add 5 in sample detection hole and micro-rise Enteromorpha Crude polysaccharides protective skin cream sample, if 2 repetitions; Mixed even gently. 37 DEG C hatch 3-5 minute after record standardized solution and Enteromorpha Crude polysaccharides protective skin cream mean OD value at 595nm place, obtain typical curve: y=1.221x+0.042, specifically as shown in Figure 1.
The absorbancy calculating 1mmol/LFeSO4 standardized solution according to typical curve is 1.263, Enteromorpha Crude polysaccharides protective skin cream is at 595nm place mean OD value 0.762, total antioxidant capacity is: (0.762/1.263) mM/0.015g=40.22mM/g, and the more big resistance of oxidation of this numerical value is more strong.
B, moisturizing and anti-ageing performance test
Before test, inside experimenter's arm of cleaning, and clean clean with wet gauze (with deionized water), water temperature is room temperature, measuring mark is carried out at experimenter's both hands inner forearm after cleaning, each test zone interval 1cm, often test region in place's is 4cm*4cm, within before recipient site 2-3 days, can not use any cosmetic product; Experimenter sits quietly after 30min in room temperature environment, use electric capacity method moisture of skin determinator (SG-5D) to measure the moisture value in each region, measure skin collagen fibre content and elasticity indexes with 2,000,000 pixel CCD50X portable high-definition intelligent skin detection instrument (EH-800U). Evenly being applied in by test products in arm test site afterwards, carry out measurement and the observation in tested region after 40min, each region is replicate(determination) five times according to the order of sequence, draw mean value. Tested region METHOD FOR CONTINUOUS DETERMINATION six days, every day measures after product smears 40min and observes.
After result display uses six days continuously, moisture content increases by 63%, and specifically as shown in Figure 2, collagen fabric content increases by 126%, and specifically as shown in Figure 3, elasticity improves 239%, specifically as shown in Figure 4.
Detected result shows in the present embodiment anti-oxidant, the moisturizing of the Enteromorpha Crude polysaccharides protective skin cream of preparation and anti-ageing very capable.
Embodiment 2
(1) preparation of Enteromorpha Crude polysaccharides is with embodiment 1.
(2) preparation of protective skin cream
A, according to weighing (weight percent) of filling a prescription as follows:
Enteromorpha Crude polysaccharides: 3%;
Wetting Agent for Printing Inks: 6%(wherein, glycerine: 2%, amino acid humectant: 0.75%, propylene glycol 1.75%, butyleneglycol: 1.5%);
Sanitas: 0.05%(wherein, Phenoxyethanol: 0.03%, Sang Pu K15:0.02%);
Anti-allergic agent: 0.06%(wherein, water-soluble a-Hydagen B: 0.03%, Rizinsan K2 A2: 0.03%);
Nutritional additive: 1.25%(wherein, collagen protein powder: 0.5%, ceramide: 0.5%, snail mucus extract: 0.25%);
Oiliness raw material: 7%(wherein, jojoba oil: 5%, IPM:2%);
Thickening material: 1.5%(wherein, high molecular cellulose: 0.75%, xanthan gum: 0.75%);
Lavender essence oil: 0.7%;
Essence emulsifier: 1%;
Surplus is deionized water.
B, joining Enteromorpha Crude polysaccharides in deionized water constantly to stir and make it swelling, and then add glycerine, wherein, the weight ratio of Enteromorpha Crude polysaccharides and glycerine is 5:3, is heated to 70 DEG C of dissolvings; Both, 70 DEG C of heating for dissolving, are then mixed, add essence emulsifier by oiliness raw material, and homogenizing emulsifying is stirred; Emulsion is cooled to 50-60 DEG C, stirs 3 minutes after adding wetting Agent for Printing Inks, antioxidant, sanitas, anti-allergic agent, nutritional additive; Emulsion is cooled to 40-45 DEG C, adds viscosity increaser, lavender essence oil.
(3) detected result
A, total antioxidation testing method are with embodiment 1, and total antioxidant capacity is 41.05mM/g.
B, moisturizing and anti-ageing performance test methods with embodiment 1,
After result display uses six days continuously, moisture content increases by 74%, and collagen fabric content increases by 124%, and elasticity improves 237%.
Described on end, according to detected result display, anti-oxidant, the moisturizing of Enteromorpha Crude polysaccharides protective skin cream of preparation in the present invention and anti-ageing very capable is that a kind of price is cheap, the significant skin care product of cosmetic result.
The above better embodiment being the present invention, but the present invention should not be confined to the content disclosed in this embodiment. The equivalence completed under not departing from spirit disclosed in this invention so every or amendment, all fall into the scope of protection of the invention.
Claims (5)
1. an Enteromorpha Crude polysaccharides protective skin cream, it is characterised in that, comprise the raw material of following weight percent number meter:
Enteromorpha Crude polysaccharides 2.5-5%, wetting Agent for Printing Inks 4-6%, sanitas 0.05-0.1%, nutritional additive 0.5-1.5%, oiliness raw material 5-7.5%, thickening material 1-2%, anti-allergic agent 0.05-0.1%, freshener 0.5-1%, solubilizing agent 0.5-1.5%, surplus is deionized water;
Described wetting Agent for Printing Inks is glycerine, amino acid humectant, propylene glycol, butyleneglycol is the mixture of 2-4:1:2-4:2-4 mixing according to weight ratio;
Described sanitas is that Phenoxyethanol and Sang Pu K15 are according to the mixture that weight ratio is 1-2:1 mixing;
Described anti-allergic agent is that water-soluble ��-Hydagen B and Rizinsan K2 A2 are according to the mixture that weight ratio is 1-2:1 mixing;
Described nutritional additive is that collagen protein powder, ceramide and snail mucus extract are according to the mixture that weight ratio is 1-2:1-2:1 mixing.
2. Enteromorpha Crude polysaccharides protective skin cream according to claim 1, it is characterised in that: described Enteromorpha Crude polysaccharides is prepared by the following method,
Enteromorpha is immersed in the ethanol that mass concentration is 90%-95% 12-24 hour, filters, dry; The Enteromorpha dried and distilled water are soaked 2-4 hour according to the proportioning of 1g:25-45mL, smash to pieces rear 95 DEG C thermostatically heating 10-20 minute, cooling, filters and gets filtrate, and after filtrate heating is concentrated, supernatant liquor is got in centrifugation; Filtering after ethanol alcohol precipitation 24-28h, taking precipitate freeze-drying, obtains Enteromorpha Crude polysaccharides.
3. Enteromorpha Crude polysaccharides protective skin cream according to claim 1, it is characterised in that: described oiliness raw material is one or both the mixture in jojoba oil or Isopropyl myristate.
4. Enteromorpha Crude polysaccharides protective skin cream according to claim 1, it is characterised in that: described thickening material is one or both mixture of high molecular cellulose or xanthan gum; Described solubilizing agent is essence emulsifier.
5. Enteromorpha Crude polysaccharides protective skin cream according to claim 1, it is characterised in that: described freshener is lemon quintessence oil, Flos Rosae Rugosae quintessence oil, lavender essence oil, Fructus Citri Sarcodactylis essence oil, rosemary ethereal oil, the mixture of one or more in Geranium Essential.
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| CN109044942A (en) * | 2018-08-27 | 2018-12-21 | 项佳红 | A kind of multiple plant skin care item and preparation method thereof for moisturizing |
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| CN103044570A (en) * | 2013-01-25 | 2013-04-17 | 福建海兴保健食品有限公司 | Extracting process for efficiently extracting polysaccharide of enteromorpha |
| CN103396499A (en) * | 2013-08-14 | 2013-11-20 | 上海海洋大学 | Enteromorpha prolifera polysaccharide, and extraction method and application thereof |
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| CN103044570A (en) * | 2013-01-25 | 2013-04-17 | 福建海兴保健食品有限公司 | Extracting process for efficiently extracting polysaccharide of enteromorpha |
| CN103396499A (en) * | 2013-08-14 | 2013-11-20 | 上海海洋大学 | Enteromorpha prolifera polysaccharide, and extraction method and application thereof |
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Effective date of registration: 20220609 Address after: 201318 4 building, 1 Lane 99, Shen Mei Road, Pudong New Area, Shanghai, 4 Patentee after: SHANGHAI SONGHAO BIOTECHNOLOGY Co.,Ltd. Address before: 201306, No. 999, Huan Cheng Road, Pudong New Area, Shanghai Patentee before: SHANGHAI OCEAN University |